Homo sapiens

102 known processes

PTPN22

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

(Aliases: LYP1,PEP,LYP2,LYP,PTPN8)

PTPN22 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 3 0.984
positive regulation of alpha beta t cell proliferation GO:0046641 5 0.966
t cell selection GO:0045058 4 0.799
mononuclear cell proliferation GO:0032943 71 0.710
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.677
positive thymic t cell selection GO:0045059 1 0.668
biological adhesion GO:0022610 331 0.619
activation of immune response GO:0002253 114 0.605
cell adhesion GO:0007155 325 0.604
immune response GO:0006955 307 0.600
Mouse
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.596
single organism cell adhesion GO:0098602 179 0.542
immune response activating signal transduction GO:0002757 90 0.510
positive regulation of immune system process GO:0002684 283 0.508
regulation of lymphocyte activation GO:0051249 103 0.503
positive regulation of immune response GO:0050778 159 0.499
cell activation GO:0001775 213 0.442
antigen receptor mediated signaling pathway GO:0050851 38 0.434
regulation of mononuclear cell proliferation GO:0032944 65 0.428
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.426
leukocyte activation GO:0045321 164 0.404
regulation of leukocyte proliferation GO:0070663 67 0.403
ras protein signal transduction GO:0007265 73 0.374
regulation of t cell receptor signaling pathway GO:0050856 7 0.372
peptidyl tyrosine modification GO:0018212 170 0.353
small gtpase mediated signal transduction GO:0007264 78 0.336
regulation of cellular amino acid metabolic process GO:0006521 6 0.312
t cell receptor signaling pathway GO:0050852 21 0.293
cellular amino acid metabolic process GO:0006520 116 0.285
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.276
alpha beta t cell proliferation GO:0046633 5 0.268
regulation of leukocyte activation GO:0002694 115 0.267
regulation of antigen receptor mediated signaling pathway GO:0050854 10 0.258
regulation of calcium mediated signaling GO:0050848 17 0.257
regulation of immune response GO:0050776 201 0.251
amine metabolic process GO:0009308 44 0.249
leukocyte migration GO:0050900 107 0.248
melanin metabolic process GO:0006582 1 0.247
positive regulation of leukocyte activation GO:0002696 80 0.216
positive regulation of alpha beta t cell differentiation GO:0046638 4 0.207
t cell activation GO:0042110 99 0.203
positive regulation of developmental process GO:0051094 314 0.201
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.194
glycosyl compound catabolic process GO:1901658 413 0.187
immune response regulating signaling pathway GO:0002764 97 0.186
regulation of cellular amine metabolic process GO:0033238 11 0.181
purine nucleoside catabolic process GO:0006152 398 0.172
thymic t cell selection GO:0045061 2 0.171
regulation of cell activation GO:0050865 125 0.161
negative regulation of cellular amine metabolic process GO:0033239 3 0.153
positive regulation of alpha beta t cell activation GO:0046635 10 0.147
epithelial cell migration GO:0010631 119 0.138
positive regulation of cell migration GO:0030335 172 0.131
enzyme linked receptor protein signaling pathway GO:0007167 303 0.126
regulation of anatomical structure morphogenesis GO:0022603 286 0.124
regulation of t cell proliferation GO:0042129 42 0.119
vesicle mediated transport GO:0016192 371 0.118
positive regulation of lymphocyte differentiation GO:0045621 13 0.117
lymphocyte proliferation GO:0046651 70 0.116
peptidyl tyrosine dephosphorylation GO:0035335 36 0.116
dephosphorylation GO:0016311 209 0.114
nucleoside triphosphate metabolic process GO:0009141 422 0.114
calcium mediated signaling GO:0019722 44 0.113
regulation of t cell activation GO:0050863 77 0.112
response to organonitrogen compound GO:0010243 156 0.112
single organismal cell cell adhesion GO:0016337 148 0.111
