Homo sapiens

80 known processes

MFN2

mitofusin 2

(Aliases: MARF,CPRP1,CMT2A,KIAA0214,CMT2A2,HSG)

MFN2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitochondrial fission GO:0000266 14 0.340
regulation of mitochondrion organization GO:0010821 54 0.205
protein localization to organelle GO:0033365 280 0.195
positive regulation of mitochondrion organization GO:0010822 30 0.190
positive regulation of mitochondrial fission GO:0090141 7 0.167
protein localization to mitochondrion GO:0070585 25 0.152
positive regulation of developmental process GO:0051094 314 0.149
regulation of mitochondrial fission GO:0090140 8 0.135
regulation of anatomical structure morphogenesis GO:0022603 286 0.128
positive regulation of organelle organization GO:0010638 195 0.093
organelle fission GO:0048285 149 0.091
negative regulation of developmental process GO:0051093 247 0.084
oxidation reduction process GO:0055114 396 0.080
protein autoubiquitination GO:0051865 37 0.069
cell aging GO:0007569 52 0.062
positive regulation of cellular component organization GO:0051130 376 0.059
determination of adult lifespan GO:0008340 2 0.058
cytoplasmic transport GO:0016482 379 0.047
nucleoside triphosphate metabolic process GO:0009141 422 0.045
locomotory behavior GO:0007626 1 0.045
multicellular organismal aging GO:0010259 3 0.042
purine ribonucleoside metabolic process GO:0046128 437 0.040
cellular amino acid metabolic process GO:0006520 116 0.040
amine metabolic process GO:0009308 44 0.039
purine nucleoside triphosphate metabolic process GO:0009144 412 0.039
mitotic cell cycle GO:0000278 326 0.037
protein catabolic process GO:0030163 325 0.037
cellular ketone metabolic process GO:0042180 80 0.037
regulation of cell aging GO:0090342 18 0.037
cellular amine metabolic process GO:0044106 41 0.036
small gtpase mediated signal transduction GO:0007264 78 0.035
cellular macromolecule catabolic process GO:0044265 380 0.034
ras protein signal transduction GO:0007265 73 0.034
post embryonic development GO:0009791 2 0.034
neuromuscular junction development GO:0007528 3 0.034
nucleotide catabolic process GO:0009166 408 0.033
regulation of cellular amino acid metabolic process GO:0006521 6 0.033
regulation of cellular ketone metabolic process GO:0010565 50 0.033
regulation of cellular amine metabolic process GO:0033238 11 0.033
ribonucleotide catabolic process GO:0009261 405 0.032
membrane organization GO:0061024 292 0.031
intracellular protein transport GO:0006886 270 0.030
negative regulation of protein metabolic process GO:0051248 391 0.030
regulation of protein localization GO:0032880 296 0.030
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.029
aging GO:0007568 66 0.029
nucleoside phosphate catabolic process GO:1901292 412 0.029
nucleoside triphosphate catabolic process GO:0009143 394 0.028
positive regulation of hydrolase activity GO:0051345 331 0.028
generation of precursor metabolites and energy GO:0006091 68 0.028
organophosphate catabolic process GO:0046434 430 0.028
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.027
protein ubiquitination GO:0016567 314 0.027
female gamete generation GO:0007292 2 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.027
positive regulation of phosphorylation GO:0042327 394 0.026
nucleoside catabolic process GO:0009164 408 0.026
memory GO:0007613 3 0.026
purine ribonucleoside catabolic process GO:0046130 398 0.026
cell growth GO:0016049 160 0.026
nucleocytoplasmic transport GO:0006913 176 0.025
purine nucleotide catabolic process GO:0006195 405 0.025
ribonucleoside triphosphate catabolic process GO:0009203 391 0.025
mitochondrion organization GO:0007005 156 0.025
cellular lipid metabolic process GO:0044255 303 0.025
oogenesis GO:0048477 2 0.025
positive regulation of cellular amine metabolic process GO:0033240 7 0.025
negative regulation of catalytic activity GO:0043086 335 0.024
segmentation GO:0035282 4 0.024
single organism cellular localization GO:1902580 332 0.024
regulation of cell growth GO:0001558 135 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.023
protein maturation GO:0051604 233 0.023
purine nucleoside catabolic process GO:0006152 398 0.023
spermatid differentiation GO:0048515 4 0.023
