Homo sapiens

99 known processes

IL1RN

interleukin 1 receptor antagonist

(Aliases: ICIL-1RA,MGC10430,IL1RA,MVCD4,DIRA,IL-1RN,IL1F3,IL-1ra3,IL-1ra,IRAP)

IL1RN biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to nitric oxide GO:0071731 4 0.969
cytokine production GO:0001816 247 0.865
Human
response to other organism GO:0051707 261 0.824
Human Rat
positive regulation of myosin light chain kinase activity GO:0035505 1 0.815
Human
regulation of interleukin 1 mediated signaling pathway GO:2000659 3 0.805
response to external biotic stimulus GO:0043207 261 0.780
Human Rat
response to cytokine GO:0034097 232 0.768
positive regulation of granulocyte macrophage colony stimulating factor production GO:0032725 4 0.757
Human
cellular response to interleukin 1 GO:0071347 35 0.700
cellular response to molecule of bacterial origin GO:0071219 62 0.688
Human
defense response GO:0006952 315 0.674
response to molecule of bacterial origin GO:0002237 82 0.647
Human Rat
positive regulation of monocyte chemotactic protein 1 production GO:0071639 3 0.638
Human
positive regulation of organic acid transport GO:0032892 3 0.627
cellular response to cytokine stimulus GO:0071345 181 0.622
positive regulation of calcidiol 1 monooxygenase activity GO:0060559 3 0.604
Human
positive regulation of acute inflammatory response GO:0002675 2 0.585
monocyte aggregation GO:0070487 4 0.585
Human
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.570
Human
positive regulation of vitamin d biosynthetic process GO:0060557 3 0.540
Human
cytokine mediated signaling pathway GO:0019221 109 0.538
response to biotic stimulus GO:0009607 276 0.535
Human Rat
regulation of defense response GO:0031347 154 0.505
regulation of protein secretion GO:0050708 86 0.484
Human
regulation of response to external stimulus GO:0032101 222 0.450
response to inorganic substance GO:0010035 127 0.440
negative regulation of cytokine mediated signaling pathway GO:0001960 22 0.440
regulation of myosin light chain kinase activity GO:0035504 1 0.424
Human
biological adhesion GO:0022610 331 0.404
chemical homeostasis GO:0048878 306 0.386
response to oxygen containing compound GO:1901700 369 0.366
Human Rat
single organism cell adhesion GO:0098602 179 0.360
small molecule biosynthetic process GO:0044283 157 0.359
Human
positive regulation of alcohol biosynthetic process GO:1902932 9 0.351
Human
mature natural killer cell chemotaxis GO:0035782 1 0.351
cellular response to lipopolysaccharide GO:0071222 57 0.347
Human
cellular response to organic cyclic compound GO:0071407 127 0.347
Human Rat
cell adhesion GO:0007155 325 0.337
response to interleukin 1 GO:0070555 47 0.326
eosinophil activation involved in immune response GO:0002278 2 0.325
interleukin 1 mediated signaling pathway GO:0070498 12 0.324
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.323
Human
negative regulation of amine transport GO:0051953 1 0.309
Rat
single organismal cell cell adhesion GO:0016337 148 0.303
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.294
Human
negative regulation of alpha beta t cell activation GO:0046636 3 0.292
female gamete generation GO:0007292 2 0.288
negative regulation of response to cytokine stimulus GO:0060761 25 0.285
response to lipid GO:0033993 206 0.281
negative regulation of cell proliferation GO:0008285 228 0.280
Human
regulation of secretion GO:0051046 194 0.276
Human Rat
response to wounding GO:0009611 168 0.265
cellular lipid metabolic process GO:0044255 303 0.265
organic anion transport GO:0015711 103 0.256
Rat
negative regulation of lipid catabolic process GO:0050995 9 0.255
Human
positive regulation of organelle organization GO:0010638 195 0.245
Human