regulation of ras protein signal transduction GO:0046578 155 0.111
cell development GO:0048468 328 0.109
cytoplasmic transport GO:0016482 379 0.107
regulation of cellular component movement GO:0051270 334 0.107
regulation of alpha beta t cell differentiation GO:0046637 5 0.106
regulation of cell differentiation GO:0045595 393 0.106
response to external biotic stimulus GO:0043207 261 0.104
innate immune response GO:0045087 178 0.103
purine nucleotide catabolic process GO:0006195 405 0.101
defense response GO:0006952 315 0.098
cell chemotaxis GO:0060326 112 0.097
positive regulation of calcium mediated signaling GO:0050850 10 0.096
regulation of epithelial cell migration GO:0010632 93 0.096
positive regulation of lymphocyte proliferation GO:0050671 46 0.095
cellular component morphogenesis GO:0032989 314 0.095
regulation of alpha beta t cell proliferation GO:0046640 5 0.093
positive regulation of cell activation GO:0050867 81 0.092
rho protein signal transduction GO:0007266 26 0.092
muscle system process GO:0003012 81 0.089
purine nucleoside triphosphate catabolic process GO:0009146 392 0.089
regulation of lymphocyte proliferation GO:0050670 64 0.089
mapk cascade GO:0000165 288 0.089
response to wounding GO:0009611 168 0.088
positive regulation of rac gtpase activity GO:0032855 31 0.088
positive regulation of catabolic process GO:0009896 310 0.085
nucleotide catabolic process GO:0009166 408 0.085
regulation of nucleotide metabolic process GO:0006140 269 0.084
regulation of cell migration involved in sprouting angiogenesis GO:0090049 9 0.083
positive regulation of leukocyte differentiation GO:1902107 37 0.082
nucleoside catabolic process GO:0009164 408 0.081
purine ribonucleoside metabolic process GO:0046128 437 0.080
protein localization to organelle GO:0033365 280 0.080
positive regulation of kinase activity GO:0033674 204 0.079
mitotic cell cycle process GO:1903047 286 0.078
regulation of nucleoside metabolic process GO:0009118 209 0.078
ribonucleoside catabolic process GO:0042454 406 0.077
positive regulation of cell differentiation GO:0045597 211 0.077
cellular ketone metabolic process GO:0042180 80 0.076
cell morphogenesis GO:0000902 296 0.076
negative regulation of phosphorus metabolic process GO:0010563 267 0.075
leukocyte chemotaxis GO:0030595 76 0.075
positive regulation of cellular catabolic process GO:0031331 284 0.073
stem cell development GO:0048864 69 0.072
positive regulation of cytokine mediated signaling pathway GO:0001961 12 0.072
regulation of cell cycle GO:0051726 393 0.070
purine containing compound catabolic process GO:0072523 411 0.070
anatomical structure formation involved in morphogenesis GO:0048646 284 0.070
nervous system development GO:0007399 293 0.069
positive regulation of cell proliferation GO:0008284 301 0.068
metal ion transport GO:0030001 272 0.068
positive regulation of hydrolase activity GO:0051345 331 0.067
cytokine production GO:0001816 247 0.067
regulation of cell adhesion GO:0030155 166 0.067
regulation of protein serine threonine kinase activity GO:0071900 179 0.067
negative regulation of t cell receptor signaling pathway GO:0050860 4 0.067
chemotaxis GO:0006935 157 0.066
regulation of tolerance induction GO:0002643 4 0.066
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.065
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.065
positive regulation of cell adhesion GO:0045785 84 0.065
response to biotic stimulus GO:0009607 276 0.064
circulatory system development GO:0072359 262 0.064
positive regulation of b cell proliferation GO:0030890 12 0.064
ribonucleoside triphosphate metabolic process GO:0009199 412 0.064
positive regulation of lymphocyte activation GO:0051251 73 0.063
organophosphate catabolic process GO:0046434 430 0.063
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.062
endothelial cell migration GO:0043542 86 0.061
generation of neurons GO:0048699 152 0.061
