Homo sapiens

195 known processes

IGF1R

insulin-like growth factor 1 receptor

(Aliases: IGFR,MGC142172,MGC142170,IGFIR,CD221,MGC18216,JTK13)

IGF1R biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of glycogen metabolic process GO:0070873 15 0.999
Human
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.998
small gtpase mediated signal transduction GO:0007264 78 0.998
activation of mapk activity GO:0000187 45 0.996
positive regulation of map kinase activity GO:0043406 80 0.995
positive regulation of mesenchymal cell proliferation GO:0002053 2 0.994
cellular response to ph GO:0071467 9 0.993
Human
insulin like growth factor receptor signaling pathway GO:0048009 13 0.988
positive regulation of transferase activity GO:0051347 227 0.986
ras protein signal transduction GO:0007265 73 0.985
regulation of cell motility GO:2000145 299 0.983
positive regulation of catabolic process GO:0009896 310 0.981
Human
glycogen biosynthetic process GO:0005978 16 0.974
Human
regulation of cardiac muscle cell apoptotic process GO:0010665 3 0.974
Human
positive regulation of phosphorylation GO:0042327 394 0.973
transformation of host cell by virus GO:0019087 2 0.973
Human
regulation of locomotion GO:0040012 329 0.972
positive regulation of glycogen biosynthetic process GO:0045725 10 0.969
Human
regulation of activin receptor signaling pathway GO:0032925 14 0.969
cellular response to endogenous stimulus GO:0071495 336 0.969
Human Fly
rho protein signal transduction GO:0007266 26 0.968
positive regulation of glucose import in response to insulin stimulus GO:2001275 3 0.968
regulation of cell migration GO:0030334 289 0.968
positive regulation of protein phosphorylation GO:0001934 313 0.964
regulation of rho protein signal transduction GO:0035023 79 0.952
positive regulation of glycogen metabolic process GO:0070875 10 0.952
Human
positive regulation of cellular catabolic process GO:0031331 284 0.951
Human
regulation of glucan biosynthetic process GO:0010962 14 0.948
Human
enzyme linked receptor protein signaling pathway GO:0007167 303 0.946
positive regulation of mapk cascade GO:0043410 190 0.946
regulation of kinase activity GO:0043549 314 0.945
positive regulation of glycolytic process GO:0045821 4 0.944
Human
inositol lipid mediated signaling GO:0048017 55 0.942
cell development GO:0048468 328 0.939
Human Rat Fly
cellular polysaccharide biosynthetic process GO:0033692 21 0.938
Human
regulation of protein serine threonine kinase activity GO:0071900 179 0.934
erk1 and erk2 cascade GO:0070371 104 0.931
lipid metabolic process GO:0006629 381 0.925
Rat Fly
positive regulation of rho gtpase activity GO:0032321 56 0.921
positive regulation of cell migration GO:0030335 172 0.920
regulation of protein kinase activity GO:0045859 289 0.917
positive regulation of respiratory burst GO:0060267 5 0.912
Human
neuron differentiation GO:0030182 138 0.912
Human Zebrafish Rat Fly
cellular response to dna damage stimulus GO:0006974 379 0.906
Fly
cellular response to nitrogen compound GO:1901699 144 0.899
Human Fly
positive regulation of rho protein signal transduction GO:0035025 4 0.892
stem cell division GO:0017145 2 0.892
Fly
positive regulation of protein kinase activity GO:0045860 190 0.891
ion transmembrane transport GO:0034220 338 0.890
glucan biosynthetic process GO:0009250 16 0.888
Human
asymmetric stem cell division GO:0098722 1 0.886
Fly
behavior GO:0007610 112 0.881
Fly
carbohydrate transport GO:0008643 37 0.880
Human
regulation of neuron differentiation GO:0045664 70 0.879
Human
associative learning GO:0008306 1 0.879
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.877
Human
