Homo sapiens

46 known processes

MUS81

MUS81 endonuclease homolog (S. cerevisiae)

(Aliases: FLJ21012,SLX3,FLJ44872)

MUS81 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to dna integrity checkpoint signaling GO:0072402 4 0.993
double strand break repair via single strand annealing GO:0045002 4 0.988
response to dna damage checkpoint signaling GO:0072423 4 0.978
nucleotide excision repair dna incision GO:0033683 7 0.954
cellular response to biotic stimulus GO:0071216 71 0.917
response to intra s dna damage checkpoint signaling GO:0072429 4 0.886
dna catabolic process GO:0006308 49 0.878
cellular response to endogenous stimulus GO:0071495 336 0.810
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.746
response to biotic stimulus GO:0009607 276 0.739
nucleotide excision repair GO:0006289 31 0.677
response to cell cycle checkpoint signaling GO:0072396 4 0.575
double strand break repair via homologous recombination GO:0000724 50 0.512
double strand break repair GO:0006302 101 0.497
cellular response to dna damage stimulus GO:0006974 379 0.486
dna repair GO:0006281 198 0.482
negative regulation of homeostatic process GO:0032845 59 0.306
recombinational repair GO:0000725 50 0.304
dna double strand break processing GO:0000729 10 0.251
non recombinational repair GO:0000726 14 0.218
sex determination GO:0007530 3 0.213
nucleoside triphosphate metabolic process GO:0009141 422 0.194
post embryonic development GO:0009791 2 0.178
regulation of telomere maintenance GO:0032204 13 0.154
negative regulation of organelle organization GO:0010639 126 0.113
nucleotide catabolic process GO:0009166 408 0.110
anatomical structure homeostasis GO:0060249 100 0.103
negative regulation of telomere maintenance GO:0032205 9 0.098
purine ribonucleoside catabolic process GO:0046130 398 0.095
negative regulation of chromosome organization GO:2001251 48 0.092
regulation of dna metabolic process GO:0051052 153 0.092
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.084
ribonucleoside triphosphate catabolic process GO:0009203 391 0.081
replicative cell aging GO:0001302 3 0.080
glycosyl compound catabolic process GO:1901658 413 0.073
organophosphate catabolic process GO:0046434 430 0.071
determination of adult lifespan GO:0008340 2 0.066
morphogenesis of embryonic epithelium GO:0016331 4 0.059
ribonucleoside catabolic process GO:0042454 406 0.056
purine ribonucleotide catabolic process GO:0009154 404 0.056
ras protein signal transduction GO:0007265 73 0.054
ribonucleotide catabolic process GO:0009261 405 0.053
positive regulation of catabolic process GO:0009896 310 0.052
purine nucleoside triphosphate metabolic process GO:0009144 412 0.051
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.050
purine ribonucleoside metabolic process GO:0046128 437 0.049
atp catabolic process GO:0006200 157 0.048
cellular amino acid metabolic process GO:0006520 116 0.047
multicellular organismal aging GO:0010259 3 0.045
positive regulation of cellular amine metabolic process GO:0033240 7 0.045
response to ionizing radiation GO:0010212 65 0.045
embryonic epithelial tube formation GO:0001838 4 0.044
amine metabolic process GO:0009308 44 0.044
regulation of cellular amino acid metabolic process GO:0006521 6 0.043
cellular macromolecule catabolic process GO:0044265 380 0.043
positive regulation of phosphorylation GO:0042327 394 0.042
ribonucleoside monophosphate metabolic process GO:0009161 187 0.042
positive regulation of hydrolase activity GO:0051345 331 0.042
epithelium development GO:0060429 227 0.042
response to uv GO:0009411 73 0.041
embryo development GO:0009790 123 0.041
negative regulation of apoptotic process GO:0043066 316 0.041
purine containing compound catabolic process GO:0072523 411 0.040
cellular protein complex assembly GO:0043623 188 0.040
ribonucleoside triphosphate metabolic process GO:0009199 412 0.040
purine nucleoside catabolic process GO:0006152 398 0.039
base excision repair GO:0006284 21 0.038
mitotic cell cycle GO:0000278 326 0.037
Fly
