Homo sapiens

54 known processes

CASP10

caspase 10, apoptosis-related cysteine peptidase

(Aliases: ALPS2,MCH4,FLICE2)

CASP10 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
skeletal muscle satellite cell proliferation GO:0014841 1 1.000
trail activated apoptotic signaling pathway GO:0036462 4 1.000
Human
cellular response to increased oxygen levels GO:0036295 4 1.000
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.999
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.998
cellular response to hyperoxia GO:0071455 4 0.998
response to cobalt ion GO:0032025 1 0.997
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.995
programmed necrotic cell death GO:0097300 18 0.993
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.992
Human
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.985
Human
extrinsic apoptotic signaling pathway GO:0097191 119 0.984
Human
zymogen activation GO:0031638 70 0.982
Human
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.977
Human
protein processing GO:0016485 226 0.973
Human
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.970
positive regulation of release of cytochrome c from mitochondria GO:0090200 18 0.968
t cell apoptotic process GO:0070231 12 0.960
positive regulation of peptidase activity GO:0010952 88 0.956
Human
activation induced cell death of t cells GO:0006924 2 0.952
positive regulation of apoptotic signaling pathway GO:2001235 70 0.949
apoptotic signaling pathway GO:0097190 268 0.949
Human
regulation of peptidase activity GO:0052547 180 0.945
Human
regulation of myeloid cell differentiation GO:0045637 81 0.944
Human
regulation of macrophage differentiation GO:0045649 9 0.940
Human
activation of cysteine type endopeptidase activity GO:0097202 57 0.939
Human
positive regulation of cellular amine metabolic process GO:0033240 7 0.933
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 15 0.933
response to hyperoxia GO:0055093 4 0.931
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.926
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.924
i kappab kinase nf kappab signaling GO:0007249 166 0.924
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.921
positive regulation of hydrolase activity GO:0051345 331 0.920
Human
lymphocyte apoptotic process GO:0070227 20 0.916
leukocyte apoptotic process GO:0071887 31 0.909
positive regulation of endopeptidase activity GO:0010950 84 0.901
Human
positive regulation of nik nf kappab signaling GO:1901224 10 0.900
cellular response to abiotic stimulus GO:0071214 117 0.889
Human
positive regulation of map kinase activity GO:0043406 80 0.888
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.888
necroptotic process GO:0070266 16 0.887
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.882
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.878
neural tube formation GO:0001841 3 0.876
regulation of osteoclast differentiation GO:0045670 18 0.864
regulation of proteolysis GO:0030162 293 0.861
Human
positive regulation of cell death GO:0010942 263 0.849
Human
negative regulation of cell death GO:0060548 345 0.846
Human
positive regulation of nf kappab import into nucleus GO:0042346 13 0.832
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 3 0.828
cellular response to mechanical stimulus GO:0071260 39 0.822
Human
execution phase of apoptosis GO:0097194 32 0.819
Human
regulation of cellular amino acid metabolic process GO:0006521 6 0.818
regulation of cell differentiation GO:0045595 393 0.814
Human
apoptotic mitochondrial changes GO:0008637 57 0.814
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.809
positive regulation of proteolysis GO:0045862 142 0.803
Human
leukocyte differentiation GO:0002521 98 0.798
Human
cell type specific apoptotic process GO:0097285 125 0.797
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.797
intrinsic apoptotic signaling pathway GO:0097193 127 0.779
Human
regulation of release of cytochrome c from mitochondria GO:0090199 29 0.770
regulation of endopeptidase activity GO:0052548 170 0.766
Human
