Homo sapiens

0 known processes

POLD4

polymerase (DNA-directed), delta 4

(Aliases: p12,POLDS)

POLD4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cofactor metabolic process GO:0051186 87 0.134
cell projection organization GO:0030030 252 0.130
cellular amino acid metabolic process GO:0006520 116 0.116
ribonucleoside triphosphate catabolic process GO:0009203 391 0.107
oxidation reduction process GO:0055114 396 0.106
positive regulation of developmental process GO:0051094 314 0.105
purine containing compound catabolic process GO:0072523 411 0.096
cellular macromolecular complex assembly GO:0034622 324 0.094
glycosyl compound catabolic process GO:1901658 413 0.088
single organism membrane organization GO:0044802 268 0.087
regulation of cellular component biogenesis GO:0044087 281 0.086
negative regulation of cellular protein metabolic process GO:0032269 353 0.085
ribonucleoside catabolic process GO:0042454 406 0.081
purine ribonucleoside catabolic process GO:0046130 398 0.081
positive regulation of locomotion GO:0040017 186 0.080
actin filament based process GO:0030029 224 0.077
vesicle mediated transport GO:0016192 371 0.076
determination of adult lifespan GO:0008340 2 0.075
glutathione metabolic process GO:0006749 20 0.072
organophosphate catabolic process GO:0046434 430 0.071
regeneration GO:0031099 4 0.070
ribonucleotide catabolic process GO:0009261 405 0.070
positive regulation of cellular component biogenesis GO:0044089 158 0.070
nucleoside catabolic process GO:0009164 408 0.068
ras protein signal transduction GO:0007265 73 0.067
positive regulation of protein kinase activity GO:0045860 190 0.066
cellular amine metabolic process GO:0044106 41 0.066
gtp catabolic process GO:0006184 237 0.063
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.063
purine ribonucleoside metabolic process GO:0046128 437 0.062
positive regulation of gtp catabolic process GO:0033126 166 0.061
guanosine containing compound catabolic process GO:1901069 239 0.060
purine nucleoside triphosphate catabolic process GO:0009146 392 0.060
nucleoside phosphate catabolic process GO:1901292 412 0.060
cellular protein complex assembly GO:0043623 188 0.060
regulation of cellular ketone metabolic process GO:0010565 50 0.060
regulation of cellular amino acid metabolic process GO:0006521 6 0.059
cellular response to oxygen containing compound GO:1901701 276 0.058
gtp metabolic process GO:0046039 239 0.058
nucleoside triphosphate metabolic process GO:0009141 422 0.058
actin cytoskeleton organization GO:0030036 207 0.057
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.056
positive regulation of hydrolase activity GO:0051345 331 0.056
membrane organization GO:0061024 292 0.056
regulation of gtpase activity GO:0043087 180 0.056
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.055
cellular lipid metabolic process GO:0044255 303 0.054
purine nucleoside triphosphate metabolic process GO:0009144 412 0.053
cellular ketone metabolic process GO:0042180 80 0.053
regulation of anatomical structure morphogenesis GO:0022603 286 0.052
regulation of rho gtpase activity GO:0032319 66 0.052
rho protein signal transduction GO:0007266 26 0.051
purine ribonucleotide catabolic process GO:0009154 404 0.049
regulation of secretion by cell GO:1903530 177 0.048
amine metabolic process GO:0009308 44 0.047
regulation of cellular amine metabolic process GO:0033238 11 0.047
regulation of cytoskeleton organization GO:0051493 177 0.047
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.047
cell growth GO:0016049 160 0.046
positive regulation of phosphorylation GO:0042327 394 0.046
positive regulation of kinase activity GO:0033674 204 0.046
regulation of protein localization GO:0032880 296 0.045
positive regulation of cellular catabolic process GO:0031331 284 0.045
regulation of transferase activity GO:0051338 355 0.044
response to oxygen containing compound GO:1901700 369 0.044
negative regulation of cellular component organization GO:0051129 235 0.044
actin polymerization or depolymerization GO:0008154 56 0.044
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.043
regulation of gtp catabolic process GO:0033124 180 0.043
positive regulation of protein phosphorylation GO:0001934 313 0.043
positive regulation of ras gtpase activity GO:0032320 117 0.042
response to lipid GO:0033993 206 0.042
regulation of kinase activity GO:0043549 314 0.042
response to external biotic stimulus GO:0043207 261 0.042
regulation of actin filament based process GO:0032970 141 0.042
