Homo sapiens

47 known processes

CACNA1S

calcium channel, voltage-dependent, L type, alpha 1S subunit

(Aliases: hypoPP,CCHL1A3,Cav1.1,MHS5,TTPP1,HOKPP1,CACNL1A3,HOKPP)

CACNA1S biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
musculoskeletal movement GO:0050881 17 0.162
striated muscle contraction GO:0006941 52 0.136
skeletal muscle contraction GO:0003009 16 0.128
muscle system process GO:0003012 81 0.094
micturition GO:0060073 3 0.093
synaptic transmission involved in micturition GO:0060084 2 0.093
actin filament based movement GO:0030048 17 0.085
system process GO:0003008 349 0.085
actin mediated cell contraction GO:0070252 12 0.083
muscle structure development GO:0061061 98 0.071
multicellular organismal movement GO:0050879 17 0.062
regulation of ion transport GO:0043269 189 0.061
post embryonic development GO:0009791 2 0.056
cell development GO:0048468 328 0.056
nucleoside monophosphate metabolic process GO:0009123 191 0.055
purine nucleoside monophosphate catabolic process GO:0009128 158 0.053
ribonucleoside monophosphate metabolic process GO:0009161 187 0.051
cell adhesion GO:0007155 325 0.051
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.050
purine ribonucleotide catabolic process GO:0009154 404 0.049
negative regulation of acetylcholine gated cation channel activity GO:1903049 1 0.049
muscle contraction GO:0006936 73 0.049
ribonucleotide catabolic process GO:0009261 405 0.049
regulation of acetylcholine gated cation channel activity GO:1903048 1 0.047
purine nucleoside monophosphate metabolic process GO:0009126 186 0.046
biological adhesion GO:0022610 331 0.045
nucleotide catabolic process GO:0009166 408 0.044
multicellular organismal aging GO:0010259 3 0.044
glycosyl compound catabolic process GO:1901658 413 0.044
ion homeostasis GO:0050801 230 0.043
Human
ribonucleoside monophosphate catabolic process GO:0009158 158 0.043
cardiac muscle tissue development GO:0048738 39 0.043
striated muscle tissue development GO:0014706 59 0.043
purine ribonucleoside metabolic process GO:0046128 437 0.042
organophosphate catabolic process GO:0046434 430 0.042
cation transmembrane transport GO:0098655 238 0.042
nucleoside catabolic process GO:0009164 408 0.041
purine nucleoside triphosphate metabolic process GO:0009144 412 0.041
purine nucleotide catabolic process GO:0006195 405 0.041
cation transport GO:0006812 331 0.040
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.040
purine containing compound catabolic process GO:0072523 411 0.039
nucleoside triphosphate metabolic process GO:0009141 422 0.039
cardiovascular system development GO:0072358 262 0.039
actin filament based process GO:0030029 224 0.039
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.038
determination of adult lifespan GO:0008340 2 0.037
atrial cardiac muscle tissue morphogenesis GO:0055009 1 0.036
ribonucleoside triphosphate catabolic process GO:0009203 391 0.036
nucleoside phosphate catabolic process GO:1901292 412 0.036
purine nucleoside triphosphate catabolic process GO:0009146 392 0.036
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.036
nucleoside triphosphate catabolic process GO:0009143 394 0.036
heart development GO:0007507 95 0.035
atp catabolic process GO:0006200 157 0.035
locomotory behavior GO:0007626 1 0.035
circulatory system process GO:0003013 113 0.035
Human
muscle tissue development GO:0060537 62 0.035
ribonucleoside triphosphate metabolic process GO:0009199 412 0.034
regulation of ion transmembrane transporter activity GO:0032412 72 0.033
amine metabolic process GO:0009308 44 0.032
negative regulation of cellular protein metabolic process GO:0032269 353 0.032
nucleoside monophosphate catabolic process GO:0009125 159 0.032
regulation of transferase activity GO:0051338 355 0.032
purine ribonucleoside catabolic process GO:0046130 398 0.031
negative regulation of protein metabolic process GO:0051248 391 0.031
heart contraction GO:0060047 62 0.030
Human
signal transduction by phosphorylation GO:0023014 297 0.030
neuromuscular junction development GO:0007528 3 0.030
regulation of anatomical structure morphogenesis GO:0022603 286 0.030
circulatory system development GO:0072359 262 0.030
immune response GO:0006955 307 0.029
cytokine production GO:0001816 247 0.029
