Homo sapiens

0 known processes

PHLPP2

PH domain and leucine rich repeat protein phosphatase 2

(Aliases: PHLPPL,KIAA0931)

PHLPP2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein removal GO:0070646 92 0.618
protein deubiquitination GO:0016579 79 0.517
fear response GO:0042596 0 0.155
cellular protein complex disassembly GO:0043624 36 0.138
multicellular organismal response to stress GO:0033555 1 0.136
behavioral defense response GO:0002209 0 0.105
post embryonic development GO:0009791 2 0.087
behavioral response to ethanol GO:0048149 2 0.081
amine metabolic process GO:0009308 44 0.077
cellular amine metabolic process GO:0044106 41 0.075
multicellular organismal aging GO:0010259 3 0.071
cellular ketone metabolic process GO:0042180 80 0.070
regulation of cellular ketone metabolic process GO:0010565 50 0.070
cellular homeostasis GO:0019725 196 0.068
regulation of cellular amine metabolic process GO:0033238 11 0.067
regulation of cellular amino acid metabolic process GO:0006521 6 0.067
positive regulation of cell proliferation GO:0008284 301 0.066
regulation of homeostatic process GO:0032844 121 0.062
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.059
segmentation GO:0035282 4 0.056
cellular amino acid metabolic process GO:0006520 116 0.054
cellular component disassembly GO:0022411 92 0.053
vesicle mediated transport GO:0016192 371 0.049
female gamete generation GO:0007292 2 0.046
organophosphate catabolic process GO:0046434 430 0.046
glycosyl compound catabolic process GO:1901658 413 0.045
dna repair GO:0006281 198 0.044
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.043
blastoderm segmentation GO:0007350 2 0.042
nucleoside phosphate catabolic process GO:1901292 412 0.041
cellular response to dna damage stimulus GO:0006974 379 0.041
macromolecular complex disassembly GO:0032984 60 0.041
negative regulation of cellular amine metabolic process GO:0033239 3 0.041
determination of adult lifespan GO:0008340 2 0.040
oogenesis GO:0048477 2 0.039
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.039
dephosphorylation GO:0016311 209 0.038
Rat Fly
protein dephosphorylation GO:0006470 81 0.038
Rat Fly
anterior posterior axis specification GO:0009948 2 0.038
negative regulation of protein metabolic process GO:0051248 391 0.037
protein catabolic process GO:0030163 325 0.037
oocyte differentiation GO:0009994 2 0.036
mitotic cell cycle GO:0000278 326 0.035
epithelium development GO:0060429 227 0.033
negative regulation of phosphorus metabolic process GO:0010563 267 0.033
cytoplasmic transport GO:0016482 379 0.032
cellular protein catabolic process GO:0044257 261 0.032
positive regulation of catabolic process GO:0009896 310 0.032
regulation of cell migration GO:0030334 289 0.032
oocyte development GO:0048599 1 0.031
anterior posterior axis specification embryo GO:0008595 2 0.031
modification dependent protein catabolic process GO:0019941 209 0.031
ubiquitin dependent protein catabolic process GO:0006511 206 0.031
double strand break repair GO:0006302 101 0.031
defense response GO:0006952 315 0.030
locomotory behavior GO:0007626 1 0.030
response to oxygen containing compound GO:1901700 369 0.030
protein complex disassembly GO:0043241 52 0.030
purine ribonucleotide catabolic process GO:0009154 404 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
lipid metabolic process GO:0006629 381 0.029
cell adhesion GO:0007155 325 0.029
positive regulation of cellular amine metabolic process GO:0033240 7 0.029
single organism membrane organization GO:0044802 268 0.028
membrane organization GO:0061024 292 0.028
cellular macromolecule catabolic process GO:0044265 380 0.028
tripartite regional subdivision GO:0007351 2 0.028
negative regulation of catalytic activity GO:0043086 335 0.027
regulation of cellular component movement GO:0051270 334 0.027
endomembrane system organization GO:0010256 196 0.027
negative regulation of phosphate metabolic process GO:0045936 267 0.027
cellular macromolecular complex assembly GO:0034622 324 0.027
regulation of membrane potential GO:0042391 95 0.027
negative regulation of protein modification process GO:0031400 200 0.027
