Homo sapiens

17 known processes

COPS2

COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)

(Aliases: ALIEN,SGN2,TRIP15,CSN2)

COPS2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cullin deneddylation GO:0010388 9 0.993
protein deneddylation GO:0000338 10 0.911
negative regulation of cell proliferation GO:0008285 228 0.794
post embryonic development GO:0009791 2 0.773
regulation of cell cycle process GO:0010564 266 0.671
Fly
regulation of protein stability GO:0031647 87 0.665
Fly
protein modification by small protein removal GO:0070646 92 0.436
positive regulation of programmed cell death GO:0043068 249 0.409
nervous system development GO:0007399 293 0.403
Fly
positive regulation of protein kinase activity GO:0045860 190 0.387
internal protein amino acid acetylation GO:0006475 101 0.373
negative regulation of protein processing GO:0010955 142 0.370
internal peptidyl lysine acetylation GO:0018393 97 0.345
mitotic cell cycle process GO:1903047 286 0.332
Fly
cellular response to dna damage stimulus GO:0006974 379 0.320
Fly
chromatin organization GO:0006325 351 0.306
mitotic cell cycle phase transition GO:0044772 162 0.295
Fly
reproductive structure development GO:0048608 55 0.293
negative regulation of cell cycle GO:0045786 193 0.281
Fly
posttranscriptional regulation of gene expression GO:0010608 213 0.280
Fly
histone acetylation GO:0016573 93 0.278
g2 dna damage checkpoint GO:0031572 26 0.271
Fly
sex differentiation GO:0007548 45 0.266
regulation of kinase activity GO:0043549 314 0.264
regulation of cell cycle GO:0051726 393 0.249
Fly
single organism cellular localization GO:1902580 332 0.241
dna integrity checkpoint GO:0031570 71 0.239
Fly
dna repair GO:0006281 198 0.225
segmentation GO:0035282 4 0.221
protein processing GO:0016485 226 0.205
cellular macromolecular complex assembly GO:0034622 324 0.189
female gamete generation GO:0007292 2 0.182
cellular protein catabolic process GO:0044257 261 0.178
mitotic cell cycle checkpoint GO:0007093 68 0.171
Fly
oogenesis GO:0048477 2 0.159
regulation of proteolysis GO:0030162 293 0.153
vesicle mediated transport GO:0016192 371 0.148
Fly
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.146
cyclin catabolic process GO:0008054 6 0.145
positive regulation of transferase activity GO:0051347 227 0.137
activation of nf kappab inducing kinase activity GO:0007250 9 0.137
single organism reproductive process GO:0044702 98 0.135
modification dependent macromolecule catabolic process GO:0043632 212 0.128
protein acylation GO:0043543 138 0.123
positive regulation of cell death GO:0010942 263 0.123
positive regulation of protein phosphorylation GO:0001934 313 0.122
protein dna complex subunit organization GO:0071824 80 0.118
positive regulation of phosphorylation GO:0042327 394 0.113
cellular response to nitrogen compound GO:1901699 144 0.113
negative regulation of mitotic cell cycle GO:0045930 102 0.108
Fly
cell cycle checkpoint GO:0000075 117 0.108
Fly
regulation of mitotic cell cycle GO:0007346 189 0.104
Fly
protein stabilization GO:0050821 64 0.100
Fly
regulation of cellular ketone metabolic process GO:0010565 50 0.098
response to nitrogen compound GO:1901698 184 0.095
lipid biosynthetic process GO:0008610 177 0.092
cellular response to endogenous stimulus GO:0071495 336 0.092
microtubule based process GO:0007017 210 0.090
protein catabolic process GO:0030163 325 0.089
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.088
nik nf kappab signaling GO:0038061 12 0.085
embryo development ending in birth or egg hatching GO:0009792 34 0.085
Worm
establishment of spindle localization GO:0051293 12 0.084
secretion by cell GO:0032940 226 0.083
regulation of protein maturation GO:1903317 150 0.078
negative regulation of protein maturation GO:1903318 142 0.078
protein dna complex assembly GO:0065004 64 0.077
proteasomal protein catabolic process GO:0010498 176 0.077
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.076
regulation of mitotic cell cycle phase transition GO:1901990 118 0.075
Fly
protein maturation GO:0051604 233 0.074
peptidyl lysine modification GO:0018205 144 0.073