regulation of cysteine type endopeptidase activity GO:2000116 127 0.756
Human
regulation of apoptotic signaling pathway GO:2001233 175 0.756
necrotic cell death GO:0070265 21 0.752
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 24 0.748
release of cytochrome c from mitochondria GO:0001836 35 0.741
negative regulation of apoptotic process GO:0043066 316 0.730
Human
cytokine mediated signaling pathway GO:0019221 109 0.723
myeloid cell differentiation GO:0030099 117 0.716
Human
positive regulation of programmed cell death GO:0043068 249 0.711
Human
negative regulation of t cell apoptotic process GO:0070233 4 0.706
cellular response to tumor necrosis factor GO:0071356 63 0.706
positive regulation of apoptotic process GO:0043065 246 0.702
Human
positive regulation of phosphorylation GO:0042327 394 0.700
cellular response to external stimulus GO:0071496 111 0.685
Human
immune system development GO:0002520 195 0.652
Human
regulation of cellular ketone metabolic process GO:0010565 50 0.650
protein maturation GO:0051604 233 0.650
Human
positive regulation of endothelial cell apoptotic process GO:2000353 8 0.646
regulation of myoblast fusion GO:1901739 1 0.641
negative regulation of programmed cell death GO:0043069 321 0.629
Human
regulation of satellite cell proliferation GO:0014842 1 0.616
positive regulation of bone resorption GO:0045780 2 0.613
signal transduction in absence of ligand GO:0038034 22 0.611
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 12 0.611
striated muscle cell proliferation GO:0014855 7 0.600
regulation of activated t cell proliferation GO:0046006 12 0.572
positive regulation of immune system process GO:0002684 283 0.567
Human
regulation of protein processing GO:0070613 150 0.565
defense response to bacterium GO:0042742 63 0.547
positive regulation of developmental process GO:0051094 314 0.540
Human
regulation of cellular amine metabolic process GO:0033238 11 0.503
response to water GO:0009415 2 0.491
regulation of necroptotic process GO:0060544 7 0.490
response to cytokine GO:0034097 232 0.484
Human
skeletal muscle cell proliferation GO:0014856 1 0.479
signal transduction involved in cell cycle checkpoint GO:0072395 16 0.463
Human
regulation of cellular extravasation GO:0002691 8 0.452
positive regulation of mapk cascade GO:0043410 190 0.450
tissue regeneration GO:0042246 3 0.446
regulation of lymphocyte activation GO:0051249 103 0.439
regulation of endothelial cell apoptotic process GO:2000351 24 0.438
negative regulation of proteolysis GO:0045861 132 0.433
cellular amino acid metabolic process GO:0006520 116 0.429
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.419
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.415
Human
positive regulation of osteoclast differentiation GO:0045672 9 0.413
cellular ketone metabolic process GO:0042180 80 0.412
t cell homeostasis GO:0043029 3 0.409
negative regulation of mitotic cell cycle GO:0045930 102 0.406
Human
response to other organism GO:0051707 261 0.404
response to mechanical stimulus GO:0009612 51 0.398
Human
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.391
response to increased oxygen levels GO:0036296 4 0.389
negative regulation of peptidase activity GO:0010466 91 0.388
positive regulation of protein phosphorylation GO:0001934 313 0.387
spleen development GO:0048536 1 0.373
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 22 0.373
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.369
cell cycle arrest GO:0007050 71 0.368
Human
regulation of innate immune response GO:0045088 97 0.368
negative regulation of intracellular signal transduction GO:1902532 183 0.349
Human
adaptive immune response GO:0002250 49 0.347
defense response GO:0006952 315 0.346
response to biotic stimulus GO:0009607 276 0.345
jak stat cascade GO:0007259 46 0.337
thymocyte apoptotic process GO:0070242 2 0.333
positive regulation of myeloid cell differentiation GO:0045639 39 0.330
Human
endothelial cell apoptotic process GO:0072577 26 0.330
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.324
