Homo sapiens

53 known processes

SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

(Aliases: MGC110992,TIR8)

SIGIRR biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular ketone metabolic process GO:0042180 80 0.127
cellular amine metabolic process GO:0044106 41 0.091
monocarboxylic acid metabolic process GO:0032787 185 0.084
regulation of cellular ketone metabolic process GO:0010565 50 0.075
cellular amino acid metabolic process GO:0006520 116 0.067
regulation of cellular amine metabolic process GO:0033238 11 0.062
single organism carbohydrate metabolic process GO:0044723 193 0.062
negative regulation of multicellular organismal process GO:0051241 317 0.062
Mouse
cellular lipid metabolic process GO:0044255 303 0.060
amine metabolic process GO:0009308 44 0.060
negative regulation of cellular protein metabolic process GO:0032269 353 0.057
carbohydrate metabolic process GO:0005975 207 0.056
negative regulation of phosphate metabolic process GO:0045936 267 0.052
regulation of locomotion GO:0040012 329 0.051
lipid metabolic process GO:0006629 381 0.049
positive regulation of locomotion GO:0040017 186 0.049
positive regulation of cellular amine metabolic process GO:0033240 7 0.046
response to external biotic stimulus GO:0043207 261 0.045
regulation of cellular amino acid metabolic process GO:0006521 6 0.043
regulation of cell motility GO:2000145 299 0.043
enzyme linked receptor protein signaling pathway GO:0007167 303 0.043
negative regulation of phosphorylation GO:0042326 174 0.041
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.040
negative regulation of phosphorus metabolic process GO:0010563 267 0.040
response to abiotic stimulus GO:0009628 336 0.039
negative regulation of cellular component organization GO:0051129 235 0.039
negative regulation of protein modification process GO:0031400 200 0.038
negative regulation of protein metabolic process GO:0051248 391 0.037
Mouse
cellular response to dna damage stimulus GO:0006974 379 0.037
regulation of hormone levels GO:0010817 125 0.037
positive regulation of cell migration GO:0030335 172 0.037
system process GO:0003008 349 0.036
organonitrogen compound biosynthetic process GO:1901566 200 0.035
regulation of transferase activity GO:0051338 355 0.035
response to oxygen containing compound GO:1901700 369 0.034
positive regulation of cell motility GO:2000147 177 0.034
regulation of cellular component movement GO:0051270 334 0.034
response to other organism GO:0051707 261 0.034
negative regulation of catalytic activity GO:0043086 335 0.034
ribonucleotide catabolic process GO:0009261 405 0.033
mitotic cell cycle GO:0000278 326 0.033
positive regulation of cellular component movement GO:0051272 181 0.033
purine containing compound catabolic process GO:0072523 411 0.033
glycoprotein metabolic process GO:0009100 110 0.033
positive regulation of transport GO:0051050 336 0.032
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.032
regulation of cell growth GO:0001558 135 0.031
cell adhesion GO:0007155 325 0.031
regulation of anatomical structure morphogenesis GO:0022603 286 0.031
generation of precursor metabolites and energy GO:0006091 68 0.031
response to organic cyclic compound GO:0014070 204 0.030
lipid biosynthetic process GO:0008610 177 0.030
cellular response to abiotic stimulus GO:0071214 117 0.030
epithelium migration GO:0090132 119 0.029
negative regulation of protein phosphorylation GO:0001933 140 0.029
regulation of cellular component biogenesis GO:0044087 281 0.029
positive regulation of developmental process GO:0051094 314 0.028
response to biotic stimulus GO:0009607 276 0.028
negative regulation of growth GO:0045926 97 0.028
response to hormone GO:0009725 175 0.027
positive regulation of phosphorylation GO:0042327 394 0.027
cytokine production GO:0001816 247 0.027
Mouse
defense response GO:0006952 315 0.027
Mouse