interferon gamma production GO:0032609 39 0.061
epithelium migration GO:0090132 119 0.061
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.060
positive regulation of gtpase activity GO:0043547 166 0.060
regulation of cell motility GO:2000145 299 0.060
regulation of endothelial cell migration GO:0010594 67 0.060
nucleoside triphosphate catabolic process GO:0009143 394 0.058
maintenance of cell polarity GO:0030011 2 0.058
cell projection organization GO:0030030 252 0.056
cell cycle phase transition GO:0044770 173 0.056
t cell differentiation in thymus GO:0033077 4 0.055
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathway GO:0035625 4 0.055
positive regulation of gliogenesis GO:0014015 4 0.055
cellular response to dna damage stimulus GO:0006974 379 0.052
purine nucleoside triphosphate metabolic process GO:0009144 412 0.052
nucleocytoplasmic transport GO:0006913 176 0.052
nuclear transport GO:0051169 179 0.052
reactive oxygen species metabolic process GO:0072593 75 0.051
hemopoiesis GO:0030097 180 0.051
Mouse
negative regulation of catalytic activity GO:0043086 335 0.051
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.051
stress activated mapk cascade GO:0051403 93 0.050
negative regulation of phosphate metabolic process GO:0045936 267 0.050
post embryonic development GO:0009791 2 0.049
hematopoietic or lymphoid organ development GO:0048534 186 0.049
Mouse
neuron projection development GO:0031175 106 0.048
determination of adult lifespan GO:0008340 2 0.047
positive regulation of cellular amine metabolic process GO:0033240 7 0.047
multicellular organismal aging GO:0010259 3 0.047
spermatid development GO:0007286 4 0.047
neuron development GO:0048666 113 0.047
mitotic cell cycle phase transition GO:0044772 162 0.046
actin filament based process GO:0030029 224 0.046
regulation of t cell tolerance induction GO:0002664 4 0.046
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.046
regulation of reactive oxygen species metabolic process GO:2000377 41 0.045
neurogenesis GO:0022008 169 0.045
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.045
taxis GO:0042330 157 0.044
t cell differentiation GO:0030217 29 0.044
Mouse
ribonucleoside triphosphate catabolic process GO:0009203 391 0.044
muscle contraction GO:0006936 73 0.044
positive regulation of transport GO:0051050 336 0.044
regulation of cellular component biogenesis GO:0044087 281 0.044
regulation of cell cycle process GO:0010564 266 0.043
regulation of small gtpase mediated signal transduction GO:0051056 156 0.043
signal transduction by phosphorylation GO:0023014 297 0.043
regeneration GO:0031099 4 0.043
cardiovascular system development GO:0072358 262 0.043
response to other organism GO:0051707 261 0.043
regulation of cell migration GO:0030334 289 0.042
maintenance of location GO:0051235 112 0.042
positive regulation of nucleoside metabolic process GO:0045979 186 0.042
neutrophil migration GO:1990266 25 0.042
regulation of blood coagulation GO:0030193 42 0.042
jnk cascade GO:0007254 80 0.041
second messenger mediated signaling GO:0019932 78 0.041
lymphocyte differentiation GO:0030098 35 0.040
Mouse
positive regulation of mononuclear cell proliferation GO:0032946 47 0.040
protein dephosphorylation GO:0006470 81 0.039
morphogenesis of embryonic epithelium GO:0016331 4 0.039
secretion by cell GO:0032940 226 0.039
cellular lipid metabolic process GO:0044255 303 0.038
peptide transport GO:0015833 74 0.038
positive regulation of locomotion GO:0040017 186 0.038
cell projection morphogenesis GO:0048858 129 0.038
regulation of gtp catabolic process GO:0033124 180 0.038
organ morphogenesis GO:0009887 147 0.038
lymphocyte activation GO:0046649 133 0.037
regulation of body fluid levels GO:0050878 99 0.037
neuron differentiation GO:0030182 138 0.037
positive regulation of cytokine secretion GO:0050715 42 0.037
regulation of cell adhesion mediated by integrin GO:0033628 22 0.036