adult locomotory behavior GO:0008344 1 0.023
mitotic cell cycle process GO:1903047 286 0.023
negative regulation of programmed cell death GO:0043069 321 0.023
cardiac muscle cell contraction GO:0086003 4 0.023
cation transport GO:0006812 331 0.023
purine containing compound catabolic process GO:0072523 411 0.022
guanosine containing compound catabolic process GO:1901069 239 0.022
cellular macromolecular complex assembly GO:0034622 324 0.022
negative regulation of cell death GO:0060548 345 0.022
energy derivation by oxidation of organic compounds GO:0015980 43 0.022
regeneration GO:0031099 4 0.022
cation transmembrane transport GO:0098655 238 0.022
cell development GO:0048468 328 0.022
response to abiotic stimulus GO:0009628 336 0.022
ubiquitin dependent protein catabolic process GO:0006511 206 0.022
cell projection organization GO:0030030 252 0.022
purine ribonucleotide catabolic process GO:0009154 404 0.021
cell morphogenesis GO:0000902 296 0.021
organonitrogen compound biosynthetic process GO:1901566 200 0.021
chemical homeostasis GO:0048878 306 0.021
regulation of purine nucleotide metabolic process GO:1900542 264 0.021
positive regulation of programmed cell death GO:0043068 249 0.021
succinyl coa metabolic process GO:0006104 1 0.021
nervous system development GO:0007399 293 0.020
system process GO:0003008 349 0.020
carbohydrate derivative biosynthetic process GO:1901137 207 0.020
negative regulation of apoptotic process GO:0043066 316 0.020
endomembrane system organization GO:0010256 196 0.020
protein modification by small protein conjugation GO:0032446 342 0.020
glycosyl compound catabolic process GO:1901658 413 0.020
negative regulation of cellular protein metabolic process GO:0032269 353 0.020
ribonucleoside catabolic process GO:0042454 406 0.020
lipid metabolic process GO:0006629 381 0.020
ion transmembrane transport GO:0034220 338 0.020
ribonucleoside triphosphate metabolic process GO:0009199 412 0.019
regulation of transferase activity GO:0051338 355 0.019
transmembrane transport GO:0055085 399 0.019
tricarboxylic acid metabolic process GO:0072350 4 0.019
rna interference GO:0016246 4 0.019
microtubule based process GO:0007017 210 0.019
response to oxygen containing compound GO:1901700 369 0.019
proteasomal protein catabolic process GO:0010498 176 0.019
sulfur compound metabolic process GO:0006790 101 0.019
oocyte development GO:0048599 1 0.019
blastoderm segmentation GO:0007350 2 0.019
maintenance of location GO:0051235 112 0.019
photoreceptor cell differentiation GO:0046530 2 0.019
rhythmic behavior GO:0007622 2 0.019
anterior posterior axis specification GO:0009948 2 0.018
regulation of apoptotic signaling pathway GO:2001233 175 0.018
negative regulation of intracellular signal transduction GO:1902532 183 0.018
citrate metabolic process GO:0006101 2 0.018
cell adhesion GO:0007155 325 0.018
positive regulation of apoptotic process GO:0043065 246 0.018
secretion by cell GO:0032940 226 0.018
purine nucleoside monophosphate metabolic process GO:0009126 186 0.018
nuclear transport GO:0051169 179 0.018
single organism membrane organization GO:0044802 268 0.017
actin filament based process GO:0030029 224 0.017
monocarboxylic acid metabolic process GO:0032787 185 0.017
protein deubiquitination GO:0016579 79 0.017
negative regulation of cellular amine metabolic process GO:0033239 3 0.017
oocyte differentiation GO:0009994 2 0.017
mapk cascade GO:0000165 288 0.017
mitochondrial transport GO:0006839 60 0.017
rna processing GO:0006396 255 0.017
atp metabolic process GO:0046034 176 0.017
regulation of kinase activity GO:0043549 314 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
small molecule biosynthetic process GO:0044283 157 0.017
inorganic ion transmembrane transport GO:0098660 231 0.017
regulation of cellular component biogenesis GO:0044087 281 0.016
posttranscriptional regulation of gene expression GO:0010608 213 0.016
positive regulation of protein phosphorylation GO:0001934 313 0.016
dicarboxylic acid metabolic process GO:0043648 29 0.016
carbohydrate metabolic process GO:0005975 207 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
dephosphorylation GO:0016311 209 0.016
