Homo sapiens

123 known processes

COPS5

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)

(Aliases: JAB1,CSN5,MGC3149,MOV-34,SGN5)

COPS5 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cullin deneddylation GO:0010388 9 1.000
protein modification by small protein removal GO:0070646 92 1.000
protein deneddylation GO:0000338 10 1.000
cellular macromolecule catabolic process GO:0044265 380 1.000
Fly
regulation of cell cycle GO:0051726 393 0.999
Mouse Fly
post embryonic development GO:0009791 2 0.999
Worm Fly
ubiquitin dependent protein catabolic process GO:0006511 206 0.999
Fly
negative regulation of mitotic cell cycle GO:0045930 102 0.998
Fly
modification dependent macromolecule catabolic process GO:0043632 212 0.998
Fly
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.998
Fly
regulation of mitotic cell cycle GO:0007346 189 0.998
Fly
protein modification by small protein conjugation GO:0032446 342 0.997
cell cycle checkpoint GO:0000075 117 0.997
Fly
mitotic cell cycle phase transition GO:0044772 162 0.996
Fly
regulation of cell cycle process GO:0010564 266 0.995
Fly
mitotic cell cycle GO:0000278 326 0.991
Fly
modification dependent protein catabolic process GO:0019941 209 0.991
Fly
regulation of mitotic cell cycle phase transition GO:1901990 118 0.991
Fly
cellular protein catabolic process GO:0044257 261 0.990
Fly
mitotic dna damage checkpoint GO:0044773 28 0.989
Fly
mitotic cell cycle process GO:1903047 286 0.989
Fly
negative regulation of cell cycle phase transition GO:1901988 89 0.986
Fly
regulation of proteolysis GO:0030162 293 0.985
Fly
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.984
Fly
dna integrity checkpoint GO:0031570 71 0.983
Fly
protein ubiquitination GO:0016567 314 0.982
mitotic cell cycle checkpoint GO:0007093 68 0.981
Fly
regulation of cellular protein catabolic process GO:1903362 96 0.980
Fly
cellular response to dna damage stimulus GO:0006974 379 0.979
Fly
negative regulation of cell cycle process GO:0010948 121 0.971
Fly
posttranscriptional regulation of gene expression GO:0010608 213 0.969
Fly
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.964
Fly
proteasomal protein catabolic process GO:0010498 176 0.954
Fly
regulation of transferase activity GO:0051338 355 0.953
regulation of proteasomal protein catabolic process GO:0061136 87 0.953
Fly
regulation of mitosis GO:0007088 63 0.934
cell division GO:0051301 168 0.930
Worm
negative regulation of cell proliferation GO:0008285 228 0.929
Fly
protein catabolic process GO:0030163 325 0.926
Fly
dna damage checkpoint GO:0000077 68 0.917
Fly
embryo development ending in birth or egg hatching GO:0009792 34 0.914
Worm
embryo development GO:0009790 123 0.906
Worm Fly
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.891
Fly
multicellular organismal aging GO:0010259 3 0.885
positive regulation of protein catabolic process GO:0045732 75 0.836
Fly
determination of adult lifespan GO:0008340 2 0.836
mitotic dna integrity checkpoint GO:0044774 30 0.820
Fly
reproductive structure development GO:0048608 55 0.812
Worm
protein stabilization GO:0050821 64 0.805
Fly
cell cycle phase transition GO:0044770 173 0.801
Fly
protein import GO:0017038 130 0.751
regulation of nik nf kappab signaling GO:1901222 11 0.708
g2 dna damage checkpoint GO:0031572 26 0.689
Fly
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.681
Fly
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.669
Fly
single organism cellular localization GO:1902580 332 0.639
negative regulation of protein maturation GO:1903318 142 0.617
Fly
response to abiotic stimulus GO:0009628 336 0.614
regulation of cell cycle phase transition GO:1901987 126 0.551
Fly
regulation of protein stability GO:0031647 87 0.503
Fly
positive regulation of cell cycle GO:0045787 140 0.503
Fly
regulation of meiotic cell cycle GO:0051445 4 0.501
negative regulation of protein metabolic process GO:0051248 391 0.498
Fly
cell development GO:0048468 328 0.479
Worm Fly
negative regulation of cell cycle GO:0045786 193 0.477
Fly
regulation of protein catabolic process GO:0042176 155 0.471