modification dependent macromolecule catabolic process GO:0043632 212 0.027
cation transport GO:0006812 331 0.027
positive regulation of cellular component organization GO:0051130 376 0.027
purine containing compound catabolic process GO:0072523 411 0.026
nucleoside triphosphate metabolic process GO:0009141 422 0.026
endosomal transport GO:0016197 129 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.026
single organism cell adhesion GO:0098602 179 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.025
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.025
intracellular protein transport GO:0006886 270 0.025
negative regulation of intracellular signal transduction GO:1902532 183 0.025
regulation of cell cycle process GO:0010564 266 0.025
chemical homeostasis GO:0048878 306 0.025
cell development GO:0048468 328 0.025
regulation of cell cycle GO:0051726 393 0.025
epithelial cell differentiation GO:0030855 141 0.025
nervous system development GO:0007399 293 0.025
Rat
regulation of protein kinase activity GO:0045859 289 0.025
regulation of cell motility GO:2000145 299 0.024
skin development GO:0043588 76 0.024
purine nucleoside catabolic process GO:0006152 398 0.023
neuromuscular junction development GO:0007528 3 0.023
regulation of cellular component biogenesis GO:0044087 281 0.023
proteasomal protein catabolic process GO:0010498 176 0.023
dna replication GO:0006260 116 0.023
regulation of locomotion GO:0040012 329 0.023
covalent chromatin modification GO:0016569 254 0.023
peptidyl tyrosine phosphorylation GO:0018108 170 0.022
microtubule based process GO:0007017 210 0.022
system process GO:0003008 349 0.022
microtubule cytoskeleton organization GO:0000226 176 0.022
mitotic cell cycle process GO:1903047 286 0.022
negative regulation of phosphorylation GO:0042326 174 0.022
purine ribonucleoside metabolic process GO:0046128 437 0.021
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.021
single organism cellular localization GO:1902580 332 0.021
regulation of cell adhesion GO:0030155 166 0.020
neurological system process GO:0050877 163 0.020
positive regulation of nucleotide metabolic process GO:0045981 230 0.020
chromatin modification GO:0016568 298 0.020
posttranscriptional regulation of gene expression GO:0010608 213 0.020
morphogenesis of embryonic epithelium GO:0016331 4 0.020
cellular lipid metabolic process GO:0044255 303 0.020
actin filament based process GO:0030029 224 0.020
transmembrane transport GO:0055085 399 0.020
signal transduction by phosphorylation GO:0023014 297 0.020
negative regulation of cellular component organization GO:0051129 235 0.020
cellular protein complex assembly GO:0043623 188 0.020
secretion GO:0046903 254 0.020
apoptotic signaling pathway GO:0097190 268 0.020
metal ion transport GO:0030001 272 0.019
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
peptidyl tyrosine modification GO:0018212 170 0.019
cell cycle phase transition GO:0044770 173 0.019
cytokinesis GO:0000910 96 0.019
cell division GO:0051301 168 0.019
response to alcohol GO:0097305 64 0.019
behavioral fear response GO:0001662 0 0.019
protein modification by small protein conjugation GO:0032446 342 0.019
cell morphogenesis GO:0000902 296 0.019
behavior GO:0007610 112 0.018
nucleotide catabolic process GO:0009166 408 0.018
nucleoside triphosphate catabolic process GO:0009143 394 0.018
purine nucleoside triphosphate catabolic process GO:0009146 392 0.018
regulation of transferase activity GO:0051338 355 0.018
positive regulation of gtpase activity GO:0043547 166 0.018
positive regulation of transport GO:0051050 336 0.018
negative regulation of apoptotic process GO:0043066 316 0.018
ras protein signal transduction GO:0007265 73 0.018
regulation of mitotic cell cycle GO:0007346 189 0.018
regulation of cellular response to stress GO:0080135 244 0.018
regulation of dna metabolic process GO:0051052 153 0.018
positive regulation of programmed cell death GO:0043068 249 0.018
regulation of purine nucleotide metabolic process GO:1900542 264 0.018
single organismal cell cell adhesion GO:0016337 148 0.018
regulation of nucleoside metabolic process GO:0009118 209 0.018
actin cytoskeleton organization GO:0030036 207 0.018