secondary metabolic process GO:0019748 17 0.036
positive regulation of leukocyte proliferation GO:0070665 48 0.036
ribonucleotide catabolic process GO:0009261 405 0.036
response to radiation GO:0009314 151 0.036
protein localization to nucleus GO:0034504 136 0.036
purine ribonucleotide catabolic process GO:0009154 404 0.035
positive regulation of cellular component organization GO:0051130 376 0.035
neuromuscular junction development GO:0007528 3 0.035
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.035
response to abiotic stimulus GO:0009628 336 0.035
leukocyte cell cell adhesion GO:0007159 37 0.034
positive regulation of tolerance induction GO:0002645 2 0.034
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.034
response to virus GO:0009615 126 0.034
regulation of hormone levels GO:0010817 125 0.034
immune system development GO:0002520 195 0.034
Mouse
g protein coupled receptor signaling pathway GO:0007186 207 0.034
cellular response to organonitrogen compound GO:0071417 124 0.033
ameboidal type cell migration GO:0001667 135 0.033
cation transport GO:0006812 331 0.033
response to drug GO:0042493 81 0.033
regulation of secretion GO:0051046 194 0.033
cell cell signaling GO:0007267 155 0.033
cell morphogenesis involved in differentiation GO:0000904 144 0.033
regulation of b cell receptor signaling pathway GO:0050855 4 0.033
guanosine containing compound catabolic process GO:1901069 239 0.033
regulation of t cell differentiation GO:0045580 19 0.032
guanosine containing compound metabolic process GO:1901068 244 0.032
regulation of alpha beta t cell activation GO:0046634 13 0.032
positive regulation of cellular component movement GO:0051272 181 0.032
organic hydroxy compound metabolic process GO:1901615 147 0.032
organonitrogen compound biosynthetic process GO:1901566 200 0.032
positive regulation of interferon gamma production GO:0032729 26 0.032
endocytosis GO:0006897 159 0.031
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.031
cellular response to nitrogen compound GO:1901699 144 0.031
spermatid differentiation GO:0048515 4 0.031
blood vessel endothelial cell migration GO:0043534 42 0.031
positive regulation of secretion by cell GO:1903532 108 0.031
plasma membrane organization GO:0007009 115 0.030
positive regulation of antigen receptor mediated signaling pathway GO:0050857 3 0.030
tissue migration GO:0090130 119 0.030
purine ribonucleoside catabolic process GO:0046130 398 0.030
toll like receptor 2 signaling pathway GO:0034134 4 0.030
b cell activation GO:0042113 33 0.030
regulation of proteolysis GO:0030162 293 0.030
regulation of purine nucleotide catabolic process GO:0033121 205 0.030
regulation of nucleotide catabolic process GO:0030811 205 0.030
blood vessel development GO:0001568 172 0.029
positive regulation of cell development GO:0010720 92 0.029
regulation of cellular ketone metabolic process GO:0010565 50 0.029
membrane protein proteolysis GO:0033619 38 0.029
positive regulation of secretion GO:0051047 116 0.029
negative regulation of intracellular signal transduction GO:1902532 183 0.029
cell matrix adhesion GO:0007160 85 0.029
stress activated protein kinase signaling cascade GO:0031098 94 0.028
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.028
positive regulation of protein kinase b signaling GO:0051897 42 0.028
positive regulation of nucleotide metabolic process GO:0045981 230 0.028
regulation of purine nucleotide metabolic process GO:1900542 264 0.028
gtp catabolic process GO:0006184 237 0.028
cell part morphogenesis GO:0032990 137 0.028
regulation of ras gtpase activity GO:0032318 128 0.028
intracellular protein transport GO:0006886 270 0.028
regulation of b cell proliferation GO:0030888 18 0.027
blood vessel morphogenesis GO:0048514 162 0.027
regulation of b cell activation GO:0050864 24 0.027
regulation of response to wounding GO:1903034 101 0.027