Fly
positive regulation of proteolysis GO:0045862 142 0.467
Fly
negative regulation of cellular protein metabolic process GO:0032269 353 0.463
Fly
nervous system development GO:0007399 293 0.451
Fly
positive regulation of phosphorylation GO:0042327 394 0.445
positive regulation of catabolic process GO:0009896 310 0.437
Fly
intracellular protein transport GO:0006886 270 0.436
negative regulation of programmed cell death GO:0043069 321 0.427
positive regulation of meiotic cell cycle GO:0051446 2 0.408
single organism reproductive process GO:0044702 98 0.404
Worm Fly
response to radiation GO:0009314 151 0.404
positive regulation of cellular protein catabolic process GO:1903364 37 0.373
Fly
regulation of protein localization GO:0032880 296 0.368
negative regulation of protein processing GO:0010955 142 0.368
Fly
response to organic cyclic compound GO:0014070 204 0.346
mitotic g2 m transition checkpoint GO:0044818 9 0.341
Fly
cyclin catabolic process GO:0008054 6 0.333
Fly
positive regulation of cell cycle process GO:0090068 106 0.333
development of primary sexual characteristics GO:0045137 35 0.320
Worm
positive regulation of apoptotic process GO:0043065 246 0.316
gonad development GO:0008406 34 0.309
Worm
protein folding GO:0006457 38 0.307
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.307
Fly
growth GO:0040007 202 0.304
reproduction GO:0000003 63 0.296
Yeast Worm Fly
cellular macromolecular complex assembly GO:0034622 324 0.288
female gamete generation GO:0007292 2 0.283
Worm Fly
multicellular organism reproduction GO:0032504 42 0.282
Worm Fly
regulation of protein ubiquitination GO:0031396 95 0.262
chromosome separation GO:0051304 23 0.261
positive regulation of cell proliferation GO:0008284 301 0.250
regulation of chromosome segregation GO:0051983 44 0.245
regulation of mitotic sister chromatid separation GO:0010965 27 0.231
positive regulation of transferase activity GO:0051347 227 0.230
regulation of protein kinase activity GO:0045859 289 0.221
microtubule based process GO:0007017 210 0.220
regulation of protein maturation GO:1903317 150 0.220
Fly
protein localization to organelle GO:0033365 280 0.216
cytokinesis GO:0000910 96 0.193
Worm
response to uv GO:0009411 73 0.192
regulation of kinase activity GO:0043549 314 0.183
protein targeting GO:0006605 187 0.183
negative regulation of cell death GO:0060548 345 0.178
protein monoubiquitination GO:0006513 39 0.170
regulation of intracellular protein transport GO:0033157 123 0.167
cytoplasmic transport GO:0016482 379 0.162
nuclear import GO:0051170 106 0.158
protein localization to nucleus GO:0034504 136 0.157
positive regulation of programmed cell death GO:0043068 249 0.156
regulation of protein targeting GO:1903533 91 0.155
positive regulation of cell death GO:0010942 263 0.154
mitotic sister chromatid separation GO:0051306 18 0.150
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.146
nuclear transport GO:0051169 179 0.146
response to other organism GO:0051707 261 0.143
reproductive process GO:0022414 106 0.139
Yeast Worm Fly
response to light stimulus GO:0009416 87 0.134
sex differentiation GO:0007548 45 0.126
Worm
positive regulation of protein phosphorylation GO:0001934 313 0.120
establishment of organelle localization GO:0051656 59 0.118
regulation of cytokine production GO:0001817 232 0.118
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.115
developmental process involved in reproduction GO:0003006 66 0.115
Worm Fly
anterior posterior axis specification GO:0009948 2 0.111
Fly
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.109
genitalia development GO:0048806 10 0.109
Worm
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.107
Fly
regulation of cellular ketone metabolic process GO:0010565 50 0.098
single organism nuclear import GO:1902593 104 0.097
response to biotic stimulus GO:0009607 276 0.096
negative regulation of apoptotic process GO:0043066 316 0.096
lipid biosynthetic process GO:0008610 177 0.096
Yeast
positive regulation of intracellular transport GO:0032388 104 0.094
apoptotic signaling pathway GO:0097190 268 0.094