positive regulation of gtpase activity GO:0043547 166 0.877
negative regulation of secretion GO:0051048 58 0.873
cellular component morphogenesis GO:0032989 314 0.873
Rat Fly
negative regulation of programmed cell death GO:0043069 321 0.872
energy reserve metabolic process GO:0006112 22 0.870
Human
inactivation of mapkk activity GO:0051389 1 0.868
positive regulation of cell proliferation GO:0008284 301 0.863
Human Fly
axon regeneration GO:0031103 1 0.860
reactive oxygen species biosynthetic process GO:1903409 4 0.851
mapk cascade GO:0000165 288 0.851
response to ph GO:0009268 12 0.851
Human
g protein coupled receptor signaling pathway GO:0007186 207 0.849
Human
epithelium development GO:0060429 227 0.848
Mouse
morphogenesis of embryonic epithelium GO:0016331 4 0.847
multicellular organismal aging GO:0010259 3 0.845
Worm Fly
regulation of striated muscle cell apoptotic process GO:0010662 3 0.843
Human
phosphatidylinositol mediated signaling GO:0048015 55 0.842
response to oxygen containing compound GO:1901700 369 0.841
Human Rat Worm Fly
chemotaxis GO:0006935 157 0.840
Fly
regulation of embryonic development GO:0045995 20 0.839
Human
intracellular protein transport GO:0006886 270 0.839
Worm
regulation of cell cycle process GO:0010564 266 0.838
Human Mouse Rat
regulation of transferase activity GO:0051338 355 0.838
transmembrane transport GO:0055085 399 0.832
positive regulation of secretion by cell GO:1903532 108 0.812
neuron projection regeneration GO:0031102 1 0.811
actin filament based movement GO:0030048 17 0.810
regulation of small gtpase mediated signal transduction GO:0051056 156 0.810
positive regulation of locomotion GO:0040017 186 0.809
actin filament based process GO:0030029 224 0.809
Human
monosaccharide metabolic process GO:0005996 74 0.806
Human
positive regulation of protein kinase b signaling GO:0051897 42 0.802
Human Mouse
positive regulation of glucose metabolic process GO:0010907 12 0.798
Human
positive regulation of developmental process GO:0051094 314 0.794
Human Worm Fly
regulation of intracellular protein transport GO:0033157 123 0.793
Worm
activation of protein kinase activity GO:0032147 90 0.793
regulation of glycogen biosynthetic process GO:0005979 14 0.793
Human
negative regulation of cellular carbohydrate metabolic process GO:0010677 14 0.792
purine ribonucleoside metabolic process GO:0046128 437 0.782
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.774
protein heterotetramerization GO:0051290 3 0.773
Human
circadian sleep wake cycle process GO:0022410 2 0.765
Fly
mammary gland development GO:0030879 17 0.765
Mouse
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 11 0.764
circadian behavior GO:0048512 2 0.759
Fly
cell morphogenesis involved in differentiation GO:0000904 144 0.759
Rat Fly
regulation of ras protein signal transduction GO:0046578 155 0.757
cellular amine metabolic process GO:0044106 41 0.755
glucan metabolic process GO:0044042 22 0.752
Human
regulation of cellular component movement GO:0051270 334 0.752
cell cell signaling GO:0007267 155 0.751
post embryonic development GO:0009791 2 0.751
Worm
regulation of mapk cascade GO:0043408 262 0.750
regeneration GO:0031099 4 0.745
Zebrafish
negative regulation of wnt signaling pathway GO:0030178 69 0.739
regulation of cellular amino acid metabolic process GO:0006521 6 0.737
positive regulation of ras gtpase activity GO:0032320 117 0.736
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.735
response to axon injury GO:0048678 1 0.733
muscle cell migration GO:0014812 19 0.715
positive regulation of glycoprotein biosynthetic process GO:0010560 6 0.714
carbohydrate metabolic process GO:0005975 207 0.711
