Homo sapiens

23 known processes

KLK4

kallikrein-related peptidase 4

(Aliases: PSTS,MGC116827,EMSP,MGC116828,PRSS17,ARM1,KLK-L1,EMSP1,AI2A1)

KLK4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
epithelium development GO:0060429 227 0.088
Human
epidermis morphogenesis GO:0048730 3 0.074
Human
post embryonic development GO:0009791 2 0.064
organ formation GO:0048645 3 0.055
mating GO:0007618 1 0.050
Human
anatomical structure formation involved in morphogenesis GO:0048646 284 0.044
cardiovascular system development GO:0072358 262 0.043
epithelial cell differentiation GO:0030855 141 0.042
multicellular organismal aging GO:0010259 3 0.042
locomotory behavior GO:0007626 1 0.040
positive regulation of developmental process GO:0051094 314 0.040
regulation of cell differentiation GO:0045595 393 0.039
circulatory system development GO:0072359 262 0.038
cellular component morphogenesis GO:0032989 314 0.037
insemination GO:0007320 1 0.036
Human
lipid metabolic process GO:0006629 381 0.035
determination of adult lifespan GO:0008340 2 0.035
female gamete generation GO:0007292 2 0.035
hindbrain development GO:0030902 3 0.034
cell morphogenesis GO:0000902 296 0.034
regulation of cellular ketone metabolic process GO:0010565 50 0.034
cell development GO:0048468 328 0.033
regulation of cellular amino acid metabolic process GO:0006521 6 0.032
segmentation GO:0035282 4 0.032
organ morphogenesis GO:0009887 147 0.032
vasculature development GO:0001944 181 0.032
positive regulation of aldosterone metabolic process GO:0032346 2 0.031
oogenesis GO:0048477 2 0.031
regulation of cellular component movement GO:0051270 334 0.031
regulation of anatomical structure morphogenesis GO:0022603 286 0.031
nervous system development GO:0007399 293 0.031
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.029
positive regulation of cell differentiation GO:0045597 211 0.029
regulation of cellular amine metabolic process GO:0033238 11 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
purine ribonucleoside metabolic process GO:0046128 437 0.029
cellular ketone metabolic process GO:0042180 80 0.029
cellular amino acid metabolic process GO:0006520 116 0.029
regulation of locomotion GO:0040012 329 0.028
negative regulation of multicellular organismal process GO:0051241 317 0.028
positive regulation of cell proliferation GO:0008284 301 0.027
positive regulation of hydrolase activity GO:0051345 331 0.026
small gtpase mediated signal transduction GO:0007264 78 0.026
cellular response to endogenous stimulus GO:0071495 336 0.026
amine metabolic process GO:0009308 44 0.026
somitogenesis GO:0001756 2 0.026
cell cell signaling GO:0007267 155 0.026
regulation of cell cycle GO:0051726 393 0.025
negative regulation of protein metabolic process GO:0051248 391 0.025
positive regulation of steroid hormone biosynthetic process GO:0090031 2 0.025
positive regulation of cellular amine metabolic process GO:0033240 7 0.025
regulation of cell migration GO:0030334 289 0.025
protein processing GO:0016485 226 0.025
Human
epithelial cell migration GO:0010631 119 0.025
Human
morphogenesis of an epithelium GO:0002009 60 0.025
Human
protein catabolic process GO:0030163 325 0.024
Mouse
biological adhesion GO:0022610 331 0.024
head development GO:0060322 108 0.024
nucleoside triphosphate metabolic process GO:0009141 422 0.023
cell fate determination GO:0001709 3 0.023
purine nucleoside triphosphate catabolic process GO:0009146 392 0.023
anterior posterior axis specification GO:0009948 2 0.022
cellular amine metabolic process GO:0044106 41 0.022
hair follicle morphogenesis GO:0031069 2 0.022
limbic system development GO:0021761 3 0.022
epithelium migration GO:0090132 119 0.022
Human
cell adhesion GO:0007155 325 0.022
compound eye development GO:0048749 1 0.022
cell projection organization GO:0030030 252 0.022
regulation of cell motility GO:2000145 299 0.022
response to hormone GO:0009725 175 0.022
negative regulation of developmental process GO:0051093 247 0.021
central nervous system development GO:0007417 123 0.021
peripheral nervous system development GO:0007422 2 0.021
single organism cellular localization GO:1902580 332 0.021
ribonucleoside catabolic process GO:0042454 406 0.021
blastoderm segmentation GO:0007350 2 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.021
