Homo sapiens

344 known processes

CDKN2A

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

(Aliases: P16INK4A,P16,CDKN2,MTS1,INK4,MTS-1,P16-INK4A,MLM,P14,CMM2,ARF,P19,P16INK4,P14ARF,TP16,INK4A,P19ARF,CDK4I)

CDKN2A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell aggregation GO:0098743 1 0.998
negative regulation of gliogenesis GO:0014014 3 0.992
negative regulation of monocyte differentiation GO:0045656 3 0.988
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.975
cartilage condensation GO:0001502 1 0.966
regulation of epithelial cell proliferation GO:0050678 113 0.964
epithelial tube morphogenesis GO:0060562 38 0.957
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.952
regulation of peptidase activity GO:0052547 180 0.950
astrocyte differentiation GO:0048708 4 0.950
chromatin organization GO:0006325 351 0.949
positive regulation of peptidase activity GO:0010952 88 0.937
morphogenesis of a branching epithelium GO:0061138 20 0.931
negative regulation of cell cycle GO:0045786 193 0.923
branching morphogenesis of an epithelial tube GO:0048754 19 0.921
dna biosynthetic process GO:0071897 40 0.921
tissue morphogenesis GO:0048729 96 0.919
regulation of cysteine type endopeptidase activity GO:2000116 127 0.909
regulation of endopeptidase activity GO:0052548 170 0.903
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.902
morphogenesis of a branching structure GO:0001763 21 0.893
canonical wnt signaling pathway GO:0060070 116 0.883
negative regulation of astrocyte differentiation GO:0048712 1 0.880
mitotic cell cycle phase transition GO:0044772 162 0.868
regulation of proteolysis GO:0030162 293 0.796
regulation of response to dna damage stimulus GO:2001020 94 0.795
positive regulation of epithelial cell proliferation GO:0050679 65 0.794
positive regulation of programmed cell death GO:0043068 249 0.769
epithelial cell proliferation GO:0050673 128 0.767
cell cycle arrest GO:0007050 71 0.756
positive regulation of endopeptidase activity GO:0010950 84 0.751
regulation of glomerulus development GO:0090192 3 0.751
mitotic cell cycle GO:0000278 326 0.746
ion homeostasis GO:0050801 230 0.741
system process GO:0003008 349 0.736
regulation of astrocyte differentiation GO:0048710 3 0.724
regulation of canonical wnt signaling pathway GO:0060828 88 0.710
embryonic digit morphogenesis GO:0042733 6 0.702
organ morphogenesis GO:0009887 147 0.692
protein modification by small protein conjugation GO:0032446 342 0.680
skeletal system development GO:0001501 79 0.661
regulation of telomere maintenance GO:0032204 13 0.660
developmental programmed cell death GO:0010623 3 0.659
cellular response to dna damage stimulus GO:0006974 379 0.657
wnt signaling pathway GO:0016055 156 0.644
cellular ion homeostasis GO:0006873 168 0.640
tube morphogenesis GO:0035239 95 0.637
positive regulation of hydrolase activity GO:0051345 331 0.635
epidermis morphogenesis GO:0048730 3 0.626
regulation of cell cycle GO:0051726 393 0.626
negative regulation of glial cell differentiation GO:0045686 1 0.614
epithelium development GO:0060429 227 0.606
posttranscriptional regulation of gene expression GO:0010608 213 0.603
sodium ion transmembrane transport GO:0035725 59 0.584
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.570
dna repair GO:0006281 198 0.570
negative regulation of apoptotic process GO:0043066 316 0.563
positive regulation of mesenchymal cell proliferation GO:0002053 2 0.539
regulation of cell proliferation involved in kidney development GO:1901722 3 0.535
positive regulation of cell death GO:0010942 263 0.534
myeloid cell differentiation GO:0030099 117 0.534
response to uv GO:0009411 73 0.528
cell cycle phase transition GO:0044770 173 0.527
tube development GO:0035295 125 0.520
embryonic skeletal system development GO:0048706 13 0.498
bicarbonate transport GO:0015701 6 0.490
