|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
1.000
|
Mouse |
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.999
|
Mouse |
|
|
serotonin transport
|
GO:0006837 |
3 |
0.999
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.998
|
Mouse |
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.998
|
|
|
|
gamma delta t cell activation
|
GO:0046629 |
3 |
0.997
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.996
|
|
|
|
osteoclast differentiation
|
GO:0030316 |
21 |
0.994
|
|
|
|
negative regulation of tumor necrosis factor biosynthetic process
|
GO:0042536 |
3 |
0.992
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.990
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.990
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.990
|
Mouse |
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.989
|
|
|
|
organic hydroxy compound transport
|
GO:0015850 |
63 |
0.989
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.987
|
Mouse |
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.987
|
Mouse |
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.985
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
35 |
0.985
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.984
|
Mouse |
|
|
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002823 |
8 |
0.984
|
Mouse |
|
|
immune response inhibiting cell surface receptor signaling pathway
|
GO:0002767 |
4 |
0.984
|
|
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.981
|
Mouse |
|
|
immune system development
|
GO:0002520 |
195 |
0.977
|
Mouse |
|
|
monoamine transport
|
GO:0015844 |
10 |
0.977
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.977
|
Mouse |
|
|
biological adhesion
|
GO:0022610 |
331 |
0.976
|
Human Mouse |
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.976
|
Mouse |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.971
|
Human Fly |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.970
|
Mouse Fly |
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.969
|
Mouse |
|
|
b cell activation
|
GO:0042113 |
33 |
0.964
|
Mouse |
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.963
|
Mouse |
|
|
immune response
|
GO:0006955 |
307 |
0.962
|
Mouse |
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.959
|
Mouse |
|
|
positive regulation of immunoglobulin mediated immune response
|
GO:0002891 |
4 |
0.958
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
73 |
0.957
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.957
|
Mouse |
|
|
negative regulation of interleukin 10 production
|
GO:0032693 |
7 |
0.954
|
|
|
|
serotonin secretion
|
GO:0001820 |
1 |
0.954
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.953
|
Mouse |
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.952
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
40 |
0.951
|
Mouse |
|
|
interleukin 12 secretion
|
GO:0072610 |
1 |
0.950
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.948
|
|
|
|
positive regulation of gamma delta t cell activation
|
GO:0046645 |
1 |
0.946
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.943
|
|
|
|
leukocyte mediated cytotoxicity
|
GO:0001909 |
27 |
0.939
|
Mouse |
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.937
|
Mouse |
|
|
regulation of regulatory t cell differentiation
|
GO:0045589 |
4 |
0.936
|
|
|
|
negative regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
|
GO:2001189 |
1 |
0.933
|
|
|
|
regulation of myeloid leukocyte mediated immunity
|
GO:0002886 |
4 |
0.933
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
29 |
0.932
|
Mouse |
|
|
negative regulation of t cell mediated cytotoxicity
|
GO:0001915 |
1 |
0.930
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.929
|
|
|
|
regulation of gamma delta t cell activation
|
GO:0046643 |
1 |
0.926
|
|
|
|
regulation of tumor necrosis factor biosynthetic process
|
GO:0042534 |
8 |
0.926
|
|
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.924
|
Mouse |
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.924
|
|
|
|
negative regulation of peptidyl tyrosine phosphorylation
|
GO:0050732 |
20 |
0.922
|
|
|
|
negative regulation of myeloid cell differentiation
|
GO:0045638 |
42 |
0.918
|
|
|
|
negative regulation of dendritic cell differentiation
|
GO:2001199 |
2 |
0.917
|
|
|
|
negative regulation of myeloid leukocyte differentiation
|
GO:0002762 |
16 |
0.917
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.916
|
|
|
|
type i interferon secretion
|
GO:0072641 |
1 |
0.916
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.915
|
|
|
|
negative regulation of alpha beta t cell activation
|
GO:0046636 |
3 |
0.912
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.903
|
|
|
|
positive regulation of mast cell activation
|