cytoplasmic transport GO:0016482 379 0.041
positive regulation of gtpase activity GO:0043547 166 0.041
guanosine containing compound metabolic process GO:1901068 244 0.040
ion homeostasis GO:0050801 230 0.040
regulation of erk1 and erk2 cascade GO:0070372 99 0.040
positive regulation of nucleotide catabolic process GO:0030813 185 0.039
metal ion transport GO:0030001 272 0.039
regulation of epithelial cell proliferation GO:0050678 113 0.039
cellular macromolecule catabolic process GO:0044265 380 0.038
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.038
negative regulation of phosphorus metabolic process GO:0010563 267 0.038
ribonucleoside triphosphate metabolic process GO:0009199 412 0.037
vesicle organization GO:0016050 62 0.037
positive regulation of catabolic process GO:0009896 310 0.037
regulation of nucleotide metabolic process GO:0006140 269 0.036
purine nucleotide catabolic process GO:0006195 405 0.036
regulation of purine nucleotide metabolic process GO:1900542 264 0.036
microtubule based process GO:0007017 210 0.035
enzyme linked receptor protein signaling pathway GO:0007167 303 0.035
regulation of ras gtpase activity GO:0032318 128 0.034
negative regulation of protein metabolic process GO:0051248 391 0.034
positive regulation of cytoskeleton organization GO:0051495 83 0.034
negative regulation of catalytic activity GO:0043086 335 0.034
nucleotide catabolic process GO:0009166 408 0.034
regulation of cell growth GO:0001558 135 0.033
purine nucleoside catabolic process GO:0006152 398 0.033
small gtpase mediated signal transduction GO:0007264 78 0.033
regulation of protein kinase activity GO:0045859 289 0.033
epithelial cell migration GO:0010631 119 0.032
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.032
response to extracellular stimulus GO:0009991 85 0.031
multicellular organismal aging GO:0010259 3 0.031
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.031
positive regulation of transport GO:0051050 336 0.031
cellular homeostasis GO:0019725 196 0.031
regulation of actin cytoskeleton organization GO:0032956 116 0.031
growth GO:0040007 202 0.030
somatic muscle development GO:0007525 1 0.030
positive regulation of organelle organization GO:0010638 195 0.030
nucleoside triphosphate catabolic process GO:0009143 394 0.030
negative regulation of cell proliferation GO:0008285 228 0.030
positive regulation of cell projection organization GO:0031346 64 0.030
post embryonic development GO:0009791 2 0.029
sulfur compound metabolic process GO:0006790 101 0.029
cell adhesion GO:0007155 325 0.029
negative regulation of phosphate metabolic process GO:0045936 267 0.029
negative regulation of organelle organization GO:0010639 126 0.029
positive regulation of immune system process GO:0002684 283 0.029
cell projection assembly GO:0030031 126 0.029
response to biotic stimulus GO:0009607 276 0.029
peptide metabolic process GO:0006518 51 0.029
negative regulation of hydrolase activity GO:0051346 182 0.029
positive regulation of nucleoside metabolic process GO:0045979 186 0.029
positive regulation of cellular component movement GO:0051272 181 0.028
defense response GO:0006952 315 0.028
positive regulation of cell migration GO:0030335 172 0.028
chemical homeostasis GO:0048878 306 0.028
regulation of nucleotide catabolic process GO:0030811 205 0.028
endothelial cell migration GO:0043542 86 0.028
cell part morphogenesis GO:0032990 137 0.028
positive regulation of nucleotide metabolic process GO:0045981 230 0.028
organelle fusion GO:0048284 36 0.027
cell morphogenesis GO:0000902 296 0.027
endosomal transport GO:0016197 129 0.027
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.027
positive regulation of rac gtpase activity GO:0032855 31 0.027
positive regulation of cellular amine metabolic process GO:0033240 7 0.027
maintenance of cell polarity GO:0030011 2 0.027
positive regulation of cellular component organization GO:0051130 376 0.027
epithelium development GO:0060429 227 0.026
cellular response to dna damage stimulus GO:0006974 379 0.026
cellular component morphogenesis GO:0032989 314 0.026
neuron projection regeneration GO:0031102 1 0.026
regulation of cellular component movement GO:0051270 334 0.026
response to inorganic substance GO:0010035 127 0.026
biological adhesion GO:0022610 331 0.026
positive regulation of cell motility GO:2000147 177 0.025
negative regulation of cellular amine metabolic process GO:0033239 3 0.025
response to wounding GO:0009611 168 0.025
regulation of adenylate cyclase activity GO:0045761 17 0.025