Human Fly
protein heterooligomerization GO:0051291 16 0.709
Human Rat
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.707
polysaccharide biosynthetic process GO:0000271 27 0.698
Human
mitotic cell cycle GO:0000278 326 0.697
Human Mouse
purine containing compound catabolic process GO:0072523 411 0.691
ribonucleoside triphosphate catabolic process GO:0009203 391 0.691
photoreceptor cell differentiation GO:0046530 2 0.690
monocarboxylic acid metabolic process GO:0032787 185 0.689
Human
positive regulation of cellular component movement GO:0051272 181 0.687
regulation of cell cycle GO:0051726 393 0.687
Human Mouse Rat
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.685
head development GO:0060322 108 0.684
Mouse
glucose homeostasis GO:0042593 31 0.682
Human
cellular response to oxygen containing compound GO:1901701 276 0.681
Human Fly
positive regulation of peptide hormone secretion GO:0090277 15 0.668
negative regulation of cell death GO:0060548 345 0.668
positive regulation of fatty acid beta oxidation GO:0032000 5 0.664
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.661
Mouse
regulation of glucose metabolic process GO:0010906 28 0.659
Human
regulation of nucleoside metabolic process GO:0009118 209 0.658
regulation of protein transport GO:0051223 213 0.656
Worm
determination of adult lifespan GO:0008340 2 0.654
Worm Fly
regulation of ras gtpase activity GO:0032318 128 0.654
cell activation GO:0001775 213 0.652
positive regulation of cellular response to insulin stimulus GO:1900078 6 0.650
cellular polysaccharide metabolic process GO:0044264 27 0.648
Human
regulation of generation of precursor metabolites and energy GO:0043467 27 0.644
Human
monosaccharide transport GO:0015749 32 0.642
Human
regulation of anatomical structure morphogenesis GO:0022603 286 0.637
gtp metabolic process GO:0046039 239 0.636
regulation of lipid catabolic process GO:0050994 23 0.634
protein targeting GO:0006605 187 0.630
Worm
regulation of nucleotide catabolic process GO:0030811 205 0.628
neurogenesis GO:0022008 169 0.627
Human Zebrafish Rat Fly
response to other organism GO:0051707 261 0.627
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.626
Human
generation of neurons GO:0048699 152 0.623
Human Zebrafish Rat Fly
response to alkaline ph GO:0010446 2 0.618
Human
actin mediated cell contraction GO:0070252 12 0.615
oxidation reduction process GO:0055114 396 0.611
Human
male genitalia development GO:0030539 1 0.608
negative regulation of ion transmembrane transport GO:0034766 26 0.599
regulation of secretion GO:0051046 194 0.594
regulation of erk1 and erk2 cascade GO:0070372 99 0.588
positive regulation of small gtpase mediated signal transduction GO:0051057 12 0.587
peptidyl tyrosine modification GO:0018212 170 0.583
positive regulation of cell motility GO:2000147 177 0.582
protein oligomerization GO:0051259 173 0.582
negative regulation of apoptotic process GO:0043066 316 0.578
cellular amino acid metabolic process GO:0006520 116 0.577
cellular response to hormone stimulus GO:0032870 125 0.577
Human Fly
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.574
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.573
organelle fission GO:0048285 149 0.572
Human Mouse
regulation of polysaccharide metabolic process GO:0032881 21 0.572
Human
biological adhesion GO:0022610 331 0.566
regulation of cell differentiation GO:0045595 393 0.563
Human
response to organonitrogen compound GO:0010243 156 0.561
Human Fly
regulation of cell morphogenesis GO:0022604 153 0.558
regulation of behavior GO:0050795 82 0.558
Fly
regulation of nucleocytoplasmic transport GO:0046822 98 0.557
Worm
