Homo sapiens

179 known processes

HMGB1

high mobility group box 1

(Aliases: DKFZp686A04236,HMG1,SBP-1,HMG3)

HMGB1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of transcription initiation from rna polymerase ii promoter GO:0060633 3 1.000
dna ligation involved in dna repair GO:0051103 4 0.877
positive regulation of cell death GO:0010942 263 0.809
base excision repair dna ligation GO:0006288 2 0.761
protein dna complex subunit organization GO:0071824 80 0.680
positive regulation of proteolysis GO:0045862 142 0.652
positive regulation of apoptotic process GO:0043065 246 0.590
chromatin assembly or disassembly GO:0006333 78 0.570
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.563
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0017055 2 0.556
regulation of megakaryocyte differentiation GO:0045652 22 0.506
Human
nucleosome assembly GO:0006334 50 0.442
response to organic cyclic compound GO:0014070 204 0.342
nucleosome organization GO:0034728 66 0.336
dna templated transcription initiation GO:0006352 35 0.335
regeneration GO:0031099 4 0.307
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.286
dna repair GO:0006281 198 0.276
spermatid development GO:0007286 4 0.270
cellular macromolecular complex assembly GO:0034622 324 0.238
dna packaging GO:0006323 77 0.215
inflammatory response GO:0006954 79 0.210
response to other organism GO:0051707 261 0.209
Human
positive regulation of epithelial cell proliferation GO:0050679 65 0.208
Human
regulation of apoptotic signaling pathway GO:2001233 175 0.208
positive regulation of hydrolase activity GO:0051345 331 0.189
regulation of cysteine type endopeptidase activity GO:2000116 127 0.183
spermatid differentiation GO:0048515 4 0.175
positive regulation of programmed cell death GO:0043068 249 0.171
positive regulation of endopeptidase activity GO:0010950 84 0.169
cellular response to dna damage stimulus GO:0006974 379 0.156
negative regulation of apoptotic process GO:0043066 316 0.150
rna processing GO:0006396 255 0.145
regulation of cellular response to stress GO:0080135 244 0.144
small gtpase mediated signal transduction GO:0007264 78 0.144
oogenesis GO:0048477 2 0.144
regulation of cell differentiation GO:0045595 393 0.143
Human
regulation of proteolysis GO:0030162 293 0.139
response to external biotic stimulus GO:0043207 261 0.135
Human
rna interference GO:0016246 4 0.128
chromatin organization GO:0006325 351 0.124
apoptotic signaling pathway GO:0097190 268 0.123
female gamete generation GO:0007292 2 0.123
regulation of endopeptidase activity GO:0052548 170 0.122
nucleus organization GO:0006997 28 0.113
chromatin modification GO:0016568 298 0.109
nuclear export GO:0051168 69 0.109
single organism cellular localization GO:1902580 332 0.109
post embryonic development GO:0009791 2 0.105
regulation of myeloid cell differentiation GO:0045637 81 0.104
Human
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.099
response to abiotic stimulus GO:0009628 336 0.097
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 4 0.096
chromatin assembly GO:0031497 61 0.093
regulation of intracellular protein transport GO:0033157 123 0.093
regulation of hematopoietic progenitor cell differentiation GO:1901532 24 0.091
Human
regulation of response to dna damage stimulus GO:2001020 94 0.090
positive regulation of transport GO:0051050 336 0.087
immune system development GO:0002520 195 0.085
negative regulation of programmed cell death GO:0043069 321 0.083
positive regulation of dna metabolic process GO:0051054 73 0.083
protein maturation GO:0051604 233 0.079
inflammatory response to antigenic stimulus GO:0002437 4 0.079
cellular protein catabolic process GO:0044257 261 0.078
atp dependent chromatin remodeling GO:0043044 25 0.078
v d j recombination GO:0033151 3 0.077
posttranscriptional regulation of gene expression GO:0010608 213 0.077
cellular response to oxygen containing compound GO:1901701 276 0.073
Human
regulation of dna metabolic process GO:0051052 153 0.072
positive regulation of cytoplasmic transport GO:1903651 82 0.072
protein localization to organelle GO:0033365 280 0.072
taxis GO:0042330 157 0.071
Human
positive regulation of immune system process GO:0002684 283 0.071
Human
determination of adult lifespan GO:0008340 2 0.068
response to lipid GO:0033993 206 0.067
Human
regulation of cell cycle GO:0051726 393 0.066
positive regulation of hematopoietic progenitor cell differentiation GO:1901534 5 0.065
Human
positive regulation of cellular component organization GO:0051130 376 0.065
regulation of intracellular transport GO:0032386 195 0.064
base excision repair GO:0006284 21 0.064
interspecies interaction between organisms GO:0044419 156 0.064
cytoplasmic transport GO:0016482 379 0.062
hematopoietic or lymphoid organ development GO:0048534 186 0.062