regulation of cellular ketone metabolic process GO:0010565 50 0.037
purine nucleotide catabolic process GO:0006195 405 0.036
negative regulation of catalytic activity GO:0043086 335 0.035
negative regulation of protein metabolic process GO:0051248 391 0.035
nucleoside monophosphate catabolic process GO:0009125 159 0.035
regulation of transferase activity GO:0051338 355 0.035
regulation of meiotic cell cycle GO:0051445 4 0.034
cellular component disassembly GO:0022411 92 0.033
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.032
response to abiotic stimulus GO:0009628 336 0.032
regulation of cellular response to stress GO:0080135 244 0.032
regulation of cellular component biogenesis GO:0044087 281 0.031
regulation of meiosis GO:0040020 3 0.031
oxidation reduction process GO:0055114 396 0.031
dephosphorylation GO:0016311 209 0.030
protein catabolic process GO:0030163 325 0.030
regulation of cellular amine metabolic process GO:0033238 11 0.030
cellular amine metabolic process GO:0044106 41 0.030
neuroblast proliferation GO:0007405 4 0.029
regulation of neural precursor cell proliferation GO:2000177 4 0.029
dna catabolic process exonucleolytic GO:0000738 17 0.029
regulation of protein kinase activity GO:0045859 289 0.028
dna catabolic process endonucleolytic GO:0000737 37 0.028
signal transduction by phosphorylation GO:0023014 297 0.028
gtp metabolic process GO:0046039 239 0.028
cellular ketone metabolic process GO:0042180 80 0.028
negative regulation of cell cycle process GO:0010948 121 0.027
Fly
transmembrane transport GO:0055085 399 0.027
positive regulation of nucleotide metabolic process GO:0045981 230 0.027
regulation of mitotic cell cycle GO:0007346 189 0.027
Fly
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.027
mapk cascade GO:0000165 288 0.026
single organism cellular localization GO:1902580 332 0.026
regulation of kinase activity GO:0043549 314 0.026
response to oxygen containing compound GO:1901700 369 0.026
regulation of small gtpase mediated signal transduction GO:0051056 156 0.026
regulation of cell cycle GO:0051726 393 0.026
Fly
response to oxidative stress GO:0006979 121 0.025
neuromuscular junction development GO:0007528 3 0.025
regulation of nucleotide metabolic process GO:0006140 269 0.025
actin filament based process GO:0030029 224 0.025
negative regulation of phosphorus metabolic process GO:0010563 267 0.024
positive regulation of apoptotic process GO:0043065 246 0.024
regulation of purine nucleotide metabolic process GO:1900542 264 0.024
vesicle mediated transport GO:0016192 371 0.024
chromatin organization GO:0006325 351 0.024
mitotic cell cycle phase transition GO:0044772 162 0.024
Fly
purine nucleoside monophosphate catabolic process GO:0009128 158 0.024
protein maturation GO:0051604 233 0.024
negative regulation of programmed cell death GO:0043069 321 0.024
dna synthesis involved in dna repair GO:0000731 6 0.024
small gtpase mediated signal transduction GO:0007264 78 0.023
guanosine containing compound metabolic process GO:1901068 244 0.023
positive regulation of nucleotide catabolic process GO:0030813 185 0.022
locomotory behavior GO:0007626 1 0.022
regulation of nucleoside metabolic process GO:0009118 209 0.022
ubiquitin dependent protein catabolic process GO:0006511 206 0.022
gtp catabolic process GO:0006184 237 0.022
meiotic chromosome separation GO:0051307 3 0.021
regulation of protein processing GO:0070613 150 0.021
positive regulation of programmed cell death GO:0043068 249 0.021
membrane organization GO:0061024 292 0.021
protein oligomerization GO:0051259 173 0.021
positive regulation of transferase activity GO:0051347 227 0.021
mitochondrion organization GO:0007005 156 0.021
immune response GO:0006955 307 0.021
regulation of mapk cascade GO:0043408 262 0.020
positive regulation of cellular catabolic process GO:0031331 284 0.020
nucleoside catabolic process GO:0009164 408 0.020
regulation of protein transport GO:0051223 213 0.020
rho protein signal transduction GO:0007266 26 0.020