carbohydrate metabolic process GO:0005975 207 0.029
cellular amino acid metabolic process GO:0006520 116 0.028
regulation of transmembrane transporter activity GO:0022898 74 0.028
postsynaptic membrane organization GO:0001941 2 0.028
purine nucleoside catabolic process GO:0006152 398 0.028
heart process GO:0003015 62 0.028
Human
anatomical structure formation involved in morphogenesis GO:0048646 284 0.028
tissue morphogenesis GO:0048729 96 0.028
blood circulation GO:0008015 113 0.028
Human
cellular macromolecular complex assembly GO:0034622 324 0.027
chemical homeostasis GO:0048878 306 0.027
Human
ribonucleoside catabolic process GO:0042454 406 0.027
negative regulation of apoptotic process GO:0043066 316 0.027
regulation of cellular ketone metabolic process GO:0010565 50 0.027
regulation of cell differentiation GO:0045595 393 0.027
synaptic transmission cholinergic GO:0007271 2 0.026
negative regulation of programmed cell death GO:0043069 321 0.026
calcium ion transport GO:0006816 147 0.026
negative regulation of catalytic activity GO:0043086 335 0.026
regulation of cellular amino acid metabolic process GO:0006521 6 0.026
positive regulation of cellular component organization GO:0051130 376 0.025
positive regulation of catabolic process GO:0009896 310 0.025
nervous system development GO:0007399 293 0.025
cellular response to dna damage stimulus GO:0006974 379 0.025
metal ion transport GO:0030001 272 0.025
response to wounding GO:0009611 168 0.025
reactive oxygen species metabolic process GO:0072593 75 0.025
cellular ketone metabolic process GO:0042180 80 0.025
atp metabolic process GO:0046034 176 0.024
regulation of mapk cascade GO:0043408 262 0.023
regulation of ion transmembrane transport GO:0034765 132 0.023
somatic muscle development GO:0007525 1 0.023
regeneration GO:0031099 4 0.023
neurological system process GO:0050877 163 0.023
Human
organ morphogenesis GO:0009887 147 0.023
mapk cascade GO:0000165 288 0.023
negative regulation of cell death GO:0060548 345 0.022
negative regulation of hydrolase activity GO:0051346 182 0.022
negative regulation of phosphate metabolic process GO:0045936 267 0.022
single organism carbohydrate metabolic process GO:0044723 193 0.022
segmentation GO:0035282 4 0.022
regulation of cellular amine metabolic process GO:0033238 11 0.022
protein oligomerization GO:0051259 173 0.022
chromatin organization GO:0006325 351 0.021
protein catabolic process GO:0030163 325 0.021
cell projection organization GO:0030030 252 0.021
cellular amine metabolic process GO:0044106 41 0.021
taxis GO:0042330 157 0.021
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.021
ion transmembrane transport GO:0034220 338 0.021
response to oxidative stress GO:0006979 121 0.021
memory GO:0007613 3 0.021
actin cytoskeleton organization GO:0030036 207 0.021
regulation of proteolysis GO:0030162 293 0.021
regulation of transmembrane transport GO:0034762 139 0.021
female gamete generation GO:0007292 2 0.021
cellular component morphogenesis GO:0032989 314 0.020
membrane organization GO:0061024 292 0.020
chemotaxis GO:0006935 157 0.020
response to external biotic stimulus GO:0043207 261 0.020
rhythmic behavior GO:0007622 2 0.020
regulation of purine nucleotide catabolic process GO:0033121 205 0.020
negative regulation of protein modification process GO:0031400 200 0.020
cell morphogenesis GO:0000902 296 0.020
response to oxygen containing compound GO:1901700 369 0.020
heart morphogenesis GO:0003007 48 0.020
maintenance of location GO:0051235 112 0.020
regulation of cellular component movement GO:0051270 334 0.020
ras protein signal transduction GO:0007265 73 0.020
cellular protein complex assembly GO:0043623 188 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
wound healing GO:0042060 115 0.019
blood coagulation GO:0007596 76 0.019
regulation of transporter activity GO:0032409 82 0.019
inorganic ion transmembrane transport GO:0098660 231 0.019
chromatin modification GO:0016568 298 0.019
regulation of heart rate GO:0002027 38 0.019
Human
protein maturation GO:0051604 233 0.019
regulation of protein processing GO:0070613 150 0.018
muscle organ development GO:0007517 56 0.018
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.018
transmembrane transport GO:0055085 399 0.018
visual behavior GO:0007632 2 0.018
