Homo sapiens

149 known processes

P2RX4

purinergic receptor P2X, ligand-gated ion channel, 4

(Aliases: P2X4,P2X4R)

P2RX4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular amino acid metabolic process GO:0006521 6 0.077
lipid metabolic process GO:0006629 381 0.074
cation transport GO:0006812 331 0.069
cellular amino acid metabolic process GO:0006520 116 0.068
cellular amine metabolic process GO:0044106 41 0.062
negative regulation of dendritic cell differentiation GO:2001199 2 0.061
amine metabolic process GO:0009308 44 0.057
carbohydrate metabolic process GO:0005975 207 0.055
regulation of cellular amine metabolic process GO:0033238 11 0.053
system process GO:0003008 349 0.051
single organism carbohydrate metabolic process GO:0044723 193 0.051
post embryonic development GO:0009791 2 0.050
cellular ketone metabolic process GO:0042180 80 0.050
regulation of cellular ketone metabolic process GO:0010565 50 0.047
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.043
cellular lipid metabolic process GO:0044255 303 0.041
locomotory behavior GO:0007626 1 0.040
positive regulation of phosphorylation GO:0042327 394 0.038
multicellular organismal aging GO:0010259 3 0.038
metal ion transport GO:0030001 272 0.036
cell projection organization GO:0030030 252 0.035
Human
determination of adult lifespan GO:0008340 2 0.034
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.033
single organism cellular localization GO:1902580 332 0.033
regulation of transferase activity GO:0051338 355 0.033
biological adhesion GO:0022610 331 0.032
immune response GO:0006955 307 0.031
positive regulation of cellular amine metabolic process GO:0033240 7 0.031
anion transport GO:0006820 161 0.031
antigen processing and presentation via mhc class ib GO:0002475 3 0.031
cellular chemical homeostasis GO:0055082 180 0.030
positive regulation of transport GO:0051050 336 0.030
cytoplasmic transport GO:0016482 379 0.029
negative regulation of programmed cell death GO:0043069 321 0.029
cell adhesion GO:0007155 325 0.029
response to other organism GO:0051707 261 0.029
protein localization to organelle GO:0033365 280 0.028
regulation of secretion GO:0051046 194 0.028
Human
sensory perception of bitter taste GO:0050913 28 0.028
negative regulation of multicellular organismal process GO:0051241 317 0.027
regulation of regulatory t cell differentiation GO:0045589 4 0.027
nucleoside catabolic process GO:0009164 408 0.027
cellular macromolecule catabolic process GO:0044265 380 0.026
positive regulation of protein phosphorylation GO:0001934 313 0.026
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
single organism membrane organization GO:0044802 268 0.026
regulation of protein kinase activity GO:0045859 289 0.026
vacuole organization GO:0007033 44 0.026
small gtpase mediated signal transduction GO:0007264 78 0.025
positive regulation of protein kinase activity GO:0045860 190 0.025
response to abiotic stimulus GO:0009628 336 0.025
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.025
response to biotic stimulus GO:0009607 276 0.025
regulation of kinase activity GO:0043549 314 0.025
chemical homeostasis GO:0048878 306 0.024
cellular ion homeostasis GO:0006873 168 0.024
intracellular protein transport GO:0006886 270 0.024
epithelium development GO:0060429 227 0.024
peripheral nervous system development GO:0007422 2 0.024
negative regulation of cellular amine metabolic process GO:0033239 3 0.024
cation transmembrane transport GO:0098655 238 0.024
cytokine production GO:0001816 247 0.024
Human
negative regulation of apoptotic process GO:0043066 316 0.024
negative regulation of catalytic activity GO:0043086 335 0.024
memory GO:0007613 3 0.023
cellular homeostasis GO:0019725 196 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.023
cell morphogenesis GO:0000902 296 0.023
response to oxygen containing compound GO:1901700 369 0.023
immune system development GO:0002520 195 0.023
defense response GO:0006952 315 0.023
signal transduction by phosphorylation GO:0023014 297 0.023
positive regulation of transferase activity GO:0051347 227 0.022
innate immune response GO:0045087 178 0.022
membrane organization GO:0061024 292 0.022
regulation of cell differentiation GO:0045595 393 0.022
anatomical structure homeostasis GO:0060249 100 0.022
neurological system process GO:0050877 163 0.022
Human Rat