metencephalon development GO:0022037 2 0.021
cellular response to dna damage stimulus GO:0006974 379 0.021
purine nucleoside triphosphate metabolic process GO:0009144 412 0.021
cellular macromolecule catabolic process GO:0044265 380 0.021
positive regulation of aldosterone biosynthetic process GO:0032349 2 0.021
neuromuscular junction development GO:0007528 3 0.020
regeneration GO:0031099 4 0.020
growth GO:0040007 202 0.020
immune response GO:0006955 307 0.020
oocyte differentiation GO:0009994 2 0.020
negative regulation of cellular protein metabolic process GO:0032269 353 0.020
response to lipid GO:0033993 206 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
system process GO:0003008 349 0.019
generation of neurons GO:0048699 152 0.019
single organism membrane organization GO:0044802 268 0.019
oocyte development GO:0048599 1 0.019
blood vessel development GO:0001568 172 0.019
brain development GO:0007420 97 0.019
neuron fate commitment GO:0048663 2 0.019
organophosphate catabolic process GO:0046434 430 0.019
positive regulation of odontogenesis GO:0042482 3 0.019
embryonic forelimb morphogenesis GO:0035115 4 0.019
forelimb morphogenesis GO:0035136 4 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.019
ras protein signal transduction GO:0007265 73 0.019
negative regulation of protein modification process GO:0031400 200 0.018
epidermis development GO:0008544 59 0.018
Human
negative regulation of cellular component movement GO:0051271 106 0.018
regulation of proteolysis GO:0030162 293 0.018
mitotic cell cycle GO:0000278 326 0.018
regulation of gtpase activity GO:0043087 180 0.018
regulation of nervous system development GO:0051960 88 0.018
purine containing compound catabolic process GO:0072523 411 0.018
positive regulation of proteolysis GO:0045862 142 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
spermatid differentiation GO:0048515 4 0.018
cell morphogenesis involved in differentiation GO:0000904 144 0.018
glycosyl compound catabolic process GO:1901658 413 0.018
cardiac right ventricle morphogenesis GO:0003215 3 0.018
cytoplasmic transport GO:0016482 379 0.018
purine nucleotide catabolic process GO:0006195 405 0.018
guanosine containing compound catabolic process GO:1901069 239 0.018
negative regulation of cell death GO:0060548 345 0.018
endomembrane system organization GO:0010256 196 0.017
protein maturation GO:0051604 233 0.017
Human
enzyme linked receptor protein signaling pathway GO:0007167 303 0.017
regulation of hormone levels GO:0010817 125 0.017
nucleoside triphosphate catabolic process GO:0009143 394 0.017
ribonucleoside triphosphate catabolic process GO:0009203 391 0.017
regulation of cell development GO:0060284 161 0.017
lipid biosynthetic process GO:0008610 177 0.017
hematopoietic or lymphoid organ development GO:0048534 186 0.017
negative regulation of cellular component organization GO:0051129 235 0.017
cellular protein catabolic process GO:0044257 261 0.017
negative regulation of catalytic activity GO:0043086 335 0.017
post embryonic organ development GO:0048569 1 0.017
regulation of transferase activity GO:0051338 355 0.017
actin filament based process GO:0030029 224 0.017
adult locomotory behavior GO:0008344 1 0.017
positive regulation of phosphorylation GO:0042327 394 0.017
regulation of cytoskeleton organization GO:0051493 177 0.017
circadian behavior GO:0048512 2 0.017
associative learning GO:0008306 1 0.017
cranial nerve development GO:0021545 4 0.017
regulation of kinase activity GO:0043549 314 0.017
blood vessel morphogenesis GO:0048514 162 0.017
photoreceptor cell differentiation GO:0046530 2 0.017
transmembrane transport GO:0055085 399 0.016
ribonucleotide catabolic process GO:0009261 405 0.016
positive regulation of cellular component organization GO:0051130 376 0.016
negative regulation of cell cycle GO:0045786 193 0.016
spinal cord development GO:0021510 4 0.016
nucleotide catabolic process GO:0009166 408 0.016
tissue morphogenesis GO:0048729 96 0.016
Human
negative regulation of programmed cell death GO:0043069 321 0.016
purine nucleoside catabolic process GO:0006152 398 0.016
neurogenesis GO:0022008 169 0.016
cellular response to hormone stimulus GO:0032870 125 0.016
regulation of growth GO:0040008 165 0.016