mitotic dna damage checkpoint GO:0044773 28 0.323
Human
angiogenesis GO:0001525 147 0.319
t cell activation GO:0042110 99 0.318
positive regulation of jak stat cascade GO:0046427 35 0.317
negative regulation of defense response GO:0031348 47 0.308
regulation of homotypic cell cell adhesion GO:0034110 8 0.299
innate immune response GO:0045087 178 0.297
regulation of intracellular transport GO:0032386 195 0.296
regulation of leukocyte differentiation GO:1902105 61 0.295
Human
cellular response to water stimulus GO:0071462 1 0.291
positive regulation of cellular extravasation GO:0002693 3 0.286
negative regulation of striated muscle cell differentiation GO:0051154 8 0.282
negative regulation of necroptotic process GO:0060546 2 0.280
defense response to other organism GO:0098542 129 0.278
regulation of jak stat cascade GO:0046425 44 0.273
pigment metabolic process GO:0042440 16 0.269
activation of nf kappab inducing kinase activity GO:0007250 9 0.266
regulation of nucleocytoplasmic transport GO:0046822 98 0.261
regulation of necrotic cell death GO:0010939 9 0.261
regulation of protein targeting GO:1903533 91 0.260
negative regulation of muscle cell differentiation GO:0051148 17 0.257
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.251
regulation of inflammatory response GO:0050727 46 0.250
positive regulation of protein kinase activity GO:0045860 190 0.250
negative regulation of protein processing GO:0010955 142 0.249
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 4 0.245
positive regulation of cell activation GO:0050867 81 0.241
response to external biotic stimulus GO:0043207 261 0.237
regulation of mitochondrion organization GO:0010821 54 0.234
response to virus GO:0009615 126 0.233
mitotic cell cycle GO:0000278 326 0.233
Human
amine metabolic process GO:0009308 44 0.231
engulfment of apoptotic cell GO:0043652 2 0.230
inflammatory cell apoptotic process GO:0006925 3 0.222
regeneration GO:0031099 4 0.219
apoptotic cell clearance GO:0043277 12 0.217
mitotic cell cycle process GO:1903047 286 0.216
Human
leukocyte migration GO:0050900 107 0.214
macrophage differentiation GO:0030225 11 0.212
Human
regulation of cell cycle arrest GO:0071156 36 0.210
Human
positive regulation of immune response GO:0050778 159 0.208
cytoplasmic sequestering of nf kappab GO:0007253 7 0.207
response to organic cyclic compound GO:0014070 204 0.205
negative regulation of endopeptidase activity GO:0010951 84 0.203
necroptotic signaling pathway GO:0097527 6 0.201
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.199
lymphocyte homeostasis GO:0002260 4 0.198
myoblast fusion GO:0007520 1 0.195
hemopoiesis GO:0030097 180 0.195
Human
cell fate determination GO:0001709 3 0.194
negative regulation of response to external stimulus GO:0032102 83 0.189
positive regulation of type i interferon mediated signaling pathway GO:0060340 4 0.188
response to uv GO:0009411 73 0.186
Human
negative regulation of apoptotic signaling pathway GO:2001234 97 0.186
positive regulation of cell proliferation GO:0008284 301 0.184
cardiovascular system development GO:0072358 262 0.182
regulation of lymphocyte mediated immunity GO:0002706 33 0.178
negative regulation of i kappab kinase nf kappab signaling GO:0043124 32 0.178
Human
cell projection organization GO:0030030 252 0.177
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9 0.177
Human
regulation of skeletal muscle cell proliferation GO:0014857 1 0.175
cellular response to cytokine stimulus GO:0071345 181 0.174
regulation of cell cycle GO:0051726 393 0.174
Human
syncytium formation by plasma membrane fusion GO:0000768 2 0.169
negative regulation of catalytic activity GO:0043086 335 0.168
regulation of cell activation GO:0050865 125 0.167
anatomical structure formation involved in morphogenesis GO:0048646 284 0.166
cell development GO:0048468 328 0.165
positive regulation of cell cycle arrest GO:0071158 23 0.164
Human
protein homooligomerization GO:0051260 100 0.164
melanin metabolic process GO:0006582 1 0.160
erythrocyte homeostasis GO:0034101 31 0.159
Human
