Homo sapiens

22 known processes

INTS6

integrator complex subunit 6

(Aliases: DDX26,DDX26A,DKFZp434B105,Notchl2,INT6,HDB,DICE1,DBI-1)

INTS6 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
rna processing GO:0006396 255 0.198
cellular macromolecule catabolic process GO:0044265 380 0.116
cellular response to dna damage stimulus GO:0006974 379 0.109
multicellular organismal aging GO:0010259 3 0.106
determination of adult lifespan GO:0008340 2 0.092
post embryonic development GO:0009791 2 0.091
mitotic cell cycle GO:0000278 326 0.086
protein ubiquitination GO:0016567 314 0.078
response to radiation GO:0009314 151 0.075
cell morphogenesis GO:0000902 296 0.069
response to abiotic stimulus GO:0009628 336 0.065
mitotic cell cycle process GO:1903047 286 0.065
chromatin organization GO:0006325 351 0.063
snrna metabolic process GO:0016073 15 0.061
negative regulation of catalytic activity GO:0043086 335 0.059
growth GO:0040007 202 0.059
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.056
chromatin modification GO:0016568 298 0.053
locomotory behavior GO:0007626 1 0.049
actin filament based process GO:0030029 224 0.049
cellular ketone metabolic process GO:0042180 80 0.049
oogenesis GO:0048477 2 0.048
regulation of mitotic cell cycle GO:0007346 189 0.048
cellular amino acid metabolic process GO:0006520 116 0.045
endomembrane system organization GO:0010256 196 0.045
regulation of cell cycle GO:0051726 393 0.045
cellular macromolecular complex assembly GO:0034622 324 0.045
purine nucleotide catabolic process GO:0006195 405 0.044
female gamete generation GO:0007292 2 0.044
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.044
histone modification GO:0016570 251 0.044
regulation of cellular component biogenesis GO:0044087 281 0.043
single organism membrane organization GO:0044802 268 0.043
cellular component morphogenesis GO:0032989 314 0.043
ncrna processing GO:0034470 83 0.041
ribonucleoside triphosphate catabolic process GO:0009203 391 0.041
ribonucleoside triphosphate metabolic process GO:0009199 412 0.041
positive regulation of cellular amine metabolic process GO:0033240 7 0.041
response to ionizing radiation GO:0010212 65 0.040
mitotic cell cycle phase transition GO:0044772 162 0.040
dna damage checkpoint GO:0000077 68 0.040
cell cycle phase transition GO:0044770 173 0.040
purine nucleoside triphosphate catabolic process GO:0009146 392 0.039
ncrna metabolic process GO:0034660 108 0.039
regulation of mitotic cell cycle phase transition GO:1901990 118 0.039
negative regulation of cell death GO:0060548 345 0.038
regulation of cellular amine metabolic process GO:0033238 11 0.038
negative regulation of cellular protein metabolic process GO:0032269 353 0.037
amine metabolic process GO:0009308 44 0.037
regulation of chromosome organization GO:0033044 103 0.037
cellular amine metabolic process GO:0044106 41 0.036
single organism cellular localization GO:1902580 332 0.036
nucleoside triphosphate catabolic process GO:0009143 394 0.036
negative regulation of programmed cell death GO:0043069 321 0.036
regulation of nucleotide catabolic process GO:0030811 205 0.035
cellular protein complex assembly GO:0043623 188 0.035
gene silencing GO:0016458 49 0.035
purine containing compound catabolic process GO:0072523 411 0.034
posttranscriptional regulation of gene expression GO:0010608 213 0.033
protein modification by small protein conjugation GO:0032446 342 0.033
muscle structure development GO:0061061 98 0.032
regulation of cellular amino acid metabolic process GO:0006521 6 0.031
negative regulation of protein metabolic process GO:0051248 391 0.031
regulation of cellular ketone metabolic process GO:0010565 50 0.031
nucleoside phosphate catabolic process GO:1901292 412 0.031
dna repair GO:0006281 198 0.031
cell development GO:0048468 328 0.030
chromosome segregation GO:0007059 114 0.030
neuromuscular junction development GO:0007528 3 0.030
negative regulation of phosphate metabolic process GO:0045936 267 0.030
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.028
regulation of cell cycle process GO:0010564 266 0.028
cell cycle checkpoint GO:0000075 117 0.028
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.028
vesicle mediated transport GO:0016192 371 0.028
cytoplasmic transport GO:0016482 379 0.028
positive regulation of cell death GO:0010942 263 0.027