regulation of cell growth GO:0001558 135 0.477
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.475
chloride transport GO:0006821 41 0.470
regulation of reactive oxygen species metabolic process GO:2000377 41 0.465
regulation of myeloid cell differentiation GO:0045637 81 0.460
fibroblast proliferation GO:0048144 33 0.456
g1 s transition of mitotic cell cycle GO:0000082 78 0.454
regulation of protein serine threonine kinase activity GO:0071900 179 0.439
positive regulation of cell proliferation GO:0008284 301 0.435
negative regulation of cell cycle phase transition GO:1901988 89 0.433
cellular cation homeostasis GO:0030003 163 0.433
cell cycle g2 m phase transition GO:0044839 43 0.431
regulation of wnt signaling pathway GO:0030111 123 0.427
negative regulation of mitotic cell cycle GO:0045930 102 0.422
regulation of dna metabolic process GO:0051052 153 0.421
positive regulation of cell cycle process GO:0090068 106 0.419
regulation of neuronal synaptic plasticity GO:0048168 1 0.417
cell development GO:0048468 328 0.416
regulation of glial cell differentiation GO:0045685 3 0.413
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.411
embryonic appendage morphogenesis GO:0035113 9 0.409
skeletal system morphogenesis GO:0048705 24 0.407
negative regulation of leukocyte differentiation GO:1902106 24 0.403
regulation of leukocyte differentiation GO:1902105 61 0.402
morphogenesis of an epithelium GO:0002009 60 0.400
modification dependent macromolecule catabolic process GO:0043632 212 0.398
embryonic skeletal system morphogenesis GO:0048704 9 0.394
response to growth factor GO:0070848 205 0.390
response to ionizing radiation GO:0010212 65 0.387
iron ion homeostasis GO:0055072 15 0.383
mitotic g1 dna damage checkpoint GO:0031571 17 0.375
chemical homeostasis GO:0048878 306 0.372
negative regulation of cell cycle process GO:0010948 121 0.371
negative regulation of phosphorus metabolic process GO:0010563 267 0.370
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.369
epidermis development GO:0008544 59 0.368
intrinsic apoptotic signaling pathway GO:0097193 127 0.367
circulatory system development GO:0072359 262 0.363
regulation of cellular response to stress GO:0080135 244 0.362
male sex differentiation GO:0046661 25 0.361
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000059 3 0.360
appendage morphogenesis GO:0035107 16 0.360
cell type specific apoptotic process GO:0097285 125 0.356
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.356
regulation of glomerular mesangial cell proliferation GO:0072124 3 0.354
regulation of apoptotic process involved in morphogenesis GO:1902337 1 0.353
protein catabolic process GO:0030163 325 0.346
negative regulation of protein phosphorylation GO:0001933 140 0.344
cellular homeostasis GO:0019725 196 0.337
negative regulation of growth GO:0045926 97 0.333
regulation of translation GO:0006417 89 0.333
response to hyperoxia GO:0055093 4 0.327
response to biotic stimulus GO:0009607 276 0.323
negative regulation of myeloid cell differentiation GO:0045638 42 0.320
positive regulation of apoptotic process involved in morphogenesis GO:1902339 1 0.320
bmp signaling pathway GO:0030509 49 0.320
response to gamma radiation GO:0010332 14 0.313
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.309
enzyme linked receptor protein signaling pathway GO:0007167 303 0.308
post embryonic development GO:0009791 2 0.304
borate transport GO:0046713 1 0.299
regulation of kinase activity GO:0043549 314 0.299
positive regulation of apoptotic process GO:0043065 246 0.291
connective tissue development GO:0061448 39 0.286
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.283
positive regulation of wnt signaling pathway GO:0030177 54 0.281
apoptotic signaling pathway GO:0097190 268 0.280
embryonic limb morphogenesis GO:0030326 9 0.280