GO:0033005 |
2 |
0.903
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.901
|
Mouse |
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.898
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
48 |
0.897
|
Mouse |
|
|
regulation of gamma delta t cell activation involved in immune response
|
GO:2001191 |
1 |
0.885
|
|
|
|
positive regulation of regulatory t cell differentiation
|
GO:0045591 |
3 |
0.885
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.878
|
Mouse |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.876
|
|
|
|
regulation of alpha beta t cell activation
|
GO:0046634 |
13 |
0.874
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.873
|
Mouse |
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
37 |
0.871
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.871
|
Mouse |
|
|
negative regulation of adaptive immune response
|
GO:0002820 |
9 |
0.867
|
Mouse |
|
|
negative regulation of leukocyte differentiation
|
GO:1902106 |
24 |
0.861
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.854
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.851
|
|
|
|
regulation of transforming growth factor beta secretion
|
GO:2001201 |
1 |
0.849
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.848
|
Mouse |
|
|
defense response to virus
|
GO:0051607 |
71 |
0.846
|
|
|
|
negative regulation of leukocyte apoptotic process
|
GO:2000107 |
16 |
0.844
|
|
|
|
negative regulation of interferon beta production
|
GO:0032688 |
4 |
0.843
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.839
|
Mouse |
|
|
b cell proliferation
|
GO:0042100 |
22 |
0.834
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
25 |
0.830
|
|
|
|
fc receptor mediated inhibitory signaling pathway
|
GO:0002774 |
2 |
0.828
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.826
|
Mouse |
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
25 |
0.824
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
37 |
0.821
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.819
|
Fly |
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.817
|
|
|
|
regulation of humoral immune response mediated by circulating immunoglobulin
|
GO:0002923 |
3 |
0.809
|
Mouse |
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.809
|
|
|
|
phagocytosis recognition
|
GO:0006910 |
3 |
0.809
|
|
|
|
leukocyte migration
|
GO:0050900 |
107 |
0.802
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
46 |
0.802
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.800
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.798
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.794
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.792
|
|
|
|
regulation of osteoclast development
|
GO:2001204 |
1 |
0.791
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.789
|
Mouse |
|
|
regulation of t cell differentiation
|
GO:0045580 |
19 |
0.779
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.778
|
|
|
|
regulation of interferon beta secretion
|
GO:0035547 |
1 |
0.770
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.766
|
Mouse |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.765
|
Mouse |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.761
|
Fly |
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.761
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.758
|
Mouse |
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.753
|
Human Fly |
|
|
positive regulation of t cell tolerance induction
|
GO:0002666 |
2 |
0.749
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
37 |
0.747
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.744
|
|
|
|
myeloid cell development
|
GO:0061515 |
5 |
0.740
|
Mouse |
|
|
t cell differentiation
|
GO:0030217 |
29 |
0.731
|
|
|
|
regulation of interleukin 10 secretion
|
GO:2001179 |
4 |
0.727
|
|
|
|
menstrual cycle phase
|
GO:0022601 |
2 |
0.721
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.719
|
|
|
|
regulation of blood coagulation
|
GO:0030193 |
42 |
0.713
|
|
|
|
positive regulation of cytolysis
|
GO:0045919 |
3 |
0.711
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.710
|
|
|
|
positive regulation of b cell activation
|
GO:0050871 |
17 |
0.706
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.701
|
Fly |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.701
|
Mouse |
|
|
negative regulation of leukocyte activation
|
GO:0002695 |
26 |
0.698
|
Mouse |
|
|
immune response inhibiting signal transduction
|
GO:0002765 |
4 |
0.696
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.695
|
|
|
|
myeloid leukocyte activation
|
GO:0002274 |
34 |
0.691
|
|
|
|
t cell tolerance induction
|
GO:0002517 |
4 |
0.690
|
|
|
|
regulation of dendritic cell apoptotic process
|
GO:2000668 |
4 |
0.690