gtp catabolic process GO:0006184 237 0.027
apoptotic signaling pathway GO:0097190 268 0.026
regulation of dna metabolic process GO:0051052 153 0.026
dna integrity checkpoint GO:0031570 71 0.026
actin cytoskeleton organization GO:0030036 207 0.026
forelimb morphogenesis GO:0035136 4 0.026
covalent chromatin modification GO:0016569 254 0.025
nucleoside triphosphate metabolic process GO:0009141 422 0.025
cell growth GO:0016049 160 0.025
negative regulation of hydrolase activity GO:0051346 182 0.025
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.025
rna catabolic process GO:0006401 71 0.024
myosin filament assembly GO:0031034 2 0.024
microtubule cytoskeleton organization GO:0000226 176 0.024
myosin filament organization GO:0031033 2 0.024
snrna processing GO:0016180 14 0.024
reproductive process GO:0022414 106 0.024
organ morphogenesis GO:0009887 147 0.024
positive regulation of catabolic process GO:0009896 310 0.023
ribonucleotide catabolic process GO:0009261 405 0.023
purine ribonucleoside metabolic process GO:0046128 437 0.023
negative regulation of cell cycle phase transition GO:1901988 89 0.023
male genitalia development GO:0030539 1 0.023
muscle organ development GO:0007517 56 0.023
regulation of proteolysis GO:0030162 293 0.023
regulation of cell cycle phase transition GO:1901987 126 0.023
nervous system development GO:0007399 293 0.023
nucleosome organization GO:0034728 66 0.023
neurotransmitter secretion GO:0007269 4 0.022
metal ion transport GO:0030001 272 0.022
central nervous system development GO:0007417 123 0.022
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.022
anatomical structure formation involved in morphogenesis GO:0048646 284 0.022
mrna metabolic process GO:0016071 175 0.022
nucleoside catabolic process GO:0009164 408 0.022
positive regulation of cellular component organization GO:0051130 376 0.021
negative regulation of phosphorus metabolic process GO:0010563 267 0.021
negative regulation of mitotic cell cycle GO:0045930 102 0.021
regulation of nucleoside metabolic process GO:0009118 209 0.021
membrane organization GO:0061024 292 0.021
protein localization to organelle GO:0033365 280 0.021
histone deacetylation GO:0016575 32 0.021
neurological system process GO:0050877 163 0.021
circadian behavior GO:0048512 2 0.021
positive regulation of hydrolase activity GO:0051345 331 0.021
peptidyl lysine acetylation GO:0018394 101 0.021
cell projection organization GO:0030030 252 0.021
cellular response to abiotic stimulus GO:0071214 117 0.021
epithelium development GO:0060429 227 0.021
organophosphate catabolic process GO:0046434 430 0.020
microtubule based process GO:0007017 210 0.020
embryonic digestive tract morphogenesis GO:0048557 2 0.020
regulation of protein transport GO:0051223 213 0.020
secretion GO:0046903 254 0.020
purine nucleoside monophosphate metabolic process GO:0009126 186 0.020
purine ribonucleotide catabolic process GO:0009154 404 0.020
regulation of gene expression epigenetic GO:0040029 73 0.020
peptidyl lysine modification GO:0018205 144 0.020
negative regulation of cell cycle GO:0045786 193 0.020
negative regulation of phosphorylation GO:0042326 174 0.019
single organism reproductive process GO:0044702 98 0.019
regulation of nucleotide metabolic process GO:0006140 269 0.019
modification dependent protein catabolic process GO:0019941 209 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
protein catabolic process GO:0030163 325 0.019
striated muscle myosin thick filament assembly GO:0071688 2 0.019
regulation of cell differentiation GO:0045595 393 0.019
regulation of purine nucleotide metabolic process GO:1900542 264 0.019
macromolecule methylation GO:0043414 97 0.019
negative regulation of proteolysis GO:0045861 132 0.019
purine nucleoside catabolic process GO:0006152 398 0.019
immune response GO:0006955 307 0.019
lipid metabolic process GO:0006629 381 0.019
transmembrane transport GO:0055085 399 0.019
nucleotide catabolic process GO:0009166 408 0.018
head development GO:0060322 108 0.018
negative regulation of transport GO:0051051 176 0.018
ubiquitin dependent protein catabolic process GO:0006511 206 0.018
negative regulation of cell differentiation GO:0045596 171 0.018
regulation of apoptotic signaling pathway GO:2001233 175 0.018
mitotic nuclear division GO:0007067 119 0.018
limbic system development GO:0021761 3 0.018