cellular chemical homeostasis GO:0055082 180 0.018
Human
inorganic cation transmembrane transport GO:0098662 194 0.018
regulation of cytokine production GO:0001817 232 0.017
cellular protein catabolic process GO:0044257 261 0.017
protein modification by small protein conjugation GO:0032446 342 0.017
sequestering of calcium ion GO:0051208 17 0.017
divalent metal ion transport GO:0070838 152 0.017
positive regulation of cellular catabolic process GO:0031331 284 0.017
cellular macromolecule catabolic process GO:0044265 380 0.017
inner ear morphogenesis GO:0042472 4 0.017
negative regulation of cellular amine metabolic process GO:0033239 3 0.017
positive regulation of transport GO:0051050 336 0.017
Human
single organism membrane organization GO:0044802 268 0.017
organelle assembly GO:0070925 176 0.017
positive regulation of developmental process GO:0051094 314 0.017
dephosphorylation GO:0016311 209 0.017
cardiac muscle cell contraction GO:0086003 4 0.017
protein ubiquitination GO:0016567 314 0.017
regulation of purine nucleotide metabolic process GO:1900542 264 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
positive regulation of cell proliferation GO:0008284 301 0.017
organonitrogen compound biosynthetic process GO:1901566 200 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.017
regulation of nucleotide metabolic process GO:0006140 269 0.017
cellular homeostasis GO:0019725 196 0.017
Human
positive regulation of nucleotide metabolic process GO:0045981 230 0.017
negative regulation of multicellular organismal process GO:0051241 317 0.017
regulation of cellular response to stress GO:0080135 244 0.017
muscle cell differentiation GO:0042692 63 0.016
anatomical structure homeostasis GO:0060249 100 0.016
blastoderm segmentation GO:0007350 2 0.016
response to abiotic stimulus GO:0009628 336 0.016
Human
regulation of nucleotide catabolic process GO:0030811 205 0.016
protein localization to organelle GO:0033365 280 0.016
regulation of response to external stimulus GO:0032101 222 0.016
apoptotic signaling pathway GO:0097190 268 0.016
cardiac muscle contraction GO:0060048 34 0.016
response to other organism GO:0051707 261 0.016
positive regulation of nucleotide catabolic process GO:0030813 185 0.016
cellular ion homeostasis GO:0006873 168 0.016
Human
syncytium formation by plasma membrane fusion GO:0000768 2 0.016
oogenesis GO:0048477 2 0.016
protein processing GO:0016485 226 0.016
associative learning GO:0008306 1 0.016
protein acylation GO:0043543 138 0.016
regulation of cell motility GO:2000145 299 0.016
cell substrate adhesion GO:0031589 132 0.015
regulation of protein kinase activity GO:0045859 289 0.015
cellular response to oxygen containing compound GO:1901701 276 0.015
spermatid differentiation GO:0048515 4 0.015
mitotic cell cycle process GO:1903047 286 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.015
epithelium development GO:0060429 227 0.015
circadian behavior GO:0048512 2 0.015
response to fungus GO:0009620 4 0.015
regulation of establishment of protein localization GO:0070201 242 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.015
regulation of protein maturation GO:1903317 150 0.015
negative regulation of protein maturation GO:1903318 142 0.015
growth GO:0040007 202 0.015
cell part morphogenesis GO:0032990 137 0.015
positive regulation of cell differentiation GO:0045597 211 0.015
response to biotic stimulus GO:0009607 276 0.014
regulation of cytoskeleton organization GO:0051493 177 0.014
regulation of kinase activity GO:0043549 314 0.014
tripartite regional subdivision GO:0007351 2 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
monovalent inorganic cation transport GO:0015672 128 0.014
cell activation GO:0001775 213 0.014
regulation of cell morphogenesis GO:0022604 153 0.014
response to growth factor GO:0070848 205 0.014
post embryonic organ development GO:0048569 1 0.014
regulation of cell cycle process GO:0010564 266 0.014
positive regulation of nucleoside metabolic process GO:0045979 186 0.014
myoblast fusion GO:0007520 1 0.014
embryonic epithelial tube formation GO:0001838 4 0.014
central nervous system development GO:0007417 123 0.014
spermatid development GO:0007286 4 0.014
