Homo sapiens

61 known processes

SHARPIN

SHANK-associated RH domain interactor

(Aliases: SIPL1,DKFZp434N1923)

SHARPIN biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
single organism cellular localization GO:1902580 332 0.116
regulation of cd40 signaling pathway GO:2000348 3 0.112
regulation of protein localization GO:0032880 296 0.112
oogenesis GO:0048477 2 0.097
immune response GO:0006955 307 0.096
Human
negative regulation of programmed cell death GO:0043069 321 0.092
apoptotic signaling pathway GO:0097190 268 0.091
positive regulation of programmed cell death GO:0043068 249 0.087
nitrogen compound transport GO:0071705 191 0.085
female gamete generation GO:0007292 2 0.084
regulation of cellular amine metabolic process GO:0033238 11 0.084
positive regulation of cell death GO:0010942 263 0.074
response to axon injury GO:0048678 1 0.073
positive regulation of immune response GO:0050778 159 0.073
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.067
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.064
cellular amino acid metabolic process GO:0006520 116 0.064
positive regulation of cellular amine metabolic process GO:0033240 7 0.064
regulation of establishment of protein localization GO:0070201 242 0.062
positive regulation of apoptotic process GO:0043065 246 0.062
regulation of cellular amino acid metabolic process GO:0006521 6 0.059
cellular ketone metabolic process GO:0042180 80 0.058
protein targeting GO:0006605 187 0.057
i kappab kinase nf kappab signaling GO:0007249 166 0.057
cellular amine metabolic process GO:0044106 41 0.056
protein catabolic process GO:0030163 325 0.055
Human
regulation of cellular ketone metabolic process GO:0010565 50 0.052
modification dependent macromolecule catabolic process GO:0043632 212 0.051
Human
post embryonic development GO:0009791 2 0.050
positive regulation of immune system process GO:0002684 283 0.050
Human
regulation of immune response GO:0050776 201 0.049
Human
response to oxygen containing compound GO:1901700 369 0.049
modification dependent protein catabolic process GO:0019941 209 0.048
Human
negative regulation of cell proliferation GO:0008285 228 0.047
behavioral response to ethanol GO:0048149 2 0.047
cellular response to external stimulus GO:0071496 111 0.046
dephosphorylation GO:0016311 209 0.044
carbohydrate derivative biosynthetic process GO:1901137 207 0.043
epithelium development GO:0060429 227 0.041
Mouse
oocyte development GO:0048599 1 0.041
amine metabolic process GO:0009308 44 0.040
regulation of necroptotic process GO:0060544 7 0.040
regulation of cellular component biogenesis GO:0044087 281 0.039
segmentation GO:0035282 4 0.039
neuromuscular junction development GO:0007528 3 0.038
peptidyl serine phosphorylation GO:0018105 101 0.038
response to organic cyclic compound GO:0014070 204 0.038
positive regulation of phagocytosis engulfment GO:0060100 1 0.038
response to decreased oxygen levels GO:0036293 96 0.037
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.036
Human
cytoplasmic transport GO:0016482 379 0.036
positive regulation of developmental process GO:0051094 314 0.036
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.036
Human
regulation of transmission of nerve impulse GO:0051969 2 0.036
oocyte differentiation GO:0009994 2 0.035
regulation of peptidase activity GO:0052547 180 0.035
sensory perception of smell GO:0007608 2 0.035
epithelium migration GO:0090132 119 0.034
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.033
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.033
Human
cellular response to cytokine stimulus GO:0071345 181 0.033
negative regulation of protein metabolic process GO:0051248 391 0.033
programmed necrotic cell death GO:0097300 18 0.032
cell morphogenesis GO:0000902 296 0.032
protein import GO:0017038 130 0.031
ectoderm development GO:0007398 3 0.031
regulation of apoptotic signaling pathway GO:2001233 175 0.031
cellular response to tumor necrosis factor GO:0071356 63 0.030
regulation of endopeptidase activity GO:0052548 170 0.030
embryonic morphogenesis GO:0048598 85 0.029
