Homo sapiens

0 known processes

SIKE1

suppressor of IKBKE 1

(Aliases: SIKE,DKFZp686A0768,FLJ21168)

SIKE1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of anatomical structure morphogenesis GO:0022603 286 0.408
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.375
oocyte differentiation GO:0009994 2 0.245
negative regulation of protein phosphorylation GO:0001933 140 0.165
regulation of intracellular estrogen receptor signaling pathway GO:0033146 13 0.163
intracellular estrogen receptor signaling pathway GO:0030520 23 0.161
mapk cascade GO:0000165 288 0.128
neural tube formation GO:0001841 3 0.113
cellular component morphogenesis GO:0032989 314 0.103
locomotory behavior GO:0007626 1 0.103
canonical wnt signaling pathway GO:0060070 116 0.103
regulation of cell motility GO:2000145 299 0.103
positive regulation of stress activated mapk cascade GO:0032874 60 0.101
negative regulation of cell death GO:0060548 345 0.100
response to abiotic stimulus GO:0009628 336 0.100
jnk cascade GO:0007254 80 0.097
regulation of locomotion GO:0040012 329 0.094
negative regulation of protein metabolic process GO:0051248 391 0.088
female gamete generation GO:0007292 2 0.086
wnt signaling pathway GO:0016055 156 0.078
post embryonic development GO:0009791 2 0.074
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.068
negative regulation of developmental process GO:0051093 247 0.067
negative regulation of apoptotic process GO:0043066 316 0.066
regulation of cellular response to stress GO:0080135 244 0.061
determination of adult lifespan GO:0008340 2 0.061
response to hormone GO:0009725 175 0.061
golgi localization GO:0051645 4 0.059
regulation of interleukin 1 mediated signaling pathway GO:2000659 3 0.055
response to steroid hormone GO:0048545 80 0.054
signal transduction by phosphorylation GO:0023014 297 0.053
immune system development GO:0002520 195 0.048
positive regulation of mapk cascade GO:0043410 190 0.048
regulation of multi organism process GO:0043900 157 0.047
negative regulation of cell migration GO:0030336 102 0.047
oogenesis GO:0048477 2 0.047
cell morphogenesis GO:0000902 296 0.046
morphogenesis of embryonic epithelium GO:0016331 4 0.046
cell death in response to oxidative stress GO:0036473 29 0.044
regulation of jnk cascade GO:0046328 73 0.044
actin filament based process GO:0030029 224 0.044
regulation of protein kinase activity GO:0045859 289 0.041
positive regulation of phosphorylation GO:0042327 394 0.041
negative regulation of programmed cell death GO:0043069 321 0.041
erk1 and erk2 cascade GO:0070371 104 0.037
stress activated mapk cascade GO:0051403 93 0.037
stress activated protein kinase signaling cascade GO:0031098 94 0.036
regulation of stress activated mapk cascade GO:0032872 84 0.035
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.035
intracellular receptor signaling pathway GO:0030522 104 0.035
embryonic placenta development GO:0001892 1 0.033
positive regulation of apoptotic signaling pathway GO:2001235 70 0.033
nervous system development GO:0007399 293 0.032
vesicle mediated transport GO:0016192 371 0.032
negative regulation of phosphorylation GO:0042326 174 0.031
regulation of small gtpase mediated signal transduction GO:0051056 156 0.031
regulation of mapk cascade GO:0043408 262 0.031
response to axon injury GO:0048678 1 0.030
reproductive process GO:0022414 106 0.030
i kappab kinase nf kappab signaling GO:0007249 166 0.029
response to oxygen containing compound GO:1901700 369 0.029
regulation of transferase activity GO:0051338 355 0.029
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.029
negative regulation of multicellular organismal process GO:0051241 317 0.029
response to lipid GO:0033993 206 0.028
regulation of apoptotic signaling pathway GO:2001233 175 0.028
regulation of canonical wnt signaling pathway GO:0060828 88 0.027
embryo development GO:0009790 123 0.027
response to estrogen GO:0043627 47 0.027
