Homo sapiens

84 known processes

APEX1

APEX nuclease (multifunctional DNA repair enzyme) 1

(Aliases: APE1,APX,HAP1,APEX,REF1,APEN,APE)

APEX1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oogenesis GO:0048477 2 0.855
ribonucleoside monophosphate metabolic process GO:0009161 187 0.609
nucleoside monophosphate metabolic process GO:0009123 191 0.588
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.569
purine ribonucleoside metabolic process GO:0046128 437 0.481
negative regulation of apoptotic process GO:0043066 316 0.459
Zebrafish
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.441
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.428
atp metabolic process GO:0046034 176 0.387
ribonucleoside monophosphate catabolic process GO:0009158 158 0.372
determination of adult lifespan GO:0008340 2 0.357
apoptotic signaling pathway GO:0097190 268 0.357
base excision repair GO:0006284 21 0.342
Worm
gmp metabolic process GO:0046037 4 0.335
cellular response to cytokine stimulus GO:0071345 181 0.304
female gamete generation GO:0007292 2 0.289
positive regulation of developmental process GO:0051094 314 0.273
purine nucleoside triphosphate metabolic process GO:0009144 412 0.273
positive regulation of apoptotic process GO:0043065 246 0.265
cellular macromolecular complex assembly GO:0034622 324 0.250
nucleoside triphosphate catabolic process GO:0009143 394 0.238
ribose phosphate biosynthetic process GO:0046390 82 0.231
response to cytokine GO:0034097 232 0.227
atp catabolic process GO:0006200 157 0.205
covalent chromatin modification GO:0016569 254 0.199
purine nucleoside monophosphate catabolic process GO:0009128 158 0.174
dna packaging GO:0006323 77 0.166
ribonucleoside triphosphate catabolic process GO:0009203 391 0.159
cytoplasmic transport GO:0016482 379 0.158
regulation of atp metabolic process GO:1903578 29 0.157
purine nucleoside monophosphate metabolic process GO:0009126 186 0.157
cellular amino acid metabolic process GO:0006520 116 0.146
nervous system development GO:0007399 293 0.142
ribonucleoside triphosphate metabolic process GO:0009199 412 0.139
mrna metabolic process GO:0016071 175 0.135
negative regulation of programmed cell death GO:0043069 321 0.135
Zebrafish
translation GO:0006412 132 0.135
regulation of cellular response to stress GO:0080135 244 0.132
negative regulation of cell death GO:0060548 345 0.131
Zebrafish
dna conformation change GO:0071103 113 0.127
nucleoside triphosphate metabolic process GO:0009141 422 0.127
negative regulation of atpase activity GO:0032780 5 0.125
histone modification GO:0016570 251 0.120
dna repair GO:0006281 198 0.118
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.111
purine nucleoside triphosphate catabolic process GO:0009146 392 0.110
post embryonic development GO:0009791 2 0.108
Worm
regulation of oxidative phosphorylation GO:0002082 3 0.108
positive regulation of immune system process GO:0002684 283 0.107
regulation of dna binding GO:0051101 37 0.106
purine containing compound catabolic process GO:0072523 411 0.103
protein dna complex assembly GO:0065004 64 0.101
neuron differentiation GO:0030182 138 0.099
cellular amine metabolic process GO:0044106 41 0.094
cation homeostasis GO:0055080 189 0.086
organophosphate catabolic process GO:0046434 430 0.085
negative regulation of cell cycle GO:0045786 193 0.085
chromatin organization GO:0006325 351 0.083
guanosine containing compound metabolic process GO:1901068 244 0.081
hematopoietic or lymphoid organ development GO:0048534 186 0.073
purine containing compound biosynthetic process GO:0072522 88 0.073
regulation of feeding behavior GO:0060259 3 0.071
purine ribonucleoside catabolic process GO:0046130 398 0.068
protein dna complex subunit organization GO:0071824 80 0.067
cellular response to dna damage stimulus GO:0006974 379 0.066
nucleoside monophosphate catabolic process GO:0009125 159 0.066
growth GO:0040007 202 0.065
immune system development GO:0002520 195 0.065
transmembrane transport GO:0055085 399 0.064
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.063
regulation of nucleoside metabolic process GO:0009118 209 0.063
nucleotide biosynthetic process GO:0009165 109 0.063
multi organism cellular process GO:0044764 156 0.063
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.063
regulation of binding GO:0051098 111 0.061
positive regulation of cellular amine metabolic process GO:0033240 7 0.061
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.060
rrna modification GO:0000154 2 0.058