negative regulation of interleukin 1 mediated signaling pathway GO:2000660 2 0.244
heterotypic cell cell adhesion GO:0034113 28 0.231
positive regulation of cytokine production GO:0001819 167 0.230
Human
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.226
Human
positive regulation of heterotypic cell cell adhesion GO:0034116 8 0.224
Human
extrinsic apoptotic signaling pathway GO:0097191 119 0.222
Human
response to organic cyclic compound GO:0014070 204 0.222
regulation of cytokine production GO:0001817 232 0.220
Human
response to bacterium GO:0009617 144 0.219
Human Rat
lipid biosynthetic process GO:0008610 177 0.215
Human
response to growth factor GO:0070848 205 0.213
positive regulation of proteolysis GO:0045862 142 0.213
Human
regulation of cd8 positive alpha beta t cell activation GO:2001185 2 0.211
negative regulation of lymphocyte chemotaxis GO:1901624 2 0.208
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.207
negative regulation of cell death GO:0060548 345 0.207
Human Rat
regulation of anatomical structure morphogenesis GO:0022603 286 0.203
positive regulation of icosanoid secretion GO:0032305 3 0.203
positive regulation of cell death GO:0010942 263 0.199
response to oxidative stress GO:0006979 121 0.197
regulation of neutrophil migration GO:1902622 10 0.196
regulation of inflammatory response GO:0050727 46 0.189
positive regulation of secretion GO:0051047 116 0.185
g protein coupled receptor signaling pathway GO:0007186 207 0.181
cd8 positive alpha beta t cell activation GO:0036037 3 0.180
leukocyte migration GO:0050900 107 0.180
positive regulation of fatty acid transport GO:2000193 3 0.178
lipid localization GO:0010876 106 0.176
Human
leukocyte aggregation GO:0070486 8 0.171
Human
peptide secretion GO:0002790 51 0.170
Human Mouse
protein oligomerization GO:0051259 173 0.169
negative regulation of lymphocyte migration GO:2000402 4 0.166
positive regulation of cellular component organization GO:0051130 376 0.163
Human
negative regulation of ion transport GO:0043271 39 0.163
Rat
regulation of cell adhesion GO:0030155 166 0.162
positive regulation of apoptotic process GO:0043065 246 0.154
leukocyte cell cell adhesion GO:0007159 37 0.154
Human
positive regulation of neutrophil chemotaxis GO:0090023 7 0.154
regulation of amine transport GO:0051952 5 0.154
Rat
regulation of response to wounding GO:1903034 101 0.153
organic hydroxy compound metabolic process GO:1901615 147 0.153
Human
immune response GO:0006955 307 0.151
Human Rat
cellular response to oxygen containing compound GO:1901701 276 0.151
Human Rat
amino acid transport GO:0006865 28 0.150
Rat
eosinophil degranulation GO:0043308 2 0.148
chemokine metabolic process GO:0050755 4 0.147
cytoplasmic transport GO:0016482 379 0.146
Human
positive regulation of granulocyte chemotaxis GO:0071624 9 0.144
negative regulation of multicellular organismal process GO:0051241 317 0.142
Human
regulation of immune response GO:0050776 201 0.141
organonitrogen compound biosynthetic process GO:1901566 200 0.140
Human
chronic inflammatory response GO:0002544 2 0.140
Rat
viral life cycle GO:0019058 132 0.140
chemokine biosynthetic process GO:0042033 4 0.137
negative regulation of protein metabolic process GO:0051248 391 0.136
developmental programmed cell death GO:0010623 3 0.135
cellular chemical homeostasis GO:0055082 180 0.132
positive regulation of phosphorylation GO:0042327 394 0.132
Human Rat
regulation of cytokine biosynthetic process GO:0042035 35 0.131
Human
positive regulation of locomotion GO:0040017 186 0.130
regulation of protein localization GO:0032880 296 0.129
Human
secretion GO:0046903 254 0.128
Human Mouse Rat
tube morphogenesis GO:0035239 95 0.126