positive regulation of endothelial cell migration GO:0010595 39 0.027
motor neuron axon guidance GO:0008045 2 0.027
cellular amine metabolic process GO:0044106 41 0.027
protein maturation GO:0051604 233 0.027
positive regulation of lipid kinase activity GO:0090218 13 0.027
protein targeting GO:0006605 187 0.027
actin filament organization GO:0007015 128 0.027
positive regulation of phosphorylation GO:0042327 394 0.027
gtp metabolic process GO:0046039 239 0.027
regulation of protein localization GO:0032880 296 0.026
cell migration involved in sprouting angiogenesis GO:0002042 19 0.026
leukocyte proliferation GO:0070661 74 0.026
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.026
negative regulation of calcium mediated signaling GO:0050849 4 0.026
protein autophosphorylation GO:0046777 123 0.026
regulation of uterine smooth muscle contraction GO:0070472 1 0.026
leukocyte apoptotic process GO:0071887 31 0.026
cellular response to growth factor stimulus GO:0071363 197 0.025
regulation of gtpase activity GO:0043087 180 0.025
positive regulation of gtp catabolic process GO:0033126 166 0.025
g1 s transition of mitotic cell cycle GO:0000082 78 0.025
regulation of defense response GO:0031347 154 0.025
positive t cell selection GO:0043368 2 0.025
regulation of binding GO:0051098 111 0.025
protein import GO:0017038 130 0.025
actin cytoskeleton organization GO:0030036 207 0.025
regulation of locomotion GO:0040012 329 0.025
blood coagulation GO:0007596 76 0.025
positive regulation of nucleotide catabolic process GO:0030813 185 0.025
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.024
response to peptide GO:1901652 65 0.024
regulation of mitotic cell cycle GO:0007346 189 0.024
phosphatidylinositol mediated signaling GO:0048015 55 0.024
negative regulation of cell proliferation GO:0008285 228 0.023
regulation of secretion by cell GO:1903530 177 0.023
regulation of erk1 and erk2 cascade GO:0070372 99 0.023
negative regulation of protein metabolic process GO:0051248 391 0.023
response to nitrogen compound GO:1901698 184 0.023
regulation of map kinase activity GO:0043405 108 0.023
alpha beta t cell activation GO:0046631 15 0.022
peptidyl tyrosine phosphorylation GO:0018108 170 0.022
hematopoietic progenitor cell differentiation GO:0002244 38 0.022
cellular response to organic cyclic compound GO:0071407 127 0.022
keratinization GO:0031424 2 0.022
regulation of peptidase activity GO:0052547 180 0.022
hormone transport GO:0009914 68 0.022
cellular response to endogenous stimulus GO:0071495 336 0.022
regulation of leukocyte differentiation GO:1902105 61 0.022
multicellular organismal homeostasis GO:0048871 67 0.022
receptor transactivation GO:0035624 4 0.021
central nervous system development GO:0007417 123 0.021
smoothened signaling pathway GO:0007224 14 0.021
vasculature development GO:0001944 181 0.021
hemostasis GO:0007599 76 0.021
positive regulation of interleukin 4 production GO:0032753 3 0.021
cell type specific apoptotic process GO:0097285 125 0.021
regulation of icosanoid secretion GO:0032303 4 0.021
muscle structure development GO:0061061 98 0.021
regulation of actin filament based process GO:0032970 141 0.021
positive regulation of epithelial cell migration GO:0010634 55 0.021
integrin mediated signaling pathway GO:0007229 32 0.021
regulation of mitotic cell cycle phase transition GO:1901990 118 0.021
immune effector process GO:0002252 159 0.021
chemical homeostasis GO:0048878 306 0.020
negative regulation of protein kinase activity GO:0006469 98 0.020
b cell receptor signaling pathway GO:0050853 18 0.020
microtubule based process GO:0007017 210 0.020
semaphorin plexin signaling pathway GO:0071526 4 0.020
positive regulation of transferase activity GO:0051347 227 0.020
anterior posterior axis specification GO:0009948 2 0.020
rap protein signal transduction GO:0032486 7 0.020
