Homo sapiens

39 known processes

XRN1

5'-3' exoribonuclease 1

(Aliases: SEP1,DKFZp686B22225,DKFZp434P0721,DKFZp686F19113,FLJ41903)

XRN1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
small gtpase mediated signal transduction GO:0007264 78 0.177
ras protein signal transduction GO:0007265 73 0.141
protein ubiquitination GO:0016567 314 0.131
cellular response to endogenous stimulus GO:0071495 336 0.128
post embryonic development GO:0009791 2 0.128
Fly
cellular amine metabolic process GO:0044106 41 0.124
cellular macromolecule catabolic process GO:0044265 380 0.115
posttranscriptional regulation of gene expression GO:0010608 213 0.107
Fly
amine metabolic process GO:0009308 44 0.098
chromatin organization GO:0006325 351 0.087
positive regulation of cellular amine metabolic process GO:0033240 7 0.085
covalent chromatin modification GO:0016569 254 0.072
regulation of cellular amino acid metabolic process GO:0006521 6 0.071
cellular amino acid metabolic process GO:0006520 116 0.063
rna catabolic process GO:0006401 71 0.061
vesicle mediated transport GO:0016192 371 0.061
chromatin modification GO:0016568 298 0.059
mrna metabolic process GO:0016071 175 0.056
protein modification by small protein conjugation GO:0032446 342 0.053
dna replication GO:0006260 116 0.052
locomotory behavior GO:0007626 1 0.051
regulation of defense response GO:0031347 154 0.051
histone modification GO:0016570 251 0.051
response to wounding GO:0009611 168 0.051
Fly
regulation of ras protein signal transduction GO:0046578 155 0.049
regulation of cellular ketone metabolic process GO:0010565 50 0.047
rna processing GO:0006396 255 0.045
rhythmic behavior GO:0007622 2 0.044
endosomal transport GO:0016197 129 0.043
cytoplasmic transport GO:0016482 379 0.042
carbohydrate derivative biosynthetic process GO:1901137 207 0.042
regulation of cellular amine metabolic process GO:0033238 11 0.042
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.040
regulation of small gtpase mediated signal transduction GO:0051056 156 0.039
purine containing compound catabolic process GO:0072523 411 0.039
biological adhesion GO:0022610 331 0.039
multicellular organismal aging GO:0010259 3 0.038
positive regulation of phosphorylation GO:0042327 394 0.036
modification dependent macromolecule catabolic process GO:0043632 212 0.035
mrna catabolic process GO:0006402 56 0.035
cell morphogenesis GO:0000902 296 0.034
neuromuscular junction development GO:0007528 3 0.034
enzyme linked receptor protein signaling pathway GO:0007167 303 0.034
cellular protein complex assembly GO:0043623 188 0.033
protein modification by small protein removal GO:0070646 92 0.033
behavior GO:0007610 112 0.032
single organism carbohydrate metabolic process GO:0044723 193 0.032
determination of adult lifespan GO:0008340 2 0.032
negative regulation of cellular protein metabolic process GO:0032269 353 0.032
regulation of cell cycle GO:0051726 393 0.031
Yeast
circadian behavior GO:0048512 2 0.030
regulation of protein localization GO:0032880 296 0.030
cell development GO:0048468 328 0.029
cellular response to glucocorticoid stimulus GO:0071385 4 0.029
endomembrane system organization GO:0010256 196 0.028
ribonucleoside triphosphate metabolic process GO:0009199 412 0.027
positive regulation of catabolic process GO:0009896 310 0.027
negative regulation of cell death GO:0060548 345 0.027
ubiquitin dependent protein catabolic process GO:0006511 206 0.027
single organism cellular localization GO:1902580 332 0.027
protein deubiquitination GO:0016579 79 0.026
protein catabolic process GO:0030163 325 0.026
regulation of protein stability GO:0031647 87 0.025
protein polyubiquitination GO:0000209 110 0.025
macromolecule glycosylation GO:0043413 63 0.025
gtp metabolic process GO:0046039 239 0.025
negative regulation of protein metabolic process GO:0051248 391 0.025
positive regulation of cell proliferation GO:0008284 301 0.024
response to growth factor GO:0070848 205 0.024
purine nucleoside catabolic process GO:0006152 398 0.024
purine ribonucleoside catabolic process GO:0046130 398 0.024
regulation of nucleoside metabolic process GO:0009118 209 0.023
transmembrane transport GO:0055085 399 0.023
regulation of purine nucleotide metabolic process GO:1900542 264 0.023
nucleoside triphosphate metabolic process GO:0009141 422 0.023
peptidyl serine phosphorylation GO:0018105 101 0.023
regulation of gtpase activity GO:0043087 180 0.023
lipid metabolic process GO:0006629 381 0.023
rab protein signal transduction GO:0032482 4 0.022
purine ribonucleoside metabolic process GO:0046128 437 0.022
lung alveolus development GO:0048286 4 0.022
guanosine containing compound catabolic process GO:1901069 239 0.022