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.124
Human
response to reactive oxygen species GO:0000302 61 0.123
organic acid transport GO:0015849 65 0.122
Rat
regulation of cellular component movement GO:0051270 334 0.122
Rat
oxidation reduction process GO:0055114 396 0.120
Human
defense response to other organism GO:0098542 129 0.120
Human
regulation of stress activated mapk cascade GO:0032872 84 0.120
Rat
erk1 and erk2 cascade GO:0070371 104 0.119
positive regulation of protein phosphorylation GO:0001934 313 0.117
Human Rat
negative regulation of cellular protein metabolic process GO:0032269 353 0.116
positive regulation of protein kinase activity GO:0045860 190 0.116
Human Rat
apoptotic signaling pathway GO:0097190 268 0.115
Human
regulation of cytokine mediated signaling pathway GO:0001959 41 0.114
regulation of peptide hormone secretion GO:0090276 41 0.112
Human
positive regulation of cell motility GO:2000147 177 0.111
membrane protein proteolysis GO:0033619 38 0.111
Human
cytosolic calcium ion homeostasis GO:0051480 89 0.108
positive regulation of intracellular transport GO:0032388 104 0.107
Human
negative regulation of t cell cytokine production GO:0002725 4 0.107
positive regulation of neutrophil migration GO:1902624 7 0.107
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.105
regulation of granzyme a production GO:2000511 1 0.104
positive regulation of chemotaxis GO:0050921 57 0.103
granzyme a production GO:0035746 1 0.103
cytokine secretion GO:0050663 64 0.103
Human
inflammatory response to antigenic stimulus GO:0002437 4 0.102
Rat
positive regulation of leukocyte proliferation GO:0070665 48 0.101
Human
mapk cascade GO:0000165 288 0.098
Human Rat
reactive oxygen species metabolic process GO:0072593 75 0.098
digestive tract development GO:0048565 75 0.098
positive regulation of mapk cascade GO:0043410 190 0.097
Human Rat
activation of protein kinase activity GO:0032147 90 0.097
Human
leukocyte activation GO:0045321 164 0.097
Human
positive regulation of kinase activity GO:0033674 204 0.096
Human Rat
secretion by cell GO:0032940 226 0.092
Human Mouse Rat
regulation of peptidase activity GO:0052547 180 0.091
negative regulation of catalytic activity GO:0043086 335 0.090
positive regulation of transferase activity GO:0051347 227 0.089
Human Rat
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.089
Human
alcohol biosynthetic process GO:0046165 52 0.088
Human
hormone secretion GO:0046879 65 0.088
Human Mouse
cellular ketone metabolic process GO:0042180 80 0.087
response to xenobiotic stimulus GO:0009410 30 0.087
cell activation GO:0001775 213 0.086
Human
regulation of icosanoid secretion GO:0032303 4 0.086
positive regulation of t cell proliferation GO:0042102 33 0.086
Human
negative regulation of secretion by cell GO:1903531 52 0.086
Human Rat
negative regulation of developmental process GO:0051093 247 0.085
regulation of cytokine secretion GO:0050707 57 0.085
Human
hormone transport GO:0009914 68 0.085
Human Mouse
positive regulation of oxidoreductase activity GO:0051353 26 0.085
Human
positive regulation of lipid biosynthetic process GO:0046889 22 0.085
Human
regulation of lipid metabolic process GO:0019216 96 0.084
Human
reactive oxygen species biosynthetic process GO:1903409 4 0.084
protein localization to nucleus GO:0034504 136 0.083
Human
positive regulation of steroid metabolic process GO:0045940 13 0.083
Human
hematopoietic or lymphoid organ development GO:0048534 186 0.083
regulation of oxidoreductase activity GO:0051341 43 0.083
Human
positive regulation of leukocyte activation GO:0002696 80 0.082
Human
positive regulation of leukocyte migration GO:0002687 46 0.081
positive regulation of behavior GO:0048520 60 0.081