cellular protein catabolic process GO:0044257 261 0.157
Human
negative regulation of myotube differentiation GO:0010832 4 0.157
negative regulation of response to wounding GO:1903035 47 0.156
negative regulation of vasculature development GO:1901343 43 0.155
cellular response to organic cyclic compound GO:0071407 127 0.152
positive regulation of mononuclear cell proliferation GO:0032946 47 0.152
vasculature development GO:0001944 181 0.147
response to oxygen containing compound GO:1901700 369 0.147
tyrosine phosphorylation of stat protein GO:0007260 33 0.147
mitotic g1 s transition checkpoint GO:0044819 17 0.147
Human
cell cell signaling GO:0007267 155 0.146
positive regulation of homotypic cell cell adhesion GO:0034112 4 0.145
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.145
positive regulation of innate immune response GO:0045089 79 0.144
regulation of defense response GO:0031347 154 0.144
positive regulation of t cell migration GO:2000406 13 0.143
response to lipid GO:0033993 206 0.142
t cell differentiation in thymus GO:0033077 4 0.141
positive regulation of cell motility GO:2000147 177 0.141
neuron differentiation GO:0030182 138 0.141
regulation of cell cycle process GO:0010564 266 0.139
Human
response to toxic substance GO:0009636 37 0.138
biological adhesion GO:0022610 331 0.138
regulation of response to external stimulus GO:0032101 222 0.136
activated t cell proliferation GO:0050798 13 0.135
spermatid development GO:0007286 4 0.131
positive regulation of kinase activity GO:0033674 204 0.130
muscle system process GO:0003012 81 0.130
negative regulation of necrotic cell death GO:0060547 3 0.129
muscle cell proliferation GO:0033002 35 0.127
cellular response to radiation GO:0071478 65 0.126
Human
protein catabolic process GO:0030163 325 0.126
Human
negative regulation of cell cycle phase transition GO:1901988 89 0.124
Human
peptidyl tyrosine phosphorylation GO:0018108 170 0.122
lymphocyte mediated immunity GO:0002449 48 0.120
stress activated protein kinase signaling cascade GO:0031098 94 0.119
skeletal muscle tissue regeneration GO:0043403 2 0.119
response to hormone GO:0009725 175 0.118
developmental programmed cell death GO:0010623 3 0.118
response to abiotic stimulus GO:0009628 336 0.117
Human
cellular response to estrogen stimulus GO:0071391 16 0.116
regulation of myeloid leukocyte differentiation GO:0002761 39 0.115
Human
response to bacterium GO:0009617 144 0.114
osteoclast differentiation GO:0030316 21 0.113
leukocyte activation GO:0045321 164 0.113
positive regulation of leukocyte activation GO:0002696 80 0.113
cell cycle phase transition GO:0044770 173 0.112
Human
system process GO:0003008 349 0.111
negative regulation of transport GO:0051051 176 0.111
regulation of map kinase activity GO:0043405 108 0.110
tnfsf11 mediated signaling pathway GO:0071847 2 0.108
positive regulation of tyrosine phosphorylation of stat1 protein GO:0042511 8 0.108
positive regulation of immune effector process GO:0002699 40 0.107
synaptic transmission GO:0007268 61 0.104
vesicle mediated transport GO:0016192 371 0.104
positive regulation of cell adhesion GO:0045785 84 0.102
chemotaxis GO:0006935 157 0.102
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.102
signal transduction by phosphorylation GO:0023014 297 0.102
positive regulation of macrophage differentiation GO:0045651 7 0.102
Human
blood vessel morphogenesis GO:0048514 162 0.101
regulation of homeostatic process GO:0032844 121 0.101
dna damage checkpoint GO:0000077 68 0.101
Human
single organism cell adhesion GO:0098602 179 0.100
cellular amine metabolic process GO:0044106 41 0.100
regulation of mitotic cell cycle GO:0007346 189 0.100
Human
response to wounding GO:0009611 168 0.099
actomyosin structure organization GO:0031032 59 0.099
regulation of cell adhesion GO:0030155 166 0.098
cellular response to metal ion GO:0071248 43 0.098
maintenance of protein location in cell GO:0032507 56 0.097
morphogenesis of embryonic epithelium GO:0016331 4 0.097
regulation of leukocyte migration GO:0002685 63 0.095