aging GO:0007568 66 0.091
rna splicing GO:0008380 131 0.088
regulation of growth GO:0040008 165 0.088
protein maturation GO:0051604 233 0.086
Fly
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.085
Fly
regulation of sister chromatid segregation GO:0033045 27 0.082
cell cell signaling involved in cell fate commitment GO:0045168 5 0.081
regulation of cellular amine metabolic process GO:0033238 11 0.078
reproductive system development GO:0061458 56 0.077
Worm
cellular amine metabolic process GO:0044106 41 0.076
positive regulation of protein kinase activity GO:0045860 190 0.076
protein neddylation GO:0045116 7 0.076
regulation of ligase activity GO:0051340 29 0.075
multicellular organismal reproductive process GO:0048609 40 0.069
Worm Fly
defense response GO:0006952 315 0.065
spermatid differentiation GO:0048515 4 0.065
regulation of rna splicing GO:0043484 62 0.065
establishment of nucleus localization GO:0040023 1 0.063
regulation of protein localization to nucleus GO:1900180 85 0.062
regulation of protein processing GO:0070613 150 0.061
Fly
receptor mediated endocytosis GO:0006898 84 0.059
negative regulation of phosphate metabolic process GO:0045936 267 0.059
generation of neurons GO:0048699 152 0.059
Fly
oogenesis GO:0048477 2 0.058
Worm Fly
segmentation GO:0035282 4 0.057
Fly
regulation of stress activated mapk cascade GO:0032872 84 0.056
regulation of nuclear division GO:0051783 65 0.055
regulation of protein serine threonine kinase activity GO:0071900 179 0.055
meiotic chromosome segregation GO:0045132 4 0.055
neurogenesis GO:0022008 169 0.054
Fly
vesicle mediated transport GO:0016192 371 0.053
regulation of nucleocytoplasmic transport GO:0046822 98 0.051
activation of protein kinase activity GO:0032147 90 0.050
negative regulation of catalytic activity GO:0043086 335 0.048
negative regulation of immune system process GO:0002683 136 0.047
Fly
covalent chromatin modification GO:0016569 254 0.047
regulation of apoptotic signaling pathway GO:2001233 175 0.045
positive regulation of protein transport GO:0051222 135 0.045
protein import into nucleus GO:0006606 104 0.043
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.042
multi organism reproductive process GO:0044703 54 0.042
Yeast Worm Fly
mrna processing GO:0006397 133 0.041
regulation of establishment of protein localization GO:0070201 242 0.041
organelle fission GO:0048285 149 0.040
response to external biotic stimulus GO:0043207 261 0.039
blastoderm segmentation GO:0007350 2 0.037
Fly
mitotic g2 dna damage checkpoint GO:0007095 7 0.037
Fly
negative regulation of phosphorus metabolic process GO:0010563 267 0.036
cell type specific apoptotic process GO:0097285 125 0.035
organic acid biosynthetic process GO:0016053 97 0.035
mitotic nuclear division GO:0007067 119 0.034
organelle localization GO:0051640 84 0.034
regulation of mitotic sister chromatid segregation GO:0033047 27 0.034
negative regulation of phosphorylation GO:0042326 174 0.033
nuclear export GO:0051168 69 0.033
regulation of cell division GO:0051302 116 0.033
regulation of endopeptidase activity GO:0052548 170 0.032
spermatid development GO:0007286 4 0.032
behavior GO:0007610 112 0.031
regulation of intracellular transport GO:0032386 195 0.031
sister chromatid segregation GO:0000819 54 0.030
purine nucleoside triphosphate catabolic process GO:0009146 392 0.030
histone ubiquitination GO:0016574 31 0.030
innate immune response GO:0045087 178 0.029
neuron differentiation GO:0030182 138 0.029
Fly
single fertilization GO:0007338 11 0.029
cytokine production GO:0001816 247 0.028
response to inorganic substance GO:0010035 127 0.027
ribonucleoprotein complex biogenesis GO:0022613 116 0.027
metaphase anaphase transition of cell cycle GO:0044784 21 0.026
cell adhesion GO:0007155 325 0.026
regulation of protein transport GO:0051223 213 0.025
intrinsic apoptotic signaling pathway GO:0097193 127 0.024
endocytosis GO:0006897 159 0.024
tripartite regional subdivision GO:0007351 2 0.024
Fly
regulation of mitotic recombination GO:0000019 1 0.024