interspecies interaction between organisms GO:0044419 156 0.555
Human
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.553
peptide secretion GO:0002790 51 0.552
glycosyl compound catabolic process GO:1901658 413 0.552
cell morphogenesis GO:0000902 296 0.550
Rat Fly
cellular response to peptide hormone stimulus GO:0071375 56 0.549
Human Fly
neuroblast proliferation GO:0007405 4 0.543
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.542
positive regulation of mitotic cell cycle GO:0045931 60 0.529
Human Mouse
axon development GO:0061564 34 0.525
Rat Fly
digestive system development GO:0055123 75 0.521
Mouse
positive regulation of dna replication GO:0045740 35 0.520
regulation of immune response GO:0050776 201 0.519
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.518
regulation of establishment of protein localization GO:0070201 242 0.518
Worm
regulation of neurogenesis GO:0050767 82 0.517
Human
peripheral nervous system development GO:0007422 2 0.515
cellular glucan metabolic process GO:0006073 22 0.509
Human
glucose transport GO:0015758 30 0.509
Human
cellular response to peptide GO:1901653 59 0.506
Human Fly
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.506
muscle cell differentiation GO:0042692 63 0.502
Fly
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.501
regulation of rho gtpase activity GO:0032319 66 0.500
cellular carbohydrate biosynthetic process GO:0034637 21 0.500
Human
protein autophosphorylation GO:0046777 123 0.491
positive regulation of nucleotide catabolic process GO:0030813 185 0.489
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.480
positive regulation of nucleoside metabolic process GO:0045979 186 0.478
regulation of tyrosine phosphorylation of stat5 protein GO:0042522 12 0.478
monocarboxylic acid catabolic process GO:0072329 37 0.477
response to peptide GO:1901652 65 0.476
Human Fly
peptide transport GO:0015833 74 0.472
neuron development GO:0048666 113 0.465
Human Rat Fly
positive regulation of muscle cell apoptotic process GO:0010661 4 0.463
Human
regulation of glucose transport GO:0010827 23 0.462
Human
glucose import in response to insulin stimulus GO:0044381 4 0.462
regulation of gtpase activity GO:0043087 180 0.462
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.458
signal release GO:0023061 70 0.456
protein targeting to nucleus GO:0044744 104 0.453
Worm
regulation of peptide hormone secretion GO:0090276 41 0.453
guanosine containing compound metabolic process GO:1901068 244 0.450
protein kinase b signaling GO:0043491 69 0.450
Human Mouse
regulation of peptide secretion GO:0002791 42 0.436
negative regulation of circadian sleep wake cycle sleep GO:0042321 1 0.433
Fly
positive regulation of kinase activity GO:0033674 204 0.431
rhythmic behavior GO:0007622 2 0.428
Fly
regulation of glucose import GO:0046324 21 0.424
Human
taxis GO:0042330 157 0.420
Fly
regulation of fatty acid beta oxidation GO:0031998 8 0.420
cellular lipid metabolic process GO:0044255 303 0.419
jnk cascade GO:0007254 80 0.413
ameboidal type cell migration GO:0001667 135 0.413
cellular response to organonitrogen compound GO:0071417 124 0.412
Human Fly
reactive nitrogen species metabolic process GO:2001057 3 0.412
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.410
gastrulation GO:0007369 51 0.407
ribonucleotide catabolic process GO:0009261 405 0.406
carbohydrate biosynthetic process GO:0016051 42 0.405
Human
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 16 0.402
guanosine containing compound catabolic process GO:1901069 239 0.398
immune response GO:0006955 307 0.394
response to biotic stimulus GO:0009607 276 0.394
