Homo sapiens

83 known processes

P4HB

prolyl 4-hydroxylase, beta polypeptide

(Aliases: PHDB,GIT,P4Hbeta,PDIA1,ERBA2L,PROHB,PDI,DSI,PO4DB,PO4HB)

P4HB biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
4 hydroxyproline metabolic process GO:0019471 5 1.000
protein folding GO:0006457 38 0.997
Rat Worm
er nucleus signaling pathway GO:0006984 23 0.993
Worm
cellular response to topologically incorrect protein GO:0035967 19 0.984
Worm
endoplasmic reticulum unfolded protein response GO:0030968 16 0.936
Worm
cellular response to unfolded protein GO:0034620 16 0.876
Worm
response to endoplasmic reticulum stress GO:0034976 49 0.864
chaperone mediated protein folding GO:0061077 13 0.851
response to topologically incorrect protein GO:0035966 29 0.784
Worm
monocarboxylic acid metabolic process GO:0032787 185 0.673
protein stabilization GO:0050821 64 0.487
response to unfolded protein GO:0006986 24 0.449
Worm
hindbrain development GO:0030902 3 0.439
cytoplasmic transport GO:0016482 379 0.430
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.427
post embryonic development GO:0009791 2 0.339
Worm
regulation of meiotic cell cycle GO:0051445 4 0.336
regulation of behavior GO:0050795 82 0.305
glucan metabolic process GO:0044042 22 0.304
release of sequestered calcium ion into cytosol GO:0051209 41 0.263
carbohydrate metabolic process GO:0005975 207 0.258
regulation of homeostatic process GO:0032844 121 0.255
oxidation reduction process GO:0055114 396 0.231
posttranscriptional regulation of gene expression GO:0010608 213 0.218
response to hormone GO:0009725 175 0.217
single organism cell adhesion GO:0098602 179 0.209
negative regulation of retinoic acid receptor signaling pathway GO:0048387 4 0.172
determination of adult lifespan GO:0008340 2 0.145
maintenance of location GO:0051235 112 0.129
ubiquitin dependent protein catabolic process GO:0006511 206 0.128
positive regulation of developmental process GO:0051094 314 0.125
regulation of nuclear division GO:0051783 65 0.120
growth GO:0040007 202 0.114
locomotory behavior GO:0007626 1 0.113
positive regulation of cell development GO:0010720 92 0.106
positive regulation of transport GO:0051050 336 0.106
cellular response to external stimulus GO:0071496 111 0.102
regulation of leukocyte chemotaxis GO:0002688 46 0.098
single organism carbohydrate catabolic process GO:0044724 33 0.096
behavior GO:0007610 112 0.096
response to inorganic substance GO:0010035 127 0.094
endomembrane system organization GO:0010256 196 0.094
regulation of dna replication GO:0006275 68 0.090
cytosolic calcium ion transport GO:0060401 48 0.090
extracellular structure organization GO:0043062 41 0.089
negative regulation of catalytic activity GO:0043086 335 0.087
positive regulation of cellular component organization GO:0051130 376 0.084
canonical wnt signaling pathway GO:0060070 116 0.083
single organism carbohydrate metabolic process GO:0044723 193 0.083
response to abiotic stimulus GO:0009628 336 0.081
regulation of phagocytosis GO:0050764 21 0.079
calcium ion transport GO:0006816 147 0.079
generation of precursor metabolites and energy GO:0006091 68 0.078
regulation of protein secretion GO:0050708 86 0.078
epithelium development GO:0060429 227 0.075
response to oxygen containing compound GO:1901700 369 0.074
regulation of cellular amino acid metabolic process GO:0006521 6 0.073
regulation of chemotaxis GO:0050920 74 0.073
embryo development GO:0009790 123 0.073
Worm
transmembrane transport GO:0055085 399 0.072
brain morphogenesis GO:0048854 1 0.071
cellular divalent inorganic cation homeostasis GO:0072503 128 0.069
skeletal system development GO:0001501 79 0.068
cellular homeostasis GO:0019725 196 0.065
apoptotic signaling pathway GO:0097190 268 0.064
cellular amine metabolic process GO:0044106 41 0.064
golgi vesicle budding GO:0048194 4 0.063
glycogen catabolic process GO:0005980 4 0.060
head development GO:0060322 108 0.060
polysaccharide catabolic process GO:0000272 4 0.059
fat cell differentiation GO:0045444 32 0.059
