Homo sapiens

58 known processes

POLD1

polymerase (DNA directed), delta 1, catalytic subunit 125kDa

(Aliases: CDC2,POLD)

POLD1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna replication GO:0006260 116 0.964
cellular response to dna damage stimulus GO:0006974 379 0.895
dna repair GO:0006281 198 0.885
mitotic cell cycle GO:0000278 326 0.706
negative regulation of cell cycle GO:0045786 193 0.640
double strand break repair GO:0006302 101 0.630
dna biosynthetic process GO:0071897 40 0.549
base excision repair GO:0006284 21 0.514
post embryonic development GO:0009791 2 0.511
Worm
microtubule based process GO:0007017 210 0.470
nucleotide excision repair GO:0006289 31 0.448
determination of adult lifespan GO:0008340 2 0.379
mitotic cell cycle phase transition GO:0044772 162 0.357
dna replication initiation GO:0006270 6 0.333
regulation of cell cycle process GO:0010564 266 0.289
dna strand elongation GO:0022616 5 0.287
Yeast
cellular macromolecule catabolic process GO:0044265 380 0.252
Yeast
meiosis i GO:0007127 4 0.226
dna dependent dna replication GO:0006261 44 0.208
Yeast Mouse Rat
cell cycle checkpoint GO:0000075 117 0.206
cell development GO:0048468 328 0.203
cell cycle arrest GO:0007050 71 0.196
microtubule cytoskeleton organization GO:0000226 176 0.193
response to uv GO:0009411 73 0.183
negative regulation of mitotic cell cycle GO:0045930 102 0.182
regulation of cell cycle GO:0051726 393 0.177
translesion synthesis GO:0019985 8 0.155
embryo development GO:0009790 123 0.146
Worm
g1 s transition of mitotic cell cycle GO:0000082 78 0.140
non recombinational repair GO:0000726 14 0.136
mitotic cell cycle process GO:1903047 286 0.133
mitotic cell cycle checkpoint GO:0007093 68 0.128
dna damage checkpoint GO:0000077 68 0.127
mitotic dna damage checkpoint GO:0044773 28 0.114
cell cycle phase transition GO:0044770 173 0.113
postreplication repair GO:0006301 12 0.112
chromosome segregation GO:0007059 114 0.111
positive regulation of cell cycle process GO:0090068 106 0.102
cell cycle g2 m phase transition GO:0044839 43 0.101
single organism reproductive process GO:0044702 98 0.100
dna conformation change GO:0071103 113 0.099
cell cycle g1 s phase transition GO:0044843 80 0.095
regulation of cell cycle phase transition GO:1901987 126 0.093
reproductive process GO:0022414 106 0.092
mitotic dna integrity checkpoint GO:0044774 30 0.088
negative regulation of cell cycle process GO:0010948 121 0.086
negative regulation of cell death GO:0060548 345 0.086
regulation of dna metabolic process GO:0051052 153 0.083
multicellular organismal aging GO:0010259 3 0.078
spindle organization GO:0007051 53 0.074
organophosphate catabolic process GO:0046434 430 0.073
vesicle mediated transport GO:0016192 371 0.073
Worm
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.073
organelle fission GO:0048285 149 0.072
modification dependent macromolecule catabolic process GO:0043632 212 0.071
developmental process involved in reproduction GO:0003006 66 0.071
regulation of mitotic cell cycle phase transition GO:1901990 118 0.070
regulation of dna replication GO:0006275 68 0.069
response to abiotic stimulus GO:0009628 336 0.069
gene silencing GO:0016458 49 0.064
organelle assembly GO:0070925 176 0.062
mitotic sister chromatid cohesion GO:0007064 12 0.062
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.061
digestive tract development GO:0048565 75 0.061
oocyte differentiation GO:0009994 2 0.059
posttranscriptional regulation of gene expression GO:0010608 213 0.057
regulation of gene expression epigenetic GO:0040029 73 0.057
positive regulation of dna metabolic process GO:0051054 73 0.056
cellular amino acid metabolic process GO:0006520 116 0.054
response to reactive oxygen species GO:0000302 61 0.054
cell division GO:0051301 168 0.054
Worm
positive regulation of cell cycle GO:0045787 140 0.054
response to light stimulus GO:0009416 87 0.053