nucleoside phosphate catabolic process GO:1901292 412 0.022
glycosyl compound catabolic process GO:1901658 413 0.022
female gamete generation GO:0007292 2 0.022
negative regulation of phosphorus metabolic process GO:0010563 267 0.022
organic hydroxy compound metabolic process GO:1901615 147 0.021
nervous system development GO:0007399 293 0.021
regulation of cellular response to stress GO:0080135 244 0.021
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.021
detection of chemical stimulus GO:0009593 55 0.021
transmembrane transport GO:0055085 399 0.021
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.021
purine containing compound catabolic process GO:0072523 411 0.021
nucleotide catabolic process GO:0009166 408 0.021
hematopoietic or lymphoid organ development GO:0048534 186 0.021
negative regulation of protein metabolic process GO:0051248 391 0.021
mapk cascade GO:0000165 288 0.021
carboxylic acid transport GO:0046942 63 0.021
mitotic cell cycle GO:0000278 326 0.021
positive regulation of kinase activity GO:0033674 204 0.021
cation homeostasis GO:0055080 189 0.021
purine ribonucleoside metabolic process GO:0046128 437 0.020
negative regulation of cell proliferation GO:0008285 228 0.020
regulation of anatomical structure morphogenesis GO:0022603 286 0.020
ribonucleoside catabolic process GO:0042454 406 0.020
proteasomal protein catabolic process GO:0010498 176 0.020
secretion GO:0046903 254 0.020
Human
microtubule based process GO:0007017 210 0.020
positive regulation of cytokine production GO:0001819 167 0.020
Human
oogenesis GO:0048477 2 0.020
cellular component morphogenesis GO:0032989 314 0.020
oxidation reduction process GO:0055114 396 0.020
regulation of cytokine production GO:0001817 232 0.020
Human
negative regulation of cell death GO:0060548 345 0.020
organic anion transport GO:0015711 103 0.020
inorganic ion transmembrane transport GO:0098660 231 0.020
segmentation GO:0035282 4 0.020
alcohol metabolic process GO:0006066 114 0.020
cellular response to endogenous stimulus GO:0071495 336 0.019
mating GO:0007618 1 0.019
protein modification by small protein conjugation GO:0032446 342 0.019
nucleoside triphosphate metabolic process GO:0009141 422 0.019
purine nucleoside triphosphate metabolic process GO:0009144 412 0.019
ion homeostasis GO:0050801 230 0.019
epithelial cell proliferation GO:0050673 128 0.019
cellular protein catabolic process GO:0044257 261 0.019
protein maturation GO:0051604 233 0.019
lipid catabolic process GO:0016042 84 0.019
peptidyl tyrosine modification GO:0018212 170 0.019
ion transmembrane transport GO:0034220 338 0.019
ubiquitin dependent protein catabolic process GO:0006511 206 0.019
hemopoiesis GO:0030097 180 0.019
ras protein signal transduction GO:0007265 73 0.019
actin filament based process GO:0030029 224 0.019
vesicle mediated transport GO:0016192 371 0.019
negative regulation of developmental process GO:0051093 247 0.019
positive regulation of cellular component organization GO:0051130 376 0.019
positive regulation of developmental process GO:0051094 314 0.019
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.019
regulation of protein localization GO:0032880 296 0.019
Human
sensory perception of taste GO:0050909 36 0.018
negative regulation of intracellular signal transduction GO:1902532 183 0.018
carbohydrate derivative biosynthetic process GO:1901137 207 0.018
purine ribonucleoside catabolic process GO:0046130 398 0.018
immune response inhibiting cell surface receptor signaling pathway GO:0002767 4 0.018
response to external biotic stimulus GO:0043207 261 0.018
organophosphate catabolic process GO:0046434 430 0.018
secretion by cell GO:0032940 226 0.018
Human
growth GO:0040007 202 0.018
regulation of dendritic cell differentiation GO:2001198 3 0.018
negative regulation of phosphate metabolic process GO:0045936 267 0.018
regulation of nucleotide metabolic process GO:0006140 269 0.018
positive regulation of immune system process GO:0002684 283 0.018
cellular macromolecular complex assembly GO:0034622 324 0.018
blastoderm segmentation GO:0007350 2 0.018
rho protein signal transduction GO:0007266 26 0.018
regulation of immune response GO:0050776 201 0.018
gtp metabolic process GO:0046039 239 0.017
protein localization to membrane GO:0072657 160 0.017
enzyme linked receptor protein signaling pathway GO:0007167 303 0.017
monovalent inorganic cation transport GO:0015672 128 0.017