cytokine metabolic process GO:0042107 38 0.095
peptidyl tyrosine modification GO:0018212 170 0.095
mitotic g1 dna damage checkpoint GO:0031571 17 0.094
Human
regulation of t cell apoptotic process GO:0070232 8 0.093
neuron projection regeneration GO:0031102 1 0.093
negative regulation of lymphocyte apoptotic process GO:0070229 8 0.091
morphogenesis of an epithelium GO:0002009 60 0.091
myeloid leukocyte differentiation GO:0002573 60 0.091
Human
negative regulation of hydrolase activity GO:0051346 182 0.090
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.090
striated muscle adaptation GO:0014888 4 0.090
cell projection morphogenesis GO:0048858 129 0.090
nucleoside triphosphate metabolic process GO:0009141 422 0.090
head development GO:0060322 108 0.090
Human
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.089
Human
regulation of t cell activation GO:0050863 77 0.089
regulation of lymphocyte apoptotic process GO:0070228 15 0.088
positive regulation of t cell activation GO:0050870 54 0.088
regulation of mapk cascade GO:0043408 262 0.087
positive regulation of cell differentiation GO:0045597 211 0.087
Human
embryonic epithelial tube formation GO:0001838 4 0.087
regulation of tumor necrosis factor production GO:0032680 43 0.086
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 1 0.084
skeletal myofibril assembly GO:0014866 3 0.083
regulation of leukocyte apoptotic process GO:2000106 25 0.082
response to alcohol GO:0097305 64 0.081
activation of protein kinase activity GO:0032147 90 0.081
positive regulation of defense response GO:0031349 87 0.080
neuron cellular homeostasis GO:0070050 3 0.079
positive regulation of intracellular transport GO:0032388 104 0.079
determination of adult lifespan GO:0008340 2 0.078
transformed cell apoptotic process GO:0006927 3 0.078
regulation of cell motility GO:2000145 299 0.078
regulation of protein maturation GO:1903317 150 0.077
interferon gamma production GO:0032609 39 0.077
negative regulation of cellular component organization GO:0051129 235 0.076
epithelial cell differentiation GO:0030855 141 0.076
regulation of response to wounding GO:1903034 101 0.076
leukocyte mediated cytotoxicity GO:0001909 27 0.075
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 13 0.075
Human
generation of neurons GO:0048699 152 0.074
negative regulation of nf kappab import into nucleus GO:0042347 12 0.074
striated muscle cell differentiation GO:0051146 43 0.073
tissue morphogenesis GO:0048729 96 0.072
cell activation GO:0001775 213 0.072
positive regulation of membrane protein ectodomain proteolysis GO:0051044 13 0.071
regulation of leukocyte activation GO:0002694 115 0.071
maintenance of location GO:0051235 112 0.071
response to peptide hormone GO:0043434 61 0.070
positive regulation of transferase activity GO:0051347 227 0.069
defense response to virus GO:0051607 71 0.069
luteolysis GO:0001554 3 0.069
striated muscle tissue development GO:0014706 59 0.069
positive regulation of cell cycle process GO:0090068 106 0.069
Human
negative regulation of synaptic transmission GO:0050805 2 0.069
single organism nuclear import GO:1902593 104 0.068
response to endoplasmic reticulum stress GO:0034976 49 0.068
regulation of protein transport GO:0051223 213 0.068
protein localization to nucleus GO:0034504 136 0.068
oogenesis GO:0048477 2 0.068
leukocyte chemotaxis GO:0030595 76 0.068
t cell differentiation GO:0030217 29 0.068
wound healing GO:0042060 115 0.067
protein oligomerization GO:0051259 173 0.067
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.067
membrane tubulation GO:0097320 12 0.066
positive regulation of interleukin 8 production GO:0032757 36 0.065
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 2 0.065
toll like receptor 2 signaling pathway GO:0034134 4 0.064
leukocyte mediated immunity GO:0002443 59 0.063
nucleocytoplasmic transport GO:0006913 176 0.063
response to lithium ion GO:0010226 2 0.062
regulation of protein complex assembly GO:0043254 147 0.062
organelle assembly GO:0070925 176 0.062
positive regulation of cellular component organization GO:0051130 376 0.061
