Homo sapiens

147 known processes

PPM1B

protein phosphatase, Mg2+/Mn2+ dependent, 1B

(Aliases: PP2C-beta-X,PP2CB,MGC21657,PPC2BETAX,PP2CBETA)

PPM1B biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
purine ribonucleoside metabolic process GO:0046128 437 0.373
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.329
organophosphate catabolic process GO:0046434 430 0.313
nucleoside triphosphate metabolic process GO:0009141 422 0.293
ras protein signal transduction GO:0007265 73 0.293
Fly
small gtpase mediated signal transduction GO:0007264 78 0.263
Fly
purine nucleotide catabolic process GO:0006195 405 0.249
positive regulation of cellular component organization GO:0051130 376 0.219
nucleoside phosphate catabolic process GO:1901292 412 0.217
purine nucleoside triphosphate catabolic process GO:0009146 392 0.213
ribonucleoside triphosphate metabolic process GO:0009199 412 0.210
ribonucleoside catabolic process GO:0042454 406 0.203
nucleoside catabolic process GO:0009164 408 0.198
synaptic transmission GO:0007268 61 0.187
purine ribonucleotide catabolic process GO:0009154 404 0.181
lipid metabolic process GO:0006629 381 0.163
purine nucleoside catabolic process GO:0006152 398 0.163
purine nucleoside triphosphate metabolic process GO:0009144 412 0.157
nucleotide catabolic process GO:0009166 408 0.149
ribonucleotide catabolic process GO:0009261 405 0.144
cell projection morphogenesis GO:0048858 129 0.142
cellular macromolecule catabolic process GO:0044265 380 0.136
cell morphogenesis GO:0000902 296 0.135
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.133
mitotic cell cycle GO:0000278 326 0.127
Fly
purine ribonucleoside catabolic process GO:0046130 398 0.123
purine containing compound catabolic process GO:0072523 411 0.118
regulation of small gtpase mediated signal transduction GO:0051056 156 0.118
Fly
response to hormone GO:0009725 175 0.114
system process GO:0003008 349 0.113
cellular protein catabolic process GO:0044257 261 0.111
response to uv GO:0009411 73 0.109
Fly
cytoplasmic transport GO:0016482 379 0.107
negative regulation of protein metabolic process GO:0051248 391 0.103
Fly
microtubule based process GO:0007017 210 0.102
negative regulation of cellular component organization GO:0051129 235 0.100
Human
neuromuscular junction development GO:0007528 3 0.098
response to abiotic stimulus GO:0009628 336 0.096
Fly
regulation of ras protein signal transduction GO:0046578 155 0.094
Fly
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.093
oocyte development GO:0048599 1 0.092
ribonucleoside triphosphate catabolic process GO:0009203 391 0.090
cell projection organization GO:0030030 252 0.089
peptidyl serine phosphorylation GO:0018105 101 0.088
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.088
multicellular organismal aging GO:0010259 3 0.087
Fly
neuroblast proliferation GO:0007405 4 0.085
single organism cellular localization GO:1902580 332 0.084
determination of adult lifespan GO:0008340 2 0.083
Fly
somitogenesis GO:0001756 2 0.083
purine nucleoside monophosphate catabolic process GO:0009128 158 0.081
protein catabolic process GO:0030163 325 0.077
regulation of mapk cascade GO:0043408 262 0.076
Fly
neurological system process GO:0050877 163 0.076
response to cytokine GO:0034097 232 0.072
negative regulation of cellular protein metabolic process GO:0032269 353 0.071
Fly
regulation of cell cycle GO:0051726 393 0.070
peptidyl serine modification GO:0018209 106 0.068
cellular response to hormone stimulus GO:0032870 125 0.067
dephosphorylation GO:0016311 209 0.067
locomotory behavior GO:0007626 1 0.066
mapk cascade GO:0000165 288 0.066
Fly
cellular response to dna damage stimulus GO:0006974 379 0.065
cellular amino acid metabolic process GO:0006520 116 0.065
cell part morphogenesis GO:0032990 137 0.064