response to organic cyclic compound GO:0014070 204 0.071
negative regulation of cell growth GO:0030308 83 0.070
embryo development GO:0009790 123 0.070
Worm
ubiquitin dependent protein catabolic process GO:0006511 206 0.070
development of primary sexual characteristics GO:0045137 35 0.070
reproduction GO:0000003 63 0.069
Worm
response to fungus GO:0009620 4 0.067
negative regulation of programmed cell death GO:0043069 321 0.065
cytokinesis GO:0000910 96 0.065
Worm
regulation of cellular amine metabolic process GO:0033238 11 0.064
developmental process involved in reproduction GO:0003006 66 0.063
negative regulation of protein catabolic process GO:0042177 59 0.063
neuron differentiation GO:0030182 138 0.063
regulation of meiotic cell cycle GO:0051445 4 0.062
protein deubiquitination GO:0016579 79 0.062
circulatory system development GO:0072359 262 0.062
regulation of dna templated transcription in response to stress GO:0043620 18 0.061
covalent chromatin modification GO:0016569 254 0.061
mitotic dna damage checkpoint GO:0044773 28 0.059
Fly
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.058
positive regulation of cell proliferation GO:0008284 301 0.057
microtubule cytoskeleton organization GO:0000226 176 0.057
cellular amine metabolic process GO:0044106 41 0.055
protein modification by small protein conjugation GO:0032446 342 0.053
regulation of cellular protein catabolic process GO:1903362 96 0.053
cellular component morphogenesis GO:0032989 314 0.052
response to abiotic stimulus GO:0009628 336 0.050
positive regulation of nik nf kappab signaling GO:1901224 10 0.049
somitogenesis GO:0001756 2 0.047
histone modification GO:0016570 251 0.046
nuclear division GO:0000280 128 0.045
negative regulation of cell cycle phase transition GO:1901988 89 0.045
Fly
protein import GO:0017038 130 0.043
cell type specific apoptotic process GO:0097285 125 0.043
cell activation GO:0001775 213 0.043
blood vessel development GO:0001568 172 0.042
dna conformation change GO:0071103 113 0.041
anterior posterior axis specification GO:0009948 2 0.041
positive regulation of cellular protein catabolic process GO:1903364 37 0.041
negative regulation of cell cycle process GO:0010948 121 0.041
Fly
ribonucleoprotein complex biogenesis GO:0022613 116 0.041
regulation of mitosis GO:0007088 63 0.040
vasculature development GO:0001944 181 0.040
cellular macromolecule catabolic process GO:0044265 380 0.039
cellular response to cytokine stimulus GO:0071345 181 0.039
regulation of proteasomal protein catabolic process GO:0061136 87 0.038
cell cycle phase transition GO:0044770 173 0.038
Fly
peptidyl lysine acetylation GO:0018394 101 0.038
blastoderm segmentation GO:0007350 2 0.037
anterior posterior axis specification embryo GO:0008595 2 0.037
growth GO:0040007 202 0.037
response to cytokine GO:0034097 232 0.037
response to organonitrogen compound GO:0010243 156 0.037
apoptotic signaling pathway GO:0097190 268 0.036
small molecule biosynthetic process GO:0044283 157 0.036
negative regulation of protein metabolic process GO:0051248 391 0.036
reproductive system development GO:0061458 56 0.036
positive regulation of myeloid cell apoptotic process GO:0033034 2 0.036
cardiovascular system development GO:0072358 262 0.035
regulation of protein serine threonine kinase activity GO:0071900 179 0.035
positive regulation of meiotic cell cycle GO:0051446 2 0.034
long term memory GO:0007616 2 0.034
stem cell division GO:0017145 2 0.033
histone h4 acetylation GO:0043967 47 0.033
response to hormone GO:0009725 175 0.033
negative regulation of immune system process GO:0002683 136 0.033
cell development GO:0048468 328 0.032
cellular response to organonitrogen compound GO:0071417 124 0.031
response to glucagon GO:0033762 1 0.031
mitotic g2 m transition checkpoint GO:0044818 9 0.030
Fly
positive regulation of apoptotic process GO:0043065 246 0.030
regulation of protein kinase activity GO:0045859 289 0.029
activation of protein kinase activity GO:0032147 90 0.028
protein homooligomerization GO:0051260 100 0.028
positive regulation of catabolic process GO:0009896 310 0.027
negative regulation of proteolysis GO:0045861 132 0.027