actin cytoskeleton organization GO:0030036 207 0.061
peptidyl serine autophosphorylation GO:0036289 2 0.060
positive regulation of transport GO:0051050 336 0.060
blood vessel development GO:0001568 172 0.059
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.059
neuromuscular junction development GO:0007528 3 0.058
positive regulation of leukocyte mediated immunity GO:0002705 24 0.058
establishment of protein localization to organelle GO:0072594 172 0.058
response to metal ion GO:0010038 84 0.058
cellular response to organonitrogen compound GO:0071417 124 0.057
regulation of protein localization to nucleus GO:1900180 85 0.057
lymphocyte activation GO:0046649 133 0.057
cellular response to hormone stimulus GO:0032870 125 0.056
cellular component assembly involved in morphogenesis GO:0010927 73 0.056
small gtpase mediated signal transduction GO:0007264 78 0.055
regulation of establishment of protein localization GO:0070201 242 0.055
regulation of immune effector process GO:0002697 91 0.055
striated muscle cell development GO:0055002 27 0.055
positive regulation of leukocyte differentiation GO:1902107 37 0.054
Human
inflammatory response GO:0006954 79 0.054
hematopoietic or lymphoid organ development GO:0048534 186 0.054
Human
cellular component morphogenesis GO:0032989 314 0.054
positive regulation of cytokine mediated signaling pathway GO:0001961 12 0.054
negative regulation of protein maturation GO:1903318 142 0.054
regulation of cytokine mediated signaling pathway GO:0001959 41 0.053
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.053
Human
epithelium development GO:0060429 227 0.053
regulation of leukocyte mediated immunity GO:0002703 38 0.053
thymus development GO:0048538 3 0.052
negative regulation of phosphate metabolic process GO:0045936 267 0.052
cytoplasmic transport GO:0016482 379 0.052
organic hydroxy compound metabolic process GO:1901615 147 0.052
neuron apoptotic process GO:0051402 39 0.052
positive regulation of cell killing GO:0031343 19 0.051
secondary metabolic process GO:0019748 17 0.050
negative regulation of intracellular protein transport GO:0090317 42 0.050
endocytosis GO:0006897 159 0.050
negative regulation of leukocyte apoptotic process GO:2000107 16 0.050
membrane organization GO:0061024 292 0.049
central nervous system development GO:0007417 123 0.049
Human
tumor necrosis factor mediated signaling pathway GO:0033209 27 0.049
positive regulation of protein transport GO:0051222 135 0.049
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.049
Human
caveola assembly GO:0070836 4 0.049
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.048
regulation of cell cycle phase transition GO:1901987 126 0.048
Human
humoral immune response GO:0006959 49 0.048
mitotic cell cycle checkpoint GO:0007093 68 0.048
Human
t cell selection GO:0045058 4 0.048
regulation of b cell activation GO:0050864 24 0.048
positive regulation of t cell proliferation GO:0042102 33 0.048
response to cycloheximide GO:0046898 1 0.048
peptide metabolic process GO:0006518 51 0.047
response to drug GO:0042493 81 0.047
positive regulation of adaptive immune response GO:0002821 21 0.046
type i interferon signaling pathway GO:0060337 11 0.046
actin filament based process GO:0030029 224 0.046
response to steroid hormone GO:0048545 80 0.045
g1 dna damage checkpoint GO:0044783 18 0.044
Human
dna integrity checkpoint GO:0031570 71 0.044
Human
protein import GO:0017038 130 0.044
protein targeting GO:0006605 187 0.044
plasma membrane organization GO:0007009 115 0.044
immune response GO:0006955 307 0.044
positive regulation of cell migration GO:0030335 172 0.044
female gamete generation GO:0007292 2 0.044
single organism cellular localization GO:1902580 332 0.043
regulation of muscle cell differentiation GO:0051147 31 0.043
cellular response to type i interferon GO:0071357 12 0.042
nervous system development GO:0007399 293 0.042
Human
positive regulation of protein import into nucleus GO:0042307 46 0.042
regulation of cell cycle g1 s phase transition GO:1902806 42 0.042
