|
|
negative regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
|
GO:2001189 |
1 |
1.000
|
Human |
|
|
fc receptor mediated inhibitory signaling pathway
|
GO:0002774 |
2 |
1.000
|
Human |
|
|
cd8 positive alpha beta t cell activation
|
GO:0036037 |
3 |
0.999
|
Human |
|
|
negative regulation of cd8 positive alpha beta t cell activation
|
GO:2001186 |
1 |
0.999
|
Human |
|
|
regulation of dendritic cell apoptotic process
|
GO:2000668 |
4 |
0.999
|
Human |
|
|
regulation of interferon beta secretion
|
GO:0035547 |
1 |
0.998
|
Human |
|
|
negative regulation of serotonin secretion
|
GO:0014063 |
1 |
0.998
|
Human |
|
|
negative regulation of dendritic cell differentiation
|
GO:2001199 |
2 |
0.998
|
Human |
|
|
negative regulation of tumor necrosis factor biosynthetic process
|
GO:0042536 |
3 |
0.998
|
Human |
|
|
negative regulation of interleukin 10 production
|
GO:0032693 |
7 |
0.998
|
Human |
|
|
negative regulation of dendritic cell apoptotic process
|
GO:2000669 |
3 |
0.997
|
Human |
|
|
immune response inhibiting cell surface receptor signaling pathway
|
GO:0002767 |
4 |
0.997
|
Human |
|
|
regulation of transforming growth factor beta secretion
|
GO:2001201 |
1 |
0.995
|
Human |
|
|
negative regulation of interleukin 12 secretion
|
GO:2001183 |
1 |
0.995
|
Human |
|
|
interleukin 12 secretion
|
GO:0072610 |
1 |
0.994
|
Human |
|
|
type i interferon secretion
|
GO:0072641 |
1 |
0.984
|
Human |
|
|
interferon beta secretion
|
GO:0035546 |
1 |
0.983
|
Human |
|
|
dendritic cell apoptotic process
|
GO:0097048 |
4 |
0.980
|
Human |
|
|
regulation of osteoclast development
|
GO:2001204 |
1 |
0.973
|
Human |
|
|
interferon gamma biosynthetic process
|
GO:0042095 |
8 |
0.967
|
Human |
|
|
gamma delta t cell activation involved in immune response
|
GO:0002290 |
1 |
0.954
|
Human |
|
|
negative regulation of interferon beta production
|
GO:0032688 |
4 |
0.941
|
Human |
|
|
regulation of serotonin secretion
|
GO:0014062 |
1 |
0.932
|
Human |
|
|
osteoclast differentiation
|
GO:0030316 |
21 |
0.926
|
|
|
|
transforming growth factor beta secretion
|
GO:0038044 |
1 |
0.925
|
Human |
|
|
regulation of gamma delta t cell activation involved in immune response
|
GO:2001191 |
1 |
0.923
|
Human |
|
|
organic hydroxy compound transport
|
GO:0015850 |
63 |
0.917
|
Human |
|
|
negative regulation of t cell mediated cytotoxicity
|
GO:0001915 |
1 |
0.916
|
Human |
|
|
negative regulation of interferon beta secretion
|
GO:0035548 |
1 |
0.887
|
Human |
|
|
leukocyte apoptotic process
|
GO:0071887 |
31 |
0.866
|
Human |
|
|
regulation of interleukin 10 secretion
|
GO:2001179 |
4 |
0.846
|
Human |
|
|
positive regulation of gamma delta t cell activation
|
GO:0046645 |
1 |
0.821
|
Human |
|
|
negative regulation of type i interferon production
|
GO:0032480 |
5 |
0.818
|
Human |
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.788
|
Human |
|
|
negative regulation of myeloid leukocyte differentiation
|
GO:0002762 |
16 |
0.787
|
|
|
|
positive regulation of t cell tolerance induction
|
GO:0002666 |
2 |
0.755
|
Human |
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
46 |
0.746
|
Human |
|
|
regulation of gamma delta t cell activation
|
GO:0046643 |
1 |
0.745
|
Human |
|
|
positive regulation of regulatory t cell differentiation
|
GO:0045591 |
3 |
0.745
|
Human |
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
35 |
0.738
|
Human |
|
|
regulation of cytokine secretion involved in immune response
|
GO:0002739 |
7 |
0.730
|
Human |
|
|
regulation of cd8 positive alpha beta t cell activation
|
GO:2001185 |
2 |
0.726
|
Human |
|
|
cytokine production
|
GO:0001816 |
247 |
0.712
|
Human |
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.685
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.655
|
Human |
|
|
negative regulation of endocytosis
|
GO:0045806 |
19 |
0.653
|
Human |
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.646
|
|
|
|
antigen processing and presentation
|
GO:0019882 |
33 |
0.643
|
Human |
|
|
regulation of osteoclast differentiation
|
GO:0045670 |
18 |
0.623
|
|
|
|
negative regulation of calcium ion transport
|
GO:0051926 |
19 |
0.614
|
Human |
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.591
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.580
|
Human |
|
|
biological adhesion
|
GO:0022610 |
331 |
0.569
|
Human |
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.569
|
Human |
|
|
osteoclast development
|
GO:0036035 |
2 |
0.550
|
Human |
|
|
tumor necrosis factor biosynthetic process
|
GO:0042533 |
8 |
0.549
|
Human |
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.527
|
Human |
|
|
regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
|
GO:2001188 |
2 |
0.524
|
Human |
|
|
type i interferon production
|
GO:0032606 |
27 |
0.523
|
Human |
|
|
response to lipid
|
GO:0033993 |
206 |
0.519
|
Human |
|
|
regulation of type i interferon production
|
GO:0032479 |
26 |
0.509
|
Human |
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.503
|
Human |
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.499
|
Human |
|
|
negative regulation of myeloid cell differentiation
|
GO:0045638 |
42 |
0.495
|
|
|
|
positive regulation of defense response to virus by host
|
GO:0002230 |
14 |
0.494
|
Human |
|
|
negative regulation of transforming growth factor beta secretion
|
GO:2001202 |
1 |
0.491
|
Human |
|
|
monoamine transport
|
GO:0015844 |
10 |
0.489
|
Human |
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.481
|
Human |
|
|
positive regulation of mononuclear cell proliferation
|
GO:0032946 |
47 |
0.481
|