response to hypoxia GO:0001666 96 0.029
regulation of protein transport GO:0051223 213 0.029
positive regulation of transport GO:0051050 336 0.029
immune response activating signal transduction GO:0002757 90 0.029
Human
negative regulation of cellular protein metabolic process GO:0032269 353 0.028
cellular protein catabolic process GO:0044257 261 0.028
Human
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.028
response to hormone GO:0009725 175 0.027
response to abiotic stimulus GO:0009628 336 0.027
regulation of protein catabolic process GO:0042176 155 0.027
intracellular protein transport GO:0006886 270 0.027
positive regulation of protein transport GO:0051222 135 0.026
protein localization to organelle GO:0033365 280 0.026
regulation of cytoplasmic transport GO:1903649 149 0.026
positive regulation of protein phosphorylation GO:0001934 313 0.026
regulation of protein ubiquitination GO:0031396 95 0.026
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.026
Human
regulation of protein binding GO:0043393 66 0.026
peptidyl tyrosine phosphorylation GO:0018108 170 0.025
single organism membrane organization GO:0044802 268 0.025
negative regulation of cellular component organization GO:0051129 235 0.025
vesicle mediated transport GO:0016192 371 0.025
positive regulation of hydrolase activity GO:0051345 331 0.025
membrane organization GO:0061024 292 0.025
response to nutrient levels GO:0031667 81 0.025
response to extracellular stimulus GO:0009991 85 0.025
negative regulation of multicellular organismal process GO:0051241 317 0.025
protein targeting to nucleus GO:0044744 104 0.025
cell activation GO:0001775 213 0.025
post embryonic organ development GO:0048569 1 0.024
cellular response to growth factor stimulus GO:0071363 197 0.024
regulation of smooth muscle cell proliferation GO:0048660 28 0.024
ubiquitin dependent protein catabolic process GO:0006511 206 0.024
Human
protein modification by small protein conjugation GO:0032446 342 0.024
regulation of cytokine production GO:0001817 232 0.024
nuclear transport GO:0051169 179 0.024
regulation of anatomical structure morphogenesis GO:0022603 286 0.024
regulation of phagocytosis engulfment GO:0060099 2 0.024
regulation of intracellular protein transport GO:0033157 123 0.024
regulation of binding GO:0051098 111 0.023
establishment of protein localization to organelle GO:0072594 172 0.023
cellular response to lipid GO:0071396 127 0.023
response to drug GO:0042493 81 0.023
cell growth GO:0016049 160 0.023
muscle contraction GO:0006936 73 0.023
response to oxygen levels GO:0070482 100 0.022
positive regulation of cellular component biogenesis GO:0044089 158 0.022
pericardium development GO:0060039 2 0.022
regulation of dephosphorylation GO:0035303 96 0.022
memory GO:0007613 3 0.022
positive regulation of phosphorylation GO:0042327 394 0.022
cellular lipid metabolic process GO:0044255 303 0.022
negative regulation of transcription from rna polymerase iii promoter GO:0016480 3 0.022
regulation of phosphatase activity GO:0010921 81 0.021
nuclear import GO:0051170 106 0.021
actin filament organization GO:0007015 128 0.021
protein localization to nucleus GO:0034504 136 0.021
reactive nitrogen species metabolic process GO:2001057 3 0.021
lipid metabolic process GO:0006629 381 0.021
immune effector process GO:0002252 159 0.021
positive regulation of cell proliferation GO:0008284 301 0.021
biological adhesion GO:0022610 331 0.021
regulation of transcription factor import into nucleus GO:0042990 39 0.021
interspecies interaction between organisms GO:0044419 156 0.021
protein ubiquitination GO:0016567 314 0.021
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.021
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.021
Human
glycerolipid metabolic process GO:0046486 107 0.020
cellular macromolecule catabolic process GO:0044265 380 0.020
Human
hypotonic response GO:0006971 2 0.020
cytokine mediated signaling pathway GO:0019221 109 0.020
wnt signaling pathway GO:0016055 156 0.020
negative regulation of developmental process GO:0051093 247 0.020