female gamete generation GO:0007292 2 0.020
protein oligomerization GO:0051259 173 0.020
regulation of response to external stimulus GO:0032101 222 0.020
secretion GO:0046903 254 0.020
protein kinase b signaling GO:0043491 69 0.020
positive regulation of neuron differentiation GO:0045666 40 0.020
inflammatory response GO:0006954 79 0.020
cell cycle g1 s phase transition GO:0044843 80 0.020
lymphangiogenesis GO:0001946 7 0.020
negative regulation of transport GO:0051051 176 0.020
wound healing GO:0042060 115 0.019
negative regulation of cellular component movement GO:0051271 106 0.019
syncytium formation by plasma membrane fusion GO:0000768 2 0.019
regulation of anatomical structure size GO:0090066 101 0.019
cell division GO:0051301 168 0.019
regulation of protein kinase b signaling GO:0051896 61 0.019
divalent metal ion transport GO:0070838 152 0.019
nucleoside phosphate catabolic process GO:1901292 412 0.019
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.019
actin filament based movement GO:0030048 17 0.019
cellular macromolecule catabolic process GO:0044265 380 0.019
positive regulation of apoptotic process GO:0043065 246 0.019
t cell proliferation GO:0042098 45 0.019
cell substrate adhesion GO:0031589 132 0.019
tripartite regional subdivision GO:0007351 2 0.019
regulation of lymphocyte differentiation GO:0045619 22 0.019
regulation of cell cycle phase transition GO:1901987 126 0.018
regulation of system process GO:0044057 101 0.018
myoblast fusion GO:0007520 1 0.018
cellular protein catabolic process GO:0044257 261 0.018
single organism membrane organization GO:0044802 268 0.018
response to oxygen containing compound GO:1901700 369 0.018
g protein coupled purinergic nucleotide receptor signaling pathway GO:0035589 1 0.018
coagulation GO:0050817 78 0.018
mitotic cell cycle GO:0000278 326 0.018
oogenesis GO:0048477 2 0.018
regulation of cytoplasmic transport GO:1903649 149 0.018
myeloid leukocyte migration GO:0097529 62 0.018
striated muscle cell differentiation GO:0051146 43 0.018
t cell costimulation GO:0031295 7 0.018
cellular macromolecular complex assembly GO:0034622 324 0.018
transcription factor import into nucleus GO:0042991 40 0.018
granulocyte migration GO:0097530 40 0.018
humoral immune response GO:0006959 49 0.018
positive regulation of cytoskeleton organization GO:0051495 83 0.017
protein targeting to nucleus GO:0044744 104 0.017
regulation of cell growth GO:0001558 135 0.017
negative regulation of cell adhesion GO:0007162 64 0.017
protein import into nucleus GO:0006606 104 0.017
regulation of sequestering of calcium ion GO:0051282 41 0.017
positive regulation of t cell differentiation GO:0045582 11 0.017
peptide secretion GO:0002790 51 0.017
system process GO:0003008 349 0.017
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.017
positive regulation of apoptotic signaling pathway GO:2001235 70 0.017
regulation of cell projection organization GO:0031344 107 0.017
neuron projection morphogenesis GO:0048812 50 0.017
isotype switching GO:0045190 3 0.017
positive regulation of cytokine production GO:0001819 167 0.017
negative regulation of programmed cell death GO:0043069 321 0.017
protein modification by small protein conjugation GO:0032446 342 0.017
regulation of rho gtpase activity GO:0032319 66 0.017
negative regulation of cell cycle process GO:0010948 121 0.017
regulation of protein kinase activity GO:0045859 289 0.016
alpha beta t cell differentiation GO:0046632 7 0.016
angiogenesis GO:0001525 147 0.016
maintenance of location in cell GO:0051651 62 0.016
oocyte differentiation GO:0009994 2 0.016
regulation of endopeptidase activity GO:0052548 170 0.016
positive regulation of ras gtpase activity GO:0032320 117 0.016
lipid localization GO:0010876 106 0.016
neurological system process GO:0050877 163 0.016
negative regulation of cell cycle GO:0045786 193 0.016
memory GO:0007613 3 0.016