protein autophosphorylation GO:0046777 123 0.018
positive regulation of cellular catabolic process GO:0031331 284 0.018
tube morphogenesis GO:0035239 95 0.018
rhythmic behavior GO:0007622 2 0.017
histone lysine methylation GO:0034968 50 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
protein maturation GO:0051604 233 0.017
dephosphorylation GO:0016311 209 0.017
positive regulation of apoptotic process GO:0043065 246 0.017
secretion by cell GO:0032940 226 0.017
regulation of anatomical structure morphogenesis GO:0022603 286 0.017
dna templated transcription initiation GO:0006352 35 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.017
neurogenesis GO:0022008 169 0.017
positive regulation of immune response GO:0050778 159 0.017
negative regulation of protein modification process GO:0031400 200 0.017
glycosyl compound catabolic process GO:1901658 413 0.017
rna splicing GO:0008380 131 0.016
negative regulation of apoptotic signaling pathway GO:2001234 97 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
regulation of cellular response to stress GO:0080135 244 0.016
cellular response to radiation GO:0071478 65 0.016
nucleoside monophosphate metabolic process GO:0009123 191 0.016
nucleocytoplasmic transport GO:0006913 176 0.016
purine ribonucleoside catabolic process GO:0046130 398 0.016
modification dependent macromolecule catabolic process GO:0043632 212 0.016
protein localization to nucleus GO:0034504 136 0.016
methylation GO:0032259 106 0.016
dna dependent dna replication GO:0006261 44 0.016
meiotic chromosome segregation GO:0045132 4 0.016
positive regulation of protein complex assembly GO:0031334 86 0.016
regulation of growth GO:0040008 165 0.016
signal transduction by phosphorylation GO:0023014 297 0.015
ras protein signal transduction GO:0007265 73 0.015
response to light stimulus GO:0009416 87 0.015
regulation of chromatin organization GO:1902275 56 0.015
metencephalon development GO:0022037 2 0.015
establishment of protein localization to organelle GO:0072594 172 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
regulation of establishment of protein localization GO:0070201 242 0.015
ribonucleoside catabolic process GO:0042454 406 0.015
positive regulation of immune system process GO:0002684 283 0.015
establishment of protein localization to membrane GO:0090150 121 0.015
lipid modification GO:0030258 84 0.015
cation transport GO:0006812 331 0.015
cellular protein catabolic process GO:0044257 261 0.015
regulation of secretion GO:0051046 194 0.015
negative regulation of transferase activity GO:0051348 124 0.015
atp metabolic process GO:0046034 176 0.015
neuron differentiation GO:0030182 138 0.014
positive regulation of organelle organization GO:0010638 195 0.014
mapk cascade GO:0000165 288 0.014
regulation of protein localization GO:0032880 296 0.014
axis elongation GO:0003401 4 0.014
regulation of protein maturation GO:1903317 150 0.014
protein processing GO:0016485 226 0.014
protein deacylation GO:0035601 39 0.014
regeneration GO:0031099 4 0.014
regulation of protein stability GO:0031647 87 0.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.014
negative regulation of multicellular organismal process GO:0051241 317 0.014
negative regulation of endopeptidase activity GO:0010951 84 0.014
androgen biosynthetic process GO:0006702 3 0.014
regulation of kinase activity GO:0043549 314 0.014
proteasomal protein catabolic process GO:0010498 176 0.014
maintenance of location GO:0051235 112 0.014
reproductive structure development GO:0048608 55 0.014
autophagy GO:0006914 88 0.014
behavior GO:0007610 112 0.014
regulation of cell morphogenesis GO:0022604 153 0.013
regulation of peptidase activity GO:0052547 180 0.013
hindbrain development GO:0030902 3 0.013
positive regulation of developmental process GO:0051094 314 0.013
aging GO:0007568 66 0.013
ribonucleoside monophosphate metabolic process GO:0009161 187 0.013
muscle cell differentiation GO:0042692 63 0.013
nuclear transcribed mrna catabolic process GO:0000956 48 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.013
morphogenesis of embryonic epithelium GO:0016331 4 0.013
response to organic cyclic compound GO:0014070 204 0.013
regulation of endopeptidase activity GO:0052548 170 0.013
developmental process involved in reproduction GO:0003006 66 0.013
regulation of cell division GO:0051302 116 0.013