peptidyl tyrosine modification GO:0018212 170 0.020
extrinsic apoptotic signaling pathway GO:0097191 119 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.020
Human
glycoprotein metabolic process GO:0009100 110 0.020
endocytosis GO:0006897 159 0.020
cell projection organization GO:0030030 252 0.020
carbohydrate metabolic process GO:0005975 207 0.020
peptidyl serine modification GO:0018209 106 0.020
negative regulation of apoptotic process GO:0043066 316 0.019
positive regulation of cellular component organization GO:0051130 376 0.019
response to growth factor GO:0070848 205 0.019
amide transport GO:0042886 76 0.019
regulation of cell cycle GO:0051726 393 0.019
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.019
protein polyubiquitination GO:0000209 110 0.019
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.019
establishment of protein localization to membrane GO:0090150 121 0.019
regulation of cytokine mediated signaling pathway GO:0001959 41 0.019
positive regulation of intracellular protein transport GO:0090316 76 0.019
negative regulation of cell death GO:0060548 345 0.019
protein import into nucleus GO:0006606 104 0.018
single organismal cell cell adhesion GO:0016337 148 0.018
negative regulation of binding GO:0051100 57 0.018
protein localization to membrane GO:0072657 160 0.018
regulation of intracellular transport GO:0032386 195 0.018
protein maturation GO:0051604 233 0.018
regulation of wnt signaling pathway GO:0030111 123 0.018
nucleocytoplasmic transport GO:0006913 176 0.018
positive regulation of defense response GO:0031349 87 0.018
cellular component morphogenesis GO:0032989 314 0.018
cellular response to endogenous stimulus GO:0071495 336 0.018
endomembrane system organization GO:0010256 196 0.018
immune response regulating signaling pathway GO:0002764 97 0.018
Human
negative regulation of growth GO:0045926 97 0.018
positive regulation of catabolic process GO:0009896 310 0.018
behavior GO:0007610 112 0.018
organophosphate biosynthetic process GO:0090407 163 0.018
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.018
Human
cellular response to nutrient levels GO:0031669 69 0.018
regulation of cell morphogenesis GO:0022604 153 0.018
positive regulation of cellular component movement GO:0051272 181 0.018
viral life cycle GO:0019058 132 0.018
cellular response to abiotic stimulus GO:0071214 117 0.017
locomotory behavior GO:0007626 1 0.017
cell substrate adhesion GO:0031589 132 0.017
tissue migration GO:0090130 119 0.017
multicellular organismal aging GO:0010259 3 0.017
cell part morphogenesis GO:0032990 137 0.017
nucleoside phosphate biosynthetic process GO:1901293 109 0.017
regulation of locomotion GO:0040012 329 0.017
detection of mechanical stimulus involved in sensory perception GO:0050974 1 0.017
innate immune response GO:0045087 178 0.017
sensory perception GO:0007600 103 0.017
regulation of peptide transport GO:0090087 62 0.017
cellular response to dna damage stimulus GO:0006974 379 0.017
proteasomal protein catabolic process GO:0010498 176 0.017
Human
cellular response to hormone stimulus GO:0032870 125 0.017
protein processing GO:0016485 226 0.016
t cell receptor signaling pathway GO:0050852 21 0.016
Human
positive regulation of cell adhesion GO:0045785 84 0.016
renal system process GO:0003014 25 0.016
lymphocyte activation GO:0046649 133 0.016
regulation of cell differentiation GO:0045595 393 0.016
defense response to fungus GO:0050832 4 0.016
t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell GO:0002291 4 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.016
single organism cell adhesion GO:0098602 179 0.016
positive regulation of cellular catabolic process GO:0031331 284 0.016
cell adhesion GO:0007155 325 0.016
zymogen activation GO:0031638 70 0.016
muscle system process GO:0003012 81 0.016
cytokine production GO:0001816 247 0.016
rna processing GO:0006396 255 0.016
actin cytoskeleton organization GO:0030036 207 0.016
regulation of protein localization to nucleus GO:1900180 85 0.016
detection of mechanical stimulus GO:0050982 4 0.016
