Homo sapiens

12 known processes

TTC8

tetratricopeptide repeat domain 8

(Aliases: RP51,BBS8)

TTC8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cilium assembly GO:0042384 63 0.351
Mouse
cilium morphogenesis GO:0060271 75 0.190
Mouse
photoreceptor cell maintenance GO:0045494 13 0.159
neural tube formation GO:0001841 3 0.138
cytoplasmic transport GO:0016482 379 0.116
regulation of locomotion GO:0040012 329 0.105
cardiovascular system development GO:0072358 262 0.101
microtubule anchoring at microtubule organizing center GO:0072393 1 0.099
photoreceptor cell differentiation GO:0046530 2 0.094
Mouse
axis elongation GO:0003401 4 0.089
embryonic epithelial tube formation GO:0001838 4 0.081
segmentation GO:0035282 4 0.081
regulation of cell motility GO:2000145 299 0.078
establishment of protein localization to membrane GO:0090150 121 0.078
cilium organization GO:0044782 68 0.076
Mouse
regulation of cell cycle GO:0051726 393 0.072
single organism membrane organization GO:0044802 268 0.070
lipid metabolic process GO:0006629 381 0.068
intracellular protein transport GO:0006886 270 0.068
membrane organization GO:0061024 292 0.066
brain morphogenesis GO:0048854 1 0.065
negative regulation of blood pressure GO:0045776 3 0.065
cell projection organization GO:0030030 252 0.060
Mouse
protein localization to organelle GO:0033365 280 0.056
cellular amino acid metabolic process GO:0006520 116 0.055
positive regulation of catabolic process GO:0009896 310 0.054
tube development GO:0035295 125 0.054
Mouse
cellular response to endogenous stimulus GO:0071495 336 0.053
spermatid differentiation GO:0048515 4 0.052
golgi vesicle transport GO:0048193 80 0.050
nervous system development GO:0007399 293 0.048
Mouse
cellular component assembly involved in morphogenesis GO:0010927 73 0.048
Mouse
cellular component morphogenesis GO:0032989 314 0.047
Mouse
single organism cellular localization GO:1902580 332 0.047
organelle assembly GO:0070925 176 0.046
Mouse
regulation of cell morphogenesis GO:0022604 153 0.045
cell morphogenesis GO:0000902 296 0.045
Mouse
neural tube closure GO:0001843 3 0.044
anatomical structure formation involved in morphogenesis GO:0048646 284 0.042
Mouse
regulation of response to external stimulus GO:0032101 222 0.042
cellular macromolecule catabolic process GO:0044265 380 0.042
sensory perception of chemical stimulus GO:0007606 38 0.041
Mouse
cellular response to cytokine stimulus GO:0071345 181 0.041
amine metabolic process GO:0009308 44 0.040
modification dependent macromolecule catabolic process GO:0043632 212 0.040
axis elongation involved in somitogenesis GO:0090245 1 0.039
morphogenesis of embryonic epithelium GO:0016331 4 0.038
post embryonic development GO:0009791 2 0.038
positive regulation of cellular catabolic process GO:0031331 284 0.038
circulatory system development GO:0072359 262 0.038
regulation of cellular component movement GO:0051270 334 0.037
convergent extension involved in gastrulation GO:0060027 1 0.037
protein localization to membrane GO:0072657 160 0.037
cell projection assembly GO:0030031 126 0.037
Mouse
protein catabolic process GO:0030163 325 0.036
protein localization to plasma membrane GO:0072659 93 0.036
regulation of cell projection organization GO:0031344 107 0.036
central nervous system development GO:0007417 123 0.036
Mouse
maintenance of location GO:0051235 112 0.035
primary neural tube formation GO:0014020 3 0.035
convergent extension GO:0060026 1 0.035
cell part morphogenesis GO:0032990 137 0.035
Mouse
response to food GO:0032094 1 0.035
establishment of protein localization to plasma membrane GO:0090002 68 0.034
eye photoreceptor cell differentiation GO:0001754 2 0.034
Mouse
ubiquitin dependent protein catabolic process GO:0006511 206 0.033
cellular amine metabolic process GO:0044106 41 0.032
regulation of cilium movement GO:0003352 3 0.032
microtubule based process GO:0007017 210 0.032
somitogenesis GO:0001756 2 0.032
regulation of cellular amine metabolic process GO:0033238 11 0.032
head development GO:0060322 108 0.032
Mouse
cellular ketone metabolic process GO:0042180 80 0.030
intraciliary transport GO:0042073 7 0.030
blood circulation GO:0008015 113 0.030
regulation of cellular amino acid metabolic process GO:0006521 6 0.030
mitotic cell cycle GO:0000278 326 0.029
anatomical structure homeostasis GO:0060249 100 0.029
organ morphogenesis GO:0009887 147 0.028
Mouse
multicellular organismal aging GO:0010259 3 0.028