regulation of nucleotide metabolic process GO:0006140 269 0.016
apoptotic signaling pathway GO:0097190 268 0.016
purine nucleoside triphosphate catabolic process GO:0009146 392 0.016
regulation of protein kinase activity GO:0045859 289 0.016
nucleoside monophosphate metabolic process GO:0009123 191 0.016
sleep GO:0030431 2 0.016
regulation of cell cycle GO:0051726 393 0.016
positive regulation of cellular catabolic process GO:0031331 284 0.016
peripheral nervous system development GO:0007422 2 0.016
nitrogen compound transport GO:0071705 191 0.016
covalent chromatin modification GO:0016569 254 0.016
cellular protein complex assembly GO:0043623 188 0.016
regulation of intracellular transport GO:0032386 195 0.015
metal ion transport GO:0030001 272 0.015
carboxylic acid biosynthetic process GO:0046394 97 0.015
regulation of small gtpase mediated signal transduction GO:0051056 156 0.015
positive regulation of catabolic process GO:0009896 310 0.015
circadian behavior GO:0048512 2 0.015
vesicle mediated transport GO:0016192 371 0.015
signal transduction by phosphorylation GO:0023014 297 0.015
reactive nitrogen species metabolic process GO:2001057 3 0.015
nucleus localization GO:0051647 1 0.015
nuclear migration GO:0007097 1 0.015
anion transport GO:0006820 161 0.015
neurotransmitter secretion GO:0007269 4 0.015
negative regulation of organelle organization GO:0010639 126 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.015
positive regulation of transport GO:0051050 336 0.015
biological adhesion GO:0022610 331 0.015
ribonucleoside monophosphate metabolic process GO:0009161 187 0.015
positive regulation of cell death GO:0010942 263 0.015
response to fungus GO:0009620 4 0.015
protein polyubiquitination GO:0000209 110 0.015
reactive oxygen species metabolic process GO:0072593 75 0.015
inner ear morphogenesis GO:0042472 4 0.015
guanosine containing compound metabolic process GO:1901068 244 0.014
secretion GO:0046903 254 0.014
startle response GO:0001964 3 0.014
regulation of mapk cascade GO:0043408 262 0.014
protein targeting GO:0006605 187 0.014
negative regulation of cellular component organization GO:0051129 235 0.014
anterior posterior axis specification embryo GO:0008595 2 0.014
positive regulation of nucleotide metabolic process GO:0045981 230 0.014
establishment of nucleus localization GO:0040023 1 0.014
negative regulation of transport GO:0051051 176 0.014
organelle localization GO:0051640 84 0.014
regulation of cell differentiation GO:0045595 393 0.014
cellular component disassembly GO:0022411 92 0.014
positive regulation of immune system process GO:0002684 283 0.014
actin mediated cell contraction GO:0070252 12 0.014
regulation of transporter activity GO:0032409 82 0.014
tripartite regional subdivision GO:0007351 2 0.014
cell fate determination GO:0001709 3 0.014
neurological system process GO:0050877 163 0.014
nuclear division GO:0000280 128 0.014
positive regulation of gtp catabolic process GO:0033126 166 0.014
compound eye development GO:0048749 1 0.014
negative regulation of phosphorus metabolic process GO:0010563 267 0.014
inorganic cation transmembrane transport GO:0098662 194 0.014
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.014
regulation of neural precursor cell proliferation GO:2000177 4 0.014
regulation of cellular component movement GO:0051270 334 0.014
negative regulation of growth GO:0045926 97 0.013
regulation of nucleotide catabolic process GO:0030811 205 0.013
hindbrain development GO:0030902 3 0.013
regulation of secretion GO:0051046 194 0.013
associative learning GO:0008306 1 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.013
cellular ion homeostasis GO:0006873 168 0.013
microtubule cytoskeleton organization GO:0000226 176 0.013
rho protein signal transduction GO:0007266 26 0.013
lipid biosynthetic process GO:0008610 177 0.013
regulation of ras protein signal transduction GO:0046578 155 0.013
sequestering of metal ion GO:0051238 24 0.013
regulation of neurotransmitter secretion GO:0046928 3 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
regulation of cell cycle process GO:0010564 266 0.013
cellular response to oxygen containing compound GO:1901701 276 0.013