nucleoside triphosphate catabolic process GO:0009143 394 0.064
glycosyl compound catabolic process GO:1901658 413 0.064
cell morphogenesis involved in differentiation GO:0000904 144 0.064
cellular lipid metabolic process GO:0044255 303 0.063
cell development GO:0048468 328 0.062
Fly
oogenesis GO:0048477 2 0.062
behavioral response to ethanol GO:0048149 2 0.058
nucleoside monophosphate metabolic process GO:0009123 191 0.057
signal transduction by phosphorylation GO:0023014 297 0.057
Fly
response to oxygen containing compound GO:1901700 369 0.056
secretion GO:0046903 254 0.056
regulation of growth GO:0040008 165 0.053
positive regulation of hydrolase activity GO:0051345 331 0.053
oocyte differentiation GO:0009994 2 0.053
cellular component morphogenesis GO:0032989 314 0.053
female gamete generation GO:0007292 2 0.052
regulation of body fluid levels GO:0050878 99 0.051
single organism membrane organization GO:0044802 268 0.051
gtp catabolic process GO:0006184 237 0.051
intracellular protein transport GO:0006886 270 0.049
post embryonic development GO:0009791 2 0.048
Fly
actin filament based movement GO:0030048 17 0.047
generation of neurons GO:0048699 152 0.047
Fly
cellular response to endogenous stimulus GO:0071495 336 0.047
Human Zebrafish
negative regulation of protein modification process GO:0031400 200 0.047
Fly
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.045
cellular response to oxygen containing compound GO:1901701 276 0.045
microtubule bundle formation GO:0001578 15 0.045
cell division GO:0051301 168 0.045
positive regulation of programmed cell death GO:0043068 249 0.045
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.044
positive regulation of cellular amine metabolic process GO:0033240 7 0.044
regulation of anatomical structure morphogenesis GO:0022603 286 0.044
Fly
organelle assembly GO:0070925 176 0.043
proteasomal protein catabolic process GO:0010498 176 0.043
enzyme linked receptor protein signaling pathway GO:0007167 303 0.042
Human Zebrafish
positive regulation of catabolic process GO:0009896 310 0.041
positive regulation of cell proliferation GO:0008284 301 0.041
apoptotic signaling pathway GO:0097190 268 0.041
response to light stimulus GO:0009416 87 0.040
Fly
spermatid differentiation GO:0048515 4 0.040
positive regulation of cell death GO:0010942 263 0.040
metal ion transport GO:0030001 272 0.040
regulation of cellular amino acid metabolic process GO:0006521 6 0.040
regulation of kinase activity GO:0043549 314 0.039
Fly
mitotic cell cycle process GO:1903047 286 0.039
endomembrane system organization GO:0010256 196 0.039
regulation of cell projection organization GO:0031344 107 0.038
neuron differentiation GO:0030182 138 0.038
Fly
regulation of vesicle mediated transport GO:0060627 130 0.038
nervous system development GO:0007399 293 0.038
Fly
organic hydroxy compound metabolic process GO:1901615 147 0.037
behavior GO:0007610 112 0.037
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.037
ribonucleoside monophosphate catabolic process GO:0009158 158 0.036
atp catabolic process GO:0006200 157 0.036
nuclear division GO:0000280 128 0.036
lipid transport GO:0006869 90 0.036
cellular response to cytokine stimulus GO:0071345 181 0.036
regulation of cellular ketone metabolic process GO:0010565 50 0.036
carbohydrate metabolic process GO:0005975 207 0.035
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.035
positive regulation of phosphorylation GO:0042327 394 0.035
regulation of multi organism process GO:0043900 157 0.035
negative regulation of multicellular organismal process GO:0051241 317 0.035
ribonucleoside monophosphate metabolic process GO:0009161 187 0.035
positive regulation of cellular catabolic process GO:0031331 284 0.035
neurotransmitter secretion GO:0007269 4 0.035