Human |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.476
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.475
|
Human |
|
|
regulation of natural killer cell mediated cytotoxicity
|
GO:0042269 |
16 |
0.474
|
Human |
|
|
response to bacterium
|
GO:0009617 |
144 |
0.471
|
Human |
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.471
|
Human |
|
|
immune system development
|
GO:0002520 |
195 |
0.470
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.467
|
|
|
|
cytolysis
|
GO:0019835 |
8 |
0.467
|
Human |
|
|
defense response to virus
|
GO:0051607 |
71 |
0.465
|
Human |
|
|
myeloid cell development
|
GO:0061515 |
5 |
0.462
|
Human |
|
|
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002823 |
8 |
0.456
|
Human |
|
|
regulation of tumor necrosis factor biosynthetic process
|
GO:0042534 |
8 |
0.452
|
Human |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.443
|
Human |
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.443
|
Human |
|
|
interferon gamma secretion
|
GO:0072643 |
6 |
0.440
|
Human |
|
|
regulation of interleukin 12 secretion
|
GO:2001182 |
1 |
0.439
|
Human |
|
|
interleukin 10 secretion
|
GO:0072608 |
5 |
0.434
|
Human |
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.433
|
Human |
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.430
|
Human |
|
|
t cell proliferation involved in immune response
|
GO:0002309 |
1 |
0.426
|
Human |
|
|
interferon beta production
|
GO:0032608 |
23 |
0.421
|
Human |
|
|
dendritic cell differentiation
|
GO:0097028 |
13 |
0.409
|
Human |
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.404
|
Human |
|
|
regulation of cytokine secretion
|
GO:0050707 |
57 |
0.393
|
Human |
|
|
negative regulation of secretion by cell
|
GO:1903531 |
52 |
0.392
|
Human |
|
|
immune response inhibiting signal transduction
|
GO:0002765 |
4 |
0.389
|
Human |
|
|
defense response
|
GO:0006952 |
315 |
0.383
|
Human |
|
|
negative regulation of interferon gamma biosynthetic process
|
GO:0045077 |
1 |
0.376
|
Human |
|
|
cytokine production involved in immune response
|
GO:0002367 |
27 |
0.372
|
Human |
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.361
|
Human |
|
|
negative regulation of tumor necrosis factor production
|
GO:0032720 |
20 |
0.349
|
Human |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.348
|
Human |
|
|
protein secretion
|
GO:0009306 |
98 |
0.347
|
Human |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.344
|
Human |
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.335
|
Human |
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
40 |
0.328
|
Human |
|
|
negative regulation of leukocyte apoptotic process
|
GO:2000107 |
16 |
0.326
|
Human |
|
|
negative regulation of production of molecular mediator of immune response
|
GO:0002701 |
13 |
0.324
|
Human |
|
|
regulation of regulatory t cell differentiation
|
GO:0045589 |
4 |
0.322
|
Human |
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.322
|
Human |
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.319
|
Human |
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
0.312
|
Human |
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.312
|
Human |
|
|
negative regulation of osteoclast differentiation
|
GO:0045671 |
8 |
0.306
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.305
|
Human |
|
|
lymphocyte mediated immunity
|
GO:0002449 |
48 |
0.301
|
Human |
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.298
|
Human |
|
|
regulation of t cell mediated cytotoxicity
|
GO:0001914 |
8 |
0.297
|
Human |
|
|
negative regulation of t cell mediated immunity
|
GO:0002710 |
5 |
0.297
|
Human |
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.294
|
Human |
|
|
t cell tolerance induction
|
GO:0002517 |
4 |
0.292
|
Human |
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.286
|
Human |
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.281
|
Human |
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.273
|
Human |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.264
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.264
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.263
|
|
|
|
gamma delta t cell activation
|
GO:0046629 |
3 |
0.261
|
Human |
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.253
|
Human |
|
|
regulation of t cell tolerance induction
|
GO:0002664 |
4 |
0.249
|
Human |
|
|
t cell activation
|
GO:0042110 |
99 |
0.246
|
Human |
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.243
|
|
|
|
t cell mediated immunity
|
GO:0002456 |
25 |
0.237
|
Human |
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
73 |
0.236
|
Human |
|
|
negative regulation of alpha beta t cell activation
|
GO:0046636 |
3 |
0.227
|
Human |
|
|
regulation of natural killer cell mediated immunity
|
GO:0002715 |
16 |
0.216
|
Human |
|
|
negative regulation of interleukin 12 production
|
GO:0032695 |
6 |
0.212
|
Human |
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.211
|
Human |
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.209
|
Human |
|
|
cell activation
|
GO:0001775 |
213 |
0.209
|
Human |
|
|
negative regulation of cytokine production involved in immune response
|
GO:0002719 |
13 |
0.206
|
Human |
|
|
cytokine secretion involved in immune response
|
GO:0002374 |
7 |
0.204
|
Human |
|
|
secretion by cell
|
GO:0032940 |
226 |
0.198
|
Human |
|
|
regulation of interferon gamma biosynthetic process
|
GO:0045072 |
8 |
0.190
|
Human |
|
|
negative regulation of protein secretion
|
GO:0050709 |
29 |
0.189
|
Human |
|
|
serotonin secretion
|
GO:0001820 |
1 |
0.186
|
Human |
|
