Homo sapiens

64 known processes

PHB2

prohibitin 2

(Aliases: BAP,BCAP37,Bap37,PNAS-141,p22,REA,MGC117268)

PHB2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.817
ribose phosphate biosynthetic process GO:0046390 82 0.708
nucleotide biosynthetic process GO:0009165 109 0.594
translation GO:0006412 132 0.584
oxidation reduction process GO:0055114 396 0.562
nucleoside monophosphate metabolic process GO:0009123 191 0.557
Worm
purine nucleoside monophosphate metabolic process GO:0009126 186 0.496
Worm
determination of adult lifespan GO:0008340 2 0.467
Worm
ribonucleoside monophosphate metabolic process GO:0009161 187 0.299
Worm
multicellular organismal aging GO:0010259 3 0.282
Worm
purine ribonucleoside monophosphate biosynthetic process GO:0009168 16 0.266
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.219
Worm
membrane organization GO:0061024 292 0.211
purine ribonucleotide biosynthetic process GO:0009152 79 0.210
cellular macromolecular complex assembly GO:0034622 324 0.204
purine nucleoside triphosphate biosynthetic process GO:0009145 11 0.199
rrna modification GO:0000154 2 0.180
mitochondrion organization GO:0007005 156 0.174
Worm
apoptotic signaling pathway GO:0097190 268 0.173
protein oligomerization GO:0051259 173 0.155
purine containing compound biosynthetic process GO:0072522 88 0.147
embryo development GO:0009790 123 0.134
Worm
generation of precursor metabolites and energy GO:0006091 68 0.133
Worm
cellular amino acid metabolic process GO:0006520 116 0.131
cellular respiration GO:0045333 21 0.126
purine ribonucleoside metabolic process GO:0046128 437 0.122
Worm
positive regulation of dna metabolic process GO:0051054 73 0.112
ribonucleoside triphosphate metabolic process GO:0009199 412 0.111
Worm
purine nucleoside triphosphate metabolic process GO:0009144 412 0.109
Worm
energy derivation by oxidation of organic compounds GO:0015980 43 0.105
purine nucleotide biosynthetic process GO:0006164 84 0.105
transmembrane transport GO:0055085 399 0.101
ribonucleotide biosynthetic process GO:0009260 81 0.101
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.099
atp biosynthetic process GO:0006754 11 0.099
demethylation GO:0070988 37 0.093
cellular homeostasis GO:0019725 196 0.093
single organism membrane organization GO:0044802 268 0.092
ribonucleoside biosynthetic process GO:0042455 25 0.090
negative regulation of apoptotic signaling pathway GO:2001234 97 0.083
positive regulation of apoptotic process GO:0043065 246 0.079
negative regulation of phosphate metabolic process GO:0045936 267 0.074
embryo development ending in birth or egg hatching GO:0009792 34 0.072
Worm
excretion GO:0007588 9 0.068
Worm
organonitrogen compound biosynthetic process GO:1901566 200 0.066
atp transport GO:0015867 4 0.063
ion transmembrane transport GO:0034220 338 0.060
regulation of anatomical structure morphogenesis GO:0022603 286 0.058
Mouse
posttranscriptional regulation of gene expression GO:0010608 213 0.057
nucleoside triphosphate metabolic process GO:0009141 422 0.056
Worm
aging GO:0007568 66 0.056
Worm
endocytosis GO:0006897 159 0.055
atp metabolic process GO:0046034 176 0.055
Worm
cellular protein complex assembly GO:0043623 188 0.055
receptor mediated endocytosis GO:0006898 84 0.054
negative regulation of apoptotic process GO:0043066 316 0.054
dna demethylation GO:0080111 12 0.053
glycosyl compound biosynthetic process GO:1901659 27 0.051
cellular response to cytokine stimulus GO:0071345 181 0.050
cation transport GO:0006812 331 0.050
negative regulation of cellular component organization GO:0051129 235 0.050
regulation of cellular amino acid metabolic process GO:0006521 6 0.050
negative regulation of cell death GO:0060548 345 0.045
chemical homeostasis GO:0048878 306 0.045
phosphate ion transmembrane transport GO:0035435 4 0.044
inorganic ion transmembrane transport GO:0098660 231 0.044
nucleoside phosphate biosynthetic process GO:1901293 109 0.044