regulation of nucleoside metabolic process GO:0009118 209 0.025
response to nutrient levels GO:0031667 81 0.025
lipid metabolic process GO:0006629 381 0.025
viral life cycle GO:0019058 132 0.024
regulation of purine nucleotide catabolic process GO:0033121 205 0.024
secretion by cell GO:0032940 226 0.024
myeloid cell differentiation GO:0030099 117 0.024
positive regulation of transferase activity GO:0051347 227 0.024
negative regulation of multicellular organismal process GO:0051241 317 0.024
mapk cascade GO:0000165 288 0.024
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.023
regulation of secretion GO:0051046 194 0.023
cellular cation homeostasis GO:0030003 163 0.023
calcium ion transport GO:0006816 147 0.023
microtubule cytoskeleton organization GO:0000226 176 0.023
neurological system process GO:0050877 163 0.022
regulation of cell migration GO:0030334 289 0.022
regulation of establishment of protein localization GO:0070201 242 0.022
cellular chemical homeostasis GO:0055082 180 0.022
regulation of ras protein signal transduction GO:0046578 155 0.022
cellular response to nutrient levels GO:0031669 69 0.022
interspecies interaction between organisms GO:0044419 156 0.021
epithelial cell proliferation GO:0050673 128 0.021
regulation of protein serine threonine kinase activity GO:0071900 179 0.021
secretion GO:0046903 254 0.021
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.021
nervous system development GO:0007399 293 0.021
small molecule biosynthetic process GO:0044283 157 0.021
regulation of cellular response to stress GO:0080135 244 0.021
wound healing GO:0042060 115 0.021
hemopoiesis GO:0030097 180 0.021
protein polymerization GO:0051258 71 0.021
response to other organism GO:0051707 261 0.021
regulation of cell morphogenesis GO:0022604 153 0.021
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.020
cellular response to endogenous stimulus GO:0071495 336 0.020
response to oxidative stress GO:0006979 121 0.020
mitotic cell cycle GO:0000278 326 0.020
negative regulation of apoptotic process GO:0043066 316 0.020
cellular amide metabolic process GO:0043603 69 0.020
protein maturation GO:0051604 233 0.020
autophagy GO:0006914 88 0.020
immune system development GO:0002520 195 0.020
organonitrogen compound biosynthetic process GO:1901566 200 0.020
positive regulation of mapk cascade GO:0043410 190 0.020
vacuole organization GO:0007033 44 0.020
erk1 and erk2 cascade GO:0070371 104 0.020
organelle assembly GO:0070925 176 0.019
regulation of small gtpase mediated signal transduction GO:0051056 156 0.019
mitochondrion organization GO:0007005 156 0.019
response to acid chemical GO:0001101 66 0.019
cation transport GO:0006812 331 0.019
tissue migration GO:0090130 119 0.019
regulation of vesicle mediated transport GO:0060627 130 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.019
intracellular protein transport GO:0006886 270 0.019
single organism cellular localization GO:1902580 332 0.018
cellular modified amino acid metabolic process GO:0006575 64 0.018
epithelium migration GO:0090132 119 0.018
positive regulation of axon extension GO:0045773 4 0.018
anatomical structure formation involved in morphogenesis GO:0048646 284 0.018
cellular ion homeostasis GO:0006873 168 0.018
cell projection morphogenesis GO:0048858 129 0.018
cell division GO:0051301 168 0.018
regulation of cellular component size GO:0032535 82 0.018
regulation of intracellular transport GO:0032386 195 0.018
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.017
protein kinase b signaling GO:0043491 69 0.017
regulation of protein polymerization GO:0032271 63 0.017
ubiquitin dependent protein catabolic process GO:0006511 206 0.017
neuron development GO:0048666 113 0.017
response to abiotic stimulus GO:0009628 336 0.017
reactive nitrogen species metabolic process GO:2001057 3 0.017
g protein coupled receptor signaling pathway GO:0007186 207 0.017
single organism cell adhesion GO:0098602 179 0.017
lytic vacuole organization GO:0080171 24 0.017
regulation of immune response GO:0050776 201 0.017
nucleotide biosynthetic process GO:0009165 109 0.017
actin filament organization GO:0007015 128 0.017
regulation of anatomical structure size GO:0090066 101 0.017
regulation of protein transport GO:0051223 213 0.016
modification dependent macromolecule catabolic process GO:0043632 212 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
cellular response to growth factor stimulus GO:0071363 197 0.016
adult locomotory behavior GO:0008344 1 0.016