mitotic cell cycle GO:0000278 326 0.016
negative regulation of catalytic activity GO:0043086 335 0.015
cellular response to extracellular stimulus GO:0031668 72 0.015
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.015
detection of stimulus GO:0051606 85 0.015
hindbrain development GO:0030902 3 0.015
negative regulation of protein binding GO:0032091 35 0.015
regulation of behavior GO:0050795 82 0.015
negative regulation of locomotion GO:0040013 118 0.015
blastoderm segmentation GO:0007350 2 0.015
response to wounding GO:0009611 168 0.015
Mouse
cellular response to biotic stimulus GO:0071216 71 0.015
negative regulation of protein modification process GO:0031400 200 0.015
intrinsic apoptotic signaling pathway GO:0097193 127 0.015
regulation of cellular response to stress GO:0080135 244 0.015
translation GO:0006412 132 0.015
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.015
Human
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.014
cell projection morphogenesis GO:0048858 129 0.014
nucleoside triphosphate metabolic process GO:0009141 422 0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.014
system process GO:0003008 349 0.014
transcription factor import into nucleus GO:0042991 40 0.014
negative regulation of cell cycle GO:0045786 193 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
positive regulation of locomotion GO:0040017 186 0.014
activation of immune response GO:0002253 114 0.014
Human
cellular extravasation GO:0045123 21 0.014
regeneration GO:0031099 4 0.014
regulation of response to external stimulus GO:0032101 222 0.014
Mouse
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.014
response to external biotic stimulus GO:0043207 261 0.014
nephron development GO:0072006 30 0.014
antigen receptor mediated signaling pathway GO:0050851 38 0.014
Human
phosphatidylinositol metabolic process GO:0046488 53 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
taxis GO:0042330 157 0.014
cell cycle phase transition GO:0044770 173 0.014
organ morphogenesis GO:0009887 147 0.014
intracellular receptor signaling pathway GO:0030522 104 0.014
regulation of response to cytokine stimulus GO:0060759 46 0.014
peripheral nervous system development GO:0007422 2 0.014
positive regulation of intracellular transport GO:0032388 104 0.014
single organism nuclear import GO:1902593 104 0.014
purine nucleoside triphosphate metabolic process GO:0009144 412 0.013
positive regulation of transcription factor import into nucleus GO:0042993 25 0.013
ameboidal type cell migration GO:0001667 135 0.013
necrotic cell death GO:0070265 21 0.013
regulation of cellular response to growth factor stimulus GO:0090287 76 0.013
ion transmembrane transport GO:0034220 338 0.013
regulation of mitotic cell cycle GO:0007346 189 0.013
plasma membrane organization GO:0007009 115 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.013
tissue morphogenesis GO:0048729 96 0.013
sensory perception of pain GO:0019233 4 0.013
response to organonitrogen compound GO:0010243 156 0.013
response to oxidative stress GO:0006979 121 0.013
regulation of growth GO:0040008 165 0.013
tube development GO:0035295 125 0.013
determination of adult lifespan GO:0008340 2 0.013
negative regulation of protein ubiquitination GO:0031397 35 0.013
positive regulation of apoptotic signaling pathway GO:2001235 70 0.013
regulation of synaptic plasticity GO:0048167 3 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
response to lipid GO:0033993 206 0.013
cd40 signaling pathway GO:0023035 3 0.013
nervous system development GO:0007399 293 0.013
Rat
response to acid chemical GO:0001101 66 0.013
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.012
hemopoiesis GO:0030097 180 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
anterior posterior axis specification GO:0009948 2 0.012
purine containing compound catabolic process GO:0072523 411 0.012
chemotaxis GO:0006935 157 0.012
actin filament based process GO:0030029 224 0.012
regulation of protein import into nucleus GO:0042306 78 0.012