cellular response to abiotic stimulus GO:0071214 117 0.278
cell division GO:0051301 168 0.270
regulation of dna biosynthetic process GO:2000278 18 0.266
glomerular mesangial cell proliferation GO:0072110 3 0.266
regulation of cell development GO:0060284 161 0.265
inorganic anion transmembrane transport GO:0098661 47 0.264
response to radiation GO:0009314 151 0.263
positive regulation of myeloid cell apoptotic process GO:0033034 2 0.263
autophagic cell death GO:0048102 3 0.262
response to lipid GO:0033993 206 0.262
cellular macromolecule catabolic process GO:0044265 380 0.252
dna replication GO:0006260 116 0.250
limb morphogenesis GO:0035108 16 0.246
regulation of transferase activity GO:0051338 355 0.243
response to abiotic stimulus GO:0009628 336 0.242
male gonad development GO:0008584 23 0.241
response to decreased oxygen levels GO:0036293 96 0.239
mitochondrion organization GO:0007005 156 0.238
regulation of cell cycle process GO:0010564 266 0.238
hemopoiesis GO:0030097 180 0.238
regulation of mesenchymal cell proliferation GO:0010464 5 0.237
regulation of cell cycle phase transition GO:1901987 126 0.234
cell growth GO:0016049 160 0.234
regulation of cardiac muscle cell proliferation GO:0060043 4 0.233
regulation of mitotic cell cycle GO:0007346 189 0.233
cytoplasmic transport GO:0016482 379 0.233
negative regulation of cell death GO:0060548 345 0.228
blastoderm segmentation GO:0007350 2 0.227
response to cocaine GO:0042220 1 0.225
determination of adult lifespan GO:0008340 2 0.225
response to other organism GO:0051707 261 0.224
cellular metal ion homeostasis GO:0006875 146 0.223
cation homeostasis GO:0055080 189 0.223
embryonic viscerocranium morphogenesis GO:0048703 1 0.221
hematopoietic or lymphoid organ development GO:0048534 186 0.218
positive regulation of fibroblast proliferation GO:0048146 21 0.211
cell proliferation involved in kidney development GO:0072111 3 0.210
regulation of vasculature development GO:1901342 97 0.210
protein maturation GO:0051604 233 0.209
telomere maintenance GO:0000723 32 0.208
regulation of myeloid leukocyte differentiation GO:0002761 39 0.207
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.205
negative regulation of epithelial cell proliferation GO:0050680 48 0.204
regulation of cell cycle arrest GO:0071156 36 0.203
regulation of homeostatic process GO:0032844 121 0.202
mitotic g1 s transition checkpoint GO:0044819 17 0.198
negative regulation of programmed cell death GO:0043069 321 0.197
cellular protein catabolic process GO:0044257 261 0.194
positive regulation of phosphorylation GO:0042327 394 0.194
blood vessel development GO:0001568 172 0.193
endocrine system development GO:0035270 26 0.189
mitotic cell cycle checkpoint GO:0007093 68 0.188
regulation of cell division GO:0051302 116 0.188
oxidative stress induced premature senescence GO:0090403 3 0.188
development of primary male sexual characteristics GO:0046546 23 0.185
positive regulation of dna metabolic process GO:0051054 73 0.185
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.185
purine nucleoside triphosphate catabolic process GO:0009146 392 0.183
borate transmembrane transport GO:0035445 1 0.183
actin filament based process GO:0030029 224 0.182
oxidation reduction process GO:0055114 396 0.181
proteasomal protein catabolic process GO:0010498 176 0.181
cellular response to radiation GO:0071478 65 0.177
embryonic cranial skeleton morphogenesis GO:0048701 6 0.177
negative regulation of cell growth GO:0030308 83 0.176
notch signaling pathway GO:0007219 31 0.176
cellular response to hypoxia GO:0071456 51 0.176
epithelial cell migration GO:0010631 119 0.175
chromatin modification GO:0016568 298 0.174
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.172
positive regulation of mitotic cell cycle GO:0045931 60 0.172
gliogenesis GO:0042063 21 0.171
positive regulation of proteolysis GO:0045862 142 0.171