Rat
dephosphorylation GO:0016311 209 0.017
ribonucleoside triphosphate metabolic process GO:0009199 412 0.017
nucleoside triphosphate catabolic process GO:0009143 394 0.017
positive regulation of regulatory t cell differentiation GO:0045591 3 0.017
ribonucleoside triphosphate catabolic process GO:0009203 391 0.017
inorganic cation transmembrane transport GO:0098662 194 0.017
positive regulation of cellular catabolic process GO:0031331 284 0.017
organonitrogen compound biosynthetic process GO:1901566 200 0.017
regulation of cell motility GO:2000145 299 0.017
regulation of cell migration GO:0030334 289 0.017
regulation of defense response GO:0031347 154 0.017
metal ion homeostasis GO:0055065 169 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.017
regulation of mapk cascade GO:0043408 262 0.017
maintenance of location GO:0051235 112 0.016
regeneration GO:0031099 4 0.016
regulation of purine nucleotide metabolic process GO:1900542 264 0.016
regulation of establishment of protein localization GO:0070201 242 0.016
Human
purine ribonucleotide catabolic process GO:0009154 404 0.016
positive regulation of synaptic transmission GO:0050806 4 0.016
neurotransmitter secretion GO:0007269 4 0.016
negative regulation of hydrolase activity GO:0051346 182 0.016
positive regulation of cell differentiation GO:0045597 211 0.016
positive regulation of mapk cascade GO:0043410 190 0.016
protein catabolic process GO:0030163 325 0.016
ribonucleotide catabolic process GO:0009261 405 0.016
generation of neurons GO:0048699 152 0.016
positive regulation of hydrolase activity GO:0051345 331 0.016
lytic vacuole organization GO:0080171 24 0.016
nitrogen compound transport GO:0071705 191 0.016
positive regulation of cell death GO:0010942 263 0.016
regulation of cellular component movement GO:0051270 334 0.016
response to bacterium GO:0009617 144 0.016
protein targeting GO:0006605 187 0.016
purine nucleoside triphosphate catabolic process GO:0009146 392 0.016
positive regulation of catabolic process GO:0009896 310 0.016
purine nucleoside catabolic process GO:0006152 398 0.016
neuromuscular junction development GO:0007528 3 0.015
regulation of ion transport GO:0043269 189 0.015
detection of stimulus GO:0051606 85 0.015
protein processing GO:0016485 226 0.015
purine nucleotide catabolic process GO:0006195 405 0.015
small molecule biosynthetic process GO:0044283 157 0.015
regulation of locomotion GO:0040012 329 0.015
modification dependent macromolecule catabolic process GO:0043632 212 0.015
divalent inorganic cation homeostasis GO:0072507 136 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
reactive nitrogen species metabolic process GO:2001057 3 0.015
positive regulation of immune response GO:0050778 159 0.015
cellular amide metabolic process GO:0043603 69 0.015
cell growth GO:0016049 160 0.015
organic acid transport GO:0015849 65 0.015
divalent inorganic cation transport GO:0072511 158 0.015
organophosphate biosynthetic process GO:0090407 163 0.015
regulation of cell adhesion GO:0030155 166 0.014
liposaccharide metabolic process GO:1903509 27 0.014
sphingolipid metabolic process GO:0006665 38 0.014
actin cytoskeleton organization GO:0030036 207 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
spermatid differentiation GO:0048515 4 0.014
positive regulation of organelle organization GO:0010638 195 0.014
regulation of cell cycle GO:0051726 393 0.014
positive regulation of cell activation GO:0050867 81 0.014
cell development GO:0048468 328 0.014
morphogenesis of a polarized epithelium GO:0001738 3 0.014
positive regulation of defense response GO:0031349 87 0.014
immune response regulating signaling pathway GO:0002764 97 0.014
cellular response to dna damage stimulus GO:0006974 379 0.014
neurogenesis GO:0022008 169 0.014
lymphocyte activation GO:0046649 133 0.014
motor neuron axon guidance GO:0008045 2 0.014
cellular cation homeostasis GO:0030003 163 0.014
actin filament based movement GO:0030048 17 0.014
regulation of response to external stimulus GO:0032101 222 0.013
regulation of protein maturation GO:1903317 150 0.013
adult locomotory behavior GO:0008344 1 0.013
cellular protein complex assembly GO:0043623 188 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.013
modification dependent protein catabolic process GO:0019941 209 0.013
response to growth factor GO:0070848 205 0.013