dna recombination GO:0006310 77 0.052
cellular response to growth factor stimulus GO:0071363 197 0.052
mitotic spindle organization GO:0007052 27 0.052
tube development GO:0035295 125 0.052
regulation of dna dependent dna replication initiation GO:0030174 3 0.051
rna processing GO:0006396 255 0.051
dna integrity checkpoint GO:0031570 71 0.049
regulation of mitotic cell cycle GO:0007346 189 0.049
female gamete generation GO:0007292 2 0.049
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.048
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.047
dna duplex unwinding GO:0032508 30 0.047
dna synthesis involved in dna repair GO:0000731 6 0.046
atp catabolic process GO:0006200 157 0.044
embryo development ending in birth or egg hatching GO:0009792 34 0.044
Worm
negative regulation of programmed cell death GO:0043069 321 0.043
dna geometric change GO:0032392 32 0.042
ras protein signal transduction GO:0007265 73 0.040
negative regulation of phosphate metabolic process GO:0045936 267 0.040
regulation of chromosome organization GO:0033044 103 0.039
purine containing compound catabolic process GO:0072523 411 0.039
ribonucleoside triphosphate catabolic process GO:0009203 391 0.038
regulation of cell cycle arrest GO:0071156 36 0.037
ribonucleoside catabolic process GO:0042454 406 0.037
chromatin silencing GO:0006342 12 0.037
protein catabolic process GO:0030163 325 0.036
sex differentiation GO:0007548 45 0.036
positive regulation of hydrolase activity GO:0051345 331 0.036
nucleoside monophosphate catabolic process GO:0009125 159 0.035
anatomical structure formation involved in morphogenesis GO:0048646 284 0.035
covalent chromatin modification GO:0016569 254 0.034
positive regulation of cell proliferation GO:0008284 301 0.034
chromatin modification GO:0016568 298 0.034
positive regulation of cell cycle arrest GO:0071158 23 0.033
nuclear division GO:0000280 128 0.033
negative regulation of protein metabolic process GO:0051248 391 0.033
response to oxygen containing compound GO:1901700 369 0.033
negative regulation of apoptotic process GO:0043066 316 0.033
response to inorganic substance GO:0010035 127 0.032
cellular component morphogenesis GO:0032989 314 0.032
purine nucleoside triphosphate catabolic process GO:0009146 392 0.031
cellular macromolecular complex assembly GO:0034622 324 0.031
positive regulation of protein phosphorylation GO:0001934 313 0.031
purine ribonucleotide catabolic process GO:0009154 404 0.030
dephosphorylation GO:0016311 209 0.030
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.029
positive regulation of mitotic cell cycle GO:0045931 60 0.029
regulation of dna repair GO:0006282 47 0.029
protein processing GO:0016485 226 0.029
oocyte maturation GO:0001556 1 0.029
gene conversion GO:0035822 1 0.028
centrosome organization GO:0051297 58 0.028
nucleoside catabolic process GO:0009164 408 0.028
nucleoside triphosphate metabolic process GO:0009141 422 0.027
purine nucleotide catabolic process GO:0006195 405 0.027
protein modification by small protein conjugation GO:0032446 342 0.026
atp metabolic process GO:0046034 176 0.026
regulation of cell cycle g1 s phase transition GO:1902806 42 0.026
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.026
Yeast Mouse
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
nervous system development GO:0007399 293 0.026
negative regulation of gene expression epigenetic GO:0045814 19 0.025
regulation of response to dna damage stimulus GO:2001020 94 0.025
sister chromatid cohesion GO:0007062 24 0.024
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 3 0.024
myosin filament assembly GO:0031034 2 0.024
glycosyl compound catabolic process GO:1901658 413 0.024
purine ribonucleoside metabolic process GO:0046128 437 0.024
regulation of proteolysis GO:0030162 293 0.023
positive regulation of programmed cell death GO:0043068 249 0.023