single organism cellular localization GO:1902580 332 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
innate immune response GO:0045087 178 0.014
muscle organ morphogenesis GO:0048644 19 0.014
cellular response to abiotic stimulus GO:0071214 117 0.014
striated muscle cell differentiation GO:0051146 43 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
atrial cardiac muscle tissue development GO:0003228 1 0.013
tissue regeneration GO:0042246 3 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.013
regulation of system process GO:0044057 101 0.013
Human
regulation of ion homeostasis GO:2000021 73 0.013
regulation of protein localization GO:0032880 296 0.013
histone modification GO:0016570 251 0.013
muscle tissue morphogenesis GO:0060415 19 0.013
oxidation reduction process GO:0055114 396 0.013
response to inorganic substance GO:0010035 127 0.013
modification dependent protein catabolic process GO:0019941 209 0.013
metal ion homeostasis GO:0055065 169 0.013
Human
sodium ion transport GO:0006814 61 0.013
positive regulation of cellular component biogenesis GO:0044089 158 0.013
visual learning GO:0008542 1 0.013
rna processing GO:0006396 255 0.013
peripheral nervous system development GO:0007422 2 0.013
regulation of nucleoside metabolic process GO:0009118 209 0.013
positive regulation of organelle organization GO:0010638 195 0.013
immune system development GO:0002520 195 0.013
modification dependent macromolecule catabolic process GO:0043632 212 0.013
morphogenesis of embryonic epithelium GO:0016331 4 0.013
positive regulation of transferase activity GO:0051347 227 0.013
anterior posterior axis specification embryo GO:0008595 2 0.013
sodium ion transmembrane transport GO:0035725 59 0.013
adult locomotory behavior GO:0008344 1 0.013
mitotic cell cycle GO:0000278 326 0.013
negative regulation of cellular component organization GO:0051129 235 0.013
negative regulation of proteolysis GO:0045861 132 0.013
cell growth GO:0016049 160 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
single organism cell adhesion GO:0098602 179 0.012
neural crest cell migration GO:0001755 2 0.012
regulation of actin filament based process GO:0032970 141 0.012
regulation of membrane potential GO:0042391 95 0.012
Human
actin filament organization GO:0007015 128 0.012
positive regulation of kinase activity GO:0033674 204 0.012
cell fate determination GO:0001709 3 0.012
hindbrain development GO:0030902 3 0.012
cellular cation homeostasis GO:0030003 163 0.012
Human
muscle cell cellular homeostasis GO:0046716 3 0.012
negative regulation of transport GO:0051051 176 0.012
blood vessel morphogenesis GO:0048514 162 0.012
carbohydrate derivative biosynthetic process GO:1901137 207 0.012
vesicle mediated transport GO:0016192 371 0.012
regulation of protein catabolic process GO:0042176 155 0.012
epithelial cell differentiation GO:0030855 141 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
regulation of dna metabolic process GO:0051052 153 0.012
actomyosin structure organization GO:0031032 59 0.012
positive regulation of hydrolase activity GO:0051345 331 0.012
ubiquitin dependent protein catabolic process GO:0006511 206 0.012
motor neuron axon guidance GO:0008045 2 0.012
response to hypoxia GO:0001666 96 0.012
sequestering of metal ion GO:0051238 24 0.012
regulation of growth GO:0040008 165 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
cardiac muscle tissue morphogenesis GO:0055008 18 0.012
cofactor metabolic process GO:0051186 87 0.012
cd8 positive alpha beta t cell differentiation involved in immune response GO:0002302 1 0.012
regulation of intracellular transport GO:0032386 195 0.011
compound eye development GO:0048749 1 0.011
regulation of body fluid levels GO:0050878 99 0.011
cytoplasmic transport GO:0016482 379 0.011
negative regulation of organelle organization GO:0010639 126 0.011
regulation of small gtpase mediated signal transduction GO:0051056 156 0.011
regulation of reactive oxygen species metabolic process GO:2000377 41 0.011
intrinsic apoptotic signaling pathway GO:0097193 127 0.011
skeletal muscle tissue growth GO:0048630 2 0.011
negative regulation of growth GO:0045926 97 0.011
covalent chromatin modification GO:0016569 254 0.011
dna repair GO:0006281 198 0.011
organelle fission GO:0048285 149 0.011
regulation of atpase activity GO:0043462 25 0.011