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.682
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
33 |
0.680
|
|
|
|
cell killing
|
GO:0001906 |
34 |
0.677
|
Mouse |
|
|
mast cell activation involved in immune response
|
GO:0002279 |
4 |
0.666
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.662
|
Fly |
|
|
regulation of osteoclast differentiation
|
GO:0045670 |
18 |
0.656
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.653
|
Mouse |
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.649
|
|
|
|
negative regulation of cell activation
|
GO:0050866 |
33 |
0.648
|
Mouse |
|
|
positive regulation of lymphocyte differentiation
|
GO:0045621 |
13 |
0.644
|
|
|
|
regulation of b cell proliferation
|
GO:0030888 |
18 |
0.644
|
|
|
|
positive regulation of t cell differentiation
|
GO:0045582 |
11 |
0.641
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.632
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.626
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.625
|
|
|
|
negative regulation of osteoclast development
|
GO:2001205 |
1 |
0.622
|
|
|
|
negative regulation of t cell mediated immunity
|
GO:0002710 |
5 |
0.617
|
|
|
|
memory
|
GO:0007613 |
3 |
0.612
|
|
|
|
t cell mediated immunity
|
GO:0002456 |
25 |
0.605
|
|
|
|
regulation of natural killer cell mediated cytotoxicity
|
GO:0042269 |
16 |
0.595
|
|
|
|
immunoglobulin mediated immune response
|
GO:0016064 |
10 |
0.592
|
Mouse |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.588
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.586
|
Mouse |
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.576
|
|
|
|
negative regulation of cytokine biosynthetic process
|
GO:0042036 |
11 |
0.575
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.568
|
Mouse |
|
|
t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
|
GO:0002291 |
4 |
0.567
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.565
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.564
|
Mouse |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.559
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.557
|
|
|
|
regulation of tolerance induction
|
GO:0002643 |
4 |
0.555
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.554
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
31 |
0.536
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.527
|
|
|
|
dendritic cell apoptotic process
|
GO:0097048 |
4 |
0.525
|
|
|
|
negative regulation of secretion by cell
|
GO:1903531 |
52 |
0.524
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.522
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.514
|
|
|
|
positive regulation of b cell proliferation
|
GO:0030890 |
12 |
0.510
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
30 |
0.510
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.505
|
|
|
|
negative regulation of leukocyte mediated cytotoxicity
|
GO:0001911 |
5 |
0.501
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
40 |
0.501
|
|
|
|
negative regulation of immune response
|
GO:0050777 |
40 |
0.500
|
Mouse |
|
|
regulation of mast cell activation involved in immune response
|
GO:0033006 |
3 |
0.499
|
|
|
|
negative regulation of lymphocyte proliferation
|
GO:0050672 |
15 |
0.498
|
Mouse |
|
|
regulation of immunoglobulin mediated immune response
|
GO:0002889 |
7 |
0.491
|
Mouse |
|
|
metal ion transport
|
GO:0030001 |
272 |
0.488
|
Mouse |
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.478
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.469
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.469
|
Mouse |
|
|
glucan metabolic process
|
GO:0044042 |
22 |
0.458
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.456
|
|
|
|
positive regulation of b cell differentiation
|
GO:0045579 |
1 |
0.455
|
|
|
|
positive regulation of alpha beta t cell proliferation
|
GO:0046641 |
5 |
0.453
|
|
|
|
regulation of alpha beta t cell differentiation
|
GO:0046637 |
5 |
0.441
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.438
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.437
|
|
|
|
negative regulation of osteoclast differentiation
|
GO:0045671 |
8 |
0.437
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.436
|
Human |
|
|
nervous system development
|
GO:0007399 |
293 |
0.435
|
Human Fly |
|
|
t cell receptor signaling pathway
|
GO:0050852 |
21 |
0.432
|
Mouse |
|
|
positive regulation of t cell activation
|
GO:0050870 |
54 |
0.431
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.430
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.428
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.427
|
Mouse |
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.419
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.415
|
Mouse |
|
|