|
regulation of cytolysis
|
GO:0042268 |
6 |
0.182
|
Human |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.181
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.179
|
Human |
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.178
|
Human |
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.178
|
Human |
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
48 |
0.170
|
|
|
|
regulation of defense response to virus by host
|
GO:0050691 |
22 |
0.162
|
Human |
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.162
|
Human |
|
|
endocytosis
|
GO:0006897 |
159 |
0.161
|
Human |
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.160
|
Human |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.159
|
Human |
|
|
t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
|
GO:0002291 |
4 |
0.151
|
Human |
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
37 |
0.141
|
Human |
|
|
regulation of alpha beta t cell activation
|
GO:0046634 |
13 |
0.141
|
Human |
|
|
cell killing
|
GO:0001906 |
34 |
0.141
|
Human |
|
|
leukocyte mediated cytotoxicity
|
GO:0001909 |
27 |
0.140
|
Human |
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.140
|
Human |
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.139
|
Human |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.138
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.138
|
Human |
|
|
regulation of interferon beta production
|
GO:0032648 |
22 |
0.138
|
Human |
|
|
negative regulation of leukocyte differentiation
|
GO:1902106 |
24 |
0.132
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.127
|
Human |
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.127
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.126
|
Human |
|
|
cell adhesion
|
GO:0007155 |
325 |
0.124
|
Human |
|
|
positive regulation of t cell activation
|
GO:0050870 |
54 |
0.123
|
Human |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.118
|
Human |
|
|
regulation of interferon gamma production
|
GO:0032649 |
36 |
0.108
|
Human |
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
20 |
0.107
|
Human |
|
|
negative regulation of cytokine secretion
|
GO:0050710 |
20 |
0.107
|
Human |
|
|
negative regulation of leukocyte activation
|
GO:0002695 |
26 |
0.106
|
Human |
|
|
regulation of defense response to virus
|
GO:0050688 |
33 |
0.106
|
Human |
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.106
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.103
|
Human |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.103
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.100
|
Human |
|
|
negative regulation of immune response
|
GO:0050777 |
40 |
0.096
|
Human |
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
22 |
0.093
|
Human |
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.092
|
|
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.092
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
37 |
0.091
|
Human |
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
25 |
0.088
|
Human |
|
|
serotonin transport
|
GO:0006837 |
3 |
0.088
|
Human |
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.087
|
Human |
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.087
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.085
|
|
|
|
negative regulation of cytokine biosynthetic process
|
GO:0042036 |
11 |
0.085
|
Human |
|
|
phagocytosis engulfment
|
GO:0006911 |
7 |
0.085
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.083
|
Human |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.080
|
Human |
|
|
immune effector process
|
GO:0002252 |
159 |
0.080
|
Human |
|
|
negative regulation of ion transport
|
GO:0043271 |
39 |
0.080
|
Human |
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.080
|
Human |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.079
|
|
|
|
inflammatory response
|
GO:0006954 |
79 |
0.079
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.079
|
Human |
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.072
|
Human |
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.071
|
Human |
|
|
complement component c5a signaling pathway
|
GO:0038178 |
1 |
0.071
|
|
|
|
negative regulation of mononuclear cell proliferation
|
GO:0032945 |
15 |
0.069
|
Human |
|
|
innate immune response
|
GO:0045087 |
178 |
0.065
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.062
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.061
|
Human |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.060
|
Human |
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.060
|
Human |
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.059
|
Human |
|
|
leukocyte migration
|
GO:0050900 |
107 |
0.059
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.058
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.058
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.058
|
|
|
|
tolerance induction
|
GO:0002507 |
6 |
0.057
|
Human |
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.056
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.055
|
Human |
|
|
negative regulation of t cell proliferation
|
GO:0042130 |
8 |
0.055
|
Human |
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.054
|
Human |
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
29 |
0.053
|
Human |
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.052
|
|
|
|
t cell mediated cytotoxicity
|
GO:0001913 |
9 |
0.052
|
Human |
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.051
|
Human |
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.051
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.050