pericardium development GO:0060039 2 0.171
embryonic morphogenesis GO:0048598 85 0.165
ras protein signal transduction GO:0007265 73 0.164
glomerular basement membrane development GO:0032836 3 0.162
negative regulation of fibroblast proliferation GO:0048147 12 0.162
cellular response to gonadotropin stimulus GO:0071371 4 0.161
response to endoplasmic reticulum stress GO:0034976 49 0.159
mitotic dna integrity checkpoint GO:0044774 30 0.158
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.158
regulation of cellular protein catabolic process GO:1903362 96 0.158
oogenesis GO:0048477 2 0.156
monocyte differentiation GO:0030224 15 0.156
associative learning GO:0008306 1 0.155
response to oxygen containing compound GO:1901700 369 0.155
gland development GO:0048732 48 0.154
positive regulation of response to dna damage stimulus GO:2001022 43 0.153
response to cytokine GO:0034097 232 0.152
lens development in camera type eye GO:0002088 2 0.151
guanosine containing compound metabolic process GO:1901068 244 0.151
g2 m transition of mitotic cell cycle GO:0000086 41 0.150
response to oxygen levels GO:0070482 100 0.149
protein ubiquitination GO:0016567 314 0.149
t cell differentiation in thymus GO:0033077 4 0.149
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 1 0.148
negative regulation of catalytic activity GO:0043086 335 0.145
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.143
dna damage response signal transduction resulting in transcription GO:0042772 12 0.143
positive regulation of organelle organization GO:0010638 195 0.142
regeneration GO:0031099 4 0.141
negative regulation of cell proliferation GO:0008285 228 0.140
positive regulation of nucleoside metabolic process GO:0045979 186 0.140
regulation of cell matrix adhesion GO:0001952 42 0.138
negative regulation of cell differentiation GO:0045596 171 0.136
response to light stimulus GO:0009416 87 0.135
embryonic organ development GO:0048568 36 0.135
regulation of protein stability GO:0031647 87 0.135
positive regulation of apoptotic signaling pathway GO:2001235 70 0.135
signal transduction by phosphorylation GO:0023014 297 0.135
regulation of cell adhesion GO:0030155 166 0.134
type b pancreatic cell development GO:0003323 4 0.134
oocyte differentiation GO:0009994 2 0.134
mapk cascade GO:0000165 288 0.133
oocyte development GO:0048599 1 0.132
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.131
positive regulation of dna biosynthetic process GO:2000573 8 0.131
double strand break repair GO:0006302 101 0.131
cell cycle g1 s phase transition GO:0044843 80 0.128
appendage development GO:0048736 23 0.126
hormone metabolic process GO:0042445 61 0.126
ubiquitin dependent protein catabolic process GO:0006511 206 0.126
segmentation GO:0035282 4 0.126
zymogen activation GO:0031638 70 0.126
regulation of cell migration GO:0030334 289 0.126
endomembrane system organization GO:0010256 196 0.125
respiratory system development GO:0060541 22 0.125
g1 dna damage checkpoint GO:0044783 18 0.123
somatic muscle development GO:0007525 1 0.122
negative regulation of phosphate metabolic process GO:0045936 267 0.122
cell morphogenesis GO:0000902 296 0.122
transmembrane transport GO:0055085 399 0.121
regulation of cell cycle g1 s phase transition GO:1902806 42 0.121
negative regulation of immune system process GO:0002683 136 0.120
purine nucleoside catabolic process GO:0006152 398 0.120
regulation of purine nucleotide metabolic process GO:1900542 264 0.119
positive regulation of cellular amine metabolic process GO:0033240 7 0.119
cellular transition metal ion homeostasis GO:0046916 21 0.118
nucleoside triphosphate catabolic process GO:0009143 394 0.117
cellular response to drug GO:0035690 27 0.116
negative regulation of developmental process GO:0051093 247 0.116
chemotaxis GO:0006935 157 0.116
intracellular protein transport GO:0006886 270 0.115