response to steroid hormone GO:0048545 80 0.027
regulation of cellular component biogenesis GO:0044087 281 0.027
chordate embryonic development GO:0043009 34 0.027
positive regulation of dna repair GO:0045739 25 0.027
cellular response to peptide hormone stimulus GO:0071375 56 0.027
regulation of cellular amino acid metabolic process GO:0006521 6 0.027
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.026
signal transduction in response to dna damage GO:0042770 57 0.026
regulation of apoptotic signaling pathway GO:2001233 175 0.026
chromatin modification GO:0016568 298 0.026
protein acetylation GO:0006473 116 0.026
gonad development GO:0008406 34 0.025
lipid metabolic process GO:0006629 381 0.025
response to oxygen containing compound GO:1901700 369 0.025
mitotic cell cycle GO:0000278 326 0.025
Fly
generation of neurons GO:0048699 152 0.024
modification dependent protein catabolic process GO:0019941 209 0.024
system process GO:0003008 349 0.024
cell projection organization GO:0030030 252 0.024
secretion GO:0046903 254 0.024
actomyosin structure organization GO:0031032 59 0.023
locomotory behavior GO:0007626 1 0.023
nucleocytoplasmic transport GO:0006913 176 0.023
organ morphogenesis GO:0009887 147 0.023
cellular response to growth factor stimulus GO:0071363 197 0.022
immune system development GO:0002520 195 0.022
gene silencing GO:0016458 49 0.022
positive regulation of immune system process GO:0002684 283 0.021
regulation of cellular response to insulin stimulus GO:1900076 17 0.021
enzyme linked receptor protein signaling pathway GO:0007167 303 0.021
nucleosome organization GO:0034728 66 0.021
multicellular organismal aging GO:0010259 3 0.021
hematopoietic or lymphoid organ development GO:0048534 186 0.021
regulation of lipid biosynthetic process GO:0046890 47 0.021
oocyte development GO:0048599 1 0.020
regulation of protein catabolic process GO:0042176 155 0.020
response to peptide GO:1901652 65 0.020
positive regulation of kinase activity GO:0033674 204 0.020
regulation of protein complex assembly GO:0043254 147 0.020
negative regulation of cellular protein metabolic process GO:0032269 353 0.020
oocyte differentiation GO:0009994 2 0.020
ribosome biogenesis GO:0042254 48 0.020
regulation of protein processing GO:0070613 150 0.020
response to acid chemical GO:0001101 66 0.020
chemical homeostasis GO:0048878 306 0.020
negative regulation of cell death GO:0060548 345 0.020
sterol metabolic process GO:0016125 28 0.019
negative regulation of catalytic activity GO:0043086 335 0.019
cell division GO:0051301 168 0.019
Worm
organelle fission GO:0048285 149 0.019
neurotransmitter secretion GO:0007269 4 0.019
regulation of lymphocyte activation GO:0051249 103 0.019
protein localization to membrane GO:0072657 160 0.018
memory GO:0007613 3 0.018
regulation of anatomical structure size GO:0090066 101 0.018
cell morphogenesis GO:0000902 296 0.018
negative regulation of cellular protein catabolic process GO:1903363 38 0.018
hindbrain development GO:0030902 3 0.018
tripartite regional subdivision GO:0007351 2 0.018
cell cell signaling GO:0007267 155 0.018
positive regulation of cell cycle GO:0045787 140 0.018
reproductive process GO:0022414 106 0.018
Worm
response to wounding GO:0009611 168 0.018
multi organism reproductive process GO:0044703 54 0.018
Worm
regulation of cell cycle phase transition GO:1901987 126 0.018
Fly
establishment of protein localization to mitochondrion GO:0072655 22 0.018
positive regulation of protein catabolic process GO:0045732 75 0.018
meiosis i GO:0007127 4 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
neurogenesis GO:0022008 169 0.017
Fly
purine nucleoside monophosphate catabolic process GO:0009128 158 0.017
mitotic nuclear division GO:0007067 119 0.017
neuron development GO:0048666 113 0.017
regulation of cellular response to growth factor stimulus GO:0090287 76 0.017
single organism carbohydrate metabolic process GO:0044723 193 0.017
multicellular organismal metabolic process GO:0044236 34 0.017
establishment of protein localization to organelle GO:0072594 172 0.017