Human
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.059
negative regulation of catalytic activity GO:0043086 335 0.058
chromosome segregation GO:0007059 114 0.058
oocyte differentiation GO:0009994 2 0.058
ras protein signal transduction GO:0007265 73 0.057
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 3 0.057
protein dna complex assembly GO:0065004 64 0.056
regulation of cell cycle process GO:0010564 266 0.056
positive regulation of homeostatic process GO:0032846 47 0.056
Human
positive regulation of peptidase activity GO:0010952 88 0.055
reproductive process GO:0022414 106 0.055
oocyte development GO:0048599 1 0.055
regulation of nucleocytoplasmic transport GO:0046822 98 0.055
regulation of protein export from nucleus GO:0046825 15 0.055
viral process GO:0016032 146 0.055
histone serine phosphorylation GO:0035404 4 0.054
positive regulation of cellular catabolic process GO:0031331 284 0.053
regulation of cellular component biogenesis GO:0044087 281 0.053
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.053
negative regulation of apoptotic signaling pathway GO:2001234 97 0.053
cellular amino acid metabolic process GO:0006520 116 0.052
cellular response to hormone stimulus GO:0032870 125 0.051
hematopoietic progenitor cell differentiation GO:0002244 38 0.050
Human
cell cycle phase transition GO:0044770 173 0.050
regulation of establishment of protein localization GO:0070201 242 0.049
cell death in response to oxidative stress GO:0036473 29 0.049
mitotic nuclear division GO:0007067 119 0.048
dna conformation change GO:0071103 113 0.048
single organism reproductive process GO:0044702 98 0.047
regulation of protein transport GO:0051223 213 0.046
histone modification GO:0016570 251 0.046
dna recombination GO:0006310 77 0.046
negative regulation of developmental process GO:0051093 247 0.045
response to bacterium GO:0009617 144 0.045
Human
nervous system development GO:0007399 293 0.045
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.044
nuclear transport GO:0051169 179 0.044
development of primary sexual characteristics GO:0045137 35 0.043
cell cycle checkpoint GO:0000075 117 0.043
regulation of mitotic cell cycle GO:0007346 189 0.042
reproductive system development GO:0061458 56 0.042
modification dependent macromolecule catabolic process GO:0043632 212 0.042
positive regulation of protein export from nucleus GO:0046827 6 0.042
histone exchange GO:0043486 3 0.042
meiosis i GO:0007127 4 0.042
positive regulation of protein transport GO:0051222 135 0.042
negative regulation of chromosome organization GO:2001251 48 0.041
proteasomal protein catabolic process GO:0010498 176 0.041
amine metabolic process GO:0009308 44 0.041
reproductive structure development GO:0048608 55 0.041
growth GO:0040007 202 0.041
developmental process involved in reproduction GO:0003006 66 0.040
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.040
negative regulation of dna templated transcription initiation GO:2000143 3 0.040
hemopoiesis GO:0030097 180 0.040
Human
gene silencing by rna GO:0031047 26 0.040
regulation of cell growth GO:0001558 135 0.040
regulation of dna binding GO:0051101 37 0.039
positive regulation of myeloid cell differentiation GO:0045639 39 0.039
Human
regulation of nuclease activity GO:0032069 11 0.038
Human
mitotic cell cycle process GO:1903047 286 0.038
regulation of cellular amine metabolic process GO:0033238 11 0.038
positive regulation of mitotic cell cycle GO:0045931 60 0.037
anterior posterior axis specification GO:0009948 2 0.037
regulation of peptidase activity GO:0052547 180 0.037
negative regulation of cell death GO:0060548 345 0.037
negative regulation of cellular protein metabolic process GO:0032269 353 0.037
autophagy GO:0006914 88 0.037
regulation of protein complex assembly GO:0043254 147 0.036
gene silencing GO:0016458 49 0.036
positive regulation of intracellular transport GO:0032388 104 0.036
regulation of multi organism process GO:0043900 157 0.036
protein processing GO:0016485 226 0.035
response to cytokine GO:0034097 232 0.035
response to steroid hormone GO:0048545 80 0.035
regulation of protein stability GO:0031647 87 0.035
covalent chromatin modification GO:0016569 254 0.035
meiotic chromosome segregation GO:0045132 4 0.034
gonad development GO:0008406 34 0.034
regulation of endothelial cell proliferation GO:0001936 56 0.033
Human
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.033
segmentation GO:0035282 4 0.033
negative regulation of cell differentiation GO:0045596 171 0.033
regulation of cellular ketone metabolic process GO:0010565 50 0.032
mitotic cell cycle checkpoint GO:0007093 68 0.031
cellular response to cytokine stimulus GO:0071345 181 0.031
positive regulation of dna binding GO:0043388 17 0.031