positive regulation of secretion by cell GO:1903532 108 0.081
cation transport GO:0006812 331 0.079
regulation of cellular amino acid metabolic process GO:0006521 6 0.079
negative regulation of hydrolase activity GO:0051346 182 0.079
vesicle mediated transport GO:0016192 371 0.078
protein targeting to nucleus GO:0044744 104 0.078
Human
positive regulation of cd8 positive alpha beta t cell proliferation GO:2000566 1 0.078
myeloid dendritic cell chemotaxis GO:0002408 3 0.077
nitrogen compound transport GO:0071705 191 0.077
Human Mouse Rat
positive regulation of lymphocyte activation GO:0051251 73 0.076
Human
cellular response to biotic stimulus GO:0071216 71 0.076
Human
chemokine mediated signaling pathway GO:0070098 16 0.076
interferon gamma production GO:0032609 39 0.076
Human
regulation of proteolysis GO:0030162 293 0.076
Human
regulation of reactive oxygen species metabolic process GO:2000377 41 0.075
regulation of locomotion GO:0040012 329 0.075
Rat
regulation of homeostatic process GO:0032844 121 0.075
positive regulation of catabolic process GO:0009896 310 0.074
Human
interleukin 1 beta production GO:0032611 22 0.073
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.072
regulation of cell migration GO:0030334 289 0.072
Rat
positive regulation of macrophage chemotaxis GO:0010759 3 0.072
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.072
regulation of hormone secretion GO:0046883 57 0.072
Human
positive regulation of cell differentiation GO:0045597 211 0.071
tube development GO:0035295 125 0.071
nuclear transport GO:0051169 179 0.071
Human
mitotic nuclear division GO:0007067 119 0.071
Human
regulation of hormone levels GO:0010817 125 0.071
Human Mouse
negative regulation of alpha beta t cell proliferation GO:0046642 1 0.070
regulation of cell cell adhesion GO:0022407 57 0.070
metal ion transport GO:0030001 272 0.070
endocrine process GO:0050886 25 0.069
regulation of mitosis GO:0007088 63 0.069
Human
cellular hormone metabolic process GO:0034754 41 0.069
vascular endothelial growth factor production GO:0010573 15 0.069
Human
cell cell adhesion involved in gastrulation GO:0070586 6 0.069
regulation of establishment of protein localization GO:0070201 242 0.069
Human
regulation of cell cycle process GO:0010564 266 0.069
Human
negative regulation of cell differentiation GO:0045596 171 0.069
regulation of leukocyte chemotaxis GO:0002688 46 0.068
positive regulation of cd8 positive alpha beta t cell activation GO:2001187 1 0.068
regulation of cytoplasmic transport GO:1903649 149 0.068
Human
glial cell migration GO:0008347 4 0.067
positive regulation of interferon gamma production GO:0032729 26 0.067
Human
regulation of cellular ketone metabolic process GO:0010565 50 0.066
response to radiation GO:0009314 151 0.066
regulation of astrocyte differentiation GO:0048710 3 0.066
neutrophil migration GO:1990266 25 0.065
regulation of granzyme b production GO:0071661 1 0.065
cellular divalent inorganic cation homeostasis GO:0072503 128 0.064
positive regulation of cell proliferation GO:0008284 301 0.064
Human
regulation of protein import into nucleus GO:0042306 78 0.064
Human
enzyme linked receptor protein signaling pathway GO:0007167 303 0.064
positive regulation of vitamin metabolic process GO:0046136 3 0.064
Human
activation of immune response GO:0002253 114 0.063
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.063
positive regulation of steroid biosynthetic process GO:0010893 6 0.063
Human
regulation of mapk cascade GO:0043408 262 0.062
Human Rat
response to estrogen GO:0043627 47 0.062
establishment of lymphocyte polarity GO:0001767 2 0.062
regulation of intracellular transport GO:0032386 195 0.061
Human