monovalent inorganic cation transport GO:0015672 128 0.013
mating GO:0007618 1 0.013
dna repair GO:0006281 198 0.013
actin filament based movement GO:0030048 17 0.013
positive regulation of nucleotide catabolic process GO:0030813 185 0.013
fatty acid metabolic process GO:0006631 115 0.013
cellular component morphogenesis GO:0032989 314 0.013
response to external biotic stimulus GO:0043207 261 0.013
regulation of protein catabolic process GO:0042176 155 0.013
negative regulation of proteolysis GO:0045861 132 0.013
cellular response to nutrient levels GO:0031669 69 0.013
reactive oxygen species biosynthetic process GO:1903409 4 0.013
organ formation GO:0048645 3 0.013
single organism carbohydrate metabolic process GO:0044723 193 0.013
tricarboxylic acid cycle GO:0006099 4 0.013
meiotic chromosome segregation GO:0045132 4 0.013
regulation of gtpase activity GO:0043087 180 0.013
mrna metabolic process GO:0016071 175 0.013
protein processing GO:0016485 226 0.013
regulation of immune response GO:0050776 201 0.013
nerve development GO:0021675 4 0.012
metencephalon development GO:0022037 2 0.012
response to axon injury GO:0048678 1 0.012
small molecule catabolic process GO:0044282 92 0.012
protein localization to membrane GO:0072657 160 0.012
single organism membrane fusion GO:0044801 37 0.012
embryonic epithelial tube formation GO:0001838 4 0.012
cell projection morphogenesis GO:0048858 129 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
syncytium formation by plasma membrane fusion GO:0000768 2 0.012
regulation of synaptic plasticity GO:0048167 3 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
regulation of membrane potential GO:0042391 95 0.012
positive regulation of gtpase activity GO:0043547 166 0.012
neurogenesis GO:0022008 169 0.012
negative regulation of protein processing GO:0010955 142 0.012
epithelium development GO:0060429 227 0.012
response to hormone GO:0009725 175 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
anterograde axon cargo transport GO:0008089 1 0.012
metal ion homeostasis GO:0055065 169 0.012
sequestering of calcium ion GO:0051208 17 0.012
positive regulation of synaptic transmission GO:0050806 4 0.012
cardiovascular system development GO:0072358 262 0.012
visual behavior GO:0007632 2 0.012
positive regulation of secretion GO:0051047 116 0.012
establishment of protein localization to membrane GO:0090150 121 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
cell cell signaling GO:0007267 155 0.012
regulation of ion transport GO:0043269 189 0.011
axon cargo transport GO:0008088 2 0.011
regulation of cytokine production GO:0001817 232 0.011
tissue regeneration GO:0042246 3 0.011
regulation of growth GO:0040008 165 0.011
divalent metal ion transport GO:0070838 152 0.011
organic acid biosynthetic process GO:0016053 97 0.011
defense response GO:0006952 315 0.011
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
cofactor biosynthetic process GO:0051188 31 0.011
ribonucleoside monophosphate catabolic process GO:0009158 158 0.011
mitotic nuclear division GO:0007067 119 0.011
ion homeostasis GO:0050801 230 0.011
cellular metal ion homeostasis GO:0006875 146 0.011
plasma membrane organization GO:0007009 115 0.011
organelle assembly GO:0070925 176 0.011
mitochondrial membrane organization GO:0007006 40 0.011
calcium ion transport GO:0006816 147 0.011
embryo development GO:0009790 123 0.011
autophagy GO:0006914 88 0.011
response to cytokine GO:0034097 232 0.011
long term memory GO:0007616 2 0.011
atp catabolic process GO:0006200 157 0.011
regulation of peptidase activity GO:0052547 180 0.011
regulation of secretion by cell GO:1903530 177 0.011
negative regulation of gliogenesis GO:0014014 3 0.011
positive regulation of transferase activity GO:0051347 227 0.011
regulation of cell morphogenesis GO:0022604 153 0.011
cellular response to misfolded protein GO:0071218 2 0.011
immune response GO:0006955 307 0.011
regulation of cell migration GO:0030334 289 0.011
regulation of ras gtpase activity GO:0032318 128 0.011
generation of neurons GO:0048699 152 0.011
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.011
positive regulation of proteolysis GO:0045862 142 0.011