regulation of chromosome segregation GO:0051983 44 0.023
chromatin organization GO:0006325 351 0.023
organ morphogenesis GO:0009887 147 0.023
spermatid development GO:0007286 4 0.022
alpha amino acid metabolic process GO:1901605 72 0.022
nucleoside monophosphate metabolic process GO:0009123 191 0.022
nucleoside phosphate catabolic process GO:1901292 412 0.022
leukocyte apoptotic process GO:0071887 31 0.022
regulation of cellular ketone metabolic process GO:0010565 50 0.022
neurogenesis GO:0022008 169 0.022
immune response GO:0006955 307 0.022
stem cell differentiation GO:0048863 93 0.021
positive regulation of dna repair GO:0045739 25 0.021
response to oxidative stress GO:0006979 121 0.021
negative regulation of catalytic activity GO:0043086 335 0.021
regulation of cellular amino acid metabolic process GO:0006521 6 0.021
response to growth factor GO:0070848 205 0.021
response to other organism GO:0051707 261 0.021
interspecies interaction between organisms GO:0044419 156 0.021
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.021
rna interference GO:0016246 4 0.020
positive regulation of cellular catabolic process GO:0031331 284 0.020
purine ribonucleoside catabolic process GO:0046130 398 0.020
response to radiation GO:0009314 151 0.020
regulation of meiotic cell cycle GO:0051445 4 0.020
cellular response to abiotic stimulus GO:0071214 117 0.019
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.019
dna damage response signal transduction resulting in transcription GO:0042772 12 0.019
ribonucleotide catabolic process GO:0009261 405 0.019
negative regulation of intracellular signal transduction GO:1902532 183 0.019
protein maturation GO:0051604 233 0.019
negative regulation of cell cycle phase transition GO:1901988 89 0.019
ubiquitin dependent protein catabolic process GO:0006511 206 0.018
positive regulation of catabolic process GO:0009896 310 0.018
myosin filament organization GO:0031033 2 0.018
generation of neurons GO:0048699 152 0.018
mitotic nuclear division GO:0007067 119 0.018
detection of stimulus GO:0051606 85 0.018
ribonucleoside triphosphate metabolic process GO:0009199 412 0.018
protein ubiquitination GO:0016567 314 0.018
digestive system development GO:0055123 75 0.018
purine nucleoside monophosphate metabolic process GO:0009126 186 0.017
cellular protein catabolic process GO:0044257 261 0.017
gonad development GO:0008406 34 0.017
oogenesis GO:0048477 2 0.017
multi organism cellular process GO:0044764 156 0.017
regulation of peptidase activity GO:0052547 180 0.017
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.017
response to biotic stimulus GO:0009607 276 0.017
cellular modified amino acid metabolic process GO:0006575 64 0.016
microtubule organizing center organization GO:0031023 62 0.016
sister chromatid segregation GO:0000819 54 0.016
positive regulation of cellular amine metabolic process GO:0033240 7 0.016
epithelium development GO:0060429 227 0.016
spermatid differentiation GO:0048515 4 0.016
histone modification GO:0016570 251 0.016
g2 m transition of mitotic cell cycle GO:0000086 41 0.016
cell morphogenesis GO:0000902 296 0.016
regulation of apoptotic signaling pathway GO:2001233 175 0.016
membrane organization GO:0061024 292 0.016
cell growth GO:0016049 160 0.015
multi organism reproductive process GO:0044703 54 0.015
nucleotide catabolic process GO:0009166 408 0.015
positive regulation of proteolysis GO:0045862 142 0.015
regulation of multi organism process GO:0043900 157 0.015
apoptotic signaling pathway GO:0097190 268 0.015
reproduction GO:0000003 63 0.015
humoral immune response GO:0006959 49 0.015
response to oxygen levels GO:0070482 100 0.015
regulation of cell diameter GO:0060305 1 0.015
regeneration GO:0031099 4 0.015
signal transduction in response to dna damage GO:0042770 57 0.015
positive regulation of response to dna damage stimulus GO:2001022 43 0.014