small gtpase mediated signal transduction GO:0007264 78 0.061
signal transduction by phosphorylation GO:0023014 297 0.061
Human Rat
establishment of protein localization to organelle GO:0072594 172 0.060
Human
myeloid leukocyte migration GO:0097529 62 0.060
regulation of multi organism process GO:0043900 157 0.060
negative regulation of cytokine production involved in immune response GO:0002719 13 0.060
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.060
Rat
granulocyte migration GO:0097530 40 0.060
positive regulation of cell migration GO:0030335 172 0.060
positive regulation of homotypic cell cell adhesion GO:0034112 4 0.060
positive regulation of gliogenesis GO:0014015 4 0.059
response to phenylpropanoid GO:0080184 1 0.059
cellular response to lipid GO:0071396 127 0.059
Human
regulation of lymphocyte proliferation GO:0050670 64 0.058
Human
regulation of lipid biosynthetic process GO:0046890 47 0.058
Human
regulation of innate immune response GO:0045088 97 0.058
regeneration GO:0031099 4 0.058
negative regulation of protein modification process GO:0031400 200 0.058
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.058
Rat
positive regulation of t cell activation GO:0050870 54 0.057
Human
granulocyte chemotaxis GO:0071621 37 0.057
lipid transport GO:0006869 90 0.057
positive regulation of protein catabolic process GO:0045732 75 0.057
Human
positive regulation of lipid metabolic process GO:0045834 50 0.057
Human
negative regulation of natural killer cell chemotaxis GO:2000502 1 0.057
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.057
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.056
leukocyte proliferation GO:0070661 74 0.055
Human
regulation of cellular response to stress GO:0080135 244 0.055
Rat
regulation of endopeptidase activity GO:0052548 170 0.055
regulation of c c chemokine binding GO:2001263 1 0.055
peptide hormone secretion GO:0030072 50 0.055
Human Mouse
interleukin 6 production GO:0032635 37 0.054
regulation of cell activation GO:0050865 125 0.054
Human
response to transition metal nanoparticle GO:1990267 29 0.054
cellular response to abiotic stimulus GO:0071214 117 0.053
Human
response to transforming growth factor beta GO:0071559 94 0.053
regulation of protein transport GO:0051223 213 0.053
Human
ribonucleotide catabolic process GO:0009261 405 0.053
negative regulation of cd4 positive alpha beta t cell proliferation GO:2000562 1 0.053
regulation of insulin secretion GO:0050796 33 0.052
Human
regulation of mononuclear cell proliferation GO:0032944 65 0.052
Human
negative regulation of apoptotic process GO:0043066 316 0.052
Human Rat
cytokine metabolic process GO:0042107 38 0.051
Human
positive regulation of cytokine secretion GO:0050715 42 0.051
positive regulation of jnk cascade GO:0046330 52 0.051
Rat
glucose homeostasis GO:0042593 31 0.050
cellular metal ion homeostasis GO:0006875 146 0.050
viral process GO:0016032 146 0.050
regulation of lymphocyte migration GO:2000401 22 0.050
cell chemotaxis GO:0060326 112 0.050
negative regulation of transferase activity GO:0051348 124 0.050
regulation of peptide secretion GO:0002791 42 0.049
Human
actin filament based process GO:0030029 224 0.049
metal ion homeostasis GO:0055065 169 0.049
alcohol metabolic process GO:0006066 114 0.049
Human
glycoprotein metabolic process GO:0009100 110 0.048
positive regulation of cell adhesion GO:0045785 84 0.048
Human
carbohydrate homeostasis GO:0033500 31 0.048
response to heat GO:0009408 21 0.047
digestive system development GO:0055123 75 0.047
cellular cation homeostasis GO:0030003 163 0.047
response to abiotic stimulus GO:0009628 336 0.047
Human
regulation of protein kinase activity GO:0045859 289 0.047
Human Rat