ion homeostasis GO:0050801 230 0.018
histone modification GO:0016570 251 0.018
organelle assembly GO:0070925 176 0.018
purine nucleoside triphosphate metabolic process GO:0009144 412 0.017
immune response GO:0006955 307 0.017
protein maturation GO:0051604 233 0.017
striated muscle myosin thick filament assembly GO:0071688 2 0.017
tube development GO:0035295 125 0.017
endocytosis GO:0006897 159 0.017
regulation of mitosis GO:0007088 63 0.017
endosome to lysosome transport GO:0008333 21 0.017
myosin filament assembly GO:0031034 2 0.017
regeneration GO:0031099 4 0.017
negative regulation of cell death GO:0060548 345 0.017
regulation of cytoskeleton organization GO:0051493 177 0.017
regulation of protein ubiquitination GO:0031396 95 0.017
mitotic nuclear division GO:0007067 119 0.017
response to abiotic stimulus GO:0009628 336 0.017
carbohydrate derivative biosynthetic process GO:1901137 207 0.017
organelle fission GO:0048285 149 0.017
cellular component morphogenesis GO:0032989 314 0.016
spermatid differentiation GO:0048515 4 0.016
protein processing GO:0016485 226 0.016
cell projection assembly GO:0030031 126 0.016
regulation of kinase activity GO:0043549 314 0.016
mitotic cell cycle phase transition GO:0044772 162 0.016
organonitrogen compound biosynthetic process GO:1901566 200 0.016
spermatid development GO:0007286 4 0.016
positive regulation of phosphorylation GO:0042327 394 0.016
regulation of epithelial cell proliferation GO:0050678 113 0.016
positive regulation of cellular component biogenesis GO:0044089 158 0.016
gtp catabolic process GO:0006184 237 0.016
memory GO:0007613 3 0.016
nucleoside catabolic process GO:0009164 408 0.016
protein depolymerization GO:0051261 30 0.016
regulation of cell division GO:0051302 116 0.016
biological adhesion GO:0022610 331 0.016
inorganic ion transmembrane transport GO:0098660 231 0.016
nuclear division GO:0000280 128 0.016
guanosine containing compound catabolic process GO:1901069 239 0.016
regulation of protein localization GO:0032880 296 0.016
epithelial cell proliferation GO:0050673 128 0.016
positive regulation of epithelial cell proliferation GO:0050679 65 0.015
negative regulation of programmed cell death GO:0043069 321 0.015
regulation of cell cell adhesion GO:0022407 57 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.015
positive regulation of organelle organization GO:0010638 195 0.015
plasma membrane organization GO:0007009 115 0.015
regulation of proteolysis GO:0030162 293 0.015
regulation of vesicle mediated transport GO:0060627 130 0.015
negative regulation of protein phosphorylation GO:0001933 140 0.015
protein localization to plasma membrane GO:0072659 93 0.015
ion transmembrane transport GO:0034220 338 0.015
adult locomotory behavior GO:0008344 1 0.015
associative learning GO:0008306 1 0.015
cation transmembrane transport GO:0098655 238 0.015
myosin filament organization GO:0031033 2 0.015
regulation of ras protein signal transduction GO:0046578 155 0.015
regulation of anatomical structure morphogenesis GO:0022603 286 0.014
positive regulation of nucleoside metabolic process GO:0045979 186 0.014
ameboidal type cell migration GO:0001667 135 0.014
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.014
sensory perception GO:0007600 103 0.014
response to radiation GO:0009314 151 0.014
protein ubiquitination GO:0016567 314 0.014
regulation of immune response GO:0050776 201 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
carbohydrate metabolic process GO:0005975 207 0.014
regulation of mapk cascade GO:0043408 262 0.014
actin filament organization GO:0007015 128 0.014
cellular response to oxygen containing compound GO:1901701 276 0.014
ribonucleoside triphosphate metabolic process GO:0009199 412 0.014
regulation of apoptotic signaling pathway GO:2001233 175 0.014
negative regulation of multicellular organismal process GO:0051241 317 0.014
cellular chemical homeostasis GO:0055082 180 0.014
cellular component assembly involved in morphogenesis GO:0010927 73 0.014
regulation of nucleotide metabolic process GO:0006140 269 0.014
reactive oxygen species biosynthetic process GO:1903409 4 0.014
positive regulation of immune system process GO:0002684 283 0.014