negative regulation of cellular protein metabolic process GO:0032269 353 0.020
actin cytoskeleton organization GO:0030036 207 0.020
positive regulation of cell death GO:0010942 263 0.020
cell type specific apoptotic process GO:0097285 125 0.019
golgi inheritance GO:0048313 2 0.019
negative regulation of t cell apoptotic process GO:0070233 4 0.019
lipid metabolic process GO:0006629 381 0.019
enzyme linked receptor protein signaling pathway GO:0007167 303 0.018
positive regulation of developmental process GO:0051094 314 0.018
protein localization to organelle GO:0033365 280 0.018
microtubule based process GO:0007017 210 0.018
positive regulation of gtp catabolic process GO:0033126 166 0.018
guanosine containing compound catabolic process GO:1901069 239 0.018
system process GO:0003008 349 0.018
g2 m transition of mitotic cell cycle GO:0000086 41 0.018
negative regulation of phosphorylation GO:0042326 174 0.018
cytoplasmic transport GO:0016482 379 0.018
morphogenesis of a polarized epithelium GO:0001738 3 0.018
negative regulation of proteolysis GO:0045861 132 0.018
negative regulation of cell death GO:0060548 345 0.018
negative regulation of cell cycle GO:0045786 193 0.018
Fly
regulation of homeostatic process GO:0032844 121 0.017
regulation of cell migration GO:0030334 289 0.017
negative regulation of meiotic cell cycle GO:0051447 2 0.017
positive regulation of ras gtpase activity GO:0032320 117 0.017
female gamete generation GO:0007292 2 0.017
tissue migration GO:0090130 119 0.017
mitotic cell cycle process GO:1903047 286 0.017
Fly
primary neural tube formation GO:0014020 3 0.017
nucleoside phosphate catabolic process GO:1901292 412 0.017
cellular lipid metabolic process GO:0044255 303 0.017
regulation of ras protein signal transduction GO:0046578 155 0.017
oogenesis GO:0048477 2 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
response to radiation GO:0009314 151 0.017
microtubule nucleation GO:0007020 6 0.016
neural tube closure GO:0001843 3 0.016
regulation of purine nucleotide catabolic process GO:0033121 205 0.016
spermatid development GO:0007286 4 0.016
apoptotic signaling pathway GO:0097190 268 0.016
negative regulation of protein phosphorylation GO:0001933 140 0.016
negative regulation of protein modification process GO:0031400 200 0.016
nitrogen compound transport GO:0071705 191 0.016
regulation of protein serine threonine kinase activity GO:0071900 179 0.016
modification dependent protein catabolic process GO:0019941 209 0.016
intracellular protein transport GO:0006886 270 0.016
negative regulation of cell cycle phase transition GO:1901988 89 0.016
Fly
spermatid differentiation GO:0048515 4 0.015
chromatin modification GO:0016568 298 0.015
cardiovascular system development GO:0072358 262 0.015
regulation of nucleotide catabolic process GO:0030811 205 0.015
positive regulation of protein phosphorylation GO:0001934 313 0.015
rna catabolic process GO:0006401 71 0.015
negative regulation of cellular catabolic process GO:0031330 83 0.015
anterior posterior axis specification GO:0009948 2 0.015
ion transmembrane transport GO:0034220 338 0.015
neurotransmitter secretion GO:0007269 4 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.015
reciprocal dna recombination GO:0035825 4 0.015
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.015
regulation of establishment of protein localization GO:0070201 242 0.015
cellular response to cytokine stimulus GO:0071345 181 0.015
single organism membrane organization GO:0044802 268 0.015
cell activation GO:0001775 213 0.015
negative regulation of catabolic process GO:0009895 104 0.015
circulatory system development GO:0072359 262 0.015
adult locomotory behavior GO:0008344 1 0.015
lipid biosynthetic process GO:0008610 177 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.014
negative regulation of multicellular organismal process GO:0051241 317 0.014
nerve development GO:0021675 4 0.014
regulation of gtpase activity GO:0043087 180 0.014
regeneration GO:0031099 4 0.014