protein tetramerization GO:0051262 47 0.047
positive regulation of immune system process GO:0002684 283 0.047
Human
regulation of interleukin 2 production GO:0032663 19 0.047
Human
circulatory system development GO:0072359 262 0.046
positive regulation of cellular catabolic process GO:0031331 284 0.046
Human
negative regulation of transport GO:0051051 176 0.046
Human Rat
positive regulation of interleukin 8 production GO:0032757 36 0.046
Human
regulation of macrophage chemotaxis GO:0010758 4 0.046
prostaglandin transport GO:0015732 2 0.046
positive regulation of transport GO:0051050 336 0.046
Human
purine ribonucleoside catabolic process GO:0046130 398 0.045
regulation of vascular endothelial growth factor production GO:0010574 13 0.045
Human
t cell proliferation GO:0042098 45 0.045
Human
monocyte chemotactic protein 1 production GO:0071605 6 0.044
Human
activation of mapk activity GO:0000187 45 0.044
Human
ras protein signal transduction GO:0007265 73 0.044
i kappab kinase nf kappab signaling GO:0007249 166 0.043
Human
vitamin d metabolic process GO:0042359 10 0.043
Human
jnk cascade GO:0007254 80 0.043
Rat
ribonucleoside catabolic process GO:0042454 406 0.043
regulation of cell differentiation GO:0045595 393 0.043
hyaluronan metabolic process GO:0030212 15 0.043
Human
positive regulation of chemokine production GO:0032722 22 0.042
Human
multi organism cellular process GO:0044764 156 0.042
negative regulation of c c chemokine binding GO:2001264 1 0.042
negative regulation of lipid metabolic process GO:0045833 38 0.042
Human
negative regulation of intracellular signal transduction GO:1902532 183 0.042
positive regulation of response to external stimulus GO:0032103 88 0.042
positive regulation of immune response GO:0050778 159 0.042
purine containing compound catabolic process GO:0072523 411 0.042
monocyte chemotaxis GO:0002548 20 0.042
nucleoside triphosphate metabolic process GO:0009141 422 0.041
positive regulation of mitosis GO:0045840 25 0.041
Human
eosinophil mediated immunity GO:0002447 2 0.041
chemokine production GO:0032602 32 0.040
Human
leukocyte apoptotic process GO:0071887 31 0.040
cellular ion homeostasis GO:0006873 168 0.040
regulation of sensory perception of pain GO:0051930 3 0.040
mitotic cell cycle GO:0000278 326 0.040
Human
negative regulation of cd4 positive alpha beta t cell activation GO:2000515 1 0.040
positive regulation of prostaglandin secretion GO:0032308 1 0.039
epithelium development GO:0060429 227 0.039
system process GO:0003008 349 0.039
Rat
organelle fission GO:0048285 149 0.039
Human
positive regulation of map kinase activity GO:0043406 80 0.039
Human Rat
negative regulation of programmed cell death GO:0043069 321 0.039
Human Rat
astrocyte differentiation GO:0048708 4 0.039
positive regulation of jun kinase activity GO:0043507 23 0.039
Rat
cellular homeostasis GO:0019725 196 0.039
endocrine hormone secretion GO:0060986 13 0.039
cellular amine metabolic process GO:0044106 41 0.039
regulation of glial cell differentiation GO:0045685 3 0.039
regulation of protein processing GO:0070613 150 0.038
negative regulation of cell adhesion GO:0007162 64 0.038
regulation of neutrophil chemotaxis GO:0090022 10 0.038
regulation of vitamin metabolic process GO:0030656 9 0.038
Human
post embryonic development GO:0009791 2 0.037
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.037
Human
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.037
negative regulation of catabolic process GO:0009895 104 0.037
Human
regulation of glucose transport GO:0010827 23 0.037
negative regulation of phosphorus metabolic process GO:0010563 267 0.037
regulation of granulocyte chemotaxis GO:0071622 16 0.037