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.017
cell aging GO:0007569 52 0.017
actin filament based process GO:0030029 224 0.017
regulation of locomotion GO:0040012 329 0.017
regulation of ligase activity GO:0051340 29 0.016
regionalization GO:0003002 29 0.016
prostanoid metabolic process GO:0006692 17 0.016
cytoplasmic transport GO:0016482 379 0.016
negative regulation of neuron apoptotic process GO:0043524 23 0.016
regulation of protein localization GO:0032880 296 0.016
multicellular organismal reproductive process GO:0048609 40 0.016
Worm
regulation of cellular response to stress GO:0080135 244 0.016
neuron death GO:0070997 65 0.016
regulation of gene expression epigenetic GO:0040029 73 0.015
negative regulation of apoptotic signaling pathway GO:2001234 97 0.015
leukocyte proliferation GO:0070661 74 0.015
ribonucleoprotein complex export from nucleus GO:0071426 4 0.015
protein localization to organelle GO:0033365 280 0.015
mitotic dna integrity checkpoint GO:0044774 30 0.015
Fly
hemopoiesis GO:0030097 180 0.015
cellular amino acid metabolic process GO:0006520 116 0.014
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.014
interspecies interaction between organisms GO:0044419 156 0.014
dna damage checkpoint GO:0000077 68 0.014
Fly
cytokine mediated signaling pathway GO:0019221 109 0.014
regulation of cell activation GO:0050865 125 0.014
cell cell signaling involved in cell fate commitment GO:0045168 5 0.014
cell fate commitment GO:0045165 27 0.014
intracellular protein transport GO:0006886 270 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
spermatid differentiation GO:0048515 4 0.014
blood vessel morphogenesis GO:0048514 162 0.014
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.013
lymphocyte activation GO:0046649 133 0.013
cellular response to peptide GO:1901653 59 0.013
tissue regeneration GO:0042246 3 0.013
glial cell migration GO:0008347 4 0.013
regulation of growth GO:0040008 165 0.013
amine metabolic process GO:0009308 44 0.013
dna packaging GO:0006323 77 0.013
regulation of nuclear division GO:0051783 65 0.013
positive regulation of leukocyte activation GO:0002696 80 0.013
organelle assembly GO:0070925 176 0.013
cellular protein complex assembly GO:0043623 188 0.012
protein targeting GO:0006605 187 0.012
organic hydroxy compound metabolic process GO:1901615 147 0.012
protein polyubiquitination GO:0000209 110 0.012
regulation of system process GO:0044057 101 0.012
positive regulation of cellular component organization GO:0051130 376 0.012
determination of adult lifespan GO:0008340 2 0.012
endocytosis GO:0006897 159 0.012
Fly
cellular chemical homeostasis GO:0055082 180 0.012
positive regulation of cytoplasmic transport GO:1903651 82 0.012
icosanoid biosynthetic process GO:0046456 18 0.012
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 12 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
nitrogen compound transport GO:0071705 191 0.012
regulation of alcohol biosynthetic process GO:1902930 22 0.012
neuron projection development GO:0031175 106 0.012
regulation of chromosome organization GO:0033044 103 0.012
golgi vesicle transport GO:0048193 80 0.012
nuclear transport GO:0051169 179 0.012
regulation of neuron apoptotic process GO:0043523 35 0.011
regulation of response to external stimulus GO:0032101 222 0.011
negative regulation of cellular catabolic process GO:0031330 83 0.011
pattern specification process GO:0007389 43 0.011
response to uv GO:0009411 73 0.011
organ formation GO:0048645 3 0.011
negative regulation of growth GO:0045926 97 0.011
spermatid development GO:0007286 4 0.011
blastocyst development GO:0001824 3 0.011
gene silencing by rna GO:0031047 26 0.011
cellular response to external stimulus GO:0071496 111 0.011
metal ion homeostasis GO:0055065 169 0.011
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 30 0.011
ribonucleoprotein complex assembly GO:0022618 78 0.011
regulation of dna repair GO:0006282 47 0.010
cation homeostasis GO:0055080 189 0.010
atp catabolic process GO:0006200 157 0.010
neuromuscular junction development GO:0007528 3 0.010

COPS2 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.017