negative regulation of protein kinase b signaling GO:0051898 17 0.014
peripheral nervous system development GO:0007422 2 0.014
negative regulation of transport GO:0051051 176 0.014
divalent metal ion transport GO:0070838 152 0.014
rhythmic behavior GO:0007622 2 0.014
nitrogen compound transport GO:0071705 191 0.014
gtp metabolic process GO:0046039 239 0.014
regulation of cell growth GO:0001558 135 0.014
negative regulation of cell adhesion GO:0007162 64 0.013
carboxylic acid biosynthetic process GO:0046394 97 0.013
cell projection organization GO:0030030 252 0.013
sister chromatid segregation GO:0000819 54 0.013
mitotic sister chromatid segregation GO:0000070 53 0.013
regulation of chromosome organization GO:0033044 103 0.013
protein localization to membrane GO:0072657 160 0.013
neurotransmitter secretion GO:0007269 4 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
cation homeostasis GO:0055080 189 0.013
negative regulation of cell proliferation GO:0008285 228 0.013
negative regulation of dna metabolic process GO:0051053 57 0.013
mapk cascade GO:0000165 288 0.013
cellular response to abiotic stimulus GO:0071214 117 0.013
mitotic sister chromatid separation GO:0051306 18 0.013
enzyme linked receptor protein signaling pathway GO:0007167 303 0.013
regulation of protein maturation GO:1903317 150 0.013
cell projection morphogenesis GO:0048858 129 0.013
nerve development GO:0021675 4 0.013
notch signaling pathway GO:0007219 31 0.013
reproductive process GO:0022414 106 0.013
compound eye development GO:0048749 1 0.013
motor neuron axon guidance GO:0008045 2 0.013
establishment of protein localization to membrane GO:0090150 121 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.012
positive regulation of developmental process GO:0051094 314 0.012
inorganic cation transmembrane transport GO:0098662 194 0.012
regulation of protein kinase b signaling GO:0051896 61 0.012
regulation of secretion GO:0051046 194 0.012
ribonucleoside catabolic process GO:0042454 406 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
small gtpase mediated signal transduction GO:0007264 78 0.012
response to growth factor GO:0070848 205 0.012
anion transport GO:0006820 161 0.012
forebrain development GO:0030900 26 0.012
Rat
glial cell migration GO:0008347 4 0.012
hippocampus development GO:0021766 1 0.012
Rat
limbic system development GO:0021761 3 0.012
Rat
metaphase anaphase transition of cell cycle GO:0044784 21 0.012
negative regulation of proteolysis GO:0045861 132 0.012
oxidation reduction process GO:0055114 396 0.012
positive regulation of cell death GO:0010942 263 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
negative regulation of cell cycle GO:0045786 193 0.012
cellular cation homeostasis GO:0030003 163 0.012
positive regulation of cell migration GO:0030335 172 0.012
regulation of neural precursor cell proliferation GO:2000177 4 0.012
purine nucleotide catabolic process GO:0006195 405 0.012
protein localization to organelle GO:0033365 280 0.012
cellular ion homeostasis GO:0006873 168 0.012
response to ethanol GO:0045471 11 0.012
organelle localization GO:0051640 84 0.012
chromosome segregation GO:0007059 114 0.012
jak stat cascade GO:0007259 46 0.012
dna recombination GO:0006310 77 0.012
positive regulation of cell differentiation GO:0045597 211 0.011
protein kinase c signaling GO:0070528 17 0.011
negative regulation of organelle organization GO:0010639 126 0.011
rho protein signal transduction GO:0007266 26 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
generation of neurons GO:0048699 152 0.011
mating GO:0007618 1 0.011
divalent inorganic cation transport GO:0072511 158 0.011
regulation of intracellular transport GO:0032386 195 0.011
protein oligomerization GO:0051259 173 0.011
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.011
neurogenesis GO:0022008 169 0.011
response to light stimulus GO:0009416 87 0.011
growth GO:0040007 202 0.011
single organism carbohydrate metabolic process GO:0044723 193 0.011
taxis GO:0042330 157 0.011
monocarboxylic acid metabolic process GO:0032787 185 0.011
chromosome separation GO:0051304 23 0.011
regulation of cell morphogenesis GO:0022604 153 0.011