cyclic nucleotide metabolic process GO:0009187 82 0.036
immune response activating signal transduction GO:0002757 90 0.036
regulation of leukocyte migration GO:0002685 63 0.036
inflammatory response GO:0006954 79 0.036
negative regulation of protein maturation GO:1903318 142 0.036
positive regulation of cell division GO:0051781 59 0.036
Human
regulation of cellular amine metabolic process GO:0033238 11 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.036
response to nitrogen compound GO:1901698 184 0.036
Rat
ion homeostasis GO:0050801 230 0.036
purine nucleoside catabolic process GO:0006152 398 0.036
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.035
Human Rat
regulation of intracellular protein transport GO:0033157 123 0.035
Human
response to acid chemical GO:0001101 66 0.035
response to drug GO:0042493 81 0.035
Human Rat
negative regulation of multi organism process GO:0043901 92 0.035
zymogen activation GO:0031638 70 0.035
nuclear import GO:0051170 106 0.035
Human
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.035
Human
positive regulation of programmed cell death GO:0043068 249 0.035
nucleoside phosphate catabolic process GO:1901292 412 0.035
cellular response to external stimulus GO:0071496 111 0.035
Human
innate immune response GO:0045087 178 0.035
positive regulation of granzyme a production GO:2000513 1 0.034
response to nutrient GO:0007584 20 0.034
regulation of angiogenesis GO:0045765 92 0.034
negative regulation of peptidase activity GO:0010466 91 0.034
maintenance of location GO:0051235 112 0.034
Human
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.034
cellular calcium ion homeostasis GO:0006874 117 0.033
leukocyte mediated cytotoxicity GO:0001909 27 0.033
negative regulation of chemokine mediated signaling pathway GO:0070100 5 0.033
interleukin 1 production GO:0032612 26 0.033
organic acid biosynthetic process GO:0016053 97 0.033
negative regulation of immune system process GO:0002683 136 0.033
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.033
regulation of kinase activity GO:0043549 314 0.033
Human Rat
negative regulation of phosphate metabolic process GO:0045936 267 0.033
protein processing GO:0016485 226 0.033
regulation of cytokine production involved in immune response GO:0002718 22 0.033
cellular response to endogenous stimulus GO:0071495 336 0.033
Rat
negative regulation of t helper 1 cell activation GO:2000518 1 0.032
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.032
interleukin 8 mediated signaling pathway GO:0038112 2 0.032
single organism cellular localization GO:1902580 332 0.032
Human
purine nucleoside triphosphate metabolic process GO:0009144 412 0.032
regulation of chemotaxis GO:0050920 74 0.032
steroid biosynthetic process GO:0006694 46 0.032
Human
determination of adult lifespan GO:0008340 2 0.032
negative regulation of protein processing GO:0010955 142 0.032
regulation of release of sequestered calcium ion into cytosol GO:0051279 27 0.032
protein import GO:0017038 130 0.032
Human
response to temperature stimulus GO:0009266 22 0.032
nucleobase metabolic process GO:0009112 8 0.032
regulation of nuclear division GO:0051783 65 0.032
Human
regulation of vasculature development GO:1901342 97 0.032
phospholipid metabolic process GO:0006644 99 0.032
positive regulation of cellular component movement GO:0051272 181 0.032
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.032
embryonic morphogenesis GO:0048598 85 0.031
response to organonitrogen compound GO:0010243 156 0.031
Rat
regulation of apoptotic signaling pathway GO:2001233 175 0.031
Human
regulation of erk1 and erk2 cascade GO:0070372 99 0.031
lymphocyte chemotaxis GO:0048247 17 0.031