establishment of protein localization to organelle GO:0072594 172 0.014
telomere maintenance GO:0000723 32 0.014
positive regulation of nucleoside metabolic process GO:0045979 186 0.014
reactive oxygen species metabolic process GO:0072593 75 0.014
regulation of gtp catabolic process GO:0033124 180 0.014
epithelium migration GO:0090132 119 0.014
regulation of cellular protein catabolic process GO:1903362 96 0.014
neural tube formation GO:0001841 3 0.014
epithelial cell differentiation GO:0030855 141 0.014
i kappab kinase nf kappab signaling GO:0007249 166 0.014
myosin filament assembly GO:0031034 2 0.014
purine nucleotide biosynthetic process GO:0006164 84 0.014
regulation of protein maturation GO:1903317 150 0.014
hindbrain development GO:0030902 3 0.014
covalent chromatin modification GO:0016569 254 0.013
regulation of intracellular transport GO:0032386 195 0.013
negative regulation of cell differentiation GO:0045596 171 0.013
execution phase of apoptosis GO:0097194 32 0.013
purine nucleoside triphosphate catabolic process GO:0009146 392 0.013
carbohydrate derivative biosynthetic process GO:1901137 207 0.013
cell aging GO:0007569 52 0.013
biological adhesion GO:0022610 331 0.013
salivary gland morphogenesis GO:0007435 4 0.013
memory GO:0007613 3 0.013
negative regulation of protein kinase activity GO:0006469 98 0.013
response to gamma radiation GO:0010332 14 0.013
response to cytokine GO:0034097 232 0.013
regulation of protein catabolic process GO:0042176 155 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
positive regulation of protein complex assembly GO:0031334 86 0.013
cell morphogenesis GO:0000902 296 0.013
actin filament based movement GO:0030048 17 0.013
negative regulation of cellular amine metabolic process GO:0033239 3 0.013
nucleoside monophosphate metabolic process GO:0009123 191 0.013
response to fungus GO:0009620 4 0.013
atp metabolic process GO:0046034 176 0.013
regulation of immune effector process GO:0002697 91 0.013
positive regulation of kinase activity GO:0033674 204 0.013
organophosphate biosynthetic process GO:0090407 163 0.012
nucleus localization GO:0051647 1 0.012
negative regulation of protein processing GO:0010955 142 0.012
negative regulation of intracellular signal transduction GO:1902532 183 0.012
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.012
protein processing GO:0016485 226 0.012
blastoderm segmentation GO:0007350 2 0.012
somatic stem cell division GO:0048103 1 0.012
regulation of response to external stimulus GO:0032101 222 0.012
anion transport GO:0006820 161 0.012
protein localization to membrane GO:0072657 160 0.012
positive regulation of gtpase activity GO:0043547 166 0.012
tissue morphogenesis GO:0048729 96 0.012
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.012
cellular component morphogenesis GO:0032989 314 0.012
endosomal transport GO:0016197 129 0.012
organ formation GO:0048645 3 0.012
dna recombination GO:0006310 77 0.012
cytokine mediated signaling pathway GO:0019221 109 0.012
regulation of microtubule based process GO:0032886 74 0.012
demethylation GO:0070988 37 0.012
sequestering of calcium ion GO:0051208 17 0.012
regulation of protein complex assembly GO:0043254 147 0.012
protein targeting GO:0006605 187 0.012
aging GO:0007568 66 0.012
inner ear morphogenesis GO:0042472 4 0.012
regulation of growth GO:0040008 165 0.012
regulation of response to dna damage stimulus GO:2001020 94 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
positive regulation of protein kinase activity GO:0045860 190 0.011
protein polymerization GO:0051258 71 0.011
mitotic nuclear division GO:0007067 119 0.011
negative regulation of protein maturation GO:1903318 142 0.011
regulation of cell differentiation GO:0045595 393 0.011
nervous system development GO:0007399 293 0.011
meiotic chromosome segregation GO:0045132 4 0.011
protein modification by small protein conjugation GO:0032446 342 0.011
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.011
positive regulation of response to dna damage stimulus GO:2001022 43 0.011