cellular amino acid metabolic process GO:0006520 116 0.058
actin filament based process GO:0030029 224 0.058
response to mercury ion GO:0046689 4 0.055
startle response GO:0001964 3 0.055
metal ion homeostasis GO:0055065 169 0.055
divalent metal ion transport GO:0070838 152 0.054
heart development GO:0007507 95 0.053
extracellular matrix organization GO:0030198 41 0.053
brain development GO:0007420 97 0.052
sequestering of calcium ion GO:0051208 17 0.051
regulation of wnt protein secretion GO:0061356 1 0.051
cellular senescence GO:0090398 34 0.051
regulation of endocytosis GO:0030100 72 0.050
cell chemotaxis GO:0060326 112 0.049
membrane protein proteolysis GO:0033619 38 0.048
carbohydrate catabolic process GO:0016052 36 0.048
protein maturation GO:0051604 233 0.047
regulation of sequestering of calcium ion GO:0051282 41 0.046
generation of neurons GO:0048699 152 0.046
negative regulation of multicellular organismal process GO:0051241 317 0.044
chemotaxis GO:0006935 157 0.044
reproduction GO:0000003 63 0.044
cellular ketone metabolic process GO:0042180 80 0.043
regulation of multi organism process GO:0043900 157 0.043
response to hypoxia GO:0001666 96 0.042
divalent inorganic cation transport GO:0072511 158 0.042
positive regulation of developmental growth GO:0048639 16 0.041
peptidyl tyrosine modification GO:0018212 170 0.041
negative regulation of cellular protein metabolic process GO:0032269 353 0.040
regulation of growth GO:0040008 165 0.040
protein localization to organelle GO:0033365 280 0.040
organ morphogenesis GO:0009887 147 0.039
regulation of cell morphogenesis GO:0022604 153 0.038
regulation of cell motility GO:2000145 299 0.038
regulation of meiosis GO:0040020 3 0.038
cellular response to inorganic substance GO:0071241 45 0.037
central nervous system development GO:0007417 123 0.036
cellular chemical homeostasis GO:0055082 180 0.036
response to axon injury GO:0048678 1 0.036
metencephalon development GO:0022037 2 0.036
multicellular organismal aging GO:0010259 3 0.035
positive regulation of cellular amine metabolic process GO:0033240 7 0.035
cellular response to metal ion GO:0071248 43 0.034
positive regulation of phosphorylation GO:0042327 394 0.033
reproductive process GO:0022414 106 0.033
embryo development ending in birth or egg hatching GO:0009792 34 0.033
Worm
positive regulation of dna replication GO:0045740 35 0.032
regulation of vesicle mediated transport GO:0060627 130 0.032
aging GO:0007568 66 0.032
modification dependent protein catabolic process GO:0019941 209 0.031
regulation of protein stability GO:0031647 87 0.031
response to organic cyclic compound GO:0014070 204 0.031
nervous system development GO:0007399 293 0.030
neurogenesis GO:0022008 169 0.030
regulation of cell division GO:0051302 116 0.030
cell morphogenesis GO:0000902 296 0.030
single organism reproductive process GO:0044702 98 0.029
vesicle mediated transport GO:0016192 371 0.029
regulation of cell migration GO:0030334 289 0.029
regulation of cell cycle GO:0051726 393 0.028
positive regulation of secretion by cell GO:1903532 108 0.028
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.028
antigen processing and presentation of peptide antigen GO:0048002 18 0.028
striated muscle tissue development GO:0014706 59 0.028
positive regulation of growth GO:0045927 58 0.027
golgi organization GO:0007030 38 0.026
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.026
regulation of response to external stimulus GO:0032101 222 0.026
cytosolic calcium ion homeostasis GO:0051480 89 0.026
protein secretion GO:0009306 98 0.026
positive regulation of dna metabolic process GO:0051054 73 0.026
circulatory system development GO:0072359 262 0.025
primary neural tube formation GO:0014020 3 0.025
regulation of cell cycle process GO:0010564 266 0.025
cellular metal ion homeostasis GO:0006875 146 0.024
intracellular protein transport GO:0006886 270 0.024
response to lithium ion GO:0010226 2 0.024
glycoprotein biosynthetic process GO:0009101 91 0.024