nucleoside catabolic process GO:0009164 408 0.057
cell type specific apoptotic process GO:0097285 125 0.057
nucleosome assembly GO:0006334 50 0.056
single organism reproductive process GO:0044702 98 0.056
positive regulation of defense response GO:0031349 87 0.055
regulation of growth GO:0040008 165 0.055
hemopoiesis GO:0030097 180 0.053
response to other organism GO:0051707 261 0.053
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.052
response to abiotic stimulus GO:0009628 336 0.052
nucleotide catabolic process GO:0009166 408 0.050
columnar cuboidal epithelial cell differentiation GO:0002065 14 0.049
response to virus GO:0009615 126 0.048
chromatin modification GO:0016568 298 0.046
nucleoside phosphate biosynthetic process GO:1901293 109 0.046
gland development GO:0048732 48 0.046
defense response GO:0006952 315 0.045
glycosyl compound catabolic process GO:1901658 413 0.045
multicellular organismal aging GO:0010259 3 0.045
cellular cation homeostasis GO:0030003 163 0.045
cell growth GO:0016049 160 0.043
regulation of epithelial cell proliferation GO:0050678 113 0.043
positive regulation of protein transport GO:0051222 135 0.042
cell morphogenesis GO:0000902 296 0.042
mitochondrial membrane organization GO:0007006 40 0.042
reproductive system development GO:0061458 56 0.041
nucleoside phosphate catabolic process GO:1901292 412 0.041
response to oxygen containing compound GO:1901700 369 0.041
organonitrogen compound biosynthetic process GO:1901566 200 0.040
purine nucleotide biosynthetic process GO:0006164 84 0.040
protein maturation GO:0051604 233 0.039
protein tetramerization GO:0051262 47 0.039
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.039
regulation of cell differentiation GO:0045595 393 0.039
regulation of nucleotide metabolic process GO:0006140 269 0.039
embryo development GO:0009790 123 0.039
Zebrafish Worm
chemotaxis GO:0006935 157 0.038
purine ribonucleotide biosynthetic process GO:0009152 79 0.038
negative regulation of cell proliferation GO:0008285 228 0.038
double strand break repair GO:0006302 101 0.038
trna metabolic process GO:0006399 35 0.038
purine nucleoside catabolic process GO:0006152 398 0.038
system process GO:0003008 349 0.037
Zebrafish
negative regulation of cellular catabolic process GO:0031330 83 0.037
circulatory system development GO:0072359 262 0.037
Zebrafish
carbohydrate derivative biosynthetic process GO:1901137 207 0.036
secretion by cell GO:0032940 226 0.036
mitotic nuclear division GO:0007067 119 0.036
meiotic chromosome segregation GO:0045132 4 0.036
dna replication GO:0006260 116 0.035
negative regulation of catabolic process GO:0009895 104 0.035
generation of neurons GO:0048699 152 0.034
peptidyl serine phosphorylation GO:0018105 101 0.034
purine nucleotide catabolic process GO:0006195 405 0.034
cytokine production GO:0001816 247 0.034
mitochondrion organization GO:0007005 156 0.033
ribonucleoprotein complex biogenesis GO:0022613 116 0.033
positive regulation of cell differentiation GO:0045597 211 0.032
viral process GO:0016032 146 0.032
regulation of cellular amino acid metabolic process GO:0006521 6 0.032
negative regulation of protein metabolic process GO:0051248 391 0.031
regulation of purine nucleotide metabolic process GO:1900542 264 0.030
negative regulation of cell growth GO:0030308 83 0.030
positive regulation of transport GO:0051050 336 0.030
ion homeostasis GO:0050801 230 0.030
regulation of behavior GO:0050795 82 0.030
regulation of intracellular transport GO:0032386 195 0.029
negative regulation of apoptotic signaling pathway GO:2001234 97 0.029
histone arginine methylation GO:0034969 6 0.029
chromatin assembly GO:0031497 61 0.029
regulation of nuclease activity GO:0032069 11 0.028
cellular component morphogenesis GO:0032989 314 0.028
ribonucleoprotein complex subunit organization GO:0071826 81 0.028
negative regulation of cell cycle process GO:0010948 121 0.028
protein processing GO:0016485 226 0.027
behavior GO:0007610 112 0.027
purine ribonucleotide catabolic process GO:0009154 404 0.027
mitotic cell cycle GO:0000278 326 0.026
translational initiation GO:0006413 48 0.026
epithelial cell proliferation GO:0050673 128 0.026
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.026
rna processing GO:0006396 255 0.026
cell development GO:0048468 328 0.026
developmental process involved in reproduction GO:0003006 66 0.025
amine metabolic process GO:0009308 44 0.025
cellular ketone metabolic process GO:0042180 80 0.024
immune effector process GO:0002252 159 0.024