spermatid differentiation GO:0048515 4 0.016
cellular protein catabolic process GO:0044257 261 0.016
divalent inorganic cation transport GO:0072511 158 0.016
regulation of cell projection organization GO:0031344 107 0.016
regulation of locomotion GO:0040012 329 0.016
regulation of wnt signaling pathway GO:0030111 123 0.016
regulation of cell cycle GO:0051726 393 0.016
blood vessel development GO:0001568 172 0.016
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.016
protein ubiquitination GO:0016567 314 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
response to organic cyclic compound GO:0014070 204 0.015
segmentation GO:0035282 4 0.015
negative regulation of phosphorylation GO:0042326 174 0.015
protein oligomerization GO:0051259 173 0.015
neuron projection development GO:0031175 106 0.015
ribonucleotide biosynthetic process GO:0009260 81 0.015
peptidyl tyrosine modification GO:0018212 170 0.015
angiogenesis GO:0001525 147 0.015
coenzyme metabolic process GO:0006732 65 0.015
maintenance of location GO:0051235 112 0.015
positive regulation of synaptic transmission GO:0050806 4 0.015
dna repair GO:0006281 198 0.015
cellular response to extracellular stimulus GO:0031668 72 0.015
positive regulation of stress activated mapk cascade GO:0032874 60 0.015
system process GO:0003008 349 0.015
response to organonitrogen compound GO:0010243 156 0.015
divalent metal ion transport GO:0070838 152 0.014
negative regulation of cytoskeleton organization GO:0051494 45 0.014
carbohydrate metabolic process GO:0005975 207 0.014
immune response GO:0006955 307 0.014
single organism carbohydrate metabolic process GO:0044723 193 0.014
regulation of jnk cascade GO:0046328 73 0.014
hematopoietic or lymphoid organ development GO:0048534 186 0.014
dephosphorylation GO:0016311 209 0.014
innate immune response GO:0045087 178 0.014
response to growth factor GO:0070848 205 0.014
regulation of growth GO:0040008 165 0.014
fatty acid biosynthetic process GO:0006633 46 0.014
negative regulation of protein modification process GO:0031400 200 0.014
negative regulation of programmed cell death GO:0043069 321 0.014
head development GO:0060322 108 0.014
modification dependent protein catabolic process GO:0019941 209 0.014
protein localization to membrane GO:0072657 160 0.014
regulation of ion transport GO:0043269 189 0.014
positive regulation of rho gtpase activity GO:0032321 56 0.014
organic acid biosynthetic process GO:0016053 97 0.014
membrane fusion GO:0061025 43 0.014
cell cycle arrest GO:0007050 71 0.014
regulation of multi organism process GO:0043900 157 0.014
response to bacterium GO:0009617 144 0.014
multi organism cellular process GO:0044764 156 0.014
carboxylic acid biosynthetic process GO:0046394 97 0.014
regulation of cell projection assembly GO:0060491 47 0.014
negative regulation of protein phosphorylation GO:0001933 140 0.014
dna replication GO:0006260 116 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
protein glycosylation GO:0006486 62 0.013
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.013
positive regulation of response to external stimulus GO:0032103 88 0.013
cellular response to cytokine stimulus GO:0071345 181 0.013
female gamete generation GO:0007292 2 0.013
regulation of cell adhesion GO:0030155 166 0.013
response to fungus GO:0009620 4 0.013
cell morphogenesis involved in differentiation GO:0000904 144 0.013
regulation of defense response GO:0031347 154 0.013
viral process GO:0016032 146 0.013
establishment of protein localization to membrane GO:0090150 121 0.013
positive regulation of epithelial cell proliferation GO:0050679 65 0.013
regulation of mapk cascade GO:0043408 262 0.013
locomotory behavior GO:0007626 1 0.013
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.013
cellular response to external stimulus GO:0071496 111 0.013
regulation of dna metabolic process GO:0051052 153 0.013
nucleoside phosphate biosynthetic process GO:1901293 109 0.013
protein acylation GO:0043543 138 0.013
wnt signaling pathway GO:0016055 156 0.013
cell development GO:0048468 328 0.013
monocarboxylic acid metabolic process GO:0032787 185 0.013
regulation of camp biosynthetic process GO:0030817 45 0.013
cellular response to abiotic stimulus GO:0071214 117 0.013
negative regulation of catabolic process GO:0009895 104 0.012
positive regulation of ion transport GO:0043270 87 0.012
positive regulation of protein transport GO:0051222 135 0.012
negative regulation of cell death GO:0060548 345 0.012
