Homo sapiens

0 known processes

MSH4

mutS homolog 4 (E. coli)

MSH4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
meiosis i GO:0007127 4 0.720
Yeast
reciprocal meiotic recombination GO:0007131 4 0.633
Yeast
female gamete generation GO:0007292 2 0.473
post embryonic development GO:0009791 2 0.465
reciprocal dna recombination GO:0035825 4 0.397
Yeast
meiotic chromosome segregation GO:0045132 4 0.341
programmed cell death in response to reactive oxygen species GO:0097468 4 0.153
organelle fission GO:0048285 149 0.134
Yeast
chromosome segregation GO:0007059 114 0.122
cation transport GO:0006812 331 0.108
reproductive process GO:0022414 106 0.104
regulation of interleukin 2 secretion GO:1900040 2 0.092
interleukin 2 secretion GO:0070970 3 0.091
hydrogen peroxide mediated programmed cell death GO:0010421 4 0.081
negative regulation of phagocytosis GO:0050765 4 0.072
cellular amino acid metabolic process GO:0006520 116 0.058
regulation of phagocytosis engulfment GO:0060099 2 0.051
oogenesis GO:0048477 2 0.050
neuromuscular junction development GO:0007528 3 0.050
response to abiotic stimulus GO:0009628 336 0.050
regulation of cellular amino acid metabolic process GO:0006521 6 0.049
regulation of cellular ketone metabolic process GO:0010565 50 0.047
amine metabolic process GO:0009308 44 0.045
single organism reproductive process GO:0044702 98 0.045
divalent metal ion transport GO:0070838 152 0.042
protein ubiquitination GO:0016567 314 0.041
positive regulation of cellular amine metabolic process GO:0033240 7 0.041
regulation of cell cycle GO:0051726 393 0.040
chromatin organization GO:0006325 351 0.040
cellular amine metabolic process GO:0044106 41 0.039
blood circulation GO:0008015 113 0.038
associative learning GO:0008306 1 0.037
g protein coupled receptor signaling pathway GO:0007186 207 0.037
astrocyte differentiation GO:0048708 4 0.035
cellular cation homeostasis GO:0030003 163 0.035
reproduction GO:0000003 63 0.034
Yeast
negative regulation of phosphorus metabolic process GO:0010563 267 0.033
immune response GO:0006955 307 0.032
axis elongation GO:0003401 4 0.032
regulation of cellular amine metabolic process GO:0033238 11 0.032
cellular macromolecular complex assembly GO:0034622 324 0.031
multicellular organismal aging GO:0010259 3 0.031
determination of adult lifespan GO:0008340 2 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.031
cellular ion homeostasis GO:0006873 168 0.030
negative regulation of phosphate metabolic process GO:0045936 267 0.030
locomotory behavior GO:0007626 1 0.029
cellular response to dna damage stimulus GO:0006974 379 0.029
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.029
regulation of transferase activity GO:0051338 355 0.029
metal ion transport GO:0030001 272 0.029
negative regulation of catalytic activity GO:0043086 335 0.028
negative regulation of cell motility GO:2000146 104 0.028
motor neuron axon guidance GO:0008045 2 0.028
cellular ketone metabolic process GO:0042180 80 0.028
sequestering of metal ion GO:0051238 24 0.028
thymus development GO:0048538 3 0.027
secretion GO:0046903 254 0.027
response to external biotic stimulus GO:0043207 261 0.027
cellular macromolecule catabolic process GO:0044265 380 0.027
response to biotic stimulus GO:0009607 276 0.027
negative regulation of phospholipase activity GO:0010519 3 0.027
regulation of growth GO:0040008 165 0.027
positive regulation of extracellular matrix organization GO:1903055 3 0.026
cation homeostasis GO:0055080 189 0.026
negative regulation of protein metabolic process GO:0051248 391 0.026
positive regulation of vasoconstriction GO:0045907 3 0.025
regulation of meiotic cell cycle GO:0051445 4 0.025
regulation of non canonical wnt signaling pathway GO:2000050 4 0.025
oocyte development GO:0048599 1 0.024
oocyte differentiation GO:0009994 2 0.024
positive regulation of developmental process GO:0051094 314 0.024
negative regulation of hydrolase activity GO:0051346 182 0.024
protein processing GO:0016485 226 0.024
nuclear division GO:0000280 128 0.024
Yeast
mitotic cell cycle process GO:1903047 286 0.024
embryo development GO:0009790 123 0.024