regulation of cellular amine metabolic process GO:0033238 11 0.014
maintenance of dna repeat elements GO:0043570 4 0.014
generation of precursor metabolites and energy GO:0006091 68 0.014
cellular amine metabolic process GO:0044106 41 0.014
positive regulation of cell death GO:0010942 263 0.014
maintenance of location GO:0051235 112 0.014
negative regulation of cell proliferation GO:0008285 228 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
deoxyribose phosphate metabolic process GO:0019692 6 0.014
response to fungus GO:0009620 4 0.014
reproductive system development GO:0061458 56 0.013
response to external biotic stimulus GO:0043207 261 0.013
regulation of cellular response to stress GO:0080135 244 0.013
purine nucleoside catabolic process GO:0006152 398 0.013
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.013
2 deoxyribonucleotide metabolic process GO:0009394 6 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.013
compound eye development GO:0048749 1 0.013
regulation of immune effector process GO:0002697 91 0.012
cilium morphogenesis GO:0060271 75 0.012
response to organic cyclic compound GO:0014070 204 0.012
signal transduction by p53 class mediator GO:0072331 72 0.012
positive regulation of organelle organization GO:0010638 195 0.012
cell projection organization GO:0030030 252 0.012
sensory organ development GO:0007423 52 0.012
growth GO:0040007 202 0.012
dna packaging GO:0006323 77 0.012
nucleotide biosynthetic process GO:0009165 109 0.012
small gtpase mediated signal transduction GO:0007264 78 0.012
nucleoside triphosphate catabolic process GO:0009143 394 0.012
rna phosphodiester bond hydrolysis GO:0090501 35 0.012
cell fate determination GO:0001709 3 0.012
viral life cycle GO:0019058 132 0.012
nucleus organization GO:0006997 28 0.012
regulation of proteasomal protein catabolic process GO:0061136 87 0.012
regulation of protein localization GO:0032880 296 0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.012
cellular component assembly involved in morphogenesis GO:0010927 73 0.011
immune effector process GO:0002252 159 0.011
positive regulation of developmental process GO:0051094 314 0.011
multicellular organismal reproductive process GO:0048609 40 0.011
negative regulation of dna metabolic process GO:0051053 57 0.011
peptidyl tyrosine dephosphorylation GO:0035335 36 0.011
intrinsic apoptotic signaling pathway GO:0097193 127 0.011
protein localization to organelle GO:0033365 280 0.011
peptidyl lysine modification GO:0018205 144 0.011
epithelial cell differentiation GO:0030855 141 0.011
lymphocyte activation GO:0046649 133 0.011
metaphase anaphase transition of cell cycle GO:0044784 21 0.011
eye development GO:0001654 42 0.010
cilium assembly GO:0042384 63 0.010
regulation of kinase activity GO:0043549 314 0.010
adult locomotory behavior GO:0008344 1 0.010
positive regulation of apoptotic process GO:0043065 246 0.010
protein oligomerization GO:0051259 173 0.010
purine nucleoside triphosphate metabolic process GO:0009144 412 0.010
meiotic chromosome segregation GO:0045132 4 0.010
regulation of viral genome replication GO:0045069 48 0.010
hemopoiesis GO:0030097 180 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.010

POLD1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.079
disease of cellular proliferation DOID:14566 174 0.079
disease of metabolism DOID:0014667 295 0.035
musculoskeletal system disease DOID:17 223 0.029
bone disease DOID:0080001 88 0.029
connective tissue disease DOID:65 109 0.029
bone development disease DOID:0080006 55 0.028
peripheral neuropathy DOID:0060053 12 0.014
nervous system disease DOID:863 431 0.014
neuropathy DOID:870 52 0.014
organ system cancer DOID:0050686 164 0.013
dysostosis DOID:1934 22 0.013
gastrointestinal system cancer DOID:3119 52 0.011
large intestine cancer DOID:5672 29 0.005
intestinal cancer DOID:10155 29 0.005
colorectal cancer DOID:9256 29 0.004