positive regulation of protein phosphorylation GO:0001934 313 0.013
ribonucleoside monophosphate catabolic process GO:0009158 158 0.013
glycerophospholipid metabolic process GO:0006650 84 0.013
nuclear transport GO:0051169 179 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.013
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.013
system process GO:0003008 349 0.012
small gtpase mediated signal transduction GO:0007264 78 0.012
negative regulation of protein maturation GO:1903318 142 0.012
protein localization to plasma membrane GO:0072659 93 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
negative regulation of cellular component organization GO:0051129 235 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
sensory perception GO:0007600 103 0.012
organelle assembly GO:0070925 176 0.012
circulatory system development GO:0072359 262 0.012
positive regulation of cell cycle process GO:0090068 106 0.012
immune system development GO:0002520 195 0.012
embryonic morphogenesis GO:0048598 85 0.012
negative regulation of immune system process GO:0002683 136 0.012
ion transmembrane transport GO:0034220 338 0.011
regulation of chromatin modification GO:1903308 51 0.011
cytokinesis GO:0000910 96 0.011
heart development GO:0007507 95 0.011
negative regulation of growth GO:0045926 97 0.011
gtp metabolic process GO:0046039 239 0.011
cellular response to external stimulus GO:0071496 111 0.011
macromolecule deacylation GO:0098732 41 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.011
plasma membrane organization GO:0007009 115 0.011
dna packaging GO:0006323 77 0.011
cell adhesion GO:0007155 325 0.011
brain development GO:0007420 97 0.011
regulation of neural precursor cell proliferation GO:2000177 4 0.011
neuron development GO:0048666 113 0.011
purine nucleoside monophosphate catabolic process GO:0009128 158 0.011
phospholipid metabolic process GO:0006644 99 0.011
positive regulation of cell proliferation GO:0008284 301 0.011
regulation of response to external stimulus GO:0032101 222 0.011
hematopoietic or lymphoid organ development GO:0048534 186 0.011
response to axon injury GO:0048678 1 0.011
positive regulation of synaptic transmission GO:0050806 4 0.011
regulation of protein complex assembly GO:0043254 147 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.011
regulation of binding GO:0051098 111 0.011
negative regulation of kinase activity GO:0033673 106 0.011
mrna catabolic process GO:0006402 56 0.011
protein modification by small protein removal GO:0070646 92 0.011
spermatid differentiation GO:0048515 4 0.011
regulation of gtpase activity GO:0043087 180 0.011
translation GO:0006412 132 0.011
regulation of rna splicing GO:0043484 62 0.011
regulation of purine nucleotide catabolic process GO:0033121 205 0.011
cellular response to extracellular stimulus GO:0031668 72 0.011
positive regulation of cell cycle GO:0045787 140 0.011
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.011
embryonic viscerocranium morphogenesis GO:0048703 1 0.010
defense response GO:0006952 315 0.010
intracellular protein transport GO:0006886 270 0.010
regulation of intracellular transport GO:0032386 195 0.010
nitrogen compound transport GO:0071705 191 0.010
atp catabolic process GO:0006200 157 0.010
convergent extension GO:0060026 1 0.010
histone h3 acetylation GO:0043966 45 0.010
cardiovascular system development GO:0072358 262 0.010
cellular lipid metabolic process GO:0044255 303 0.010
lipid localization GO:0010876 106 0.010
regulation of mapk cascade GO:0043408 262 0.010
regulation of transferase activity GO:0051338 355 0.010
biological adhesion GO:0022610 331 0.010
nucleoside monophosphate catabolic process GO:0009125 159 0.010
negative regulation of protein processing GO:0010955 142 0.010
positive regulation of cellular component biogenesis GO:0044089 158 0.010
intrinsic apoptotic signaling pathway GO:0097193 127 0.010
carbohydrate metabolic process GO:0005975 207 0.010
dna conformation change GO:0071103 113 0.010

INTS6 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.027
disease of cellular proliferation DOID:14566 174 0.027
organ system cancer DOID:0050686 164 0.017
bone disease DOID:0080001 88 0.010
musculoskeletal system disease DOID:17 223 0.010
connective tissue disease DOID:65 109 0.010
sensory system disease DOID:0050155 203 0.010
nervous system disease DOID:863 431 0.010