sexual reproduction GO:0019953 37 0.024
Yeast Worm Fly
regulation of transcription factor import into nucleus GO:0042990 39 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.023
cytoskeleton dependent cytokinesis GO:0061640 22 0.023
regulation of centriole replication GO:0046599 7 0.023
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.023
secretion GO:0046903 254 0.023
fertilization GO:0009566 12 0.023
negative regulation of protein modification process GO:0031400 200 0.022
cell projection organization GO:0030030 252 0.022
Fly
establishment of protein localization to organelle GO:0072594 172 0.022
positive regulation of hydrolase activity GO:0051345 331 0.022
cellular component morphogenesis GO:0032989 314 0.022
Fly
trna metabolic process GO:0006399 35 0.022
nucleus localization GO:0051647 1 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
Fly
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.021
rna processing GO:0006396 255 0.021
negative regulation of cellular catabolic process GO:0031330 83 0.021
Fly
protein targeting to nucleus GO:0044744 104 0.020
regulation of cellular response to stress GO:0080135 244 0.020
microtubule cytoskeleton organization GO:0000226 176 0.020
positive regulation of protein ubiquitination GO:0031398 53 0.020
regulation of peptidase activity GO:0052547 180 0.019
cellular ketone metabolic process GO:0042180 80 0.019
jnk cascade GO:0007254 80 0.019
regulation of developmental growth GO:0048638 30 0.019
regulation of epithelial cell proliferation GO:0050678 113 0.018
mitotic sister chromatid segregation GO:0000070 53 0.018
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.018
Fly
transcription factor import into nucleus GO:0042991 40 0.018
positive regulation of transport GO:0051050 336 0.017
response to bacterium GO:0009617 144 0.017
gamete generation GO:0007276 25 0.017
Worm Fly
nuclear division GO:0000280 128 0.017
nik nf kappab signaling GO:0038061 12 0.017
meiotic nuclear division GO:0007126 10 0.016
regulation of membrane potential GO:0042391 95 0.016
oxidation reduction process GO:0055114 396 0.016
response to oxygen containing compound GO:1901700 369 0.015
positive regulation of intracellular protein transport GO:0090316 76 0.015
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.015
positive regulation of cytoplasmic transport GO:1903651 82 0.015
meiotic cell cycle GO:0051321 13 0.015
mapk cascade GO:0000165 288 0.015
regulation of protein import into nucleus GO:0042306 78 0.015
mitochondrial transport GO:0006839 60 0.014
regulation of cytoplasmic transport GO:1903649 149 0.014
immune response GO:0006955 307 0.014
meiotic cell cycle process GO:1903046 8 0.014
response to lipid GO:0033993 206 0.014
gene looping GO:0090202 1 0.014
regulation of response to biotic stimulus GO:0002831 55 0.014
response to virus GO:0009615 126 0.013
chromatin organization GO:0006325 351 0.013
positive regulation of mitotic cell cycle GO:0045931 60 0.013
stem cell differentiation GO:0048863 93 0.013
regulation of histone h4 k16 acetylation GO:2000618 1 0.012
negative regulation of protein transport GO:0051224 75 0.012
regulation of ubiquitin protein transferase activity GO:0051438 28 0.012
establishment of mitotic spindle localization GO:0040001 8 0.012
negative regulation of protein catabolic process GO:0042177 59 0.012
Fly
positive regulation of cellular component organization GO:0051130 376 0.012
positive regulation of cellular amine metabolic process GO:0033240 7 0.012
regulation of chromosome organization GO:0033044 103 0.012
chromosome segregation GO:0007059 114 0.012
dna repair GO:0006281 198 0.012
germ cell development GO:0007281 8 0.011
Worm Fly
cell growth GO:0016049 160 0.011
chromatin modification GO:0016568 298 0.011
positive regulation of apoptotic signaling pathway GO:2001235 70 0.011
response to steroid hormone GO:0048545 80 0.011
anterior posterior pattern specification GO:0009952 9 0.011
Fly
muscle organ development GO:0007517 56 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.010

COPS5 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.021