positive regulation of cellular catabolic process GO:0031331 284 0.011
regulation of protein processing GO:0070613 150 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
positive regulation of cytoskeleton organization GO:0051495 83 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.011
intrinsic apoptotic signaling pathway GO:0097193 127 0.011
response to fungus GO:0009620 4 0.011
chromatin organization GO:0006325 351 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
cell cell junction organization GO:0045216 69 0.011
sensory perception of smell GO:0007608 2 0.011
protein monoubiquitination GO:0006513 39 0.011
positive regulation of cellular component movement GO:0051272 181 0.011
ribonucleoside monophosphate metabolic process GO:0009161 187 0.011
rna interference GO:0016246 4 0.011
response to cytokine GO:0034097 232 0.011
regulation of establishment of protein localization GO:0070201 242 0.011
response to lipid GO:0033993 206 0.011
organophosphate biosynthetic process GO:0090407 163 0.011
blood vessel development GO:0001568 172 0.011
positive regulation of hydrolase activity GO:0051345 331 0.011
regulation of dna replication GO:0006275 68 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.011
blood vessel morphogenesis GO:0048514 162 0.011
lysosomal transport GO:0007041 33 0.011
negative regulation of transferase activity GO:0051348 124 0.011
purine nucleoside monophosphate metabolic process GO:0009126 186 0.011
i kappab kinase nf kappab signaling GO:0007249 166 0.011
meiosis i GO:0007127 4 0.011
regulation of response to dna damage stimulus GO:2001020 94 0.011
response to nitrogen compound GO:1901698 184 0.011
photoreceptor cell differentiation GO:0046530 2 0.011
metal ion homeostasis GO:0055065 169 0.010
cellular metal ion homeostasis GO:0006875 146 0.010
innate immune response GO:0045087 178 0.010
regulation of cysteine type endopeptidase activity GO:2000116 127 0.010
positive regulation of synaptic transmission GO:0050806 4 0.010
regulation of ion transport GO:0043269 189 0.010
regulation of gtp catabolic process GO:0033124 180 0.010
regulation of nucleotide catabolic process GO:0030811 205 0.010
alcohol metabolic process GO:0006066 114 0.010
negative regulation of hydrolase activity GO:0051346 182 0.010
regulation of endopeptidase activity GO:0052548 170 0.010
cell fate determination GO:0001709 3 0.010
cell part morphogenesis GO:0032990 137 0.010
circadian behavior GO:0048512 2 0.010
regulation of protein transport GO:0051223 213 0.010
mitochondrion organization GO:0007005 156 0.010
cerebellum development GO:0021549 2 0.010
regulation of lymphocyte migration GO:2000401 22 0.010
regulation of protein catabolic process GO:0042176 155 0.010
negative regulation of protein processing GO:0010955 142 0.010
positive regulation of endocytosis GO:0045807 42 0.010
interspecies interaction between organisms GO:0044419 156 0.010
phospholipid metabolic process GO:0006644 99 0.010
leukocyte migration GO:0050900 107 0.010
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 18 0.010
reactive nitrogen species metabolic process GO:2001057 3 0.010
hippo signaling GO:0035329 20 0.010
maintenance of location GO:0051235 112 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.010
sensory perception of pain GO:0019233 4 0.010
regulation of peptidase activity GO:0052547 180 0.010
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.010
lipid biosynthetic process GO:0008610 177 0.010

PHLPP2 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.051
nervous system disease DOID:863 431 0.051
auditory system disease DOID:2742 53 0.023
nonsyndromic deafness DOID:0050563 50 0.023
disease of metabolism DOID:0014667 295 0.023
central nervous system disease DOID:331 186 0.021
inherited metabolic disorder DOID:655 242 0.015
autosomal recessive nonsyndromic deafness DOID:0050565 33 0.015
cancer DOID:162 167 0.014
disease of cellular proliferation DOID:14566 174 0.014
organ system cancer DOID:0050686 164 0.014
musculoskeletal system disease DOID:17 223 0.014
eye and adnexa disease DOID:1492 150 0.013
eye disease DOID:5614 149 0.013
neurodegenerative disease DOID:1289 102 0.010