organonitrogen compound biosynthetic process GO:1901566 200 0.035
secretion by cell GO:0032940 226 0.035
negative regulation of growth GO:0045926 97 0.035
positive regulation of transport GO:0051050 336 0.035
positive regulation of mapk cascade GO:0043410 190 0.034
protein autophosphorylation GO:0046777 123 0.034
microtubule cytoskeleton organization GO:0000226 176 0.034
amine metabolic process GO:0009308 44 0.034
cellular amine metabolic process GO:0044106 41 0.033
organelle fission GO:0048285 149 0.032
vesicle mediated transport GO:0016192 371 0.032
organic hydroxy compound transport GO:0015850 63 0.032
response to other organism GO:0051707 261 0.032
mitochondrion organization GO:0007005 156 0.032
regulation of cell morphogenesis GO:0022604 153 0.032
negative regulation of programmed cell death GO:0043069 321 0.032
glycerophospholipid metabolic process GO:0006650 84 0.031
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.031
protein localization to organelle GO:0033365 280 0.031
negative regulation of catalytic activity GO:0043086 335 0.031
Fly
positive regulation of peptidase activity GO:0010952 88 0.031
regulation of cell cycle process GO:0010564 266 0.031
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.031
regulation of cellular component biogenesis GO:0044087 281 0.031
Human
negative regulation of cell death GO:0060548 345 0.031
reproductive process GO:0022414 106 0.030
epithelium development GO:0060429 227 0.030
Fly
cellular ketone metabolic process GO:0042180 80 0.030
embryo development GO:0009790 123 0.030
Fly
defense response GO:0006952 315 0.030
negative regulation of phosphorus metabolic process GO:0010563 267 0.030
Fly
regulation of exocytosis GO:0017157 46 0.029
dna repair GO:0006281 198 0.029
endosomal transport GO:0016197 129 0.029
regulation of cellular component size GO:0032535 82 0.029
protein localization to plasma membrane GO:0072659 93 0.029
regulation of protein serine threonine kinase activity GO:0071900 179 0.029
Fly
response to growth factor GO:0070848 205 0.028
Human Zebrafish
protein maturation GO:0051604 233 0.028
plasma membrane organization GO:0007009 115 0.028
response to biotic stimulus GO:0009607 276 0.028
response to insulin GO:0032868 45 0.028
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.028
segmentation GO:0035282 4 0.028
cellular response to nitrogen compound GO:1901699 144 0.027
growth GO:0040007 202 0.027
gtp metabolic process GO:0046039 239 0.027
glycerolipid metabolic process GO:0046486 107 0.027
response to lipid GO:0033993 206 0.027
fatty acid metabolic process GO:0006631 115 0.027
aging GO:0007568 66 0.027
Fly
regulation of protein localization GO:0032880 296 0.027
nucleoside monophosphate catabolic process GO:0009125 159 0.026
embryonic morphogenesis GO:0048598 85 0.026
Fly
modification dependent macromolecule catabolic process GO:0043632 212 0.026
sensory perception GO:0007600 103 0.026
mitotic cell cycle phase transition GO:0044772 162 0.026
chromosome segregation GO:0007059 114 0.026
response to virus GO:0009615 126 0.026
regulation of secretion GO:0051046 194 0.026
regulation of cell differentiation GO:0045595 393 0.025
Fly
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.025
regulation of proteolysis GO:0030162 293 0.025
positive regulation of proteolysis GO:0045862 142 0.025
chromatin modification GO:0016568 298 0.025
spermatid development GO:0007286 4 0.025
regulation of ion transport GO:0043269 189 0.025
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.025
transmembrane transport GO:0055085 399 0.024
monocarboxylic acid metabolic process GO:0032787 185 0.024
purine nucleoside monophosphate metabolic process GO:0009126 186 0.023
positive regulation of nucleotide metabolic process GO:0045981 230 0.023
hindbrain development GO:0030902 3 0.023
regulation of cytoskeleton organization GO:0051493 177 0.023