negative regulation of endopeptidase activity GO:0010951 84 0.031
t helper 1 cell activation GO:0035711 1 0.031
cytokine biosynthetic process GO:0042089 37 0.030
Human
purine ribonucleoside metabolic process GO:0046128 437 0.030
epithelial cell differentiation GO:0030855 141 0.030
cellular glucose homeostasis GO:0001678 11 0.030
positive regulation of gtpase activity GO:0043547 166 0.030
sequestering of triglyceride GO:0030730 11 0.030
Human
positive regulation of protein complex assembly GO:0031334 86 0.030
negative regulation of leukocyte apoptotic process GO:2000107 16 0.030
protein homooligomerization GO:0051260 100 0.030
positive regulation of cell development GO:0010720 92 0.030
lymphocyte differentiation GO:0030098 35 0.030
regulation of endothelial cell proliferation GO:0001936 56 0.030
response to hormone GO:0009725 175 0.030
lipid catabolic process GO:0016042 84 0.030
Human
purine ribonucleotide catabolic process GO:0009154 404 0.030
cell morphogenesis GO:0000902 296 0.030
actin filament organization GO:0007015 128 0.030
protein catabolic process GO:0030163 325 0.030
Human
skin development GO:0043588 76 0.030
positive regulation of hydrolase activity GO:0051345 331 0.029
regulation of chemokine mediated signaling pathway GO:0070099 6 0.029
nitric oxide biosynthetic process GO:0006809 20 0.029
Human
chemotaxis GO:0006935 157 0.029
regulation of nitric oxide biosynthetic process GO:0045428 17 0.029
Human
negative regulation of cellular component organization GO:0051129 235 0.029
protein import into nucleus GO:0006606 104 0.029
Human
response to virus GO:0009615 126 0.029
divalent inorganic cation transport GO:0072511 158 0.029
homotypic cell cell adhesion GO:0034109 47 0.029
Human
immune response regulating signaling pathway GO:0002764 97 0.029
regulation of vitamin d biosynthetic process GO:0060556 8 0.029
Human
regulation of gastrulation GO:0010470 12 0.029
negative regulation of proteolysis GO:0045861 132 0.029
immune system development GO:0002520 195 0.029
regulation of secretion by cell GO:1903530 177 0.029
Human Rat
regulation of protein targeting GO:1903533 91 0.028
Human
response to oxygen levels GO:0070482 100 0.028
neurological system process GO:0050877 163 0.028
Rat
response to hexose GO:0009746 20 0.028
defense response to fungus GO:0050832 4 0.028
Human
response to ionizing radiation GO:0010212 65 0.028
negative regulation of homeostatic process GO:0032845 59 0.028
response to fungus GO:0009620 4 0.028
Human
organophosphate catabolic process GO:0046434 430 0.028
positive regulation of nucleotide metabolic process GO:0045981 230 0.028
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.028
ion transmembrane transport GO:0034220 338 0.027
nervous system development GO:0007399 293 0.027
regulation of calcium ion transport into cytosol GO:0010522 33 0.027
granzyme b production GO:0071613 1 0.027
negative regulation of neural precursor cell proliferation GO:2000178 1 0.027
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.027
positive regulation of chemokine biosynthetic process GO:0045080 3 0.027
positive regulation of nucleotide catabolic process GO:0030813 185 0.027
estrogen metabolic process GO:0008210 6 0.027
nucleoside catabolic process GO:0009164 408 0.027
cellular response to glucose stimulus GO:0071333 10 0.027
regulation of monooxygenase activity GO:0032768 22 0.026
Human
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.026

IL1RN disease predictions

Disease DO term ID Size Probability Func Analog Org
gastrointestinal system cancer DOID:3119 52 0.090
cancer DOID:162 167 0.090
disease of cellular proliferation DOID:14566 174 0.090
organ system cancer DOID:0050686 164 0.090
disease of metabolism DOID:0014667 295 0.032