ribonucleoside triphosphate metabolic process GO:0009199 412 0.389
regulation of immune effector process GO:0002697 91 0.388
single organism behavior GO:0044708 28 0.387
Fly
cardiovascular system development GO:0072358 262 0.384
Human Zebrafish
positive regulation of nucleotide metabolic process GO:0045981 230 0.380
negative regulation of fatty acid transport GO:2000192 6 0.377
mammary gland involution GO:0060056 1 0.376
response to manganese ion GO:0010042 2 0.367
positive regulation of fatty acid metabolic process GO:0045923 11 0.364
regulation of hormone secretion GO:0046883 57 0.364
positive regulation of cell cycle GO:0045787 140 0.362
Human Mouse Rat
cell projection morphogenesis GO:0048858 129 0.360
Rat Fly
neuron projection morphogenesis GO:0048812 50 0.358
Rat Fly
generation of precursor metabolites and energy GO:0006091 68 0.357
Human
glycogen metabolic process GO:0005977 22 0.356
Human
cognition GO:0050890 43 0.356
regulation of intracellular transport GO:0032386 195 0.346
Worm
positive regulation of cellular amine metabolic process GO:0033240 7 0.338
organophosphate catabolic process GO:0046434 430 0.335
positive regulation of hormone secretion GO:0046887 25 0.333
regulation of secretion by cell GO:1903530 177 0.332
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.330
glucose import GO:0046323 24 0.329
Human
regulation of cellular ketone metabolic process GO:0010565 50 0.328
tube morphogenesis GO:0035239 95 0.325
Zebrafish
response to mechanical stimulus GO:0009612 51 0.325
nucleoside triphosphate metabolic process GO:0009141 422 0.323
digestive tract morphogenesis GO:0048546 56 0.321
regulation of reactive oxygen species metabolic process GO:2000377 41 0.321
Fly
mitotic sister chromatid segregation GO:0000070 53 0.319
regulation of purine nucleotide metabolic process GO:1900542 264 0.319
negative regulation of secretion by cell GO:1903531 52 0.319
regulation of protein localization to nucleus GO:1900180 85 0.318
Worm
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.318
hexose metabolic process GO:0019318 55 0.316
Human
modification dependent macromolecule catabolic process GO:0043632 212 0.307
cellular lipid catabolic process GO:0044242 65 0.305
fatty acid catabolic process GO:0009062 29 0.305
vascular endothelial growth factor receptor signaling pathway GO:0048010 19 0.303
positive regulation of dna metabolic process GO:0051054 73 0.303
anatomical structure homeostasis GO:0060249 100 0.301
Fly
multi organism cellular process GO:0044764 156 0.301
Human
nervous system development GO:0007399 293 0.297
Human Zebrafish Mouse Rat Fly
negative regulation of protein transport GO:0051224 75 0.295
Worm
negative regulation of cytoplasmic transport GO:1903650 46 0.292
Worm
peptide hormone secretion GO:0030072 50 0.290
positive regulation of vasoconstriction GO:0045907 3 0.290
energy derivation by oxidation of organic compounds GO:0015980 43 0.289
Human
apoptotic signaling pathway GO:0097190 268 0.288
activation of protein kinase b activity GO:0032148 14 0.288
Human
positive regulation of cell death GO:0010942 263 0.288
Human
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 18 0.286
positive regulation of insulin receptor signaling pathway GO:0046628 3 0.284
signal transduction by phosphorylation GO:0023014 297 0.284
regulation of purine nucleotide catabolic process GO:0033121 205 0.281
purine nucleoside triphosphate catabolic process GO:0009146 392 0.280
regulation of proteolysis GO:0030162 293 0.276
Zebrafish
sex determination GO:0007530 3 0.273
Mouse
gland development GO:0048732 48 0.273
Mouse
neuron apoptotic process GO:0051402 39 0.272
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.270