protein catabolic process GO:0030163 325 0.026
negative regulation of cell proliferation GO:0008285 228 0.026
oocyte development GO:0048599 1 0.026
negative regulation of phosphate metabolic process GO:0045936 267 0.026
negative regulation of transferase activity GO:0051348 124 0.026
regulation of protein serine threonine kinase activity GO:0071900 179 0.025
amine metabolic process GO:0009308 44 0.025
negative regulation of interleukin 1 mediated signaling pathway GO:2000660 2 0.025
negative regulation of cellular protein metabolic process GO:0032269 353 0.024
negative regulation of phosphorus metabolic process GO:0010563 267 0.024
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.023
positive regulation of jnk cascade GO:0046330 52 0.023
cellular amino acid metabolic process GO:0006520 116 0.023
regeneration GO:0031099 4 0.023
regulation of cell migration GO:0030334 289 0.023
regulation of wnt signaling pathway GO:0030111 123 0.022
negative regulation of immune system process GO:0002683 136 0.022
regulation of erk1 and erk2 cascade GO:0070372 99 0.021
hematopoietic or lymphoid organ development GO:0048534 186 0.021
positive regulation of protein kinase activity GO:0045860 190 0.021
negative regulation of cell differentiation GO:0045596 171 0.021
regulation of cytokine production GO:0001817 232 0.021
response to alcohol GO:0097305 64 0.020
neuromuscular junction development GO:0007528 3 0.020
regulation of nervous system development GO:0051960 88 0.020
cell type specific apoptotic process GO:0097285 125 0.020
response to oxidative stress GO:0006979 121 0.020
negative regulation of cell motility GO:2000146 104 0.020
cellular ketone metabolic process GO:0042180 80 0.020
response to organic cyclic compound GO:0014070 204 0.019
regulation of cell differentiation GO:0045595 393 0.019
small gtpase mediated signal transduction GO:0007264 78 0.019
morphogenesis of an epithelium GO:0002009 60 0.019
positive regulation of kinase activity GO:0033674 204 0.019
phagocytosis GO:0006909 42 0.019
negative regulation of catalytic activity GO:0043086 335 0.019
rna processing GO:0006396 255 0.019
regulation of cellular amine metabolic process GO:0033238 11 0.019
positive regulation of small gtpase mediated signal transduction GO:0051057 12 0.018
membrane organization GO:0061024 292 0.018
cell development GO:0048468 328 0.018
response to cytokine GO:0034097 232 0.018
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.018
cellular protein catabolic process GO:0044257 261 0.018
cellular response to oxygen containing compound GO:1901701 276 0.017
positive regulation of cellular component biogenesis GO:0044089 158 0.017
regulation of cellular amino acid metabolic process GO:0006521 6 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.016
regulation of proteolysis GO:0030162 293 0.016
microtubule organizing center organization GO:0031023 62 0.016
hard palate development GO:0060022 1 0.016
multicellular organismal aging GO:0010259 3 0.016
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.016
endocytosis GO:0006897 159 0.016
translation GO:0006412 132 0.016
cellular amine metabolic process GO:0044106 41 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
protein modification by small protein removal GO:0070646 92 0.015
mitotic cell cycle GO:0000278 326 0.015
central nervous system development GO:0007417 123 0.015
blood vessel morphogenesis GO:0048514 162 0.015
regulation of cellular component biogenesis GO:0044087 281 0.015
developmental process involved in reproduction GO:0003006 66 0.015
blood vessel development GO:0001568 172 0.015
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.015
neuron differentiation GO:0030182 138 0.014
regulation of cellular ketone metabolic process GO:0010565 50 0.014
defense response GO:0006952 315 0.014
positive regulation of transferase activity GO:0051347 227 0.014
regulation of protein binding GO:0043393 66 0.014