positive regulation of transport GO:0051050 336 0.022
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.022
regulation of nucleotide metabolic process GO:0006140 269 0.021
system process GO:0003008 349 0.021
secretion GO:0046903 254 0.021
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.021
ribonucleotide catabolic process GO:0009261 405 0.020
nuclear transport GO:0051169 179 0.020
positive regulation of secretion by cell GO:1903532 108 0.020
defense response to virus GO:0051607 71 0.020
purine nucleoside triphosphate metabolic process GO:0009144 412 0.020
regulation of synaptic plasticity GO:0048167 3 0.020
positive regulation of protein phosphorylation GO:0001934 313 0.020
protein glycosylation GO:0006486 62 0.020
positive regulation of nucleoside metabolic process GO:0045979 186 0.020
defense response GO:0006952 315 0.020
cell projection organization GO:0030030 252 0.020
angiotensin activated signaling pathway GO:0038166 4 0.019
single organism membrane organization GO:0044802 268 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.019
memory GO:0007613 3 0.019
central nervous system development GO:0007417 123 0.019
segmentation GO:0035282 4 0.019
endocrine process GO:0050886 25 0.019
cellular response to hypoxia GO:0071456 51 0.019
regulation of intracellular transport GO:0032386 195 0.018
cellular protein catabolic process GO:0044257 261 0.018
regulation of protein transport GO:0051223 213 0.018
regulation of vesicle mediated transport GO:0060627 130 0.018
cellular response to nitrogen compound GO:1901699 144 0.018
ribonucleoside triphosphate catabolic process GO:0009203 391 0.018
cellular response to decreased oxygen levels GO:0036294 51 0.018
peptidyl lysine modification GO:0018205 144 0.017
regulation of cell differentiation GO:0045595 393 0.017
regulation of intracellular protein transport GO:0033157 123 0.017
neuroblast proliferation GO:0007405 4 0.017
cellular response to hormone stimulus GO:0032870 125 0.017
cellular component morphogenesis GO:0032989 314 0.017
response to hormone GO:0009725 175 0.017
organophosphate catabolic process GO:0046434 430 0.017
nervous system development GO:0007399 293 0.017
neurogenesis GO:0022008 169 0.017
dna repair GO:0006281 198 0.017
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.017
Yeast Fly
regulation of immune response GO:0050776 201 0.017
positive regulation of protein transport GO:0051222 135 0.017
positive regulation of immune system process GO:0002684 283 0.017
protein localization to membrane GO:0072657 160 0.016
actin mediated cell contraction GO:0070252 12 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.016
response to nitrogen compound GO:1901698 184 0.016
membrane organization GO:0061024 292 0.016
immune effector process GO:0002252 159 0.016
response to biotic stimulus GO:0009607 276 0.016
regulation of rab protein signal transduction GO:0032483 39 0.016
cell morphogenesis involved in differentiation GO:0000904 144 0.016
cellular ketone metabolic process GO:0042180 80 0.016
response to hypoxia GO:0001666 96 0.016
actin filament based process GO:0030029 224 0.015
actin cytoskeleton organization GO:0030036 207 0.015
cellular response to organic cyclic compound GO:0071407 127 0.015
cellular response to organonitrogen compound GO:0071417 124 0.015
reproductive process GO:0022414 106 0.015
Fly
cell substrate adhesion GO:0031589 132 0.015
cellular response to dna damage stimulus GO:0006974 379 0.015
purine nucleotide catabolic process GO:0006195 405 0.015
regulation of cellular component biogenesis GO:0044087 281 0.015
Yeast Fly
glycosyl compound catabolic process GO:1901658 413 0.015
mitotic cell cycle GO:0000278 326 0.015
Yeast
nucleotide catabolic process GO:0009166 408 0.015
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.015
regulation of secretion by cell GO:1903530 177 0.015
cellular response to oxygen containing compound GO:1901701 276 0.015
regulation of cell cycle process GO:0010564 266 0.014
Yeast
nucleoside triphosphate catabolic process GO:0009143 394 0.014
regulation of dna metabolic process GO:0051052 153 0.014
guanosine containing compound metabolic process GO:1901068 244 0.014
negative regulation of catalytic activity GO:0043086 335 0.014
cellular response to cytokine stimulus GO:0071345 181 0.014
positive regulation of nucleotide catabolic process GO:0030813 185 0.014
nucleoside phosphate catabolic process GO:1901292 412 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
nucleocytoplasmic transport GO:0006913 176 0.014
ncrna processing GO:0034470 83 0.014
modification dependent protein catabolic process GO:0019941 209 0.014