Human
regulation of purine nucleotide metabolic process GO:1900542 264 0.041
negative regulation of cell cycle process GO:0010948 121 0.041
Human
negative regulation of cell proliferation GO:0008285 228 0.041
regulation of response to dna damage stimulus GO:2001020 94 0.040
Human
positive regulation of protein homooligomerization GO:0032464 7 0.040
regulation of mononuclear cell proliferation GO:0032944 65 0.040
negative regulation of cellular protein metabolic process GO:0032269 353 0.040
response to decreased oxygen levels GO:0036293 96 0.040
neuron development GO:0048666 113 0.040
cellular homeostasis GO:0019725 196 0.039
female gonad development GO:0008585 10 0.039
positive regulation of nucleotide metabolic process GO:0045981 230 0.039
positive regulation of leukocyte proliferation GO:0070665 48 0.039
cellular response to acid chemical GO:0071229 44 0.039
circulatory system development GO:0072359 262 0.039
cell cycle g1 s phase transition GO:0044843 80 0.039
Human
negative regulation of cell differentiation GO:0045596 171 0.039
multicellular organismal aging GO:0010259 3 0.038
regulation of angiogenesis GO:0045765 92 0.038
cell adhesion GO:0007155 325 0.038
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.037
neuron death GO:0070997 65 0.037
negative regulation of b cell activation GO:0050869 6 0.037
cell cycle checkpoint GO:0000075 117 0.037
Human
cell projection assembly GO:0030031 126 0.037
interleukin 8 production GO:0032637 51 0.037
substantia nigra development GO:0021762 45 0.037
Human
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.036
muscle adaptation GO:0043500 12 0.036
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.036
Human
negative regulation of inflammatory response GO:0050728 22 0.036
neuromuscular synaptic transmission GO:0007274 5 0.036
cellular response to dna damage stimulus GO:0006974 379 0.036
Human
spermatid differentiation GO:0048515 4 0.036
cellular response to oxygen containing compound GO:1901701 276 0.036
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.036
tyrosine phosphorylation of stat1 protein GO:0042508 11 0.036
positive regulation of organelle organization GO:0010638 195 0.036
production of molecular mediator of immune response GO:0002440 37 0.036
regulation of mitotic cell cycle phase transition GO:1901990 118 0.035
Human
negative regulation of protein import into nucleus GO:0042308 30 0.035
negative regulation of cell cycle GO:0045786 193 0.035
Human
growth GO:0040007 202 0.035
cellular response to lipid GO:0071396 127 0.035
response to oxygen levels GO:0070482 100 0.035
activation of immune response GO:0002253 114 0.035
regulation of transcription factor import into nucleus GO:0042990 39 0.035
nitrogen compound transport GO:0071705 191 0.035
response to light stimulus GO:0009416 87 0.035
Human
cellular response to lithium ion GO:0071285 2 0.034
positive regulation of leukocyte migration GO:0002687 46 0.034
homotypic cell cell adhesion GO:0034109 47 0.034
amide transport GO:0042886 76 0.034
antibacterial humoral response GO:0019731 24 0.034
developmental growth GO:0048589 48 0.034
positive regulation of antimicrobial humoral response GO:0002760 1 0.033
brain development GO:0007420 97 0.033
Human
reproductive system development GO:0061458 56 0.033
intracellular protein transport GO:0006886 270 0.032
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 11 0.032

CASP10 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.951
hypersensitivity reaction type iv disease DOID:2916 6 0.374
hypersensitivity reaction disease DOID:0060056 25 0.374
disease of cellular proliferation DOID:14566 174 0.160
breast cancer DOID:1612 21 0.151
Human
thoracic cancer DOID:5093 21 0.151
Human
cancer DOID:162 167 0.151
organ system cancer DOID:0050686 164 0.151
respiratory system cancer DOID:0050615 16 0.064
Human
gastrointestinal system cancer DOID:3119 52 0.044
central nervous system disease DOID:331 186 0.034
neurodegenerative disease DOID:1289 102 0.034
nervous system disease DOID:863 431 0.034