response to nitrogen compound GO:1901698 184 0.011
cerebellum development GO:0021549 2 0.011
response to organic cyclic compound GO:0014070 204 0.011
protein acylation GO:0043543 138 0.011
neural tube formation GO:0001841 3 0.011
regulation of gtp catabolic process GO:0033124 180 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
thymus development GO:0048538 3 0.011
regulation of mitotic cell cycle GO:0007346 189 0.011
response to inorganic substance GO:0010035 127 0.011
endocytosis GO:0006897 159 0.011
cell projection assembly GO:0030031 126 0.011
motor neuron axon guidance GO:0008045 2 0.011
detection of stimulus GO:0051606 85 0.011
positive regulation of protein transport GO:0051222 135 0.011
regulation of protein complex assembly GO:0043254 147 0.011
protein modification by small protein removal GO:0070646 92 0.011
cation homeostasis GO:0055080 189 0.011
lipid localization GO:0010876 106 0.011
neuroblast proliferation GO:0007405 4 0.011
regulation of protein transport GO:0051223 213 0.011
cell activation GO:0001775 213 0.011
neuron development GO:0048666 113 0.011
positive regulation of kinase activity GO:0033674 204 0.010
regulation of cellular response to stress GO:0080135 244 0.010
spindle elongation GO:0051231 4 0.010
2 oxoglutarate metabolic process GO:0006103 4 0.010
extrinsic apoptotic signaling pathway GO:0097191 119 0.010
cellular response to external stimulus GO:0071496 111 0.010
regulation of meiosis GO:0040020 3 0.010
establishment of planar polarity GO:0001736 3 0.010
somitogenesis GO:0001756 2 0.010
response to oxidative stress GO:0006979 121 0.010
glycoprotein biosynthetic process GO:0009101 91 0.010
growth GO:0040007 202 0.010
epidermis morphogenesis GO:0048730 3 0.010
response to other organism GO:0051707 261 0.010
regulation of dna metabolic process GO:0051052 153 0.010
nucleoside monophosphate catabolic process GO:0009125 159 0.010
circadian sleep wake cycle GO:0042745 2 0.010
protein localization to nucleus GO:0034504 136 0.010
i kappab kinase nf kappab signaling GO:0007249 166 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
positive regulation of secretion by cell GO:1903532 108 0.010
phospholipid metabolic process GO:0006644 99 0.010
cell part morphogenesis GO:0032990 137 0.010
somatic muscle development GO:0007525 1 0.010
circadian sleep wake cycle sleep GO:0050802 2 0.010
striated muscle contraction GO:0006941 52 0.010
nuclear export GO:0051168 69 0.010
morphogenesis of embryonic epithelium GO:0016331 4 0.010
innate immune response GO:0045087 178 0.010
positive regulation of protein kinase activity GO:0045860 190 0.010
melanin metabolic process GO:0006582 1 0.010
response to hypoxia GO:0001666 96 0.010
regulation of cytoplasmic transport GO:1903649 149 0.010
regulation of intracellular protein transport GO:0033157 123 0.010
stress activated protein kinase signaling cascade GO:0031098 94 0.010
spermatid development GO:0007286 4 0.010
synaptic vesicle endocytosis GO:0048488 2 0.010
regulation of chromosome organization GO:0033044 103 0.010

MFN2 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.037
nervous system disease DOID:863 431 0.037
disease of metabolism DOID:0014667 295 0.037
sensory system disease DOID:0050155 203 0.036
inherited metabolic disorder DOID:655 242 0.035
eye and adnexa disease DOID:1492 150 0.034
eye disease DOID:5614 149 0.034
musculoskeletal system disease DOID:17 223 0.030
myopathy DOID:423 104 0.023
muscular disease DOID:0080000 114 0.023
muscle tissue disease DOID:66 113 0.023
cancer DOID:162 167 0.020
disease of cellular proliferation DOID:14566 174 0.020
organ system cancer DOID:0050686 164 0.020
neurodegenerative disease DOID:1289 102 0.019
retinal disease DOID:5679 118 0.018
retinal degeneration DOID:8466 89 0.017
cardiovascular system disease DOID:1287 106 0.015
immune system disease DOID:2914 155 0.012
muscular dystrophy DOID:9884 51 0.012
brain disease DOID:936 73 0.011
heart disease DOID:114 68 0.011
retinitis pigmentosa DOID:10584 51 0.010
neuropathy DOID:870 52 0.008
neuromuscular disease DOID:440 38 0.007
charcot marie tooth disease DOID:10595 33 0.005
charcot marie tooth disease type 2 DOID:0050539 15 0.003