regulation of fatty acid transport GO:2000191 8 0.267
blastoderm segmentation GO:0007350 2 0.267
negative regulation of intracellular transport GO:0032387 60 0.267
Worm
nucleoside phosphate catabolic process GO:1901292 412 0.265
regulation of cytokine production GO:0001817 232 0.262
regulation of nuclear division GO:0051783 65 0.262
Human Mouse
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.261
hydrogen peroxide metabolic process GO:0042743 20 0.261
cytoplasmic transport GO:0016482 379 0.260
Worm
purine nucleotide catabolic process GO:0006195 405 0.260
cell division GO:0051301 168 0.259
Human Mouse Rat Fly
regulation of nucleotide metabolic process GO:0006140 269 0.256
hormone secretion GO:0046879 65 0.255
negative regulation of feeding behavior GO:2000252 1 0.255
Fly
nucleoside catabolic process GO:0009164 408 0.254
central nervous system development GO:0007417 123 0.254
Zebrafish Mouse
regulation of glucose import in response to insulin stimulus GO:2001273 4 0.251
regulation of protein localization GO:0032880 296 0.250
Worm
negative regulation of protein phosphorylation GO:0001933 140 0.250
reproductive process GO:0022414 106 0.246
Zebrafish Mouse Worm Fly
taurine metabolic process GO:0019530 1 0.246
embryonic viscerocranium morphogenesis GO:0048703 1 0.244
brain development GO:0007420 97 0.242
Mouse
single organism cellular localization GO:1902580 332 0.242
Worm
secretion by cell GO:0032940 226 0.242
purine nucleoside catabolic process GO:0006152 398 0.241
gtp catabolic process GO:0006184 237 0.240
regulation of nervous system development GO:0051960 88 0.239
Human
positive regulation of transport GO:0051050 336 0.238
Human
regulation of transmembrane transport GO:0034762 139 0.238
small molecule catabolic process GO:0044282 92 0.237
nitrogen compound transport GO:0071705 191 0.236
negative regulation of erk1 and erk2 cascade GO:0070373 14 0.236
steroid metabolic process GO:0008202 94 0.234
Rat
lipid localization GO:0010876 106 0.234
Worm
positive regulation of hydrolase activity GO:0051345 331 0.233
response to hormone GO:0009725 175 0.232
Human Fly
cellular protein catabolic process GO:0044257 261 0.230
protein processing GO:0016485 226 0.230
Zebrafish
developmental growth GO:0048589 48 0.230
Human Zebrafish Worm Fly
peptidyl tyrosine phosphorylation GO:0018108 170 0.229
neuron remodeling GO:0016322 2 0.227
Fly
embryonic morphogenesis GO:0048598 85 0.226
Zebrafish Fly
neuron death GO:0070997 65 0.225
regulation of cellular response to stress GO:0080135 244 0.224
female gamete generation GO:0007292 2 0.223
Fly
positive regulation of smooth muscle cell proliferation GO:0048661 14 0.222
positive regulation of secretion GO:0051047 116 0.218
neurological system process GO:0050877 163 0.218
response to growth factor GO:0070848 205 0.217
tissue morphogenesis GO:0048729 96 0.216
Mouse
regulation of transcription factor import into nucleus GO:0042990 39 0.216
Worm
morphogenesis of an epithelium GO:0002009 60 0.215
Mouse
nucleotide catabolic process GO:0009166 408 0.215
system process GO:0003008 349 0.215
regulation of feeding behavior GO:0060259 3 0.215
Fly
regulation of mitosis GO:0007088 63 0.215
Human Mouse
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.215
Human
activation of mapkk activity GO:0000186 18 0.214
protein localization to nucleus GO:0034504 136 0.214
Worm
anatomical structure formation involved in morphogenesis GO:0048646 284 0.214
Fly
regulation of carbohydrate biosynthetic process GO:0043255 27 0.214
Human
regulation of mitotic cell cycle phase transition GO:1901990 118 0.213
metaphase anaphase transition of cell cycle GO:0044784 21 0.212