positive regulation of protein complex assembly GO:0031334 86 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.012
regulation of cysteine type endopeptidase activity GO:2000116 127 0.012
epithelial cell migration GO:0010631 119 0.012
purine nucleoside catabolic process GO:0006152 398 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 10 0.012
leukocyte migration GO:0050900 107 0.012
skeletal system development GO:0001501 79 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.012
liposaccharide metabolic process GO:1903509 27 0.012
mitotic cell cycle process GO:1903047 286 0.012
positive regulation of response to external stimulus GO:0032103 88 0.012
necroptotic process GO:0070266 16 0.012
epithelial cell differentiation GO:0030855 141 0.012
Mouse
somatic muscle development GO:0007525 1 0.012
neuron differentiation GO:0030182 138 0.012
spermatid differentiation GO:0048515 4 0.012
glycoprotein biosynthetic process GO:0009101 91 0.012
cellular cation homeostasis GO:0030003 163 0.012
anterior posterior axis specification embryo GO:0008595 2 0.012
regulation of cellular component movement GO:0051270 334 0.012
glycerolipid biosynthetic process GO:0045017 51 0.012
response to fungus GO:0009620 4 0.012
wound healing GO:0042060 115 0.011
cellular response to organic cyclic compound GO:0071407 127 0.011
response to activity GO:0014823 0 0.011
protein localization to plasma membrane GO:0072659 93 0.011
hematopoietic or lymphoid organ development GO:0048534 186 0.011
growth GO:0040007 202 0.011
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.011
phospholipid metabolic process GO:0006644 99 0.011
positive regulation of transferase activity GO:0051347 227 0.011
compound eye development GO:0048749 1 0.011
nucleotide biosynthetic process GO:0009165 109 0.011
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.011
embryo development GO:0009790 123 0.011
response to other organism GO:0051707 261 0.011
positive regulation of cell motility GO:2000147 177 0.011
regulation of cell adhesion GO:0030155 166 0.011
syncytium formation by plasma membrane fusion GO:0000768 2 0.011
tripartite regional subdivision GO:0007351 2 0.011
regulation of nucleocytoplasmic transport GO:0046822 98 0.011
response to nutrient GO:0007584 20 0.011
ribonucleoside triphosphate catabolic process GO:0009203 391 0.011
morphogenesis of embryonic epithelium GO:0016331 4 0.011
regulation of response to wounding GO:1903034 101 0.011
Mouse
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.011
leukocyte activation GO:0045321 164 0.011
cell morphogenesis involved in differentiation GO:0000904 144 0.011
regulation of protein serine threonine kinase activity GO:0071900 179 0.011
regulation of tumor necrosis factor mediated signaling pathway GO:0010803 12 0.011
cellular response to oxygen containing compound GO:1901701 276 0.010
kidney development GO:0001822 53 0.010
regulation of bmp signaling pathway GO:0030510 27 0.010
regulation of actin filament based process GO:0032970 141 0.010
epithelial cell proliferation GO:0050673 128 0.010
cell matrix adhesion GO:0007160 85 0.010
negative regulation of intracellular signal transduction GO:1902532 183 0.010
negative regulation of catabolic process GO:0009895 104 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
chromatin organization GO:0006325 351 0.010
regulation of kinase activity GO:0043549 314 0.010
regulation of mitotic cell cycle phase transition GO:1901990 118 0.010
bmp signaling pathway GO:0030509 49 0.010
positive regulation of peptidase activity GO:0010952 88 0.010
negative regulation of cell motility GO:2000146 104 0.010

SHARPIN disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.023
connective tissue disease DOID:65 109 0.023
central nervous system disease DOID:331 186 0.015
nervous system disease DOID:863 431 0.015
disease of metabolism DOID:0014667 295 0.015
cancer DOID:162 167 0.013
disease of cellular proliferation DOID:14566 174 0.013
organ system cancer DOID:0050686 164 0.013
skin disease DOID:37 33 0.012
integumentary system disease DOID:16 43 0.012
immune system disease DOID:2914 155 0.011