positive regulation of protein phosphorylation GO:0001934 313 0.023
phospholipid metabolic process GO:0006644 99 0.023
positive regulation of ras gtpase activity GO:0032320 117 0.023
chemical homeostasis GO:0048878 306 0.023
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.022
anatomical structure formation involved in morphogenesis GO:0048646 284 0.022
defense response to other organism GO:0098542 129 0.022
regulation of peptidase activity GO:0052547 180 0.022
neuron development GO:0048666 113 0.022
actin filament based process GO:0030029 224 0.022
signal release GO:0023061 70 0.021
monovalent inorganic cation transport GO:0015672 128 0.021
modification dependent protein catabolic process GO:0019941 209 0.021
negative regulation of transferase activity GO:0051348 124 0.021
Fly
exocytosis GO:0006887 71 0.021
negative regulation of transport GO:0051051 176 0.021
maintenance of cell polarity GO:0030011 2 0.021
macromolecule methylation GO:0043414 97 0.021
cellular protein complex assembly GO:0043623 188 0.020
Human
response to peptide GO:1901652 65 0.020
serine phosphorylation of stat protein GO:0042501 4 0.020
regulation of erk1 and erk2 cascade GO:0070372 99 0.020
Fly
regulation of stress activated mapk cascade GO:0032872 84 0.020
Fly
negative regulation of intracellular signal transduction GO:1902532 183 0.020
protein complex disassembly GO:0043241 52 0.020
negative regulation of protein phosphorylation GO:0001933 140 0.019
Fly
single organism carbohydrate metabolic process GO:0044723 193 0.019
atp metabolic process GO:0046034 176 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
protein ubiquitination GO:0016567 314 0.019
cation transmembrane transport GO:0098655 238 0.019
regulation of apoptotic signaling pathway GO:2001233 175 0.019
regulation of nucleocytoplasmic transport GO:0046822 98 0.019
positive regulation of kinase activity GO:0033674 204 0.019
cell cell signaling GO:0007267 155 0.019
regulation of viral process GO:0050792 103 0.018
regulation of neuron projection development GO:0010975 57 0.018
protein targeting GO:0006605 187 0.018
maintenance of location GO:0051235 112 0.018
regulation of protein ubiquitination GO:0031396 95 0.018
positive regulation of apoptotic process GO:0043065 246 0.018
associative learning GO:0008306 1 0.018
primary neural tube formation GO:0014020 3 0.018
regulation of cell division GO:0051302 116 0.018
jnk cascade GO:0007254 80 0.018
Fly
response to radiation GO:0009314 151 0.018
Fly
protein alkylation GO:0008213 74 0.018
positive regulation of protein kinase activity GO:0045860 190 0.018
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.017
Fly
regulation of protein complex assembly GO:0043254 147 0.017
Human
protein methylation GO:0006479 74 0.017
memory GO:0007613 3 0.017
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.017
cation transport GO:0006812 331 0.017
regulation of ras gtpase activity GO:0032318 128 0.017
golgi vesicle transport GO:0048193 80 0.017
membrane organization GO:0061024 292 0.017
regulation of intracellular transport GO:0032386 195 0.017
regulation of meiosis GO:0040020 3 0.017
biological adhesion GO:0022610 331 0.017
organelle localization GO:0051640 84 0.016
guanosine containing compound metabolic process GO:1901068 244 0.016
sleep GO:0030431 2 0.016
cellular response to insulin stimulus GO:0032869 41 0.016
regulation of cell growth GO:0001558 135 0.016
regulation of response to external stimulus GO:0032101 222 0.016
morphogenesis of embryonic epithelium GO:0016331 4 0.016
Fly
positive regulation of transferase activity GO:0051347 227 0.016
response to external biotic stimulus GO:0043207 261 0.016
intrinsic apoptotic signaling pathway GO:0097193 127 0.015
protein oligomerization GO:0051259 173 0.015
regulation of mitotic cell cycle GO:0007346 189 0.015