extrinsic apoptotic signaling pathway GO:0097191 119 0.211
peptidyl serine phosphorylation GO:0018105 101 0.210
mitotic nuclear division GO:0007067 119 0.210
Human Mouse
cell part morphogenesis GO:0032990 137 0.209
Rat Fly
regulation of multicellular organism growth GO:0040014 8 0.208
Worm Fly
negative regulation of leukocyte apoptotic process GO:2000107 16 0.204
response to organic cyclic compound GO:0014070 204 0.202
Rat Fly
cation homeostasis GO:0055080 189 0.202
establishment of protein localization to plasma membrane GO:0090002 68 0.202
proteasomal protein catabolic process GO:0010498 176 0.199
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.198
regulation of cytoplasmic transport GO:1903649 149 0.195
Worm
regulation of respiratory burst GO:0060263 8 0.193
Human
response to nitrogen compound GO:1901698 184 0.189
Human Fly
hormone transport GO:0009914 68 0.188
single organism membrane organization GO:0044802 268 0.188
oogenesis GO:0048477 2 0.188
Fly
segmentation GO:0035282 4 0.185
nerve development GO:0021675 4 0.183
cellular ketone metabolic process GO:0042180 80 0.183
regulation of neural precursor cell proliferation GO:2000177 4 0.183
regulation of ion transmembrane transport GO:0034765 132 0.182
response to abiotic stimulus GO:0009628 336 0.182
Human Worm Fly
single organism carbohydrate catabolic process GO:0044724 33 0.180
Human
pyruvate metabolic process GO:0006090 26 0.180
Human
embryo development GO:0009790 123 0.177
Human Zebrafish Fly
response to insulin GO:0032868 45 0.177
Human Fly
regulation of gtp catabolic process GO:0033124 180 0.175
positive regulation of glucose transport GO:0010828 17 0.173
Human
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.173
positive regulation of developmental growth GO:0048639 16 0.173
Human Worm Fly
regulation of cellular amine metabolic process GO:0033238 11 0.172
glycerolipid metabolic process GO:0046486 107 0.171
digestive tract development GO:0048565 75 0.170
cellular response to insulin stimulus GO:0032869 41 0.170
Human Fly
stem cell proliferation GO:0072089 25 0.168
positive regulation of apoptotic process GO:0043065 246 0.168
Human
regulation of insulin secretion GO:0050796 33 0.166
regulation of nitric oxide biosynthetic process GO:0045428 17 0.166
Human
apoptotic mitochondrial changes GO:0008637 57 0.165
cytokine production GO:0001816 247 0.164
viral process GO:0016032 146 0.164
Human
positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 6 0.164
amine metabolic process GO:0009308 44 0.164
actin filament organization GO:0007015 128 0.162
positive regulation of jak stat cascade GO:0046427 35 0.159
smooth muscle cell migration GO:0014909 18 0.156
protein import GO:0017038 130 0.156
Worm
response to cytokine GO:0034097 232 0.155
positive regulation of gtp catabolic process GO:0033126 166 0.155
positive regulation of cell cycle process GO:0090068 106 0.154
Human Mouse Rat
axon guidance GO:0007411 12 0.154
Fly
negative regulation of cell proliferation GO:0008285 228 0.154
cranial nerve development GO:0021545 4 0.153
pancreas development GO:0031016 19 0.152
Mouse
cellular carbohydrate metabolic process GO:0044262 84 0.152
Human
cellular divalent inorganic cation homeostasis GO:0072503 128 0.152
calcium mediated signaling using intracellular calcium source GO:0035584 7 0.150
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.145
hexose transport GO:0008645 30 0.144
Human
protein localization to organelle GO:0033365 280 0.142
Worm
skeletal system development GO:0001501 79 0.140
muscle system process GO:0003012 81 0.139
lipid modification GO:0030258 84 0.139
response to nutrient levels GO:0031667 81 0.139