regulation of cellular component biogenesis GO:0044087 281 0.024
response to other organism GO:0051707 261 0.024
mapk cascade GO:0000165 288 0.023
ion homeostasis GO:0050801 230 0.023
growth GO:0040007 202 0.023
regulation of cell differentiation GO:0045595 393 0.023
circulatory system process GO:0003013 113 0.023
cellular protein catabolic process GO:0044257 261 0.022
apoptotic signaling pathway GO:0097190 268 0.022
regulation of cytokine production GO:0001817 232 0.022
defense response GO:0006952 315 0.022
response to fungus GO:0009620 4 0.022
cerebellum development GO:0021549 2 0.021
establishment of tissue polarity GO:0007164 3 0.021
positive regulation of cell proliferation GO:0008284 301 0.021
regulation of kinase activity GO:0043549 314 0.021
mating GO:0007618 1 0.021
organonitrogen compound biosynthetic process GO:1901566 200 0.021
regulation of mapk cascade GO:0043408 262 0.021
compound eye development GO:0048749 1 0.021
negative regulation of cellular protein metabolic process GO:0032269 353 0.021
positive regulation of cellular component organization GO:0051130 376 0.021
cell growth GO:0016049 160 0.020
metencephalon development GO:0022037 2 0.020
ion transmembrane transport GO:0034220 338 0.020
negative regulation of apoptotic process GO:0043066 316 0.020
mitotic cell cycle GO:0000278 326 0.020
transmembrane transport GO:0055085 399 0.020
cellular response to endogenous stimulus GO:0071495 336 0.020
metal ion homeostasis GO:0055065 169 0.020
protein modification by small protein conjugation GO:0032446 342 0.020
negative regulation of cellular component movement GO:0051271 106 0.020
regulation of protein kinase activity GO:0045859 289 0.020
anterior posterior axis specification GO:0009948 2 0.020
negative regulation of cellular component organization GO:0051129 235 0.019
anion transport GO:0006820 161 0.019
regulation of vesicle mediated transport GO:0060627 130 0.019
segmentation GO:0035282 4 0.019
positive regulation of immune system process GO:0002684 283 0.019
regulation of cell growth GO:0001558 135 0.019
meiotic cell cycle GO:0051321 13 0.019
Yeast
positive regulation of osteoblast proliferation GO:0033690 3 0.019
cytokine production GO:0001816 247 0.019
establishment of planar polarity GO:0001736 3 0.019
regulation of cellular component movement GO:0051270 334 0.019
signal transduction by phosphorylation GO:0023014 297 0.019
protein autophosphorylation GO:0046777 123 0.019
response to organic cyclic compound GO:0014070 204 0.019
lipid metabolic process GO:0006629 381 0.019
positive regulation of phosphorylation GO:0042327 394 0.019
maintenance of location GO:0051235 112 0.019
spermatid differentiation GO:0048515 4 0.018
meiotic nuclear division GO:0007126 10 0.018
Yeast
positive regulation of hydrolase activity GO:0051345 331 0.018
cytoplasmic transport GO:0016482 379 0.018
regulation of protein serine threonine kinase activity GO:0071900 179 0.018
regulation of proteolysis GO:0030162 293 0.018
response to oxygen containing compound GO:1901700 369 0.018
cation transmembrane transport GO:0098655 238 0.017
response to cytokine GO:0034097 232 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.017
negative regulation of cell death GO:0060548 345 0.017
oxidation reduction process GO:0055114 396 0.017
regulation of ion transport GO:0043269 189 0.017
memory GO:0007613 3 0.017
response to oxidative stress GO:0006979 121 0.017
response to organonitrogen compound GO:0010243 156 0.017
regulation of cellular response to oxidative stress GO:1900407 26 0.017
regulation of cell cycle process GO:0010564 266 0.017
regulation of system process GO:0044057 101 0.017
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.017
divalent inorganic cation transport GO:0072511 158 0.017
posttranscriptional regulation of gene expression GO:0010608 213 0.017
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.016
rna processing GO:0006396 255 0.016
protein maturation GO:0051604 233 0.016
positive regulation of non canonical wnt signaling pathway GO:2000052 3 0.016
negative regulation of protein modification process GO:0031400 200 0.016
chemical homeostasis GO:0048878 306 0.016