positive regulation of nervous system development
|
GO:0051962 |
54 |
0.414
|
|
|
|
negative regulation of dendritic cell apoptotic process
|
GO:2000669 |
3 |
0.409
|
|
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.407
|
|
|
|
interferon beta secretion
|
GO:0035546 |
1 |
0.407
|
|
|
|
alpha beta t cell activation
|
GO:0046631 |
15 |
0.403
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.401
|
|
|
|
regulation of mast cell degranulation
|
GO:0043304 |
3 |
0.400
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.397
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.395
|
|
|
|
positive regulation of leukocyte degranulation
|
GO:0043302 |
3 |
0.392
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.389
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.387
|
Mouse |
|
|
lymphocyte differentiation
|
GO:0030098 |
35 |
0.384
|
Mouse |
|
|
positive regulation of b cell mediated immunity
|
GO:0002714 |
4 |
0.383
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.378
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.370
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.369
|
|
|
|
negative regulation of serotonin secretion
|
GO:0014063 |
1 |
0.369
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.366
|
Fly |
|
|
negative regulation of t cell activation
|
GO:0050868 |
18 |
0.353
|
Mouse |
|
|
macrophage activation involved in immune response
|
GO:0002281 |
1 |
0.351
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.349
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.346
|
Mouse Fly |
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.338
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.338
|
Human |
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.337
|
|
|
|
mast cell degranulation
|
GO:0043303 |
4 |
0.335
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.330
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
20 |
0.330
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.329
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.327
|
|
|
|
regulation of anion transport
|
GO:0044070 |
25 |
0.326
|
|
|
|
regulation of type i interferon production
|
GO:0032479 |
26 |
0.324
|
|
|
|
negative regulation of cell development
|
GO:0010721 |
48 |
0.323
|
|
|
|
cd8 positive alpha beta t cell activation
|
GO:0036037 |
3 |
0.318
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.314
|
Mouse |
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.313
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.312
|
Mouse |
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.311
|
Mouse |
|
|
regulation of immunoglobulin production
|
GO:0002637 |
4 |
0.311
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.310
|
Mouse |
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.309
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.307
|
Human |
|
|
negative regulation of type 2 immune response
|
GO:0002829 |
3 |
0.305
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.305
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.305
|
|
|
|
cytokine production involved in immune response
|
GO:0002367 |
27 |
0.304
|
|
|
|
negative regulation of ion transport
|
GO:0043271 |
39 |
0.302
|
|
|
|
negative regulation of protein secretion
|
GO:0050709 |
29 |
0.296
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.295
|
|
|
|
positive regulation of mononuclear cell proliferation
|
GO:0032946 |
47 |
0.295
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.289
|
Mouse |
|
|
response to estradiol
|
GO:0032355 |
23 |
0.289
|
|
|
|
positive regulation of myeloid leukocyte mediated immunity
|
GO:0002888 |
1 |
0.289
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.288
|
Fly |
|
|
immune response in mucosal associated lymphoid tissue
|
GO:0002386 |
1 |
0.286
|
|
|
|
regulation of dendritic cell differentiation
|
GO:2001198 |
3 |
0.285
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.285
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.284
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.284
|
Mouse |
|
|
endothelial cell migration
|
GO:0043542 |
86 |
0.281
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
48 |
0.281
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.275
|
Fly |
|
|
tumor necrosis factor biosynthetic process
|
GO:0042533 |
8 |
0.274
|
|
|
|
b cell differentiation
|
GO:0030183 |
6 |
0.273
|
Mouse |
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
0.272
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.272
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
2 |
0.270
|
Fly |
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.269
|
Mouse |
|
|
secretion
|
GO:0046903 |
254 |
0.257
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
33 |
0.255
|
|
|
|