mitotic cell cycle process GO:1903047 286 0.013
nerve development GO:0021675 4 0.013
cell projection assembly GO:0030031 126 0.013
Human
multicellular organismal homeostasis GO:0048871 67 0.013
actin mediated cell contraction GO:0070252 12 0.013
protein ubiquitination GO:0016567 314 0.013
regulation of protein transport GO:0051223 213 0.013
Human
negative regulation of immune system process GO:0002683 136 0.013
reactive oxygen species biosynthetic process GO:1903409 4 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.013
reactive oxygen species metabolic process GO:0072593 75 0.013
lysosome organization GO:0007040 24 0.013
establishment of planar polarity GO:0001736 3 0.013
tissue homeostasis GO:0001894 63 0.013
regulation of proteolysis GO:0030162 293 0.013
organic acid biosynthetic process GO:0016053 97 0.013
negative regulation of cell cycle GO:0045786 193 0.013
protein oligomerization GO:0051259 173 0.013
Human Rat
regulation of cell cycle process GO:0010564 266 0.012
endomembrane system organization GO:0010256 196 0.012
blastocyst development GO:0001824 3 0.012
circulatory system development GO:0072359 262 0.012
monocarboxylic acid metabolic process GO:0032787 185 0.012
t cell tolerance induction GO:0002517 4 0.012
head development GO:0060322 108 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
leukocyte differentiation GO:0002521 98 0.012
positive regulation of innate immune response GO:0045089 79 0.012
positive regulation of locomotion GO:0040017 186 0.012
cellular lipid catabolic process GO:0044242 65 0.012
cardiac muscle cell contraction GO:0086003 4 0.012
organelle assembly GO:0070925 176 0.012
response to axon injury GO:0048678 1 0.012
cell projection morphogenesis GO:0048858 129 0.012
positive regulation of nucleoside metabolic process GO:0045979 186 0.012
regulation of cell activation GO:0050865 125 0.012
spermatid development GO:0007286 4 0.012
purine containing compound biosynthetic process GO:0072522 88 0.012
glial cell migration GO:0008347 4 0.012
cell type specific apoptotic process GO:0097285 125 0.012
regulation of cytoskeleton organization GO:0051493 177 0.012
establishment of protein localization to membrane GO:0090150 121 0.012
regulation of protein serine threonine kinase activity GO:0071900 179 0.012
regulation of synaptic plasticity GO:0048167 3 0.012
regulation of peptidase activity GO:0052547 180 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.012
oocyte development GO:0048599 1 0.012
salivary gland morphogenesis GO:0007435 4 0.012
single organism cell adhesion GO:0098602 179 0.012
oocyte differentiation GO:0009994 2 0.012
regulation of protein catabolic process GO:0042176 155 0.012
endosomal transport GO:0016197 129 0.012
positive regulation of t cell tolerance induction GO:0002666 2 0.012
prostate gland development GO:0030850 3 0.012
apoptotic signaling pathway GO:0097190 268 0.012
regulation of cellular component biogenesis GO:0044087 281 0.012
cell cycle phase transition GO:0044770 173 0.012
wnt signaling pathway GO:0016055 156 0.012
sulfur compound metabolic process GO:0006790 101 0.011
negative regulation of proteolysis GO:0045861 132 0.011
regulation of vesicle mediated transport GO:0060627 130 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.011
regulation of protein processing GO:0070613 150 0.011
cellular metal ion homeostasis GO:0006875 146 0.011
guanosine containing compound metabolic process GO:1901068 244 0.011
immune effector process GO:0002252 159 0.011
sensory perception of pain GO:0019233 4 0.011
Rat
compound eye development GO:0048749 1 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.011
peptidyl tyrosine phosphorylation GO:0018108 170 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
sex determination GO:0007530 3 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
protein acylation GO:0043543 138 0.011
hindbrain development GO:0030902 3 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
monosaccharide metabolic process GO:0005996 74 0.011
establishment of tissue polarity GO:0007164 3 0.011
protein glycosylation GO:0006486 62 0.011
regulation of lipid metabolic process GO:0019216 96 0.011
nucleoside phosphate biosynthetic process GO:1901293 109 0.011
lipid biosynthetic process GO:0008610 177 0.011
inner ear morphogenesis GO:0042472 4 0.011
anterior posterior axis specification GO:0009948 2 0.011