regulation of endopeptidase activity GO:0052548 170 0.016
regulation of protein kinase activity GO:0045859 289 0.016
cell part morphogenesis GO:0032990 137 0.016
dephosphorylation GO:0016311 209 0.016
cellular lipid metabolic process GO:0044255 303 0.016
positive regulation of apoptotic process GO:0043065 246 0.015
tissue migration GO:0090130 119 0.015
Human
rhythmic behavior GO:0007622 2 0.015
defense response GO:0006952 315 0.015
purine ribonucleotide catabolic process GO:0009154 404 0.015
nucleoside phosphate catabolic process GO:1901292 412 0.015
gtp metabolic process GO:0046039 239 0.015
gtp catabolic process GO:0006184 237 0.015
negative regulation of cell proliferation GO:0008285 228 0.015
morphogenesis of embryonic epithelium GO:0016331 4 0.015
endothelial cell migration GO:0043542 86 0.015
Human
cerebellum development GO:0021549 2 0.015
negative regulation of phosphate metabolic process GO:0045936 267 0.015
regulation of mitotic cell cycle GO:0007346 189 0.015
regulation of cellular response to stress GO:0080135 244 0.015
regulation of protein transport GO:0051223 213 0.015
protein localization to organelle GO:0033365 280 0.015
response to oxygen containing compound GO:1901700 369 0.015
spermatid development GO:0007286 4 0.015
negative regulation of phosphorylation GO:0042326 174 0.015
muscle structure development GO:0061061 98 0.015
regulation of cytokine production GO:0001817 232 0.015
negative regulation of hydrolase activity GO:0051346 182 0.015
carbohydrate derivative biosynthetic process GO:1901137 207 0.015
regulation of purine nucleotide metabolic process GO:1900542 264 0.015
regulation of cell cycle process GO:0010564 266 0.015
reproductive process GO:0022414 106 0.015
Human
negative regulation of cell migration GO:0030336 102 0.015
negative regulation of testicular blood vessel morphogenesis GO:0061369 1 0.015
glycoprotein metabolic process GO:0009100 110 0.014
regulation of cell adhesion GO:0030155 166 0.014
mesonephric duct development GO:0072177 3 0.014
embryo development GO:0009790 123 0.014
positive regulation of catabolic process GO:0009896 310 0.014
regulation of vasculature development GO:1901342 97 0.014
specification of organ identity GO:0010092 3 0.014
ribonucleoside triphosphate metabolic process GO:0009199 412 0.014
positive regulation of nucleotide metabolic process GO:0045981 230 0.014
positive regulation of tooth mineralization GO:0070172 2 0.014
mitotic cell cycle process GO:1903047 286 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.014
cell growth GO:0016049 160 0.014
cellular response to oxygen containing compound GO:1901701 276 0.014
positive regulation of transport GO:0051050 336 0.014
ameboidal type cell migration GO:0001667 135 0.014
Human
membrane organization GO:0061024 292 0.014
neuron differentiation GO:0030182 138 0.014
pattern specification process GO:0007389 43 0.014
anterior posterior axis specification embryo GO:0008595 2 0.014
plasma membrane organization GO:0007009 115 0.014
memory GO:0007613 3 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.014
response to abiotic stimulus GO:0009628 336 0.014
response to fungus GO:0009620 4 0.014
cardiac muscle cell contraction GO:0086003 4 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
syncytium formation by plasma membrane fusion GO:0000768 2 0.014
response to organic cyclic compound GO:0014070 204 0.014
regulation of peptidase activity GO:0052547 180 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
regulation of protein localization GO:0032880 296 0.014
rna processing GO:0006396 255 0.014
negative regulation of locomotion GO:0040013 118 0.014
regulation of nucleotide metabolic process GO:0006140 269 0.014
purine ribonucleoside catabolic process GO:0046130 398 0.013
inner ear morphogenesis GO:0042472 4 0.013
protein localization to membrane GO:0072657 160 0.013
actin filament based movement GO:0030048 17 0.013
detection of chemical stimulus involved in sensory perception of sweet taste GO:0001582 2 0.013
negative regulation of cell motility GO:2000146 104 0.013
microtubule based process GO:0007017 210 0.013
hemopoiesis GO:0030097 180 0.013
small molecule biosynthetic process GO:0044283 157 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
nerve development GO:0021675 4 0.013