ribonucleoside catabolic process GO:0042454 406 0.024
response to lipid GO:0033993 206 0.024
membrane organization GO:0061024 292 0.024
regulation of multi organism process GO:0043900 157 0.024
viral life cycle GO:0019058 132 0.024
cellular macromolecule catabolic process GO:0044265 380 0.024
sex differentiation GO:0007548 45 0.024
regulation of cellular ketone metabolic process GO:0010565 50 0.023
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.023
cellular homeostasis GO:0019725 196 0.023
Mouse
positive regulation of programmed cell death GO:0043068 249 0.023
protein localization to membrane GO:0072657 160 0.023
negative regulation of cellular component organization GO:0051129 235 0.023
single organism membrane organization GO:0044802 268 0.023
cell activation GO:0001775 213 0.023
cell part morphogenesis GO:0032990 137 0.022
regulation of protein maturation GO:1903317 150 0.022
cellular chemical homeostasis GO:0055082 180 0.022
nuclear transport GO:0051169 179 0.022
nucleosome organization GO:0034728 66 0.022
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.021
cell projection organization GO:0030030 252 0.021
positive regulation of immune response GO:0050778 159 0.021
intracellular protein transport GO:0006886 270 0.021
negative regulation of cell cycle phase transition GO:1901988 89 0.021
mitotic cell cycle phase transition GO:0044772 162 0.021
negative regulation of catalytic activity GO:0043086 335 0.021
establishment of protein localization to membrane GO:0090150 121 0.020
negative regulation of developmental process GO:0051093 247 0.020
embryonic eye morphogenesis GO:0048048 2 0.020
response to external biotic stimulus GO:0043207 261 0.020
positive regulation of cellular component organization GO:0051130 376 0.020
neurological system process GO:0050877 163 0.020
response to inorganic substance GO:0010035 127 0.020
leukocyte proliferation GO:0070661 74 0.020
response to drug GO:0042493 81 0.020
secretion GO:0046903 254 0.020
cellular calcium ion homeostasis GO:0006874 117 0.019
regulation of cell growth GO:0001558 135 0.019
regulation of protein transport GO:0051223 213 0.019
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
negative regulation of protein modification process GO:0031400 200 0.019
dna catabolic process GO:0006308 49 0.018
regulation of transferase activity GO:0051338 355 0.018
histone exchange GO:0043486 3 0.018
regulation of proteolysis GO:0030162 293 0.018
response to acid chemical GO:0001101 66 0.018
response to biotic stimulus GO:0009607 276 0.018
regulation of apoptotic signaling pathway GO:2001233 175 0.018
response to transforming growth factor beta GO:0071559 94 0.018
positive regulation of proteolysis GO:0045862 142 0.018
regulation of mitochondrion organization GO:0010821 54 0.018
negative regulation of mitotic cell cycle GO:0045930 102 0.018
cation transmembrane transport GO:0098655 238 0.018
osteoblast differentiation GO:0001649 92 0.017
developmental programmed cell death GO:0010623 3 0.017
rna splicing GO:0008380 131 0.017
mammary gland development GO:0030879 17 0.017
metal ion transport GO:0030001 272 0.017
transcription from rna polymerase i promoter GO:0006360 11 0.017
innate immune response GO:0045087 178 0.017
establishment of protein localization to organelle GO:0072594 172 0.017
negative regulation of growth GO:0045926 97 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
cell projection morphogenesis GO:0048858 129 0.016
reproductive process GO:0022414 106 0.016
neurogenesis GO:0022008 169 0.016
cell cycle phase transition GO:0044770 173 0.016
dna duplex unwinding GO:0032508 30 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.016
protein targeting GO:0006605 187 0.016
extrinsic apoptotic signaling pathway GO:0097191 119 0.016
regulation of myeloid cell differentiation GO:0045637 81 0.016
mammary gland morphogenesis GO:0060443 2 0.016
regulation of kinase activity GO:0043549 314 0.016
negative regulation of epithelial cell proliferation GO:0050680 48 0.016
glycoprotein metabolic process GO:0009100 110 0.016
response to endoplasmic reticulum stress GO:0034976 49 0.016
cellular response to abiotic stimulus GO:0071214 117 0.016
negative regulation of transport GO:0051051 176 0.016
negative regulation of atp catabolic process GO:1903290 5 0.016
development of primary sexual characteristics GO:0045137 35 0.015
mrna processing GO:0006397 133 0.015
positive regulation of intracellular transport GO:0032388 104 0.015
immune response GO:0006955 307 0.015
cell morphogenesis involved in differentiation GO:0000904 144 0.015