interferon gamma biosynthetic process
|
GO:0042095 |
8 |
0.255
|
|
|
|
regulation of platelet aggregation
|
GO:0090330 |
4 |
0.254
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.253
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.253
|
Mouse |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.253
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.248
|
Mouse |
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.248
|
Mouse |
|
|
b cell mediated immunity
|
GO:0019724 |
10 |
0.244
|
Mouse |
|
|
regulation of antigen receptor mediated signaling pathway
|
GO:0050854 |
10 |
0.244
|
Mouse |
|
|
carbohydrate transport
|
GO:0008643 |
37 |
0.242
|
Human |
|
|
gamma delta t cell activation involved in immune response
|
GO:0002290 |
1 |
0.241
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.240
|
Mouse |
|
|
immunoglobulin transcytosis in epithelial cells
|
GO:0002414 |
1 |
0.240
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.240
|
Mouse |
|
|
innate immune response
|
GO:0045087 |
178 |
0.239
|
Mouse |
|
|
negative regulation of lymphocyte mediated immunity
|
GO:0002707 |
12 |
0.235
|
Mouse |
|
|
regulation of cytokine secretion
|
GO:0050707 |
57 |
0.232
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.232
|
Mouse |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.225
|
|
|
|
positive regulation of blood vessel endothelial cell migration
|
GO:0043536 |
16 |
0.225
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.224
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.221
|
|
|
|
regulation of natural killer cell mediated immunity
|
GO:0002715 |
16 |
0.220
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
22 |
0.215
|
Mouse |
|
|
positive regulation of glucose transport
|
GO:0010828 |
17 |
0.215
|
Human |
|
|
positive regulation of alpha beta t cell differentiation
|
GO:0046638 |
4 |
0.214
|
|
|
|
regulation of b cell activation
|
GO:0050864 |
24 |
0.213
|
Mouse |
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.213
|
Mouse |
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
3 |
0.210
|
|
|
|
regulation of defense response to virus by host
|
GO:0050691 |
22 |
0.208
|
|
|
|
positive regulation of immunoglobulin production
|
GO:0002639 |
4 |
0.207
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.207
|
|
|
|
interleukin 10 production
|
GO:0032613 |
17 |
0.206
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.202
|
Fly |
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.199
|
Mouse |
|
|
monosaccharide metabolic process
|
GO:0005996 |
74 |
0.199
|
|
|
|
coagulation
|
GO:0050817 |
78 |
0.196
|
Mouse |
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.195
|
Mouse |
|
|
regulation of adaptive immune response
|
GO:0002819 |
33 |
0.194
|
Mouse |
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.193
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.193
|
Mouse |
|
|
regulation of cytokine secretion involved in immune response
|
GO:0002739 |
7 |
0.190
|
|
|
|
response to peptide hormone
|
GO:0043434 |
61 |
0.189
|
Human |
|
|
negative regulation of type i interferon production
|
GO:0032480 |
5 |
0.189
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.189
|
|
|
|
regulation of interferon beta production
|
GO:0032648 |
22 |
0.188
|
|
|
|
regulation of b cell differentiation
|
GO:0045577 |
2 |
0.188
|
Mouse |
|
|
long term memory
|
GO:0007616 |
2 |
0.187
|
|
|
|
energy reserve metabolic process
|
GO:0006112 |
22 |
0.183
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.182
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.182
|
|
|
|
blood vessel endothelial cell migration
|
GO:0043534 |
42 |
0.180
|
|
|
|
cortisol secretion
|
GO:0043400 |
4 |
0.180
|
|
|
|
regulation of t cell mediated immunity
|
GO:0002709 |
18 |
0.179
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.179
|
|
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.179
|
|
|
|
regulation of serotonin secretion
|
GO:0014062 |
1 |
0.178
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.176
|
|
|
|
regulation of hemostasis
|
GO:1900046 |
42 |
0.176
|
|
|
|
regulation of phosphate transport
|
GO:0010966 |
3 |
0.175
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
43 |
0.174
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
19 |
0.174
|
|
|
|
negative regulation of secretion
|
GO:0051048 |
58 |
0.174
|
|
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
39 |
0.173
|
|
|
|
phagocytosis engulfment
|
GO:0006911 |
7 |
0.172
|
Fly |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.171
|
Human |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.170
|
|
|
|
cell junction organization
|
GO:0034330 |
79 |
0.167
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.166
|
|
|
|
leukocyte degranulation