|
|
|
|
sensory perception of pain
|
GO:0019233 |
4 |
0.049
|
|
|
|
regulation of dendritic cell differentiation
|
GO:2001198 |
3 |
0.049
|
Human |
|
|
negative regulation of leukocyte mediated cytotoxicity
|
GO:0001911 |
5 |
0.049
|
Human |
|
|
innate immune response activating signal transduction
|
GO:0002758 |
48 |
0.048
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.047
|
Human |
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.047
|
|
|
|
t cell activation involved in immune response
|
GO:0002286 |
13 |
0.047
|
Human |
|
|
regulation of t cell differentiation
|
GO:0045580 |
19 |
0.046
|
Human |
|
|
interleukin 10 production
|
GO:0032613 |
17 |
0.046
|
Human |
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.046
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.045
|
Human |
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.044
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.043
|
Human |
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.043
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.042
|
Human |
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.041
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.041
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.041
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.041
|
Human |
|
|
negative regulation of cell activation
|
GO:0050866 |
33 |
0.040
|
Human |
|
|
regulation of adaptive immune response
|
GO:0002819 |
33 |
0.040
|
Human |
|
|
granulocyte migration
|
GO:0097530 |
40 |
0.040
|
|
|
|
regulation of chemotaxis
|
GO:0050920 |
74 |
0.039
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.039
|
Human |
|
|
negative regulation of cell development
|
GO:0010721 |
48 |
0.039
|
Human |
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.039
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
48 |
0.038
|
Human |
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.038
|
Human |
|
|
regulation of phagocytosis engulfment
|
GO:0060099 |
2 |
0.038
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.038
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.038
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.037
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.037
|
|
|
|
natural killer cell mediated immunity
|
GO:0002228 |
23 |
0.037
|
Human |
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.036
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.035
|
|
|
|
negative regulation of adaptive immune response
|
GO:0002820 |
9 |
0.035
|
Human |
|
|
regulation of cell killing
|
GO:0031341 |
22 |
0.035
|
Human |
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.035
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.034
|
Human |
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.034
|
Human |
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.034
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.034
|
Human |
|
|
regulation of antigen processing and presentation
|
GO:0002577 |
6 |
0.034
|
Human |
|
|
negative regulation of cell killing
|
GO:0031342 |
5 |
0.033
|
Human |
|
|
negative regulation of t cell activation
|
GO:0050868 |
18 |
0.033
|
Human |
|
|
response to wounding
|
GO:0009611 |
168 |
0.033
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.032
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.032
|
|
|
|
myeloid leukocyte migration
|
GO:0097529 |
62 |
0.032
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.032
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.032
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.031
|
|
|
|
positive regulation of lymphocyte differentiation
|
GO:0045621 |
13 |
0.031
|
Human |
|
|
regulation of t cell proliferation
|
GO:0042129 |
42 |
0.031
|
Human |
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.030
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.030
|
Human |
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.029
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.029
|
Human |
|
|
taxis
|
GO:0042330 |
157 |
0.029
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
35 |
0.028
|
Human |
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.028
|
|
|
|
negative regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903556 |
20 |
0.028
|
Human |
|
|
exocytosis
|
GO:0006887 |
71 |
0.028
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.028
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.028
|
|
|
|
negative regulation of immune effector process
|
GO:0002698 |
38 |
0.028
|
Human |
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.028
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.028
|
|
|
|
anatomical structure regression
|
GO:0060033 |
1 |
0.027
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.027
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.027
|
|
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.026
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.026
|
Human |
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.026
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
43 |
0.026
|
Human |
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.026
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.026
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.026
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.026
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.026
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.025
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.025
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.025
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.025