spermatid development GO:0007286 4 0.014
negative regulation of programmed cell death GO:0043069 321 0.014
positive regulation of cellular catabolic process GO:0031331 284 0.014
regulation of nucleocytoplasmic transport GO:0046822 98 0.014
glycoprotein metabolic process GO:0009100 110 0.014
regulation of cellular component movement GO:0051270 334 0.013
methylation GO:0032259 106 0.013
regulation of ras gtpase activity GO:0032318 128 0.013
female gamete generation GO:0007292 2 0.013
peptidyl serine modification GO:0018209 106 0.013
response to abiotic stimulus GO:0009628 336 0.013
apoptotic signaling pathway GO:0097190 268 0.013
rho protein signal transduction GO:0007266 26 0.013
regulation of response to external stimulus GO:0032101 222 0.013
lipid biosynthetic process GO:0008610 177 0.013
cellular response to growth factor stimulus GO:0071363 197 0.013
response to other organism GO:0051707 261 0.013
positive regulation of secretion GO:0051047 116 0.013
carbohydrate metabolic process GO:0005975 207 0.013
secretion by cell GO:0032940 226 0.013
regulation of protein catabolic process GO:0042176 155 0.013
regulation of gene expression epigenetic GO:0040029 73 0.013
Fly
positive regulation of exocytosis GO:0045921 35 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
regulation of secretion GO:0051046 194 0.012
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.012
regulation of cell motility GO:2000145 299 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
exocytosis GO:0006887 71 0.012
small molecule catabolic process GO:0044282 92 0.012
nucleoside catabolic process GO:0009164 408 0.012
epithelium development GO:0060429 227 0.012
Fly
cellular homeostasis GO:0019725 196 0.012
maintenance of location GO:0051235 112 0.012
purine nucleoside triphosphate catabolic process GO:0009146 392 0.012
regulation of cell migration GO:0030334 289 0.012
central nervous system neuron axonogenesis GO:0021955 3 0.012
blastoderm segmentation GO:0007350 2 0.012
actin filament based movement GO:0030048 17 0.012
ribonucleoside catabolic process GO:0042454 406 0.012
positive regulation of defense response GO:0031349 87 0.012
mitotic nuclear division GO:0007067 119 0.012
hemopoiesis GO:0030097 180 0.012
regulation of locomotion GO:0040012 329 0.012
protein localization to organelle GO:0033365 280 0.012
purine ribonucleotide catabolic process GO:0009154 404 0.012
protein acetylation GO:0006473 116 0.012
cation transmembrane transport GO:0098655 238 0.012
epithelial cell differentiation GO:0030855 141 0.011
gtp catabolic process GO:0006184 237 0.011
glycosylation GO:0070085 71 0.011
metencephalon development GO:0022037 2 0.011
negative regulation of binding GO:0051100 57 0.011
cytokine production GO:0001816 247 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
negative regulation of developmental process GO:0051093 247 0.011
positive regulation of rab gtpase activity GO:0032851 39 0.011
immune response GO:0006955 307 0.011
cell part morphogenesis GO:0032990 137 0.011
meiotic chromosome segregation GO:0045132 4 0.011
protein localization to nucleus GO:0034504 136 0.011
neurological system process GO:0050877 163 0.011
reactive oxygen species biosynthetic process GO:1903409 4 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.011
dna dependent dna replication GO:0006261 44 0.011
growth GO:0040007 202 0.011
glycoprotein biosynthetic process GO:0009101 91 0.011
intracellular protein transport GO:0006886 270 0.011
negative regulation of protein modification process GO:0031400 200 0.011
cellular response to lipid GO:0071396 127 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.011
regulation of system process GO:0044057 101 0.011
head development GO:0060322 108 0.010
regulation of protein complex assembly GO:0043254 147 0.010
Yeast
positive regulation of immune response GO:0050778 159 0.010
anterior posterior axis specification GO:0009948 2 0.010
positive regulation of nucleotide metabolic process GO:0045981 230 0.010
positive regulation of programmed cell death GO:0043068 249 0.010
reproduction GO:0000003 63 0.010
Fly
regulation of cellular response to stress GO:0080135 244 0.010
mitotic cell cycle process GO:1903047 286 0.010
Yeast
chemical homeostasis GO:0048878 306 0.010
digestive system development GO:0055123 75 0.010
stem cell development GO:0048864 69 0.010
negative regulation of dna metabolic process GO:0051053 57 0.010
regeneration GO:0031099 4 0.010
regulation of exocytosis GO:0017157 46 0.010
protein processing GO:0016485 226 0.010

XRN1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.010
central nervous system disease DOID:331 186 0.010
nervous system disease DOID:863 431 0.010