anatomical structure homeostasis GO:0060249 100 0.114
cellular response to decreased oxygen levels GO:0036294 51 0.113
camera type eye development GO:0043010 25 0.112
negative regulation of proteolysis GO:0045861 132 0.111
membrane organization GO:0061024 292 0.111
cartilage development GO:0051216 31 0.110
regulation of monocyte differentiation GO:0045655 5 0.110
mesenchymal cell proliferation GO:0010463 7 0.109
sodium ion transport GO:0006814 61 0.109
metanephric s shaped body morphogenesis GO:0072284 4 0.108
peptidyl tyrosine phosphorylation GO:0018108 170 0.107
renal system development GO:0072001 63 0.106
negative regulation of kinase activity GO:0033673 106 0.105
vasculature development GO:0001944 181 0.105
cellular response to oxygen levels GO:0071453 55 0.105
negative regulation of cellular protein metabolic process GO:0032269 353 0.104
regulation of protein kinase activity GO:0045859 289 0.103
regulation of mitochondrion organization GO:0010821 54 0.102
biological adhesion GO:0022610 331 0.101
positive regulation of catabolic process GO:0009896 310 0.099
hindbrain development GO:0030902 3 0.099
response to steroid hormone GO:0048545 80 0.098
cellular senescence GO:0090398 34 0.098
negative regulation of neurogenesis GO:0050768 26 0.097
growth GO:0040007 202 0.096
multicellular organismal response to stress GO:0033555 1 0.095
positive regulation of transferase activity GO:0051347 227 0.095
cellular ketone metabolic process GO:0042180 80 0.093
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.093
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.090
cellular amine metabolic process GO:0044106 41 0.090
apoptotic process involved in morphogenesis GO:0060561 3 0.089
regulation of nucleocytoplasmic transport GO:0046822 98 0.088
purine ribonucleoside metabolic process GO:0046128 437 0.088
apoptotic mitochondrial changes GO:0008637 57 0.087
regulation of fibroblast proliferation GO:0048145 32 0.085
anion transmembrane transport GO:0098656 76 0.085
protein stabilization GO:0050821 64 0.085
vesicle mediated transport GO:0016192 371 0.085
regulation of gliogenesis GO:0014013 7 0.085
response to increased oxygen levels GO:0036296 4 0.085
neurological system process GO:0050877 163 0.083
negative regulation of wnt signaling pathway GO:0030178 69 0.083
leukocyte differentiation GO:0002521 98 0.082
positive regulation of protein kinase activity GO:0045860 190 0.082
regulation of cellular component movement GO:0051270 334 0.082
response to organic cyclic compound GO:0014070 204 0.082
negative regulation of protein processing GO:0010955 142 0.082
peptidyl tyrosine modification GO:0018212 170 0.081
endothelial cell migration GO:0043542 86 0.081
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 10 0.080
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.080
positive regulation of glomerular mesangial cell proliferation GO:0072126 1 0.080
response to external biotic stimulus GO:0043207 261 0.079
ribonucleoside triphosphate catabolic process GO:0009203 391 0.078
chordate embryonic development GO:0043009 34 0.078
negative regulation of multicellular organismal process GO:0051241 317 0.077
glycosyl compound catabolic process GO:1901658 413 0.077
translation GO:0006412 132 0.077
limb development GO:0060173 23 0.076
cell morphogenesis involved in differentiation GO:0000904 144 0.076
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.074
nucleoside phosphate catabolic process GO:1901292 412 0.074
response to toxic substance GO:0009636 37 0.074
response to nutrient levels GO:0031667 81 0.074
embryonic epithelial tube formation GO:0001838 4 0.073
glial cell differentiation GO:0010001 11 0.072
regulation of cellular amine metabolic process GO:0033238 11 0.072
ribonucleoside triphosphate metabolic process GO:0009199 412 0.072
positive regulation of cell adhesion GO:0045785 84 0.071