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.025
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
25 |
0.025
|
Human |
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.025
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.025
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.024
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.024
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.024
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.024
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
33 |
0.024
|
Human |
|
|
negative regulation of osteoclast development
|
GO:2001205 |
1 |
0.024
|
Human |
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.023
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.023
|
Human |
|
|
myeloid dendritic cell activation
|
GO:0001773 |
4 |
0.023
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.023
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.022
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.022
|
|
|
|
negative regulation of lymphocyte proliferation
|
GO:0050672 |
15 |
0.022
|
Human |
|
|
alcohol metabolic process
|
GO:0006066 |
114 |
0.022
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.022
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.022
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.022
|
|
|
|
t cell proliferation
|
GO:0042098 |
45 |
0.022
|
Human |
|
|
negative regulation of natural killer cell mediated cytotoxicity
|
GO:0045953 |
5 |
0.021
|
Human |
|
|
regulation of interleukin 10 production
|
GO:0032653 |
16 |
0.021
|
Human |
|
|
protein processing
|
GO:0016485 |
226 |
0.021
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.021
|
Human |
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.021
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.021
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.021
|
Human |
|
|
cell development
|
GO:0048468 |
328 |
0.021
|
Human |
|
|
polyol metabolic process
|
GO:0019751 |
32 |
0.021
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.021
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.021
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.021
|
|
|
|
regulation of peptide hormone secretion
|
GO:0090276 |
41 |
0.020
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.020
|
|
|
|
substantia nigra development
|
GO:0021762 |
45 |
0.020
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.020
|
Human |
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.020
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.020
|
|
|
|
negative regulation of phagocytosis engulfment
|
GO:0060101 |
1 |
0.020
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.020
|
|
|
|
regulation of myeloid leukocyte mediated immunity
|
GO:0002886 |
4 |
0.020
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.019
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.019
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.019
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.019
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.019
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.019
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.019
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.019
|
|
|
|
midbrain development
|
GO:0030901 |
45 |
0.019
|
|
|
|
phagocytosis
|
GO:0006909 |
42 |
0.019
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.019
|
|
|
|
granulocyte chemotaxis
|
GO:0071621 |
37 |
0.019
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.019
|
|
|
|
negative regulation of antigen processing and presentation
|
GO:0002578 |
5 |
0.018
|
Human |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.018
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.018
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.018
|
|
|
|
complement receptor mediated signaling pathway
|
GO:0002430 |
3 |
0.018
|
|
|
|
negative regulation of interleukin 10 secretion
|
GO:2001180 |
1 |
0.018
|
Human |
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.018
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.017
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.017
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.017
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.017
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.017
|
|
|
|
glycerol metabolic process
|
GO:0006071 |
4 |
0.017
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.017
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.017
|
|
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.017
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.017
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.017
|
|
|
|
response to fungus
|
GO:0009620 |
4 |
0.017
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.017
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.017
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.017
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.017
|
|
|
|
t cell differentiation
|
GO:0030217 |
29 |
0.017
|
Human |
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.017
|
|
|
|
t cell migration
|
GO:0072678 |
16 |
0.016
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.016
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.016
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.016
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.016
|
|
|
|
alcohol biosynthetic process
|
GO:0046165 |
52 |
0.016
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.016
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.016
|
|
|
|