maintenance of location in cell GO:0051651 62 0.028
fat cell differentiation GO:0045444 32 0.028
Mouse
vesicle mediated transport GO:0016192 371 0.028
sensory perception of smell GO:0007608 2 0.028
Mouse
determination of adult lifespan GO:0008340 2 0.028
eye pigmentation GO:0048069 1 0.027
purine containing compound catabolic process GO:0072523 411 0.027
purine ribonucleoside metabolic process GO:0046128 437 0.027
regulation of anatomical structure morphogenesis GO:0022603 286 0.027
maintenance of protein location GO:0045185 57 0.027
nucleoside triphosphate catabolic process GO:0009143 394 0.027
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.027
regulation of organelle assembly GO:1902115 40 0.026
cell projection morphogenesis GO:0048858 129 0.026
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.026
regulation of cell cycle process GO:0010564 266 0.026
cilium dependent cell motility GO:0060285 4 0.025
nucleotide catabolic process GO:0009166 408 0.025
locomotory behavior GO:0007626 1 0.025
epithelial tube morphogenesis GO:0060562 38 0.025
neurological system process GO:0050877 163 0.025
Mouse
positive regulation of cellular amine metabolic process GO:0033240 7 0.025
regulation of cellular ketone metabolic process GO:0010565 50 0.025
cytokinesis GO:0000910 96 0.025
regulation of cellular component biogenesis GO:0044087 281 0.025
regulation of lipid metabolic process GO:0019216 96 0.024
epithelium development GO:0060429 227 0.024
Mouse
female gamete generation GO:0007292 2 0.024
protein localization to nucleus GO:0034504 136 0.024
sensory perception GO:0007600 103 0.024
Mouse
response to hormone GO:0009725 175 0.024
centrosome organization GO:0051297 58 0.024
cell division GO:0051301 168 0.024
hippocampus development GO:0021766 1 0.024
regulation of protein localization GO:0032880 296 0.023
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.023
mitotic cell cycle process GO:1903047 286 0.023
regulation of protein catabolic process GO:0042176 155 0.023
limbic system development GO:0021761 3 0.023
ribonucleoside catabolic process GO:0042454 406 0.023
proteasomal protein catabolic process GO:0010498 176 0.023
modification dependent protein catabolic process GO:0019941 209 0.023
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.023
negative regulation of cellular protein metabolic process GO:0032269 353 0.022
positive regulation of organelle organization GO:0010638 195 0.022
organophosphate catabolic process GO:0046434 430 0.022
regulation of proteolysis GO:0030162 293 0.022
post golgi vesicle mediated transport GO:0006892 36 0.022
cellular lipid metabolic process GO:0044255 303 0.022
regulation of growth GO:0040008 165 0.022
negative regulation of catalytic activity GO:0043086 335 0.022
regulation of nucleotide metabolic process GO:0006140 269 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.021
negative regulation of response to external stimulus GO:0032102 83 0.021
transmembrane transport GO:0055085 399 0.021
oogenesis GO:0048477 2 0.021
negative regulation of protein metabolic process GO:0051248 391 0.021
regulation of intracellular transport GO:0032386 195 0.021
nucleoside triphosphate metabolic process GO:0009141 422 0.021
cell development GO:0048468 328 0.021
Mouse
maintenance of protein location in nucleus GO:0051457 12 0.021
guanosine containing compound catabolic process GO:1901069 239 0.021
negative regulation of systemic arterial blood pressure GO:0003085 1 0.021
cellular protein catabolic process GO:0044257 261 0.021
regulation of proteasomal protein catabolic process GO:0061136 87 0.021
negative regulation of phosphorus metabolic process GO:0010563 267 0.021
pallium development GO:0021543 10 0.021
positive regulation of cellular component biogenesis GO:0044089 158 0.021
protein localization to cytoskeleton GO:0044380 11 0.021
regulation of cell division GO:0051302 116 0.021
cofactor metabolic process GO:0051186 87 0.020
neuron development GO:0048666 113 0.020
Mouse
ribonucleoside triphosphate metabolic process GO:0009199 412 0.020
positive regulation of developmental process GO:0051094 314 0.020
maintenance of protein location in cell GO:0032507 56 0.020
multicellular organismal homeostasis GO:0048871 67 0.020
purine nucleoside triphosphate metabolic process GO:0009144 412 0.020
ribonucleoside monophosphate metabolic process GO:0009161 187 0.020
regulation of protein transport GO:0051223 213 0.020