response to vitamin d GO:0033280 10 0.071
pattern specification process GO:0007389 43 0.070
single organism nuclear import GO:1902593 104 0.070
cell chemotaxis GO:0060326 112 0.070
response to nitrogen compound GO:1901698 184 0.070
cellular response to organic cyclic compound GO:0071407 127 0.070
cellular response to nutrient levels GO:0031669 69 0.069
regulation of gtp catabolic process GO:0033124 180 0.069
cellular response to nutrient GO:0031670 12 0.069
regulation of cellular component biogenesis GO:0044087 281 0.068
positive regulation of synaptic transmission GO:0050806 4 0.068
dna integrity checkpoint GO:0031570 71 0.067
negative regulation of protein modification process GO:0031400 200 0.067
metanephros development GO:0001656 16 0.067
positive regulation of cellular catabolic process GO:0031331 284 0.066
cellular response to heparin GO:0071504 2 0.066
regulation of proteasomal protein catabolic process GO:0061136 87 0.066
blood vessel endothelial cell migration GO:0043534 42 0.066
heart development GO:0007507 95 0.066
pituitary gland development GO:0021983 2 0.065
neuron apoptotic process GO:0051402 39 0.065
myeloid leukocyte differentiation GO:0002573 60 0.065
regulation of growth GO:0040008 165 0.064
protein tetramerization GO:0051262 47 0.064
rho protein signal transduction GO:0007266 26 0.064
regulation of apoptotic signaling pathway GO:2001233 175 0.064
cellular component morphogenesis GO:0032989 314 0.064
hindlimb morphogenesis GO:0035137 2 0.064
protein import GO:0017038 130 0.064
regulation of hormone levels GO:0010817 125 0.064
regulation of cell differentiation GO:0045595 393 0.064
mammary gland epithelium development GO:0061180 10 0.063
cell cycle checkpoint GO:0000075 117 0.063
glandular epithelial cell development GO:0002068 5 0.063
protein localization to nucleus GO:0034504 136 0.063
eye development GO:0001654 42 0.063
purine ribonucleoside catabolic process GO:0046130 398 0.063
chromatin assembly or disassembly GO:0006333 78 0.063
epithelium migration GO:0090132 119 0.062
positive regulation of odontogenesis GO:0042482 3 0.062
sex determination GO:0007530 3 0.062
regulation of metanephros development GO:0072215 4 0.062
negative regulation of cellular senescence GO:2000773 5 0.061
proton transport GO:0015992 22 0.061
cellular component disassembly GO:0022411 92 0.061
response to heparin GO:0071503 3 0.061
ureteric bud development GO:0001657 13 0.061
regulation of actin cytoskeleton organization GO:0032956 116 0.061
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.061
adult locomotory behavior GO:0008344 1 0.060
purine nucleotide catabolic process GO:0006195 405 0.060
actin cytoskeleton organization GO:0030036 207 0.060
embryonic organ morphogenesis GO:0048562 24 0.060
ribonucleotide catabolic process GO:0009261 405 0.059
chromatin remodeling GO:0006338 55 0.059
metanephros morphogenesis GO:0003338 9 0.059
response to lithium ion GO:0010226 2 0.058
organophosphate catabolic process GO:0046434 430 0.058
nuclear import GO:0051170 106 0.058
defense response GO:0006952 315 0.058
pml body organization GO:0030578 2 0.058
ion transmembrane transport GO:0034220 338 0.058
anterior posterior axis specification GO:0009948 2 0.058
peptidyl serine modification GO:0018209 106 0.057
positive regulation of gtp catabolic process GO:0033126 166 0.057
erythrocyte differentiation GO:0030218 28 0.057
negative regulation of heart growth GO:0061117 2 0.057
response to bacterium GO:0009617 144 0.057
negative regulation of apoptotic signaling pathway GO:2001234 97 0.057
response to hormone GO:0009725 175 0.056
regulation of small gtpase mediated signal transduction GO:0051056 156 0.056
type b pancreatic cell differentiation GO:0003309 5 0.055
cell adhesion GO:0007155 325 0.055
cell substrate adherens junction assembly GO:0007045 30 0.055