regulation of immune effector process GO:0002697 91 0.015
regulation of cell development GO:0060284 161 0.015
Fly
response to bacterium GO:0009617 144 0.015
cell fate determination GO:0001709 3 0.015
central nervous system development GO:0007417 123 0.015
reproduction GO:0000003 63 0.015
actin cytoskeleton organization GO:0030036 207 0.015
cilium morphogenesis GO:0060271 75 0.015
rho protein signal transduction GO:0007266 26 0.015
regulation of cellular amine metabolic process GO:0033238 11 0.015
inorganic cation transmembrane transport GO:0098662 194 0.015
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.015
ameboidal type cell migration GO:0001667 135 0.014
ribonucleoprotein complex biogenesis GO:0022613 116 0.014
regulation of protein kinase activity GO:0045859 289 0.014
Fly
g protein coupled receptor signaling pathway GO:0007186 207 0.014
regulation of purine nucleotide metabolic process GO:1900542 264 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
Human Zebrafish
negative regulation of protein kinase activity GO:0006469 98 0.014
Fly
detection of abiotic stimulus GO:0009582 15 0.014
stem cell division GO:0017145 2 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.014
lipid modification GO:0030258 84 0.014
regulation of neural precursor cell proliferation GO:2000177 4 0.014
circulatory system development GO:0072359 262 0.014
regulation of cell motility GO:2000145 299 0.014
response to organic cyclic compound GO:0014070 204 0.014
neural tube formation GO:0001841 3 0.014
response to tumor necrosis factor GO:0034612 76 0.014
erk1 and erk2 cascade GO:0070371 104 0.014
Fly
lipid homeostasis GO:0055088 39 0.014
taxis GO:0042330 157 0.014
regulation of homeostatic process GO:0032844 121 0.014
negative regulation of organelle organization GO:0010639 126 0.014
single organismal cell cell adhesion GO:0016337 148 0.014
autophagy GO:0006914 88 0.013
nucleoside phosphate biosynthetic process GO:1901293 109 0.013
regulation of cellular response to stress GO:0080135 244 0.013
Fly
cellular component disassembly GO:0022411 92 0.013
positive regulation of gtpase activity GO:0043547 166 0.013
response to nitrogen compound GO:1901698 184 0.013
response to organonitrogen compound GO:0010243 156 0.013
negative regulation of apoptotic signaling pathway GO:2001234 97 0.013
somatic stem cell division GO:0048103 1 0.013
metencephalon development GO:0022037 2 0.013
regulation of growth rate GO:0040009 1 0.013
receptor metabolic process GO:0043112 81 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
methylation GO:0032259 106 0.013
positive regulation of cell projection organization GO:0031346 64 0.013
positive regulation of cell development GO:0010720 92 0.013
Fly
guanosine containing compound catabolic process GO:1901069 239 0.013
establishment of organelle localization GO:0051656 59 0.013
negative regulation of secretion GO:0051048 58 0.013
cell growth GO:0016049 160 0.013
histone modification GO:0016570 251 0.013
regulation of protein catabolic process GO:0042176 155 0.013
phosphatidylinositol metabolic process GO:0046488 53 0.013
intracellular receptor signaling pathway GO:0030522 104 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
Fly
response to peptide hormone GO:0043434 61 0.013
negative regulation of protein processing GO:0010955 142 0.013
regulation of dna metabolic process GO:0051052 153 0.013
cilium assembly GO:0042384 63 0.013
translation GO:0006412 132 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.013
Human Zebrafish
monosaccharide metabolic process GO:0005996 74 0.013
i kappab kinase nf kappab signaling GO:0007249 166 0.012
negative regulation of mapk cascade GO:0043409 56 0.012
Fly
stress activated mapk cascade GO:0051403 93 0.012
Fly
protein homooligomerization GO:0051260 100 0.012