regulation of establishment of protein localization GO:0070201 242 0.020
behavior GO:0007610 112 0.020
eye development GO:0001654 42 0.019
Mouse
cellular response to oxygen containing compound GO:1901701 276 0.019
chemical homeostasis GO:0048878 306 0.019
cellular response to hormone stimulus GO:0032870 125 0.019
retina homeostasis GO:0001895 42 0.019
ribonucleotide catabolic process GO:0009261 405 0.019
cellular macromolecular complex assembly GO:0034622 324 0.019
nonmotile primary cilium assembly GO:0035058 4 0.019
tissue homeostasis GO:0001894 63 0.019
regulation of appetite GO:0032098 1 0.019
ras protein signal transduction GO:0007265 73 0.018
regulation of systemic arterial blood pressure GO:0003073 19 0.018
positive regulation of proteolysis GO:0045862 142 0.018
endomembrane system organization GO:0010256 196 0.018
regulation of cell differentiation GO:0045595 393 0.018
nucleoside phosphate catabolic process GO:1901292 412 0.018
tube morphogenesis GO:0035239 95 0.018
ribonucleoside triphosphate catabolic process GO:0009203 391 0.018
protein localization to microtubule cytoskeleton GO:0072698 10 0.018
ion transmembrane transport GO:0034220 338 0.018
purine ribonucleotide catabolic process GO:0009154 404 0.017
neuron differentiation GO:0030182 138 0.017
Mouse
smoothened signaling pathway GO:0007224 14 0.017
purine nucleoside triphosphate catabolic process GO:0009146 392 0.017
small gtpase mediated signal transduction GO:0007264 78 0.017
positive regulation of growth GO:0045927 58 0.017
purine nucleotide catabolic process GO:0006195 405 0.017
response to oxygen containing compound GO:1901700 369 0.017
purine ribonucleoside catabolic process GO:0046130 398 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
associative learning GO:0008306 1 0.017
glycosyl compound catabolic process GO:1901658 413 0.017
response to cytokine GO:0034097 232 0.017
protein maturation GO:0051604 233 0.017
posttranscriptional regulation of gene expression GO:0010608 213 0.017
embryonic morphogenesis GO:0048598 85 0.017
regulation of purine nucleotide metabolic process GO:1900542 264 0.016
regulation of kinase activity GO:0043549 314 0.016
positive regulation of transport GO:0051050 336 0.016
atp metabolic process GO:0046034 176 0.016
neuromuscular junction development GO:0007528 3 0.016
purine nucleoside catabolic process GO:0006152 398 0.016
negative regulation of protein modification process GO:0031400 200 0.016
microtubule cytoskeleton organization GO:0000226 176 0.016
cerebral cortex development GO:0021987 10 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
rho protein signal transduction GO:0007266 26 0.016
morphogenesis of an epithelium GO:0002009 60 0.016
gtp metabolic process GO:0046039 239 0.016
monocarboxylic acid metabolic process GO:0032787 185 0.016
specification of symmetry GO:0009799 16 0.016
protein processing GO:0016485 226 0.016
nucleoside catabolic process GO:0009164 408 0.016
memory GO:0007613 3 0.015
adult locomotory behavior GO:0008344 1 0.015
regulation of transferase activity GO:0051338 355 0.015
nitrogen compound transport GO:0071705 191 0.015
regulation of cellular response to stress GO:0080135 244 0.015
cilium or flagellum dependent cell motility GO:0001539 4 0.015
negative regulation of apoptotic process GO:0043066 316 0.015
cellular response to dna damage stimulus GO:0006974 379 0.015
developmental pigmentation GO:0048066 12 0.015
positive regulation of cellular component organization GO:0051130 376 0.015
blastoderm segmentation GO:0007350 2 0.015
negative regulation of multicellular organismal process GO:0051241 317 0.015
regulation of cell migration GO:0030334 289 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
actin filament based process GO:0030029 224 0.015
tripartite regional subdivision GO:0007351 2 0.015
peripheral nervous system development GO:0007422 2 0.015
protein ubiquitination GO:0016567 314 0.015
positive regulation of nucleoside metabolic process GO:0045979 186 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.015
dephosphorylation GO:0016311 209 0.014
organonitrogen compound biosynthetic process GO:1901566 200 0.014
positive regulation of nucleotide catabolic process GO:0030813 185 0.014
embryonic heart tube morphogenesis GO:0003143 8 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
microtubule organizing center organization GO:0031023 62 0.014
digestive tract morphogenesis GO:0048546 56 0.014
hindbrain development GO:0030902 3 0.014