organic anion transport GO:0015711 103 0.055
protein localization to organelle GO:0033365 280 0.055
protein heterotetramerization GO:0051290 3 0.055
regulation of protein processing GO:0070613 150 0.055
negative regulation of translation GO:0017148 37 0.055
negative regulation of cell development GO:0010721 48 0.054
anion transport GO:0006820 161 0.054
response to electrical stimulus GO:0051602 1 0.054
regulation of synaptic plasticity GO:0048167 3 0.054
response to molecule of bacterial origin GO:0002237 82 0.054
cellular response to cytokine stimulus GO:0071345 181 0.054
negative regulation of myeloid leukocyte differentiation GO:0002762 16 0.054
positive regulation of cellular component biogenesis GO:0044089 158 0.053
enteroendocrine cell differentiation GO:0035883 6 0.053
positive regulation of cell cycle GO:0045787 140 0.053
protein import into nucleus GO:0006606 104 0.053
cellular iron ion homeostasis GO:0006879 8 0.053
gonad development GO:0008406 34 0.053
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 13 0.052
negative regulation of protein kinase activity GO:0006469 98 0.052
cation transmembrane transport GO:0098655 238 0.052
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.052
anatomical structure formation involved in morphogenesis GO:0048646 284 0.052
mammary gland morphogenesis GO:0060443 2 0.052
hydrogen transport GO:0006818 23 0.052
sex differentiation GO:0007548 45 0.052
regulation of cytoskeleton organization GO:0051493 177 0.051
limbic system development GO:0021761 3 0.051
cell junction organization GO:0034330 79 0.051
cell activation GO:0001775 213 0.051
response to peptide GO:1901652 65 0.051
hair follicle morphogenesis GO:0031069 2 0.051
regulation of purine nucleotide catabolic process GO:0033121 205 0.050
oocyte maturation GO:0001556 1 0.050
ameboidal type cell migration GO:0001667 135 0.049
regulation of neurogenesis GO:0050767 82 0.049
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.049
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.049
positive regulation of nucleotide catabolic process GO:0030813 185 0.048
negative regulation of phosphorylation GO:0042326 174 0.048
kidney development GO:0001822 53 0.048
transition metal ion homeostasis GO:0055076 31 0.048
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.048
positive regulation of cell matrix adhesion GO:0001954 23 0.048
regulation of gtpase activity GO:0043087 180 0.047
negative regulation of protein maturation GO:1903318 142 0.047
multicellular organismal aging GO:0010259 3 0.047
activation of cysteine type endopeptidase activity GO:0097202 57 0.047
inorganic cation transmembrane transport GO:0098662 194 0.047
positive regulation of neuron apoptotic process GO:0043525 8 0.047
metanephric nephron morphogenesis GO:0072273 7 0.047
regulation of nucleotide metabolic process GO:0006140 269 0.047
inner ear morphogenesis GO:0042472 4 0.046
meiosis i GO:0007127 4 0.046
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.046
response to carbohydrate GO:0009743 21 0.046
nervous system development GO:0007399 293 0.046
gtp catabolic process GO:0006184 237 0.046
sensory perception GO:0007600 103 0.045
central nervous system development GO:0007417 123 0.045
negative regulation of cardiac muscle cell proliferation GO:0060044 2 0.045
cardiovascular system development GO:0072358 262 0.045
metanephric epithelium development GO:0072207 7 0.045
monovalent inorganic cation transport GO:0015672 128 0.045

CDKN2A disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.395
disease of cellular proliferation DOID:14566 174 0.395
immune system disease DOID:2914 155 0.342
anemia DOID:2355 55 0.342
hematopoietic system disease DOID:74 100 0.342
hemolytic anemia DOID:583 20 0.256
normocytic anemia DOID:720 20 0.256
organ system cancer DOID:0050686 164 0.140
gastrointestinal system cancer DOID:3119 52 0.057