negative regulation of organelle organization GO:0010639 126 0.042
response to cytokine GO:0034097 232 0.042
regulation of cellular ketone metabolic process GO:0010565 50 0.041
cellular macromolecule catabolic process GO:0044265 380 0.039
cation transmembrane transport GO:0098655 238 0.038
apoptotic mitochondrial changes GO:0008637 57 0.037
organophosphate biosynthetic process GO:0090407 163 0.035
regulation of transferase activity GO:0051338 355 0.035
negative regulation of phosphorylation GO:0042326 174 0.035
regulation of dna metabolic process GO:0051052 153 0.034
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.034
Worm
protein processing GO:0016485 226 0.033
behavior GO:0007610 112 0.032
Worm
response to abiotic stimulus GO:0009628 336 0.030
vesicle mediated transport GO:0016192 371 0.030
ion homeostasis GO:0050801 230 0.029
cell development GO:0048468 328 0.029
Worm
regulation of oxidoreductase activity GO:0051341 43 0.029
cellular chemical homeostasis GO:0055082 180 0.029
cellular response to dna damage stimulus GO:0006974 379 0.028
positive regulation of cell death GO:0010942 263 0.028
inorganic anion transmembrane transport GO:0098661 47 0.028
anion transport GO:0006820 161 0.028
regulation of cellular response to stress GO:0080135 244 0.027
cellular cation homeostasis GO:0030003 163 0.027
single organism reproductive process GO:0044702 98 0.027
Mouse Worm
purine nucleoside monophosphate biosynthetic process GO:0009127 16 0.027
phosphate ion transport GO:0006817 7 0.026
organic anion transport GO:0015711 103 0.026
isocitrate metabolic process GO:0006102 1 0.026
hematopoietic or lymphoid organ development GO:0048534 186 0.025
tube development GO:0035295 125 0.025
Mouse
ribonucleoprotein complex subunit organization GO:0071826 81 0.025
nervous system development GO:0007399 293 0.025
nucleotide catabolic process GO:0009166 408 0.025
protein maturation GO:0051604 233 0.024
immune system development GO:0002520 195 0.024
cellular amine metabolic process GO:0044106 41 0.024
system process GO:0003008 349 0.024
Worm
negative regulation of intracellular signal transduction GO:1902532 183 0.023
inorganic cation transmembrane transport GO:0098662 194 0.022
amine metabolic process GO:0009308 44 0.022
purine ribonucleoside biosynthetic process GO:0046129 23 0.022
regulation of kinase activity GO:0043549 314 0.022
growth GO:0040007 202 0.022
Worm
negative regulation of cellular protein metabolic process GO:0032269 353 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
regulation of cellular amine metabolic process GO:0033238 11 0.020
positive regulation of cellular amine metabolic process GO:0033240 7 0.020
hemopoiesis GO:0030097 180 0.020
cellular ketone metabolic process GO:0042180 80 0.020
centrosome organization GO:0051297 58 0.020
reproduction GO:0000003 63 0.020
Worm
regulation of apoptotic signaling pathway GO:2001233 175 0.019
microtubule cytoskeleton organization GO:0000226 176 0.019
rna processing GO:0006396 255 0.019
reproductive process GO:0022414 106 0.019
Mouse Worm
protein tetramerization GO:0051262 47 0.019
response to hormone GO:0009725 175 0.019
response to oxygen containing compound GO:1901700 369 0.019
ribonucleoside triphosphate biosynthetic process GO:0009201 12 0.018
microtubule based process GO:0007017 210 0.018
mitotic cell cycle GO:0000278 326 0.018
negative regulation of programmed cell death GO:0043069 321 0.018
ribonucleoside triphosphate catabolic process GO:0009203 391 0.018
cofactor transport GO:0051181 11 0.017
peptidyl tyrosine phosphorylation GO:0018108 170 0.017
positive regulation of organelle organization GO:0010638 195 0.017
ribonucleoprotein complex biogenesis GO:0022613 116 0.016
positive regulation of cell differentiation GO:0045597 211 0.016
digestive tract development GO:0048565 75 0.016
necrotic cell death GO:0070265 21 0.016
positive regulation of cellular component organization GO:0051130 376 0.015