glycerolipid metabolic process GO:0046486 107 0.027
response to drug GO:0042493 81 0.027
growth GO:0040007 202 0.026
chemical homeostasis GO:0048878 306 0.026
immune response GO:0006955 307 0.026
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.026
cell growth GO:0016049 160 0.026
secretion by cell GO:0032940 226 0.026
peptidyl tyrosine modification GO:0018212 170 0.026
organophosphate biosynthetic process GO:0090407 163 0.025
regulation of cell differentiation GO:0045595 393 0.025
negative regulation of developmental process GO:0051093 247 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.025
dephosphorylation GO:0016311 209 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.024
cellular component morphogenesis GO:0032989 314 0.024
post embryonic development GO:0009791 2 0.024
organophosphate catabolic process GO:0046434 430 0.024
ras protein signal transduction GO:0007265 73 0.023
regulation of cell migration GO:0030334 289 0.023
cellular response to endogenous stimulus GO:0071495 336 0.023
ribonucleoside triphosphate metabolic process GO:0009199 412 0.023
regulation of growth GO:0040008 165 0.023
purine nucleotide catabolic process GO:0006195 405 0.023
negative regulation of cell growth GO:0030308 83 0.023
cardiac muscle contraction GO:0060048 34 0.023
response to virus GO:0009615 126 0.022
positive regulation of protein phosphorylation GO:0001934 313 0.022
signal transduction by phosphorylation GO:0023014 297 0.022
female gamete generation GO:0007292 2 0.022
positive regulation of organelle organization GO:0010638 195 0.022
organic hydroxy compound metabolic process GO:1901615 147 0.022
cellular macromolecular complex assembly GO:0034622 324 0.022
positive regulation of cellular component organization GO:0051130 376 0.022
response to lipid GO:0033993 206 0.022
small gtpase mediated signal transduction GO:0007264 78 0.022
regulation of kinase activity GO:0043549 314 0.022
tissue migration GO:0090130 119 0.022
nucleoside triphosphate metabolic process GO:0009141 422 0.022
epithelial cell migration GO:0010631 119 0.022
negative regulation of cell death GO:0060548 345 0.022
cellular macromolecule catabolic process GO:0044265 380 0.021
purine nucleoside triphosphate metabolic process GO:0009144 412 0.021
peptidyl tyrosine phosphorylation GO:0018108 170 0.021
regulation of protein complex assembly GO:0043254 147 0.021
purine nucleoside catabolic process GO:0006152 398 0.021
regulation of proteolysis GO:0030162 293 0.021
positive regulation of cell differentiation GO:0045597 211 0.021
positive regulation of nucleotide metabolic process GO:0045981 230 0.021
regulation of cell morphogenesis GO:0022604 153 0.021
cellular protein catabolic process GO:0044257 261 0.021
response to steroid hormone GO:0048545 80 0.021
regulation of immune response GO:0050776 201 0.020
response to growth factor GO:0070848 205 0.020
cellular response to growth factor stimulus GO:0071363 197 0.020
actin filament based process GO:0030029 224 0.020
regulation of purine nucleotide metabolic process GO:1900542 264 0.020
wound healing GO:0042060 115 0.020
positive regulation of cell proliferation GO:0008284 301 0.020
striated muscle contraction GO:0006941 52 0.020
positive regulation of cellular catabolic process GO:0031331 284 0.020
positive regulation of hydrolase activity GO:0051345 331 0.019
positive regulation of cellular component biogenesis GO:0044089 158 0.019
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.019
multicellular organismal aging GO:0010259 3 0.019
purine nucleoside triphosphate catabolic process GO:0009146 392 0.019
cellular response to cytokine stimulus GO:0071345 181 0.018
Human Mouse
negative regulation of immune system process GO:0002683 136 0.018
nucleoside phosphate catabolic process GO:1901292 412 0.018
oxidation reduction process GO:0055114 396 0.018