nuclear import GO:0051170 106 0.016
behavior GO:0007610 112 0.015
establishment of protein localization to organelle GO:0072594 172 0.015
epithelial cell proliferation GO:0050673 128 0.015
regulation of glial cell differentiation GO:0045685 3 0.015
regulation of postsynaptic membrane potential GO:0060078 1 0.015
positive regulation of proteolysis GO:0045862 142 0.015
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.015
positive regulation of b cell activation GO:0050871 17 0.015
multicellular organismal response to stress GO:0033555 1 0.015
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.015
cellular response to oxygen containing compound GO:1901701 276 0.015
regulation of ion transport GO:0043269 189 0.015
regulation of muscle system process GO:0090257 53 0.015
hormone secretion GO:0046879 65 0.015
inner ear morphogenesis GO:0042472 4 0.015
single organism cellular localization GO:1902580 332 0.015
negative regulation of cellular protein metabolic process GO:0032269 353 0.015
epidermis morphogenesis GO:0048730 3 0.015
reproductive process GO:0022414 106 0.015
positive regulation of organelle organization GO:0010638 195 0.015
growth GO:0040007 202 0.014
regulation of peptide hormone secretion GO:0090276 41 0.014
cellular response to ammonium ion GO:0071242 4 0.014
regulation of cysteine type endopeptidase activity GO:2000116 127 0.014
zymogen activation GO:0031638 70 0.014
regulation of synaptic plasticity GO:0048167 3 0.014
regulation of kinase activity GO:0043549 314 0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.014
sequestering of metal ion GO:0051238 24 0.014
cytokine biosynthetic process GO:0042089 37 0.014
sprouting angiogenesis GO:0002040 29 0.014
positive regulation of interleukin 2 biosynthetic process GO:0045086 5 0.014
protein catabolic process GO:0030163 325 0.014
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.014
regulation of cellular response to stress GO:0080135 244 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.014
apoptotic signaling pathway GO:0097190 268 0.014
oxidation reduction process GO:0055114 396 0.014
hindbrain development GO:0030902 3 0.014
positive regulation of cellular component biogenesis GO:0044089 158 0.014
negative regulation of developmental process GO:0051093 247 0.014
embryonic organ morphogenesis GO:0048562 24 0.014
negative regulation of mitotic cell cycle GO:0045930 102 0.014
carbohydrate metabolic process GO:0005975 207 0.013
calcium ion transport GO:0006816 147 0.013
regulation of transferase activity GO:0051338 355 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
actin mediated cell contraction GO:0070252 12 0.013
positive regulation of cell death GO:0010942 263 0.013
negative regulation of secretion by cell GO:1903531 52 0.013
myotube differentiation GO:0014902 22 0.013
cellular chemical homeostasis GO:0055082 180 0.013
brain development GO:0007420 97 0.013
protein processing GO:0016485 226 0.013
erk1 and erk2 cascade GO:0070371 104 0.013
regulation of cellular response to growth factor stimulus GO:0090287 76 0.013
actin filament polymerization GO:0030041 45 0.013
hair follicle morphogenesis GO:0031069 2 0.013
regulation of protein complex assembly GO:0043254 147 0.013
segmentation GO:0035282 4 0.013
carbohydrate derivative biosynthetic process GO:1901137 207 0.013
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.013
cellular protein complex assembly GO:0043623 188 0.013
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.013
cell growth GO:0016049 160 0.013
tissue regeneration GO:0042246 3 0.013
endosomal transport GO:0016197 129 0.013
cytokinesis GO:0000910 96 0.013
regulation of rho protein signal transduction GO:0035023 79 0.013

PTPN22 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.034
Human
immune system disease DOID:2914 155 0.025
hematopoietic system disease DOID:74 100 0.025
cancer DOID:162 167 0.013
Human