response to nitrogen compound GO:1901698 184 0.011
positive regulation of protein phosphorylation GO:0001934 313 0.011
cell division GO:0051301 168 0.011
negative regulation of developmental process GO:0051093 247 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
regulation of muscle system process GO:0090257 53 0.011
protein targeting GO:0006605 187 0.011
cellular metal ion homeostasis GO:0006875 146 0.011
Human
cellular response to oxidative stress GO:0034599 85 0.011
organophosphate biosynthetic process GO:0090407 163 0.011
regulation of immune response GO:0050776 201 0.011
negative regulation of protein processing GO:0010955 142 0.011
myosin filament organization GO:0031033 2 0.011
enzyme linked receptor protein signaling pathway GO:0007167 303 0.011
transmission of nerve impulse GO:0019226 11 0.011
response to axon injury GO:0048678 1 0.011
protein acetylation GO:0006473 116 0.011
anterior posterior axis specification GO:0009948 2 0.011
defense response GO:0006952 315 0.011
organ formation GO:0048645 3 0.011
regulation of striated muscle contraction GO:0006942 37 0.011
cell morphogenesis involved in differentiation GO:0000904 144 0.011
single organismal cell cell adhesion GO:0016337 148 0.011
detection of mechanical stimulus GO:0050982 4 0.011
regulation of cell growth GO:0001558 135 0.011
positive regulation of cellular component movement GO:0051272 181 0.011
regulation of cell adhesion GO:0030155 166 0.011
mating GO:0007618 1 0.011
coagulation GO:0050817 78 0.011
reactive nitrogen species metabolic process GO:2001057 3 0.011
spinal cord development GO:0021510 4 0.011
multicellular organismal homeostasis GO:0048871 67 0.011
cytosolic calcium ion homeostasis GO:0051480 89 0.011
Human
regulation of protein transport GO:0051223 213 0.010
ventral spinal cord development GO:0021517 1 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.010
positive regulation of protein kinase activity GO:0045860 190 0.010
metencephalon development GO:0022037 2 0.010
intracellular protein transport GO:0006886 270 0.010
cellular response to growth factor stimulus GO:0071363 197 0.010
rho protein signal transduction GO:0007266 26 0.010
positive regulation of ion transport GO:0043270 87 0.010
Human
angiogenesis GO:0001525 147 0.010
sensory perception GO:0007600 103 0.010
Human
peptidyl lysine modification GO:0018205 144 0.010
negative regulation of transferase activity GO:0051348 124 0.010
regulation of meiotic cell cycle GO:0051445 4 0.010
neural tube closure GO:0001843 3 0.010
microtubule based process GO:0007017 210 0.010
cellular response to cytokine stimulus GO:0071345 181 0.010
action potential GO:0001508 34 0.010
Human
positive regulation of phosphorylation GO:0042327 394 0.010
regulation of cell cycle GO:0051726 393 0.010
response to light stimulus GO:0009416 87 0.010
Human
small molecule biosynthetic process GO:0044283 157 0.010
regulation of endopeptidase activity GO:0052548 170 0.010
negative regulation of ion transport GO:0043271 39 0.010
pituitary gland development GO:0021983 2 0.010
neural crest cell development GO:0014032 3 0.010
response to decreased oxygen levels GO:0036293 96 0.010
response to oxygen levels GO:0070482 100 0.010

CACNA1S disease predictions

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 114 0.371
musculoskeletal system disease DOID:17 223 0.371
cardiovascular system disease DOID:1287 106 0.182
Human
muscle tissue disease DOID:66 113 0.136
myopathy DOID:423 104 0.113
heart disease DOID:114 68 0.113
cardiomyopathy DOID:0050700 50 0.113
intrinsic cardiomyopathy DOID:0060036 50 0.083
hypertrophic cardiomyopathy DOID:11984 21 0.038
sensory system disease DOID:0050155 203 0.037
Human
nervous system disease DOID:863 431 0.037
Human
disease of metabolism DOID:0014667 295 0.031
inherited metabolic disorder DOID:655 242 0.020
immune system disease DOID:2914 155 0.018
disease of cellular proliferation DOID:14566 174 0.017
eye and adnexa disease DOID:1492 150 0.015
Human
eye disease DOID:5614 149 0.015
Human
cancer DOID:162 167 0.012
auditory system disease DOID:2742 53 0.012
organ system cancer DOID:0050686 164 0.011
retinal disease DOID:5679 118 0.011
Human
retinal degeneration DOID:8466 89 0.011
Human
metal metabolism disorder DOID:896 19 0.003