inorganic cation transmembrane transport GO:0098662 194 0.014
hemopoiesis GO:0030097 180 0.014
positive regulation of protein phosphorylation GO:0001934 313 0.014
positive regulation of developmental process GO:0051094 314 0.014
cation transmembrane transport GO:0098655 238 0.014
positive regulation of binding GO:0051099 45 0.014
negative regulation of wnt signaling pathway GO:0030178 69 0.014
purine nucleotide catabolic process GO:0006195 405 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
immune response GO:0006955 307 0.013
regulation of fat cell differentiation GO:0045598 23 0.013
negative regulation of protein kinase activity GO:0006469 98 0.013
intrinsic apoptotic signaling pathway GO:0097193 127 0.013
compound eye development GO:0048749 1 0.013
protein k63 linked deubiquitination GO:0070536 21 0.013
metal ion transport GO:0030001 272 0.013
apoptotic signaling pathway GO:0097190 268 0.013
regulation of axon regeneration GO:0048679 1 0.013
cellular macromolecule catabolic process GO:0044265 380 0.012
negative regulation of response to external stimulus GO:0032102 83 0.012
ion homeostasis GO:0050801 230 0.012
cytokine mediated signaling pathway GO:0019221 109 0.012
negative regulation of synaptic transmission GO:0050805 2 0.012
substantia nigra development GO:0021762 45 0.012
protein oligomerization GO:0051259 173 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
behavior GO:0007610 112 0.012
positive regulation of cell proliferation GO:0008284 301 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
response to biotic stimulus GO:0009607 276 0.012
cellular response to lipid GO:0071396 127 0.012
prostate gland development GO:0030850 3 0.012
regulation of binding GO:0051098 111 0.012
cellular response to cytokine stimulus GO:0071345 181 0.011
myeloid leukocyte differentiation GO:0002573 60 0.011
regulation of protein transport GO:0051223 213 0.011
regulation of cell development GO:0060284 161 0.011
positive regulation of cellular amine metabolic process GO:0033240 7 0.011
organelle fission GO:0048285 149 0.011
negative regulation of transmembrane transport GO:0034763 29 0.011
neural nucleus development GO:0048857 47 0.011
chemical homeostasis GO:0048878 306 0.011
engulfment of apoptotic cell GO:0043652 2 0.011
segmentation GO:0035282 4 0.011
innate immune response activating signal transduction GO:0002758 48 0.011
protein heterotrimerization GO:0070208 4 0.011
cortical cytoskeleton organization GO:0030865 9 0.011
angiogenesis GO:0001525 147 0.011
regulation of response to external stimulus GO:0032101 222 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.011
positive regulation of immune system process GO:0002684 283 0.011
myeloid cell differentiation GO:0030099 117 0.011
negative regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 18 0.010
response to other organism GO:0051707 261 0.010
transmembrane transport GO:0055085 399 0.010
protein deubiquitination GO:0016579 79 0.010
nitrogen compound transport GO:0071705 191 0.010
regulation of transporter activity GO:0032409 82 0.010
cell projection organization GO:0030030 252 0.010
actin cytoskeleton organization GO:0030036 207 0.010
regulation of cellular component movement GO:0051270 334 0.010
organophosphate catabolic process GO:0046434 430 0.010
secretion GO:0046903 254 0.010
memory GO:0007613 3 0.010
regulation of epithelial cell proliferation GO:0050678 113 0.010
interspecies interaction between organisms GO:0044419 156 0.010

SIKE1 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.040
eye and adnexa disease DOID:1492 150 0.040
nervous system disease DOID:863 431 0.040
eye disease DOID:5614 149 0.040
disease of metabolism DOID:0014667 295 0.019
cancer DOID:162 167 0.019
disease of cellular proliferation DOID:14566 174 0.019
organ system cancer DOID:0050686 164 0.019
retinal disease DOID:5679 118 0.017
immune system disease DOID:2914 155 0.011
retinal degeneration DOID:8466 89 0.010