maintenance of location GO:0051235 112 0.013
cellular macromolecular complex assembly GO:0034622 324 0.013
guanosine containing compound metabolic process GO:1901068 244 0.013
skeletal system development GO:0001501 79 0.013
immune system development GO:0002520 195 0.013
positive regulation of hormone biosynthetic process GO:0046886 4 0.013
regulation of cell growth GO:0001558 135 0.013
protein ubiquitination GO:0016567 314 0.013
protein modification by small protein conjugation GO:0032446 342 0.013
regulation of nucleoside metabolic process GO:0009118 209 0.013
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.013
cell projection morphogenesis GO:0048858 129 0.013
tissue regeneration GO:0042246 3 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
neuron development GO:0048666 113 0.013
single organism cell adhesion GO:0098602 179 0.013
positive regulation of cell death GO:0010942 263 0.013
regulation of dna metabolic process GO:0051052 153 0.013
organelle assembly GO:0070925 176 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
angiogenesis GO:0001525 147 0.013
positive regulation of kinase activity GO:0033674 204 0.013
cation transport GO:0006812 331 0.012
regulation of cellular component biogenesis GO:0044087 281 0.012
cell differentiation in spinal cord GO:0021515 1 0.012
stem cell differentiation GO:0048863 93 0.012
tripartite regional subdivision GO:0007351 2 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.012
establishment of protein localization to membrane GO:0090150 121 0.012
non canonical wnt signaling pathway via mapk cascade GO:0038030 4 0.012
embryonic morphogenesis GO:0048598 85 0.012
heart field specification GO:0003128 2 0.012
skin development GO:0043588 76 0.012
Human
patterning of blood vessels GO:0001569 2 0.012
single organismal cell cell adhesion GO:0016337 148 0.012
complement activation alternative pathway GO:0006957 1 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.012
regulation of synaptic plasticity GO:0048167 3 0.012
neuron projection development GO:0031175 106 0.012
intracellular protein transport GO:0006886 270 0.012
response to wounding GO:0009611 168 0.012
secretion GO:0046903 254 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
cation homeostasis GO:0055080 189 0.012
sensory perception of pain GO:0019233 4 0.012
regulation of gtp catabolic process GO:0033124 180 0.012
somatic muscle development GO:0007525 1 0.012
dna repair GO:0006281 198 0.012
cell aggregation GO:0098743 1 0.012
positive regulation of transferase activity GO:0051347 227 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.012
regulation of ion transport GO:0043269 189 0.012
heart development GO:0007507 95 0.012
sequestering of metal ion GO:0051238 24 0.012
modification dependent macromolecule catabolic process GO:0043632 212 0.012
positive regulation of cell motility GO:2000147 177 0.012
histone modification GO:0016570 251 0.011
epidermal cell differentiation GO:0009913 45 0.011
secretion by cell GO:0032940 226 0.011
positive regulation of immune system process GO:0002684 283 0.011
cellular homeostasis GO:0019725 196 0.011
regulation of meiosis GO:0040020 3 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
positive regulation of gtp catabolic process GO:0033126 166 0.011
cd8 positive alpha beta t cell activation GO:0036037 3 0.011
protein targeting GO:0006605 187 0.011
actin mediated cell contraction GO:0070252 12 0.011
chromatin modification GO:0016568 298 0.011
positive regulation of gtpase activity GO:0043547 166 0.011
metal ion homeostasis GO:0055065 169 0.011
regulation of protein catabolic process GO:0042176 155 0.011
behavior GO:0007610 112 0.011
aortic valve development GO:0003176 3 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
developmental programmed cell death GO:0010623 3 0.011
rho protein signal transduction GO:0007266 26 0.011
thymus development GO:0048538 3 0.011
positive regulation of synaptic transmission GO:0050806 4 0.011
ubiquitin dependent protein catabolic process GO:0006511 206 0.011
myoblast fusion GO:0007520 1 0.011
negative regulation of growth GO:0045926 97 0.011
visual behavior GO:0007632 2 0.011
regulation of response to external stimulus GO:0032101 222 0.011
chemotaxis GO:0006935 157 0.011