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.024
negative regulation of neuron differentiation GO:0045665 21 0.024
single organism membrane organization GO:0044802 268 0.024
regulation of cellular protein catabolic process GO:1903362 96 0.023
cardiac muscle cell contraction GO:0086003 4 0.023
cellular macromolecule catabolic process GO:0044265 380 0.023
cortical actin cytoskeleton organization GO:0030866 9 0.023
positive regulation of response to external stimulus GO:0032103 88 0.023
bone development GO:0060348 26 0.022
positive regulation of protein secretion GO:0050714 60 0.022
cell adhesion GO:0007155 325 0.022
neuron projection development GO:0031175 106 0.022
cellular response to lithium ion GO:0071285 2 0.022
regulation of cellular ketone metabolic process GO:0010565 50 0.022
developmental process involved in reproduction GO:0003006 66 0.021
regulation of ion homeostasis GO:2000021 73 0.021
glycogen metabolic process GO:0005977 22 0.021
multi multicellular organism process GO:0044706 18 0.021
organelle fission GO:0048285 149 0.021
cell projection organization GO:0030030 252 0.021
sequestering of metal ion GO:0051238 24 0.021
positive regulation of cell proliferation GO:0008284 301 0.021
negative regulation of apoptotic process GO:0043066 316 0.020
neuron differentiation GO:0030182 138 0.020
positive regulation of endocytosis GO:0045807 42 0.020
regulation of kinase activity GO:0043549 314 0.020
response to oxygen levels GO:0070482 100 0.020
regulation of protein catabolic process GO:0042176 155 0.020
protein maturation by protein folding GO:0022417 2 0.019
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.019
cellular response to organic cyclic compound GO:0071407 127 0.019
multicellular organismal homeostasis GO:0048871 67 0.019
endocytosis GO:0006897 159 0.019
cellular ion homeostasis GO:0006873 168 0.019
modification dependent macromolecule catabolic process GO:0043632 212 0.019
epidermis development GO:0008544 59 0.018
cell cycle arrest GO:0007050 71 0.018
nucleocytoplasmic transport GO:0006913 176 0.018
negative regulation of homeostatic process GO:0032845 59 0.018
positive regulation of leukocyte migration GO:0002687 46 0.018
positive regulation of chemotaxis GO:0050921 57 0.018
cellular carbohydrate metabolic process GO:0044262 84 0.018
cellular protein complex assembly GO:0043623 188 0.018
de novo protein folding GO:0006458 2 0.018
cation transport GO:0006812 331 0.018
muscle cell cellular homeostasis GO:0046716 3 0.018
response to metal ion GO:0010038 84 0.017
tissue homeostasis GO:0001894 63 0.017
positive regulation of cell motility GO:2000147 177 0.017
regulation of cell adhesion GO:0030155 166 0.017
secretion by cell GO:0032940 226 0.017
cellular protein catabolic process GO:0044257 261 0.017
negative regulation of phosphorus metabolic process GO:0010563 267 0.017
negative regulation of hydrolase activity GO:0051346 182 0.017
positive regulation of leukocyte chemotaxis GO:0002690 38 0.016
calcium ion homeostasis GO:0055074 122 0.016
protein localization to nucleus GO:0034504 136 0.016
fatty acid metabolic process GO:0006631 115 0.016
response to virus GO:0009615 126 0.016
system process GO:0003008 349 0.016
sleep GO:0030431 2 0.016
chordate embryonic development GO:0043009 34 0.016
regulation of translation GO:0006417 89 0.016
anatomical structure homeostasis GO:0060249 100 0.016
wnt protein secretion GO:0061355 1 0.016
cell morphogenesis involved in differentiation GO:0000904 144 0.015
regulation of retinoic acid receptor signaling pathway GO:0048385 9 0.015
response to decreased oxygen levels GO:0036293 96 0.015
protein glycosylation GO:0006486 62 0.015
peptidyl tyrosine phosphorylation GO:0018108 170 0.015
regulation of locomotion GO:0040012 329 0.014
gene silencing GO:0016458 49 0.014
protein localization to plasma membrane GO:0072659 93 0.014
cellular glucan metabolic process GO:0006073 22 0.014
regulation of protein processing GO:0070613 150 0.014
regulation of apoptotic signaling pathway GO:2001233 175 0.014