immune response GO:0006955 307 0.014
subpallium development GO:0021544 2 0.014
positive regulation of cell projection organization GO:0031346 64 0.014
regulation of intracellular protein transport GO:0033157 123 0.014
negative regulation of cell death GO:0060548 345 0.014
gtp catabolic process GO:0006184 237 0.014
histone modification GO:0016570 251 0.014
anterior posterior axis specification GO:0009948 2 0.014
cellular protein complex assembly GO:0043623 188 0.014
sulfur compound metabolic process GO:0006790 101 0.014
carbohydrate derivative biosynthetic process GO:1901137 207 0.014
defense response GO:0006952 315 0.014
biological adhesion GO:0022610 331 0.014
innate immune response GO:0045087 178 0.014
positive regulation of transferase activity GO:0051347 227 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
coenzyme metabolic process GO:0006732 65 0.014
guanosine containing compound metabolic process GO:1901068 244 0.014
purine nucleoside monophosphate metabolic process GO:0009126 186 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
response to abiotic stimulus GO:0009628 336 0.014
regeneration GO:0031099 4 0.014
ion homeostasis GO:0050801 230 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
oxidation reduction process GO:0055114 396 0.013
response to lipid GO:0033993 206 0.013
reactive oxygen species metabolic process GO:0072593 75 0.013
plasma membrane organization GO:0007009 115 0.013
tissue morphogenesis GO:0048729 96 0.013
Mouse
rna processing GO:0006396 255 0.013
negative regulation of response to nutrient levels GO:0032108 5 0.013
protein targeting GO:0006605 187 0.013
anterior posterior axis specification embryo GO:0008595 2 0.013
regulation of protein kinase activity GO:0045859 289 0.013
system process GO:0003008 349 0.013
Mouse
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.013
carbohydrate metabolic process GO:0005975 207 0.013
cell adhesion GO:0007155 325 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
cytokine mediated signaling pathway GO:0019221 109 0.013
negative regulation of programmed cell death GO:0043069 321 0.013
developmental growth involved in morphogenesis GO:0060560 23 0.013
regulation of nucleoside metabolic process GO:0009118 209 0.013
digestive system development GO:0055123 75 0.013
protein modification by small protein conjugation GO:0032446 342 0.013
metal ion transport GO:0030001 272 0.013
nucleoside monophosphate metabolic process GO:0009123 191 0.013
neurogenesis GO:0022008 169 0.013
Mouse
positive regulation of immune system process GO:0002684 283 0.013
heart development GO:0007507 95 0.013
organelle localization GO:0051640 84 0.013
cation homeostasis GO:0055080 189 0.013
cellular homeostasis GO:0019725 196 0.013
signal transduction by phosphorylation GO:0023014 297 0.012
positive regulation of protein catabolic process GO:0045732 75 0.012
regulation of microtubule based process GO:0032886 74 0.012
negative regulation of cellular component organization GO:0051129 235 0.012
maintenance of protein localization in organelle GO:0072595 15 0.012
cation transport GO:0006812 331 0.012
wnt signaling pathway GO:0016055 156 0.012
single organism carbohydrate metabolic process GO:0044723 193 0.012
positive regulation of cellular protein catabolic process GO:1903364 37 0.012
negative regulation of developmental process GO:0051093 247 0.012
reactive nitrogen species metabolic process GO:2001057 3 0.012
cell fate determination GO:0001709 3 0.012
cytokine production GO:0001816 247 0.012
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
mitochondrion organization GO:0007005 156 0.012
microtubule based movement GO:0007018 32 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
negative regulation of cell cycle GO:0045786 193 0.012
negative regulation of response to extracellular stimulus GO:0032105 5 0.012
positive regulation of protein transport GO:0051222 135 0.012
establishment of protein localization to organelle GO:0072594 172 0.012
growth GO:0040007 202 0.012
Mouse
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.012
positive regulation of protein phosphorylation GO:0001934 313 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.012
establishment of organelle localization GO:0051656 59 0.012
microtubule anchoring GO:0034453 24 0.012
regulation of secretion by cell GO:1903530 177 0.012
rhythmic behavior GO:0007622 2 0.012
motor neuron axon guidance GO:0008045 2 0.012
negative regulation of hydrolase activity GO:0051346 182 0.011