regulation of nucleotide catabolic process GO:0030811 205 0.018
protein modification by small protein conjugation GO:0032446 342 0.018
muscle contraction GO:0006936 73 0.018
membrane organization GO:0061024 292 0.018
regulation of protein kinase activity GO:0045859 289 0.018
ameboidal type cell migration GO:0001667 135 0.018
apoptotic signaling pathway GO:0097190 268 0.018
regulation of mitotic cell cycle GO:0007346 189 0.018
mapk cascade GO:0000165 288 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.018
positive regulation of immune system process GO:0002684 283 0.018
erk1 and erk2 cascade GO:0070371 104 0.017
pyruvate metabolic process GO:0006090 26 0.017
regulation of nucleoside metabolic process GO:0009118 209 0.017
regulation of purine nucleotide catabolic process GO:0033121 205 0.017
vesicle mediated transport GO:0016192 371 0.017
purine ribonucleotide catabolic process GO:0009154 404 0.017
phospholipid metabolic process GO:0006644 99 0.017
cellular protein complex assembly GO:0043623 188 0.017
biological adhesion GO:0022610 331 0.017
determination of adult lifespan GO:0008340 2 0.017
carbohydrate derivative biosynthetic process GO:1901137 207 0.017
cell morphogenesis GO:0000902 296 0.017
glycosyl compound catabolic process GO:1901658 413 0.017
regeneration GO:0031099 4 0.017
purine ribonucleoside metabolic process GO:0046128 437 0.017
regulation of cell cycle process GO:0010564 266 0.017
segmentation GO:0035282 4 0.017
hormone transport GO:0009914 68 0.017
compound eye development GO:0048749 1 0.017
response to wounding GO:0009611 168 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
metal ion transport GO:0030001 272 0.016
defense response to fungus GO:0050832 4 0.016
cell substrate adhesion GO:0031589 132 0.016
cell division GO:0051301 168 0.016
negative regulation of cellular amine metabolic process GO:0033239 3 0.016
cell projection assembly GO:0030031 126 0.016
glycoprotein biosynthetic process GO:0009101 91 0.016
regulation of binding GO:0051098 111 0.016
carbohydrate biosynthetic process GO:0016051 42 0.016
lung alveolus development GO:0048286 4 0.016
innate immune response GO:0045087 178 0.016
negative regulation of apoptotic process GO:0043066 316 0.016
regulation of erk1 and erk2 cascade GO:0070372 99 0.016
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.016
cell projection organization GO:0030030 252 0.016
positive regulation of transferase activity GO:0051347 227 0.016
negative regulation of hydrolase activity GO:0051346 182 0.015
protein catabolic process GO:0030163 325 0.015
nitrogen compound transport GO:0071705 191 0.015
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.015
regulation of protein localization GO:0032880 296 0.015
cation transport GO:0006812 331 0.015
single organism cellular localization GO:1902580 332 0.015
regulation of protein serine threonine kinase activity GO:0071900 179 0.015
regulation of body fluid levels GO:0050878 99 0.015
regulation of nucleotide metabolic process GO:0006140 269 0.015
glycerophospholipid metabolic process GO:0006650 84 0.015
negative regulation of programmed cell death GO:0043069 321 0.015
regulation of cell cycle GO:0051726 393 0.015
cellular cation homeostasis GO:0030003 163 0.015
guanosine containing compound catabolic process GO:1901069 239 0.015
response to salt stress GO:0009651 3 0.015
carbohydrate catabolic process GO:0016052 36 0.015
alcohol metabolic process GO:0006066 114 0.015
cell activation GO:0001775 213 0.015
neuromuscular junction development GO:0007528 3 0.015
purine ribonucleoside catabolic process GO:0046130 398 0.015
positive regulation of nucleoside metabolic process GO:0045979 186 0.014
chromatin organization GO:0006325 351 0.014
positive regulation of protein complex assembly GO:0031334 86 0.014
nucleoside catabolic process GO:0009164 408 0.014
regulation of protein transport GO:0051223 213 0.014