regulation of developmental growth GO:0048638 30 0.014
calcium ion transport into cytosol GO:0060402 48 0.014
divalent inorganic cation homeostasis GO:0072507 136 0.014
regeneration GO:0031099 4 0.014
response to testosterone GO:0033574 1 0.014
neuron projection regeneration GO:0031102 1 0.014
rna processing GO:0006396 255 0.014
cellular component morphogenesis GO:0032989 314 0.013
positive regulation of programmed cell death GO:0043068 249 0.013
regulation of anatomical structure morphogenesis GO:0022603 286 0.013
translation GO:0006412 132 0.013
nucleoside phosphate catabolic process GO:1901292 412 0.013
protein targeting to membrane GO:0006612 42 0.013
response to temperature stimulus GO:0009266 22 0.013
response to heat GO:0009408 21 0.013
odontogenesis GO:0042476 25 0.013
membrane organization GO:0061024 292 0.013
response to ethanol GO:0045471 11 0.013
positive regulation of protein transport GO:0051222 135 0.013
response to other organism GO:0051707 261 0.013
cell aging GO:0007569 52 0.012
pattern specification process GO:0007389 43 0.012
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.012
establishment of protein localization to membrane GO:0090150 121 0.012
regulation of protein localization GO:0032880 296 0.012
regulation of neuron projection development GO:0010975 57 0.012
negative regulation of developmental process GO:0051093 247 0.012
negative regulation of programmed cell death GO:0043069 321 0.012
reproductive system development GO:0061458 56 0.012
positive regulation of kinase activity GO:0033674 204 0.012
positive regulation of transferase activity GO:0051347 227 0.012
response to estradiol GO:0032355 23 0.011
multicellular organismal reproductive process GO:0048609 40 0.011
peptidyl glutamic acid modification GO:0018200 4 0.011
regulation of gene expression epigenetic GO:0040029 73 0.011
negative regulation of nervous system development GO:0051961 28 0.011
regulation of leukocyte migration GO:0002685 63 0.011
actin mediated cell contraction GO:0070252 12 0.011
regulation of binding GO:0051098 111 0.011
nuclear division GO:0000280 128 0.011
regulation of secretion by cell GO:1903530 177 0.011
cardiac muscle tissue development GO:0048738 39 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.011
regulation of cell growth GO:0001558 135 0.011
signal release GO:0023061 70 0.011
negative regulation of protein metabolic process GO:0051248 391 0.011
negative regulation of cell cycle GO:0045786 193 0.011
rna interference GO:0016246 4 0.011
regulation of establishment of protein localization GO:0070201 242 0.011
multicellular organism reproduction GO:0032504 42 0.011
protein catabolic process GO:0030163 325 0.010
ion homeostasis GO:0050801 230 0.010
leukocyte chemotaxis GO:0030595 76 0.010
positive regulation of cell differentiation GO:0045597 211 0.010
maintenance of protein location in cell GO:0032507 56 0.010
negative regulation of cell death GO:0060548 345 0.010
regionalization GO:0003002 29 0.010
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.010
proteasomal protein catabolic process GO:0010498 176 0.010
nuclear export GO:0051168 69 0.010
single organism cellular localization GO:1902580 332 0.010
i kappab kinase nf kappab signaling GO:0007249 166 0.010
regulation of secretion GO:0051046 194 0.010

P4HB disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.692
connective tissue disease DOID:65 109 0.692
osteochondrodysplasia DOID:2256 35 0.599
osteogenesis imperfecta DOID:12347 13 0.599
bone development disease DOID:0080006 55 0.599
bone disease DOID:0080001 88 0.599
cancer DOID:162 167 0.035
disease of cellular proliferation DOID:14566 174 0.035
myeloma DOID:0070004 7 0.026
immune system cancer DOID:0060083 36 0.026
hematologic cancer DOID:2531 36 0.026
organ system cancer DOID:0050686 164 0.026
bone marrow cancer DOID:4960 10 0.026
central nervous system disease DOID:331 186 0.018
neurodegenerative disease DOID:1289 102 0.018
nervous system disease DOID:863 431 0.018
disease of metabolism DOID:0014667 295 0.016