|
GO:0043299 |
11 |
0.163
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.163
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.163
|
Mouse |
|
|
epithelium migration
|
GO:0090132 |
119 |
0.162
|
Fly |
|
|
hematopoietic progenitor cell differentiation
|
GO:0002244 |
38 |
0.160
|
Mouse |
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
44 |
0.160
|
|
|
|
negative regulation of calcium ion transport
|
GO:0051926 |
19 |
0.159
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.159
|
|
|
|
t cell selection
|
GO:0045058 |
4 |
0.158
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.157
|
|
|
|
positive regulation of protein kinase b signaling
|
GO:0051897 |
42 |
0.156
|
|
|
|
positive regulation of regulated secretory pathway
|
GO:1903307 |
8 |
0.156
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.156
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.154
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.154
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.153
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.153
|
|
|
|
positive regulation of isotype switching
|
GO:0045830 |
2 |
0.153
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
56 |
0.152
|
Human |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.152
|
Human |
|
|
negative regulation of antigen processing and presentation
|
GO:0002578 |
5 |
0.148
|
|
|
|
growth
|
GO:0040007 |
202 |
0.147
|
|
|
|
positive regulation of alpha beta t cell activation
|
GO:0046635 |
10 |
0.146
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.145
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
30 |
0.144
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.144
|
|
|
|
heterotypic cell cell adhesion
|
GO:0034113 |
28 |
0.143
|
|
|
|
granulocyte migration
|
GO:0097530 |
40 |
0.141
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
38 |
0.139
|
|
|
|
regulation of coagulation
|
GO:0050818 |
44 |
0.137
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.137
|
Human Fly |
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.136
|
Fly |
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.135
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.135
|
Human |
|
|
regulation of phagocytosis
|
GO:0050764 |
21 |
0.135
|
|
|
|
response to growth hormone
|
GO:0060416 |
11 |
0.135
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.133
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.132
|
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
41 |
0.132
|
Human |
|
|
t cell proliferation
|
GO:0042098 |
45 |
0.130
|
Mouse |
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
13 |
0.130
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.129
|
Fly |
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.129
|
|
|
|
negative regulation of immune effector process
|
GO:0002698 |
38 |
0.128
|
Mouse |
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.127
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.126
|
|
|
|
lipid transport
|
GO:0006869 |
90 |
0.125
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.124
|
Mouse |
|
|
response to estrogen
|
GO:0043627 |
47 |
0.124
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.124
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.124
|
|
|
|
negative regulation of interleukin 12 secretion
|
GO:2001183 |
1 |
0.124
|
|
|
|
type i interferon production
|
GO:0032606 |
27 |
0.122
|
|
|
|
positive regulation of homeostatic process
|
GO:0032846 |
47 |
0.120
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.120
|
Human Mouse |
|
|
osteoclast development
|
GO:0036035 |
2 |
0.120
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.119
|
Fly |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.119
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.119
|
|
|
|
leukotriene metabolic process
|
GO:0006691 |
10 |
0.118
|
|
|
|
regulation of mast cell activation
|
GO:0033003 |
5 |
0.117
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.117
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.114
|
Mouse |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.113
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.112
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.111
|
Mouse |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.111
|
|
|
|
negative regulation of transforming growth factor beta secretion
|
GO:2001202 |
1 |
0.111
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.110
|
Fly |
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.109
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.109
|
Human Fly |
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
33 |
0.108
|
Mouse |
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.107