regulation of erythrocyte differentiation GO:0045646 17 0.030
Human
positive regulation of cell proliferation GO:0008284 301 0.030
Human
response to fungus GO:0009620 4 0.030
regulation of epithelial cell proliferation GO:0050678 113 0.030
Human
organelle fission GO:0048285 149 0.029
regulation of binding GO:0051098 111 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
rna splicing via transesterification reactions GO:0000375 90 0.029
negative regulation of phosphate metabolic process GO:0045936 267 0.029
system process GO:0003008 349 0.028
neuromuscular junction development GO:0007528 3 0.028
immune response GO:0006955 307 0.028
viral life cycle GO:0019058 132 0.028
protein acylation GO:0043543 138 0.028
regulation of interleukin 1 mediated signaling pathway GO:2000659 3 0.028
negative regulation of cell cycle process GO:0010948 121 0.027
cell development GO:0048468 328 0.027
regulation of cellular amino acid metabolic process GO:0006521 6 0.027
negative regulation of multi organism process GO:0043901 92 0.027
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.026
negative regulation of cellular component organization GO:0051129 235 0.026
positive regulation of cell cycle GO:0045787 140 0.026
multicellular organismal aging GO:0010259 3 0.026
neurogenesis GO:0022008 169 0.026
positive regulation of developmental process GO:0051094 314 0.026
Human
regulation of homeostatic process GO:0032844 121 0.025
Human
cellular response to organic cyclic compound GO:0071407 127 0.025
endothelial cell proliferation GO:0001935 65 0.024
Human
positive regulation of endothelial cell proliferation GO:0001938 37 0.024
Human
dna replication GO:0006260 116 0.024
cellular component morphogenesis GO:0032989 314 0.024
negative regulation of cell cycle GO:0045786 193 0.024
erythrocyte homeostasis GO:0034101 31 0.024
Human
cell junction organization GO:0034330 79 0.024
regulation of proteasomal protein catabolic process GO:0061136 87 0.024
response to oxygen containing compound GO:1901700 369 0.023
Human
positive regulation of cellular amine metabolic process GO:0033240 7 0.023
ribonucleoside triphosphate catabolic process GO:0009203 391 0.023
negative regulation of catabolic process GO:0009895 104 0.022
reproduction GO:0000003 63 0.022
organelle assembly GO:0070925 176 0.022
positive regulation of catabolic process GO:0009896 310 0.022
negative regulation of protein metabolic process GO:0051248 391 0.022
cellular macromolecule catabolic process GO:0044265 380 0.022
multi organism cellular process GO:0044764 156 0.022
regulation of protein catabolic process GO:0042176 155 0.021
posttranscriptional gene silencing GO:0016441 25 0.021
positive regulation of meiotic cell cycle GO:0051446 2 0.021
regulation of meiotic cell cycle GO:0051445 4 0.021
g1 s transition of mitotic cell cycle GO:0000082 78 0.020
rna splicing GO:0008380 131 0.020
double strand break repair GO:0006302 101 0.020
intracellular protein transport GO:0006886 270 0.020
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 15 0.020
regulation of cytoplasmic transport GO:1903649 149 0.020
cellular response to growth factor stimulus GO:0071363 197 0.019
somatic diversification of immune receptors GO:0002200 8 0.019
regulation of response to external stimulus GO:0032101 222 0.019
cell growth GO:0016049 160 0.019
response to oxidative stress GO:0006979 121 0.019
regulation of mitosis GO:0007088 63 0.019
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.019
nuclear division GO:0000280 128 0.019
negative regulation of growth GO:0045926 97 0.019
vesicle mediated transport GO:0016192 371 0.019
negative regulation of intracellular signal transduction GO:1902532 183 0.018
positive regulation of binding GO:0051099 45 0.018
mitotic cell cycle GO:0000278 326 0.018
dna ligation GO:0006266 10 0.018
response to radiation GO:0009314 151 0.018
circulatory system development GO:0072359 262 0.018
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.018
negative regulation of protein processing GO:0010955 142 0.018
regulation of small gtpase mediated signal transduction GO:0051056 156 0.017
negative regulation of protein complex assembly GO:0031333 43 0.017
regulation of protein processing GO:0070613 150 0.017
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.017
chemotaxis GO:0006935 157 0.017
Human
regulation of protein localization GO:0032880 296 0.017
regulation of dna templated transcription initiation GO:2000142 9 0.017
positive regulation of cell differentiation GO:0045597 211 0.016
Human
signal transduction by phosphorylation GO:0023014 297 0.016
axon cargo transport GO:0008088 2 0.016
defense response GO:0006952 315 0.016
regulation of cellular protein catabolic process GO:1903362 96 0.016
multicellular organismal reproductive process GO:0048609 40 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.016