regulation of viral genome replication GO:0045069 48 0.015
negative regulation of multi organism process GO:0043901 92 0.015
dna demethylation GO:0080111 12 0.015
cellular component disassembly GO:0022411 92 0.015
chromatin assembly or disassembly GO:0006333 78 0.014
ossification GO:0001503 121 0.014
cellular response to acid chemical GO:0071229 44 0.014
regulation of gene silencing GO:0060968 24 0.014
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.014
cellular ion homeostasis GO:0006873 168 0.014
intrinsic apoptotic signaling pathway GO:0097193 127 0.014
protein alkylation GO:0008213 74 0.014
regulation of neuron apoptotic process GO:0043523 35 0.014
regulation of nucleotide catabolic process GO:0030811 205 0.014
positive regulation of cell death GO:0010942 263 0.014
mitotic cell cycle process GO:1903047 286 0.013
central nervous system development GO:0007417 123 0.013
multi organism reproductive process GO:0044703 54 0.013
regulation of cell cycle process GO:0010564 266 0.013
segmentation GO:0035282 4 0.013
positive regulation of cell proliferation GO:0008284 301 0.013
dna modification GO:0006304 27 0.013
sexual reproduction GO:0019953 37 0.013
rna modification GO:0009451 27 0.013
enzyme linked receptor protein signaling pathway GO:0007167 303 0.013
ncrna metabolic process GO:0034660 108 0.013
regulation of protein complex assembly GO:0043254 147 0.013
lymphocyte proliferation GO:0046651 70 0.013
single organism carbohydrate metabolic process GO:0044723 193 0.013
reproductive structure development GO:0048608 55 0.012
regulation of dna metabolic process GO:0051052 153 0.012
positive regulation of cell development GO:0010720 92 0.012
ribonucleotide biosynthetic process GO:0009260 81 0.012
tissue morphogenesis GO:0048729 96 0.012
Zebrafish
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.012
protein import GO:0017038 130 0.012
negative regulation of organelle organization GO:0010639 126 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
neuron projection development GO:0031175 106 0.012
intrinsic apoptotic signaling pathway in response to osmotic stress GO:0008627 2 0.012
neuron apoptotic process GO:0051402 39 0.012
cellular divalent inorganic cation homeostasis GO:0072503 128 0.012
oocyte development GO:0048599 1 0.011
single organism cellular localization GO:1902580 332 0.011
negative regulation of nucleotide catabolic process GO:0030812 16 0.011
intracellular receptor signaling pathway GO:0030522 104 0.011
regulation of defense response GO:0031347 154 0.011
nuclear export GO:0051168 69 0.011
cell cycle checkpoint GO:0000075 117 0.011
developmental growth GO:0048589 48 0.011
protein localization to organelle GO:0033365 280 0.011
chemical homeostasis GO:0048878 306 0.011
protein stabilization GO:0050821 64 0.011
gtp metabolic process GO:0046039 239 0.011
negative regulation of oxidative stress induced cell death GO:1903202 17 0.011
regulation of establishment of protein localization GO:0070201 242 0.011
ribonucleoside monophosphate biosynthetic process GO:0009156 17 0.011
nucleoside monophosphate biosynthetic process GO:0009124 19 0.011
amino acid activation GO:0043038 12 0.011
regulation of cellular amine metabolic process GO:0033238 11 0.011
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.011
excretion GO:0007588 9 0.011
viral genome replication GO:0019079 50 0.011
cellular protein complex assembly GO:0043623 188 0.011
protein autoprocessing GO:0016540 4 0.011
regulation of organ morphogenesis GO:2000027 24 0.011
regulation of cellular component biogenesis GO:0044087 281 0.011
regulation of nervous system development GO:0051960 88 0.011
mrna splicing via spliceosome GO:0000398 89 0.011
organelle fission GO:0048285 149 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
ion transmembrane transport GO:0034220 338 0.010
mononuclear cell proliferation GO:0032943 71 0.010
cellular metal ion homeostasis GO:0006875 146 0.010
cellular response to oxidative stress GO:0034599 85 0.010
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.010
trna aminoacylation GO:0043039 12 0.010
positive regulation of hydrolase activity GO:0051345 331 0.010

APEX1 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.063
nervous system disease DOID:863 431 0.063
disease of metabolism DOID:0014667 295 0.024
acquired metabolic disease DOID:0060158 58 0.024
cancer DOID:162 167 0.023
disease of cellular proliferation DOID:14566 174 0.023
organ system cancer DOID:0050686 164 0.011
disease of mental health DOID:150 70 0.010