regulation of secretion by cell GO:1903530 177 0.014
covalent chromatin modification GO:0016569 254 0.014
ribonucleoside catabolic process GO:0042454 406 0.014
hormone secretion GO:0046879 65 0.014
protein oligomerization GO:0051259 173 0.014
transmembrane transport GO:0055085 399 0.014
negative regulation of organelle organization GO:0010639 126 0.014
positive regulation of kinase activity GO:0033674 204 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
response to fungus GO:0009620 4 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
protein dephosphorylation GO:0006470 81 0.014
regulation of response to external stimulus GO:0032101 222 0.014
regulation of nervous system development GO:0051960 88 0.014
muscle system process GO:0003012 81 0.014
response to extracellular stimulus GO:0009991 85 0.014
cellular response to external stimulus GO:0071496 111 0.014
monosaccharide metabolic process GO:0005996 74 0.014
actin cytoskeleton organization GO:0030036 207 0.014
mitochondrion organization GO:0007005 156 0.014
cell cycle phase transition GO:0044770 173 0.014
cytoplasmic transport GO:0016482 379 0.014
hexose metabolic process GO:0019318 55 0.014
regulation of synaptic plasticity GO:0048167 3 0.013
regulation of secretion GO:0051046 194 0.013
regulation of cellular component size GO:0032535 82 0.013
regulation of vesicle mediated transport GO:0060627 130 0.013
single organism cell adhesion GO:0098602 179 0.013
organic acid biosynthetic process GO:0016053 97 0.013
regulation of mapk cascade GO:0043408 262 0.013
positive regulation of cytokine production GO:0001819 167 0.013
negative regulation of cell proliferation GO:0008285 228 0.013
chromatin modification GO:0016568 298 0.013
positive regulation of catabolic process GO:0009896 310 0.013
small molecule biosynthetic process GO:0044283 157 0.013
regulation of response to wounding GO:1903034 101 0.013
regulation of cell activation GO:0050865 125 0.013
cellular ion homeostasis GO:0006873 168 0.013
hematopoietic or lymphoid organ development GO:0048534 186 0.013
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.013
epithelium development GO:0060429 227 0.013
positive regulation of protein kinase activity GO:0045860 190 0.013
organelle fission GO:0048285 149 0.013
glucose metabolic process GO:0006006 45 0.013
anatomical structure formation involved in morphogenesis GO:0048646 284 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.013
viral process GO:0016032 146 0.013
ion homeostasis GO:0050801 230 0.013
neuroblast proliferation GO:0007405 4 0.013
oogenesis GO:0048477 2 0.013
maintenance of location GO:0051235 112 0.013
phospholipid biosynthetic process GO:0008654 44 0.013
calcium ion transport GO:0006816 147 0.013
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.013
regulation of multi organism process GO:0043900 157 0.013
nucleoside triphosphate catabolic process GO:0009143 394 0.012
single organism membrane organization GO:0044802 268 0.012
small molecule catabolic process GO:0044282 92 0.012
divalent inorganic cation transport GO:0072511 158 0.012
positive regulation of programmed cell death GO:0043068 249 0.012
amide transport GO:0042886 76 0.012
rho protein signal transduction GO:0007266 26 0.012
regulation of lipid metabolic process GO:0019216 96 0.012
blood circulation GO:0008015 113 0.012
regulation of cell development GO:0060284 161 0.012
circulatory system process GO:0003013 113 0.012
prostate gland morphogenesis GO:0060512 1 0.012
response to estradiol GO:0032355 23 0.012
histone modification GO:0016570 251 0.012
peptide secretion GO:0002790 51 0.012
regulation of actin filament based process GO:0032970 141 0.012
cytokine mediated signaling pathway GO:0019221 109 0.012
Human Mouse
negative regulation of transferase activity GO:0051348 124 0.012
blastoderm segmentation GO:0007350 2 0.012