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.106
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.105
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.105
|
Mouse |
|
|
protein maturation
|
GO:0051604 |
233 |
0.104
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.103
|
|
|
|
positive regulation of epithelial cell migration
|
GO:0010634 |
55 |
0.102
|
|
|
|
midbrain development
|
GO:0030901 |
45 |
0.102
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.101
|
Human |
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.101
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.100
|
Human |
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.100
|
Fly |
|
|
myeloid cell homeostasis
|
GO:0002262 |
34 |
0.099
|
|
|
|
regulation of regulated secretory pathway
|
GO:1903305 |
10 |
0.098
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.097
|
Fly |
|
|
heart development
|
GO:0007507 |
95 |
0.097
|
Human |
|
|
endothelial cell proliferation
|
GO:0001935 |
65 |
0.097
|
|
|
|
cytokine secretion
|
GO:0050663 |
64 |
0.096
|
|
|
|
positive regulation of cell migration involved in sprouting angiogenesis
|
GO:0090050 |
3 |
0.096
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
4 |
0.095
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.095
|
|
|
|
cytolysis
|
GO:0019835 |
8 |
0.095
|
|
|
|
ephrin receptor signaling pathway
|
GO:0048013 |
15 |
0.095
|
Human |
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.094
|
|
|
|
negative regulation of natural killer cell mediated cytotoxicity
|
GO:0045953 |
5 |
0.093
|
|
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
25 |
0.092
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.092
|
Mouse |
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.092
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.090
|
|
|
|
thymic t cell selection
|
GO:0045061 |
2 |
0.090
|
|
|
|
fc receptor signaling pathway
|
GO:0038093 |
2 |
0.089
|
|
|
|
myeloid cell activation involved in immune response
|
GO:0002275 |
10 |
0.089
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.088
|
|
|
|
regulation of leukocyte mediated cytotoxicity
|
GO:0001910 |
19 |
0.087
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.087
|
|
|
|
positive regulation of exocytosis
|
GO:0045921 |
35 |
0.087
|
|
|
|
b cell receptor signaling pathway
|
GO:0050853 |
18 |
0.087
|
Mouse |
|
|
negative regulation of activation of jak2 kinase activity
|
GO:1902569 |
1 |
0.086
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.085
|
|
|
|
negative regulation of mononuclear cell proliferation
|
GO:0032945 |
15 |
0.084
|
Mouse |
|
|
positive regulation of neuron projection development
|
GO:0010976 |
34 |
0.083
|
|
|
|
regulation of cell shape
|
GO:0008360 |
48 |
0.083
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.082
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.082
|
Fly |
|
|
cellular polysaccharide metabolic process
|
GO:0044264 |
27 |
0.082
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
24 |
0.082
|
|
|
|
t cell activation involved in immune response
|
GO:0002286 |
13 |
0.081
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.081
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.081
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.080
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.080
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.080
|
Fly |
|
|
neutrophil apoptotic process
|
GO:0001781 |
2 |
0.080
|
|
|
|
neutrophil mediated immunity
|
GO:0002446 |
4 |
0.080
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.079
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.078
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.078
|
Mouse |
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.077
|
|
|
|
negative regulation of cytokine mediated signaling pathway
|
GO:0001960 |
22 |
0.076
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.076
|
Fly |
|
|
type 2 immune response
|
GO:0042092 |
6 |
0.075
|
|
|
|
negative regulation of cytokine production involved in immune response
|
GO:0002719 |
13 |
0.075
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.075
|
Human |
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.074
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
114 |
0.074
|
|
|
|
immunoglobulin biosynthetic process
|
GO:0002378 |
2 |
0.074
|
|
|
|
regulation of cell cell adhesion
|
GO:0022407 |
57 |
0.074
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.073
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.073
|
Mouse |
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.072
|
|
|
|
response to drug
|
GO:0042493 |
81 |
0.072
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.072
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.071
|
|