positive regulation of programmed cell death GO:0043068 249 0.015
cellular ion homeostasis GO:0006873 168 0.015
single organism cellular localization GO:1902580 332 0.015
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
regeneration GO:0031099 4 0.015
osteoblast differentiation GO:0001649 92 0.015
cytoplasmic transport GO:0016482 379 0.015
dna dealkylation GO:0035510 13 0.014
purine nucleotide catabolic process GO:0006195 405 0.014
iron coordination entity transport GO:1901678 4 0.014
cellular lipid metabolic process GO:0044255 303 0.014
positive regulation of cell proliferation GO:0008284 301 0.014
ossification GO:0001503 121 0.014
regulation of cell development GO:0060284 161 0.014
positive regulation of immune system process GO:0002684 283 0.014
ribosome biogenesis GO:0042254 48 0.014
negative regulation of kinase activity GO:0033673 106 0.014
regulation of leukocyte differentiation GO:1902105 61 0.014
locomotory behavior GO:0007626 1 0.014
tricarboxylic acid cycle GO:0006099 4 0.014
regulation of lipid metabolic process GO:0019216 96 0.013
nucleoside triphosphate biosynthetic process GO:0009142 20 0.013
myeloid leukocyte differentiation GO:0002573 60 0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.013
response to hypoxia GO:0001666 96 0.013
positive regulation of spindle checkpoint GO:0090232 7 0.013
ribonucleoside monophosphate biosynthetic process GO:0009156 17 0.013
mitochondrial membrane organization GO:0007006 40 0.013
nucleoside monophosphate catabolic process GO:0009125 159 0.013
cation homeostasis GO:0055080 189 0.013
negative regulation of transport GO:0051051 176 0.013
negative regulation of developmental process GO:0051093 247 0.013
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.012
regulation of membrane permeability GO:0090559 25 0.012
carbohydrate derivative biosynthetic process GO:1901137 207 0.012
ncrna metabolic process GO:0034660 108 0.012
energy coupled proton transport down electrochemical gradient GO:0015985 2 0.012
nucleoside triphosphate catabolic process GO:0009143 394 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
Worm
protein secretion GO:0009306 98 0.012
divalent metal ion transport GO:0070838 152 0.012
cell adhesion GO:0007155 325 0.012
purine ribonucleoside triphosphate biosynthetic process GO:0009206 11 0.012
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.011
cofactor metabolic process GO:0051186 87 0.011
defense response GO:0006952 315 0.011
negative regulation of catabolic process GO:0009895 104 0.011
purine nucleotide transport GO:0015865 6 0.011
purine ribonucleoside catabolic process GO:0046130 398 0.011
positive regulation of cell development GO:0010720 92 0.011
negative regulation of cell cycle GO:0045786 193 0.011
organelle assembly GO:0070925 176 0.011
mitotic cell cycle process GO:1903047 286 0.011
nucleoside phosphate catabolic process GO:1901292 412 0.011
nucleoside transport GO:0015858 8 0.011
negative regulation of catalytic activity GO:0043086 335 0.011
maintenance of location GO:0051235 112 0.011
anion transmembrane transport GO:0098656 76 0.011
negative regulation of cellular catabolic process GO:0031330 83 0.011
regulation of purine nucleotide metabolic process GO:1900542 264 0.011
Worm
regulation of mitochondrion organization GO:0010821 54 0.011
nucleobase containing compound transport GO:0015931 51 0.011
inorganic anion transport GO:0015698 60 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.010
Mouse
reproductive system development GO:0061458 56 0.010
Worm
cellular response to oxidative stress GO:0034599 85 0.010
aerobic respiration GO:0009060 7 0.010

PHB2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.103
central nervous system disease DOID:331 186 0.021
nervous system disease DOID:863 431 0.021
retinal disease DOID:5679 118 0.020
retinal degeneration DOID:8466 89 0.020
sensory system disease DOID:0050155 203 0.020
eye and adnexa disease DOID:1492 150 0.020
eye disease DOID:5614 149 0.020