activation of cysteine type endopeptidase activity GO:0097202 57 0.016
regulation of nuclear division GO:0051783 65 0.015
regulation of chromosome organization GO:0033044 103 0.015
protein acetylation GO:0006473 116 0.015
cellular response to oxidative stress GO:0034599 85 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.015
modification dependent protein catabolic process GO:0019941 209 0.015
negative regulation of proteolysis GO:0045861 132 0.015
regulation of chromatin assembly GO:0010847 2 0.015
cell chemotaxis GO:0060326 112 0.015
Human
mitotic cell cycle phase transition GO:0044772 162 0.015
neurological system process GO:0050877 163 0.015
embryo development GO:0009790 123 0.015
positive regulation of cell cycle process GO:0090068 106 0.015
cellular ketone metabolic process GO:0042180 80 0.015
multicellular organism reproduction GO:0032504 42 0.015
sensory perception GO:0007600 103 0.015
positive regulation of intracellular protein transport GO:0090316 76 0.015
cytokine mediated signaling pathway GO:0019221 109 0.015
regulation of phosphatase activity GO:0010921 81 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.015
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.014
negative regulation of phosphorus metabolic process GO:0010563 267 0.014
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.014
locomotory behavior GO:0007626 1 0.014
maintenance of location GO:0051235 112 0.014
protein deubiquitination GO:0016579 79 0.014
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.014
protein catabolic process GO:0030163 325 0.014
response to hormone GO:0009725 175 0.014
protein export from nucleus GO:0006611 29 0.013
negative regulation of mitotic anaphase promoting complex activity GO:0060564 4 0.013
endocytosis GO:0006897 159 0.013
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.013
regulation of immune response GO:0050776 201 0.013
tripartite regional subdivision GO:0007351 2 0.013
cellular response to endogenous stimulus GO:0071495 336 0.013
generation of neurons GO:0048699 152 0.013
protein stabilization GO:0050821 64 0.013
cell morphogenesis GO:0000902 296 0.013
sex differentiation GO:0007548 45 0.013
purine nucleoside catabolic process GO:0006152 398 0.013
cell cycle g1 s phase transition GO:0044843 80 0.012
protein modification by small protein removal GO:0070646 92 0.012
positive chemotaxis GO:0050918 33 0.012
Human
regulation of wnt signaling pathway GO:0030111 123 0.012
regulation of ras protein signal transduction GO:0046578 155 0.012
negative regulation of organelle organization GO:0010639 126 0.012
nucleocytoplasmic transport GO:0006913 176 0.012
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.012
Human
protein complex disassembly GO:0043241 52 0.012
purine nucleoside triphosphate catabolic process GO:0009146 392 0.012
metaphase anaphase transition of cell cycle GO:0044784 21 0.012
positive regulation of cellular component biogenesis GO:0044089 158 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
gamete generation GO:0007276 25 0.012
cell substrate junction assembly GO:0007044 35 0.012
cellular amine metabolic process GO:0044106 41 0.012
sexual reproduction GO:0019953 37 0.012
regulation of meiosis GO:0040020 3 0.012
posttranscriptional gene silencing by rna GO:0035194 25 0.012
methylation GO:0032259 106 0.012
regulation of dephosphorylation GO:0035303 96 0.011
response to oxygen levels GO:0070482 100 0.011
erythrocyte differentiation GO:0030218 28 0.011
Human
peptidyl lysine modification GO:0018205 144 0.011
cellular response to biotic stimulus GO:0071216 71 0.011
Human
regulation of transcription initiation from rna polymerase ii promoter GO:0060260 8 0.011
macromolecular complex disassembly GO:0032984 60 0.011
nucleosome positioning GO:0016584 3 0.011
response to wounding GO:0009611 168 0.011
regulation of mitotic cell cycle phase transition GO:1901990 118 0.011
nuclear import GO:0051170 106 0.011
negative regulation of mitotic cell cycle GO:0045930 102 0.011
positive regulation of chromatin assembly or disassembly GO:0045799 2 0.011
ribonucleoside catabolic process GO:0042454 406 0.011
negative regulation of cellular catabolic process GO:0031330 83 0.011
negative regulation of cell cycle phase transition GO:1901988 89 0.011
secretion by cell GO:0032940 226 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
stem cell development GO:0048864 69 0.010
negative regulation of hydrolase activity GO:0051346 182 0.010
regulation of oocyte development GO:0060281 1 0.010
asymmetric neuroblast division GO:0055059 1 0.010
regulation of protein import into nucleus GO:0042306 78 0.010
response to alcohol GO:0097305 64 0.010

HMGB1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.012
disease of mental health DOID:150 70 0.012