regulation of map kinase activity GO:0043405 108 0.012
Fly
regulation of anatomical structure size GO:0090066 101 0.012
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.012
carbohydrate derivative biosynthetic process GO:1901137 207 0.012
wnt signaling pathway GO:0016055 156 0.012
Human
axon development GO:0061564 34 0.012
detection of mechanical stimulus GO:0050982 4 0.012
protein localization to membrane GO:0072657 160 0.012
regulation of nuclear division GO:0051783 65 0.012
negative regulation of cell proliferation GO:0008285 228 0.012
cellular response to organonitrogen compound GO:0071417 124 0.012
regulation of cellular component movement GO:0051270 334 0.012
regulation of neurogenesis GO:0050767 82 0.012
Fly
negative regulation of cell growth GO:0030308 83 0.012
negative regulation of cell differentiation GO:0045596 171 0.012
meiosis i GO:0007127 4 0.012
peptide transport GO:0015833 74 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.011
organ morphogenesis GO:0009887 147 0.011
Fly
positive regulation of cytoskeleton organization GO:0051495 83 0.011
innate immune response GO:0045087 178 0.011
neural tube closure GO:0001843 3 0.011
central nervous system neuron axonogenesis GO:0021955 3 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
regulation of endopeptidase activity GO:0052548 170 0.011
embryonic epithelial tube formation GO:0001838 4 0.011
protein processing GO:0016485 226 0.011
negative regulation of kinase activity GO:0033673 106 0.011
Fly
response to alcohol GO:0097305 64 0.011
positive regulation of immune system process GO:0002684 283 0.011
cilium organization GO:0044782 68 0.011
regulation of chromosome organization GO:0033044 103 0.011
neuron projection morphogenesis GO:0048812 50 0.011
cardiovascular system development GO:0072358 262 0.011
cell projection assembly GO:0030031 126 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.011
Human Zebrafish
tube morphogenesis GO:0035239 95 0.011
regulation of nervous system development GO:0051960 88 0.011
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.011
protein dephosphorylation GO:0006470 81 0.011
defense response to virus GO:0051607 71 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
Fly
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.011
Human Zebrafish
embryo development ending in birth or egg hatching GO:0009792 34 0.011
Fly
alcohol metabolic process GO:0006066 114 0.010
carbohydrate biosynthetic process GO:0016051 42 0.010
detection of stimulus involved in sensory perception GO:0050906 43 0.010
gland development GO:0048732 48 0.010
protein modification by small protein conjugation GO:0032446 342 0.010
rna processing GO:0006396 255 0.010
regulation of jnk cascade GO:0046328 73 0.010
Fly
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.010
response to nutrient levels GO:0031667 81 0.010
compound eye development GO:0048749 1 0.010
Fly
circadian behavior GO:0048512 2 0.010
detection of stimulus GO:0051606 85 0.010
positive regulation of synaptic transmission GO:0050806 4 0.010
muscle tissue development GO:0060537 62 0.010
regulation of protein import into nucleus GO:0042306 78 0.010
brain development GO:0007420 97 0.010
neurogenesis GO:0022008 169 0.010
Fly
regulation of dna repair GO:0006282 47 0.010
regulation of cellular response to growth factor stimulus GO:0090287 76 0.010
Human Zebrafish
positive regulation of jnk cascade GO:0046330 52 0.010
organic acid biosynthetic process GO:0016053 97 0.010

PPM1B disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.021
disease of cellular proliferation DOID:14566 174 0.019
central nervous system disease DOID:331 186 0.018
nervous system disease DOID:863 431 0.018
cancer DOID:162 167 0.014
musculoskeletal system disease DOID:17 223 0.011
organ system cancer DOID:0050686 164 0.011