single organism carbohydrate catabolic process GO:0044724 33 0.012
response to cytokine GO:0034097 232 0.012
Human Mouse
response to alcohol GO:0097305 64 0.012
cellular homeostasis GO:0019725 196 0.012
epithelial cell proliferation GO:0050673 128 0.012
endosomal transport GO:0016197 129 0.012
regulation of cytoskeleton organization GO:0051493 177 0.012
positive regulation of apoptotic process GO:0043065 246 0.012
carboxylic acid biosynthetic process GO:0046394 97 0.012
secretion GO:0046903 254 0.012
cell cell signaling GO:0007267 155 0.012
modification dependent macromolecule catabolic process GO:0043632 212 0.012
spermatid differentiation GO:0048515 4 0.011
hemostasis GO:0007599 76 0.011
regulation of protein maturation GO:1903317 150 0.011
immune system development GO:0002520 195 0.011
organelle assembly GO:0070925 176 0.011
regulation of protein processing GO:0070613 150 0.011
macromolecule glycosylation GO:0043413 63 0.011
positive regulation of gtp catabolic process GO:0033126 166 0.011
microtubule based process GO:0007017 210 0.011
endothelial cell migration GO:0043542 86 0.011
negative regulation of cell migration GO:0030336 102 0.011
oocyte development GO:0048599 1 0.011
gtp catabolic process GO:0006184 237 0.011
positive regulation of mapk cascade GO:0043410 190 0.011
peptide transport GO:0015833 74 0.011
negative regulation of cytoskeleton organization GO:0051494 45 0.011
ubiquitin dependent protein catabolic process GO:0006511 206 0.011
negative regulation of cell cycle GO:0045786 193 0.011
regulation of dna metabolic process GO:0051052 153 0.011
behavioral response to ethanol GO:0048149 2 0.011
plasma membrane organization GO:0007009 115 0.011
protein maturation GO:0051604 233 0.011
positive regulation of cell division GO:0051781 59 0.011
memory GO:0007613 3 0.011
hemopoiesis GO:0030097 180 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
blood coagulation GO:0007596 76 0.011
regulation of cell division GO:0051302 116 0.011
nucleotide catabolic process GO:0009166 408 0.011
protein acetylation GO:0006473 116 0.011
blood vessel morphogenesis GO:0048514 162 0.011
regulation of cell adhesion GO:0030155 166 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
lipid localization GO:0010876 106 0.011
neurological system process GO:0050877 163 0.011
angiogenesis GO:0001525 147 0.011
response to radiation GO:0009314 151 0.011
inorganic cation transmembrane transport GO:0098662 194 0.011
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.010
modification dependent protein catabolic process GO:0019941 209 0.010
oocyte differentiation GO:0009994 2 0.010
positive regulation of cell death GO:0010942 263 0.010
fatty acid metabolic process GO:0006631 115 0.010
protein processing GO:0016485 226 0.010
regulation of small gtpase mediated signal transduction GO:0051056 156 0.010
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.010
positive regulation of secretion by cell GO:1903532 108 0.010
metencephalon development GO:0022037 2 0.010
nucleoside phosphate biosynthetic process GO:1901293 109 0.010
response to inorganic substance GO:0010035 127 0.010
glycerolipid biosynthetic process GO:0045017 51 0.010
mitotic nuclear division GO:0007067 119 0.010
peptide hormone secretion GO:0030072 50 0.010
regulation of intracellular transport GO:0032386 195 0.010
protein autophosphorylation GO:0046777 123 0.010

SIGIRR disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.029
inherited metabolic disorder DOID:655 242 0.029
disease of cellular proliferation DOID:14566 174 0.023
cancer DOID:162 167 0.021
organ system cancer DOID:0050686 164 0.020
sensory system disease DOID:0050155 203 0.015
nervous system disease DOID:863 431 0.015
central nervous system disease DOID:331 186 0.014
musculoskeletal system disease DOID:17 223 0.011
eye and adnexa disease DOID:1492 150 0.011
eye disease DOID:5614 149 0.011