spermatid development GO:0007286 4 0.016
protein catabolic process GO:0030163 325 0.016
epithelium development GO:0060429 227 0.016
negative regulation of programmed cell death GO:0043069 321 0.016
regulation of meiosis GO:0040020 3 0.016
multi organism reproductive process GO:0044703 54 0.016
negative regulation of cell cycle GO:0045786 193 0.016
anatomical structure formation involved in morphogenesis GO:0048646 284 0.015
dna repair GO:0006281 198 0.015
regulation of erk1 and erk2 cascade GO:0070372 99 0.015
inorganic ion transmembrane transport GO:0098660 231 0.015
positive regulation of cell differentiation GO:0045597 211 0.015
immune system development GO:0002520 195 0.015
nucleoside triphosphate metabolic process GO:0009141 422 0.015
single organism membrane organization GO:0044802 268 0.015
response to nitrogen compound GO:1901698 184 0.015
atp metabolic process GO:0046034 176 0.015
inorganic cation transmembrane transport GO:0098662 194 0.015
organophosphate catabolic process GO:0046434 430 0.015
vesicle mediated transport GO:0016192 371 0.015
cell division GO:0051301 168 0.015
regulation of homeostatic process GO:0032844 121 0.015
positive regulation of cell cycle GO:0045787 140 0.015
regulation of cell division GO:0051302 116 0.015
cellular lipid metabolic process GO:0044255 303 0.015
bmp signaling pathway GO:0030509 49 0.015
negative regulation of growth GO:0045926 97 0.015
positive regulation of programmed cell death GO:0043068 249 0.015
sequestering of calcium ion GO:0051208 17 0.015
mrna metabolic process GO:0016071 175 0.014
dephosphorylation GO:0016311 209 0.014
cellular homeostasis GO:0019725 196 0.014
divalent inorganic cation homeostasis GO:0072507 136 0.014
regulation of protein ubiquitination GO:0031396 95 0.014
regulation of lipase activity GO:0060191 37 0.014
tripartite regional subdivision GO:0007351 2 0.014
glycosyl compound catabolic process GO:1901658 413 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
calcium ion transport GO:0006816 147 0.014
system process GO:0003008 349 0.014
response to bacterium GO:0009617 144 0.014
negative regulation of locomotion GO:0040013 118 0.014
positive regulation of apoptotic process GO:0043065 246 0.014
organelle assembly GO:0070925 176 0.014
regulation of cellular response to stress GO:0080135 244 0.014
purine nucleoside triphosphate metabolic process GO:0009144 412 0.014
hindbrain development GO:0030902 3 0.014
blastoderm segmentation GO:0007350 2 0.014
membrane organization GO:0061024 292 0.014
lymphocyte homeostasis GO:0002260 4 0.014
regulation of blood vessel size GO:0050880 18 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.014
anterior posterior axis specification embryo GO:0008595 2 0.014
regulation of endopeptidase activity GO:0052548 170 0.014
visual behavior GO:0007632 2 0.014
defense response to fungus GO:0050832 4 0.013
microtubule based process GO:0007017 210 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
negative regulation of multicellular organismal process GO:0051241 317 0.013
response to drug GO:0042493 81 0.013
ribonucleoside catabolic process GO:0042454 406 0.013
ribonucleoside monophosphate metabolic process GO:0009161 187 0.013
secretion by cell GO:0032940 226 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.013
negative regulation of cell cycle process GO:0010948 121 0.013
vascular process in circulatory system GO:0003018 29 0.013
microtubule cytoskeleton organization GO:0000226 176 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
innate immune response GO:0045087 178 0.013
ribonucleotide catabolic process GO:0009261 405 0.013
regulation of protein processing GO:0070613 150 0.013
regulation of cell cycle phase transition GO:1901987 126 0.013
regulation of blood circulation GO:1903522 59 0.013
negative regulation of protein maturation GO:1903318 142 0.013
regulation of secretion GO:0051046 194 0.013
hematopoietic or lymphoid organ development GO:0048534 186 0.013
cellular response to abiotic stimulus GO:0071214 117 0.013
cellular divalent inorganic cation homeostasis GO:0072503 128 0.013
regulation of cell motility GO:2000145 299 0.013