cell division GO:0051301 168 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
protein localization to plasma membrane GO:0072659 93 0.011
heart formation GO:0060914 2 0.011
primary neural tube formation GO:0014020 3 0.011
regulation of epithelial cell proliferation GO:0050678 113 0.011
regulation of binding GO:0051098 111 0.011
nucleoside catabolic process GO:0009164 408 0.011
cell substrate adhesion GO:0031589 132 0.011
carbohydrate metabolic process GO:0005975 207 0.011
forebrain neuron differentiation GO:0021879 3 0.011
cell projection assembly GO:0030031 126 0.011
monocarboxylic acid metabolic process GO:0032787 185 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
innate immune response GO:0045087 178 0.011
regulation of heart growth GO:0060420 4 0.011
positive regulation of endopeptidase activity GO:0010950 84 0.011
covalent chromatin modification GO:0016569 254 0.011
modification dependent protein catabolic process GO:0019941 209 0.011
neural tube closure GO:0001843 3 0.011
positive regulation of cellular component movement GO:0051272 181 0.011
positive regulation of hyaluranon cable assembly GO:1900106 3 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathway GO:0035625 4 0.011
negative regulation of organelle organization GO:0010639 126 0.011
microtubule cytoskeleton organization GO:0000226 176 0.011
chromatin organization GO:0006325 351 0.011
apoptotic signaling pathway GO:0097190 268 0.011
cytokine production GO:0001816 247 0.011
organelle fission GO:0048285 149 0.010
nucleocytoplasmic transport GO:0006913 176 0.010
muscle tissue development GO:0060537 62 0.010
ossification GO:0001503 121 0.010
sex determination GO:0007530 3 0.010
postsynaptic membrane organization GO:0001941 2 0.010
regulation of wnt signaling pathway GO:0030111 123 0.010
wnt signaling pathway GO:0016055 156 0.010
single organism reproductive process GO:0044702 98 0.010
Human
blastocyst development GO:0001824 3 0.010
hormone secretion GO:0046879 65 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.010
chemical homeostasis GO:0048878 306 0.010
meiosis i GO:0007127 4 0.010
neural tube patterning GO:0021532 2 0.010
regulation of actin filament based process GO:0032970 141 0.010
cardiac muscle contraction GO:0060048 34 0.010
positive regulation of nucleoside metabolic process GO:0045979 186 0.010
negative regulation of transferase activity GO:0051348 124 0.010
forebrain generation of neurons GO:0021872 3 0.010
regulation of protein maturation GO:1903317 150 0.010
response to cytokine GO:0034097 232 0.010
g protein coupled receptor signaling pathway GO:0007186 207 0.010
Human
positive regulation of protein phosphorylation GO:0001934 313 0.010
oxidation reduction process GO:0055114 396 0.010
regulation of neural precursor cell proliferation GO:2000177 4 0.010
response to biotic stimulus GO:0009607 276 0.010
organonitrogen compound biosynthetic process GO:1901566 200 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.010
response to external biotic stimulus GO:0043207 261 0.010
single organism carbohydrate metabolic process GO:0044723 193 0.010
regulation of ras gtpase activity GO:0032318 128 0.010
positive regulation of organelle organization GO:0010638 195 0.010
pericardium development GO:0060039 2 0.010
metal ion transport GO:0030001 272 0.010
forebrain regionalization GO:0021871 3 0.010
reactive oxygen species biosynthetic process GO:1903409 4 0.010
regionalization GO:0003002 29 0.010
protein localization to nucleus GO:0034504 136 0.010

KLK4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.033
sensory system disease DOID:0050155 203 0.025
nervous system disease DOID:863 431 0.025
musculoskeletal system disease DOID:17 223 0.019
eye and adnexa disease DOID:1492 150 0.019
eye disease DOID:5614 149 0.018
bone disease DOID:0080001 88 0.013
connective tissue disease DOID:65 109 0.013
inherited metabolic disorder DOID:655 242 0.013
cancer DOID:162 167 0.011
disease of cellular proliferation DOID:14566 174 0.011
acquired metabolic disease DOID:0060158 58 0.010
gastrointestinal system disease DOID:77 36 0.007
mouth disease DOID:403 14 0.003
tooth disease DOID:1091 14 0.003
teeth hard tissue disease DOID:214 8 0.001
amelogenesis imperfecta DOID:2187 7 0.001
dental enamel hypoplasia DOID:693 7 0.001