neutrophil chemotaxis
|
GO:0030593 |
24 |
0.016
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.016
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.016
|
|
|
|
cytokine secretion
|
GO:0050663 |
64 |
0.016
|
Human |
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.016
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.016
|
|
|
|
regulation of peptide transport
|
GO:0090087 |
62 |
0.016
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.016
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.016
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.016
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.016
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.016
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.015
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.015
|
|
|
|
regulation of leukocyte mediated cytotoxicity
|
GO:0001910 |
19 |
0.015
|
Human |
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.015
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.015
|
|
|
|
positive regulation of chemotaxis
|
GO:0050921 |
57 |
0.015
|
|
|
|
cell projection assembly
|
GO:0030031 |
126 |
0.015
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.015
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.015
|
|
|
|
negative regulation of cytokine mediated signaling pathway
|
GO:0001960 |
22 |
0.015
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.015
|
|
|
|
head development
|
GO:0060322 |
108 |
0.015
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.015
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.015
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.015
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.015
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.015
|
|
|
|
positive regulation of cell cycle process
|
GO:0090068 |
106 |
0.015
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.015
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.015
|
|
|
|
response to interferon gamma
|
GO:0034341 |
39 |
0.015
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
24 |
0.015
|
|
|
|
negative regulation of response to cytokine stimulus
|
GO:0060761 |
25 |
0.015
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.015
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.015
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.015
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.014
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.014
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.014
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.014
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.014
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.014
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.014
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.014
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.014
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.014
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.014
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.014
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.014
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.014
|
|
|
|
activation of innate immune response
|
GO:0002218 |
55 |
0.014
|
|
|
|
toll like receptor signaling pathway
|
GO:0002224 |
25 |
0.014
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.014
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.013
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.013
|
|
|
|
negative regulation of activation of jak2 kinase activity
|
GO:1902569 |
1 |
0.013
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.013
|
|
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.013
|
|
|
|
regulation of interleukin 12 production
|
GO:0032655 |
15 |
0.013
|
Human |
|
|
positive regulation of leukocyte chemotaxis
|
GO:0002690 |
38 |
0.013
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.013
|
|
|
|
mast cell activation involved in immune response
|
GO:0002279 |
4 |
0.013
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.013
|
Human |
|
|
viral life cycle
|
GO:0019058 |
132 |
0.013
|
|
|
|
spermatid development
|
GO:0007286 |
4 |
0.013
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.013
|
|
|
|
regulatory t cell differentiation
|
GO:0045066 |
5 |
0.013
|
Human |
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.013
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.013
|
|
|
|
immunoglobulin transcytosis in epithelial cells
|
GO:0002414 |
1 |
0.013
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.013
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
22 |
0.013
|
Human |
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.012
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.012
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.012
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.012
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.012
|
|
|
|
interferon gamma production
|
GO:0032609 |
39 |
0.012
|
Human |
|
|
hindbrain development
|
GO:0030902 |
3 |
0.012
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.012
|
|
|
|
system process
|
GO:0003008 |
349 |
0.012
|
|
|
|
negative regulation of nk t cell activation
|
GO:0051134 |
1 |
0.012
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.012
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.012
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.012
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.012
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.012
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.012
|
|