negative regulation of protein processing GO:0010955 142 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
glycoprotein biosynthetic process GO:0009101 91 0.011
cellular response to organonitrogen compound GO:0071417 124 0.011
epithelial cell differentiation GO:0030855 141 0.011
nucleoside monophosphate metabolic process GO:0009123 191 0.011
cell fate determination GO:0001709 3 0.011
amino acid transport GO:0006865 28 0.011
sensory perception GO:0007600 103 0.011
Human Rat
regulation of immune effector process GO:0002697 91 0.011
ribonucleoside monophosphate metabolic process GO:0009161 187 0.011
response to organic cyclic compound GO:0014070 204 0.011
gtp catabolic process GO:0006184 237 0.011
detection of external biotic stimulus GO:0098581 19 0.011
regulation of growth GO:0040008 165 0.011
rhythmic behavior GO:0007622 2 0.011
regulation of neural precursor cell proliferation GO:2000177 4 0.011
response to wounding GO:0009611 168 0.011
positive regulation of cell motility GO:2000147 177 0.011
regulation of actin cytoskeleton organization GO:0032956 116 0.011
plasma membrane organization GO:0007009 115 0.011
long term memory GO:0007616 2 0.011
regulation of nucleoside metabolic process GO:0009118 209 0.011
regulation of cell growth GO:0001558 135 0.011
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.011
anatomical structure formation involved in morphogenesis GO:0048646 284 0.011
lipid transport GO:0006869 90 0.011
metencephalon development GO:0022037 2 0.011
positive regulation of cellular component biogenesis GO:0044089 158 0.011
regulation of cell projection organization GO:0031344 107 0.010
negative regulation of protein modification process GO:0031400 200 0.010
carboxylic acid biosynthetic process GO:0046394 97 0.010
rna processing GO:0006396 255 0.010
nucleotide biosynthetic process GO:0009165 109 0.010
regulation of apoptotic signaling pathway GO:2001233 175 0.010
carbohydrate catabolic process GO:0016052 36 0.010
cellular response to oxidative stress GO:0034599 85 0.010
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.010
atp metabolic process GO:0046034 176 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.010
regulation of small gtpase mediated signal transduction GO:0051056 156 0.010
regulation of wnt signaling pathway GO:0030111 123 0.010
i kappab kinase nf kappab signaling GO:0007249 166 0.010
cellular calcium ion homeostasis GO:0006874 117 0.010
protein autophosphorylation GO:0046777 123 0.010
cell part morphogenesis GO:0032990 137 0.010
mitochondrion organization GO:0007005 156 0.010
regulation of homeostatic process GO:0032844 121 0.010
response to lipid GO:0033993 206 0.010
neuron differentiation GO:0030182 138 0.010
regulation of dephosphorylation GO:0035303 96 0.010
neuroblast proliferation GO:0007405 4 0.010
macromolecule glycosylation GO:0043413 63 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.010
muscle cell cellular homeostasis GO:0046716 3 0.010
mitotic cell cycle phase transition GO:0044772 162 0.010
negative regulation of transferase activity GO:0051348 124 0.010
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.010
regulation of t cell tolerance induction GO:0002664 4 0.010
divalent metal ion transport GO:0070838 152 0.010
anterior posterior axis specification embryo GO:0008595 2 0.010
glycoprotein metabolic process GO:0009100 110 0.010
cell division GO:0051301 168 0.010
negative regulation of cell differentiation GO:0045596 171 0.010

P2RX4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.250
inherited metabolic disorder DOID:655 242 0.250
lysosomal storage disease DOID:3211 47 0.099
central nervous system disease DOID:331 186 0.039
nervous system disease DOID:863 431 0.039
immune system disease DOID:2914 155 0.029
lipid storage disease DOID:9455 28 0.026
disease of cellular proliferation DOID:14566 174 0.024
musculoskeletal system disease DOID:17 223 0.022
cancer DOID:162 167 0.020
organ system cancer DOID:0050686 164 0.020
sensory system disease DOID:0050155 203 0.015
brain disease DOID:936 73 0.014
eye and adnexa disease DOID:1492 150 0.014
eye disease DOID:5614 149 0.014
neuronal ceroid lipofuscinosis DOID:14503 11 0.014
neurodegenerative disease DOID:1289 102 0.011
retinal disease DOID:5679 118 0.011
retinal degeneration DOID:8466 89 0.011
connective tissue disease DOID:65 109 0.011
cardiovascular system disease DOID:1287 106 0.010