regulation of endopeptidase activity GO:0052548 170 0.011
establishment of nucleus localization GO:0040023 1 0.011
glycoprotein metabolic process GO:0009100 110 0.011
negative regulation of kinase activity GO:0033673 106 0.011
negative regulation of neural precursor cell proliferation GO:2000178 1 0.011
regulation of proteolysis GO:0030162 293 0.011
neurological system process GO:0050877 163 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.011
organic anion transport GO:0015711 103 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
thymocyte apoptotic process GO:0070242 2 0.011
golgi disassembly GO:0090166 2 0.011
dna strand elongation involved in dna replication GO:0006271 3 0.011
positive regulation of cellular component organization GO:0051130 376 0.011
cellular protein catabolic process GO:0044257 261 0.011
ameboidal type cell migration GO:0001667 135 0.011
nucleoside triphosphate catabolic process GO:0009143 394 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.011
cell development GO:0048468 328 0.011
rhythmic behavior GO:0007622 2 0.011
regulation of neuroblast proliferation GO:1902692 3 0.011
negative regulation of transferase activity GO:0051348 124 0.011
semaphorin plexin signaling pathway GO:0071526 4 0.011
endomembrane system organization GO:0010256 196 0.011
peripheral nervous system development GO:0007422 2 0.011
negative regulation of jun kinase activity GO:0043508 4 0.011
cation transport GO:0006812 331 0.011
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.011
anterior posterior axis specification embryo GO:0008595 2 0.011
positive regulation of immune system process GO:0002684 283 0.011
sensory perception GO:0007600 103 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
positive regulation of cell differentiation GO:0045597 211 0.011
nuclear transport GO:0051169 179 0.010
negative regulation of gliogenesis GO:0014014 3 0.010
protein ubiquitination GO:0016567 314 0.010
regulation of binding GO:0051098 111 0.010
anatomical structure formation involved in morphogenesis GO:0048646 284 0.010
establishment of tissue polarity GO:0007164 3 0.010
stem cell division GO:0017145 2 0.010
reactive oxygen species biosynthetic process GO:1903409 4 0.010
protein import GO:0017038 130 0.010
metal ion transport GO:0030001 272 0.010
establishment of planar polarity GO:0001736 3 0.010
regulation of multi organism process GO:0043900 157 0.010
peptidyl threonine modification GO:0018210 45 0.010
negative regulation of stem cell proliferation GO:2000647 3 0.010
tripartite regional subdivision GO:0007351 2 0.010
regulation of intracellular protein transport GO:0033157 123 0.010
syncytium formation by plasma membrane fusion GO:0000768 2 0.010
metencephalon development GO:0022037 2 0.010
immune effector process GO:0002252 159 0.010
hemopoiesis GO:0030097 180 0.010
positive regulation of cell cycle process GO:0090068 106 0.010
positive regulation of cell proliferation GO:0008284 301 0.010
response to wounding GO:0009611 168 0.010

MUS81 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.598
bone marrow disease DOID:4961 31 0.598
hematopoietic system disease DOID:74 100 0.598
aplastic anemia DOID:12449 30 0.382
anemia DOID:2355 55 0.382
congenital hypoplastic anemia DOID:1342 26 0.082
musculoskeletal system disease DOID:17 223 0.056
xeroderma pigmentosum DOID:0050427 8 0.045
kidney disease DOID:557 36 0.037
urinary system disease DOID:18 40 0.037
central nervous system disease DOID:331 186 0.032
nervous system disease DOID:863 431 0.032
disease of metabolism DOID:0014667 295 0.027
inherited metabolic disorder DOID:655 242 0.023
connective tissue disease DOID:65 109 0.018
sensory system disease DOID:0050155 203 0.017
fanconi s anemia DOID:13636 16 0.015
muscular disease DOID:0080000 114 0.013
disease of cellular proliferation DOID:14566 174 0.012
eye and adnexa disease DOID:1492 150 0.012
neurodegenerative disease DOID:1289 102 0.011
amino acid metabolic disorder DOID:9252 50 0.010