compound eye development GO:0048749 1 0.011
organ formation GO:0048645 3 0.011
regulation of cytokine production GO:0001817 232 0.011
regulation of reactive oxygen species metabolic process GO:2000377 41 0.011
spermatid development GO:0007286 4 0.011
chromatin organization GO:0006325 351 0.011
response to biotic stimulus GO:0009607 276 0.011
response to external biotic stimulus GO:0043207 261 0.011
pigmentation GO:0043473 22 0.011
oocyte development GO:0048599 1 0.011
nucleus localization GO:0051647 1 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
regulation of cilium assembly GO:1902017 6 0.011
sequestering of metal ion GO:0051238 24 0.011
negative regulation of proteolysis GO:0045861 132 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
apoptotic signaling pathway GO:0097190 268 0.011
regulation of cytokinesis GO:0032465 45 0.011
mapk cascade GO:0000165 288 0.011
protein oligomerization GO:0051259 173 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.011
lipid biosynthetic process GO:0008610 177 0.011
regulation of epithelial cell proliferation GO:0050678 113 0.011
nerve development GO:0021675 4 0.011
cellular chemical homeostasis GO:0055082 180 0.011
regulation of mapk cascade GO:0043408 262 0.011
cellular response to organonitrogen compound GO:0071417 124 0.011
dna repair GO:0006281 198 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
golgi to plasma membrane protein transport GO:0043001 19 0.011
cation transmembrane transport GO:0098655 238 0.011
response to fungus GO:0009620 4 0.011
chromatin modification GO:0016568 298 0.011
inner ear morphogenesis GO:0042472 4 0.011
salivary gland morphogenesis GO:0007435 4 0.011
covalent chromatin modification GO:0016569 254 0.011
cell growth GO:0016049 160 0.011
regulation of synaptic plasticity GO:0048167 3 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
actin cytoskeleton organization GO:0030036 207 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.010
developmental process involved in reproduction GO:0003006 66 0.010
inorganic ion transmembrane transport GO:0098660 231 0.010
positive regulation of kinase activity GO:0033674 204 0.010
metal ion homeostasis GO:0055065 169 0.010
response to inorganic substance GO:0010035 127 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.010
small molecule biosynthetic process GO:0044283 157 0.010
cardiac muscle cell contraction GO:0086003 4 0.010
specification of organ identity GO:0010092 3 0.010
regulation of purine nucleotide catabolic process GO:0033121 205 0.010
positive regulation of programmed cell death GO:0043068 249 0.010
generation of neurons GO:0048699 152 0.010
Mouse
sequestering of calcium ion GO:0051208 17 0.010
positive regulation of organelle assembly GO:1902117 17 0.010
response to axon injury GO:0048678 1 0.010
regulation of cytoplasmic transport GO:1903649 149 0.010
spinal cord development GO:0021510 4 0.010
endosomal transport GO:0016197 129 0.010
organic anion transport GO:0015711 103 0.010
notch signaling pathway GO:0007219 31 0.010
negative regulation of protein phosphorylation GO:0001933 140 0.010
secretion by cell GO:0032940 226 0.010
regulation of immune response GO:0050776 201 0.010
visual behavior GO:0007632 2 0.010
actin filament based movement GO:0030048 17 0.010
golgi to plasma membrane transport GO:0006893 21 0.010
response to other organism GO:0051707 261 0.010
organic hydroxy compound metabolic process GO:1901615 147 0.010

TTC8 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.039
eye and adnexa disease DOID:1492 150 0.039
nervous system disease DOID:863 431 0.039
disease of metabolism DOID:0014667 295 0.035
eye disease DOID:5614 149 0.033
musculoskeletal system disease DOID:17 223 0.025
disease of cellular proliferation DOID:14566 174 0.024
endocrine gland cancer DOID:170 26 0.024
cancer DOID:162 167 0.024
organ system cancer DOID:0050686 164 0.024
inherited metabolic disorder DOID:655 242 0.020
retinal disease DOID:5679 118 0.018
myopathy DOID:423 104 0.017
muscular disease DOID:0080000 114 0.017
muscle tissue disease DOID:66 113 0.017
central nervous system disease DOID:331 186 0.016
bone disease DOID:0080001 88 0.015
connective tissue disease DOID:65 109 0.015
immune system disease DOID:2914 155 0.013
retinal degeneration DOID:8466 89 0.011
cardiovascular system disease DOID:1287 106 0.010
muscular dystrophy DOID:9884 51 0.010
hematopoietic system disease DOID:74 100 0.010