Rat Worm
polysaccharide metabolic process GO:0005976 33 0.137
Human
fatty acid metabolic process GO:0006631 115 0.136
positive regulation of smooth muscle cell migration GO:0014911 6 0.135
nuclear transport GO:0051169 179 0.135
Worm
regulation of mitotic cell cycle GO:0007346 189 0.135
Human Mouse
positive regulation of cellular component organization GO:0051130 376 0.134
Human Mouse
somatic muscle development GO:0007525 1 0.134
Fly
positive regulation of protein localization to nucleus GO:1900182 48 0.134
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.133
positive regulation of cell projection organization GO:0031346 64 0.133
Human
regulation of leukocyte proliferation GO:0070663 67 0.132
negative regulation of intracellular signal transduction GO:1902532 183 0.131
positive regulation of cell differentiation GO:0045597 211 0.129
Human
negative regulation of transmembrane transport GO:0034763 29 0.128
regulation of axonogenesis GO:0050770 16 0.126
regulation of golgi to plasma membrane protein transport GO:0042996 3 0.125
insulin secretion GO:0030073 39 0.124
regulation of peptide transport GO:0090087 62 0.124
positive regulation of glucose import GO:0046326 16 0.123
Human
positive regulation of nitric oxide biosynthetic process GO:0045429 13 0.121
Human
regulation of polysaccharide biosynthetic process GO:0032885 20 0.121
Human
neuron projection development GO:0031175 106 0.121
Human Rat Fly
positive regulation of cell development GO:0010720 92 0.121
Human
negative regulation of transport GO:0051051 176 0.120
Worm
regulation of stem cell proliferation GO:0072091 15 0.120
regulation of autophagy GO:0010506 52 0.120
Worm Fly
peptidyl tyrosine autophosphorylation GO:0038083 5 0.120
sodium ion transmembrane transport GO:0035725 59 0.120
interleukin 12 mediated signaling pathway GO:0035722 3 0.119
response to decreased oxygen levels GO:0036293 96 0.119
Fly
negative regulation of lipid transport GO:0032369 18 0.119
multicellular organismal homeostasis GO:0048871 67 0.118
regulation of translation GO:0006417 89 0.118
response to oxidative stress GO:0006979 121 0.118
Worm Fly
regulation of hydrogen peroxide metabolic process GO:0010310 6 0.118
rhythmic process GO:0048511 31 0.117
Fly
negative regulation of protein metabolic process GO:0051248 391 0.117
response to extracellular stimulus GO:0009991 85 0.117
Rat Worm
single organism nuclear import GO:1902593 104 0.116
Worm
regulation of insulin receptor signaling pathway GO:0046626 13 0.115
regulation of neuron projection development GO:0010975 57 0.115
Human
single organism reproductive process GO:0044702 98 0.115
Zebrafish Mouse Worm Fly
embryonic placenta development GO:0001892 1 0.113
growth GO:0040007 202 0.112
Human Zebrafish Worm Fly
protein maturation GO:0051604 233 0.112
Zebrafish

IGF1R disease predictions

Disease DO term ID Size Probability Func Analog Org
hyperinsulinemic hypoglycemia DOID:13317 7 1.000
Human
disease of metabolism DOID:0014667 295 1.000
Human
carbohydrate metabolic disorder DOID:2978 55 1.000
Human
inherited metabolic disorder DOID:655 242 1.000
Human
diabetes mellitus DOID:9351 31 0.952
type 2 diabetes mellitus DOID:9352 28 0.952
carbohydrate metabolism disease DOID:0050013 32 0.952
glucose metabolism disease DOID:4194 32 0.952
acquired metabolic disease DOID:0060158 58 0.952
cancer DOID:162 167 0.842
disease of cellular proliferation DOID:14566 174 0.842
organ system cancer DOID:0050686 164 0.842
immune system cancer DOID:0060083 36 0.276
hematologic cancer DOID:2531 36 0.276
myeloid leukemia DOID:8692 18 0.123
acute myeloid leukemia DOID:9119 17 0.123
leukemia DOID:1240 21 0.123