embryonic hemopoiesis GO:0035162 4 0.012
negative regulation of cellular catabolic process GO:0031330 83 0.012
generation of precursor metabolites and energy GO:0006091 68 0.012
response to hormone GO:0009725 175 0.012
protein modification by small protein conjugation GO:0032446 342 0.012
cytokine production GO:0001816 247 0.012
ossification GO:0001503 121 0.012
memory GO:0007613 3 0.012
regulation of nervous system development GO:0051960 88 0.012
apoptotic signaling pathway GO:0097190 268 0.012
peripheral nervous system development GO:0007422 2 0.012
positive regulation of apoptotic process GO:0043065 246 0.012
regulation of actin polymerization or depolymerization GO:0008064 56 0.012
erbb signaling pathway GO:0038127 44 0.012
cellular response to organonitrogen compound GO:0071417 124 0.012
cytokine mediated signaling pathway GO:0019221 109 0.012
plasma membrane organization GO:0007009 115 0.012
negative regulation of cell cycle GO:0045786 193 0.012
regulation of vasculature development GO:1901342 97 0.012
cellular component disassembly GO:0022411 92 0.012
neuromuscular junction development GO:0007528 3 0.012
central nervous system development GO:0007417 123 0.012
regulation of cyclic nucleotide biosynthetic process GO:0030802 49 0.012
cellular response to lipid GO:0071396 127 0.011
cellular response to nitrogen compound GO:1901699 144 0.011
regulation of calcium ion transport GO:0051924 79 0.011
protein catabolic process GO:0030163 325 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
organelle fission GO:0048285 149 0.011
lysosome organization GO:0007040 24 0.011
positive regulation of secretion GO:0051047 116 0.011
generation of neurons GO:0048699 152 0.011
response to molecule of bacterial origin GO:0002237 82 0.011
response to nitrogen compound GO:1901698 184 0.011
reactive oxygen species biosynthetic process GO:1903409 4 0.011
purine nucleotide biosynthetic process GO:0006164 84 0.011
neurogenesis GO:0022008 169 0.011
defense response to other organism GO:0098542 129 0.011
stem cell division GO:0017145 2 0.011
spermatid development GO:0007286 4 0.011
blastoderm segmentation GO:0007350 2 0.011
regulation of synaptic plasticity GO:0048167 3 0.011
vasculature development GO:0001944 181 0.011
sensory perception of pain GO:0019233 4 0.011
positive regulation of cell growth GO:0030307 48 0.011
carbohydrate derivative biosynthetic process GO:1901137 207 0.011
regulation of response to external stimulus GO:0032101 222 0.011
peptidyl tyrosine phosphorylation GO:0018108 170 0.011
regulation of blood vessel remodeling GO:0060312 2 0.011
endomembrane system organization GO:0010256 196 0.011
protein acetylation GO:0006473 116 0.011
protein localization to plasma membrane GO:0072659 93 0.011
circulatory system development GO:0072359 262 0.011
cytosolic calcium ion homeostasis GO:0051480 89 0.011
positive regulation of calcium ion transport GO:0051928 51 0.011
neuroblast proliferation GO:0007405 4 0.011
lipid localization GO:0010876 106 0.011
positive regulation of secretion by cell GO:1903532 108 0.011
peptidyl lysine acetylation GO:0018394 101 0.010
positive regulation of intracellular protein transport GO:0090316 76 0.010
immune effector process GO:0002252 159 0.010
regulation of actin filament length GO:0030832 56 0.010
negative regulation of transferase activity GO:0051348 124 0.010
regulation of homeostatic process GO:0032844 121 0.010
regulation of exocytosis GO:0017157 46 0.010
cell cycle phase transition GO:0044770 173 0.010
fatty acid metabolic process GO:0006631 115 0.010
organophosphate biosynthetic process GO:0090407 163 0.010
nadph oxidation GO:0070995 3 0.010
regulation of actin filament polymerization GO:0030833 50 0.010
cyclic nucleotide biosynthetic process GO:0009190 61 0.010
response to starvation GO:0042594 59 0.010
regulation of protein localization to plasma membrane GO:1903076 40 0.010
organic hydroxy compound metabolic process GO:1901615 147 0.010
regulation of cyclase activity GO:0031279 19 0.010
negative regulation of protein kinase activity GO:0006469 98 0.010
oogenesis GO:0048477 2 0.010
inorganic cation transmembrane transport GO:0098662 194 0.010

POLD4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.047
cancer DOID:162 167 0.033
disease of metabolism DOID:0014667 295 0.032
organ system cancer DOID:0050686 164 0.025
central nervous system disease DOID:331 186 0.021
nervous system disease DOID:863 431 0.021
immune system disease DOID:2914 155 0.020
musculoskeletal system disease DOID:17 223 0.015