purine nucleoside catabolic process GO:0006152 398 0.013
cell death in response to hydrogen peroxide GO:0036474 10 0.013
regeneration GO:0031099 4 0.013
modification dependent protein catabolic process GO:0019941 209 0.013
cytosolic calcium ion transport GO:0060401 48 0.013
stem cell division GO:0017145 2 0.013
cytosolic calcium ion homeostasis GO:0051480 89 0.013
nucleoside monophosphate metabolic process GO:0009123 191 0.012
positive regulation of cytokine production GO:0001819 167 0.012
activation of immune response GO:0002253 114 0.012
regulation of stress activated mapk cascade GO:0032872 84 0.012
cellular metal ion homeostasis GO:0006875 146 0.012
positive regulation of organelle organization GO:0010638 195 0.012
sexual reproduction GO:0019953 37 0.012
purine nucleoside monophosphate metabolic process GO:0009126 186 0.012
regulation of protein stability GO:0031647 87 0.012
modification dependent macromolecule catabolic process GO:0043632 212 0.012
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
regulation of metal ion transport GO:0010959 120 0.012
cellular response to lipid GO:0071396 127 0.012
regulation of secretion by cell GO:1903530 177 0.012
regulation of locomotion GO:0040012 329 0.012
ras protein signal transduction GO:0007265 73 0.012
cell cycle checkpoint GO:0000075 117 0.012
purine nucleotide catabolic process GO:0006195 405 0.012
regulation of peptidase activity GO:0052547 180 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
regulation of sequestering of calcium ion GO:0051282 41 0.012
negative regulation of cell growth GO:0030308 83 0.012
regulation of intracellular transport GO:0032386 195 0.012
positive regulation of secretion GO:0051047 116 0.012
endochondral bone morphogenesis GO:0060350 3 0.012
regulation of immune response GO:0050776 201 0.012
collateral sprouting GO:0048668 2 0.012
response to inorganic substance GO:0010035 127 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.012
myeloid cell differentiation GO:0030099 117 0.012
positive regulation of mapk cascade GO:0043410 190 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
translation GO:0006412 132 0.012
negative regulation of developmental process GO:0051093 247 0.012
cellular response to lipopolysaccharide GO:0071222 57 0.012
regulation of cytoplasmic transport GO:1903649 149 0.012
response to lipid GO:0033993 206 0.012
negative regulation of protein kinase activity GO:0006469 98 0.012
positive regulation of transport GO:0051050 336 0.012
purine nucleoside triphosphate catabolic process GO:0009146 392 0.012
positive regulation of secretion by cell GO:1903532 108 0.012
viral process GO:0016032 146 0.011
cellular response to acid chemical GO:0071229 44 0.011
cellular calcium ion homeostasis GO:0006874 117 0.011
ubiquitin dependent protein catabolic process GO:0006511 206 0.011
response to light stimulus GO:0009416 87 0.011
neuroblast proliferation GO:0007405 4 0.011
peripheral nervous system development GO:0007422 2 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.011
nucleoside monophosphate catabolic process GO:0009125 159 0.011
nucleotide biosynthetic process GO:0009165 109 0.011
monocarboxylic acid metabolic process GO:0032787 185 0.011
positive regulation of protein phosphorylation GO:0001934 313 0.011
reactive nitrogen species metabolic process GO:2001057 3 0.011
epithelial cell differentiation GO:0030855 141 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
cellular protein complex assembly GO:0043623 188 0.011
lipid biosynthetic process GO:0008610 177 0.011
morphogenesis of a polarized epithelium GO:0001738 3 0.011
regulation of protein maturation GO:1903317 150 0.011
regulation of dna metabolic process GO:0051052 153 0.011
negative regulation of transferase activity GO:0051348 124 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
intracellular protein transport GO:0006886 270 0.011
chromatin modification GO:0016568 298 0.011
negative regulation of cell migration GO:0030336 102 0.011
regulation of establishment of protein localization GO:0070201 242 0.011
cell adhesion GO:0007155 325 0.011
multi organism cellular process GO:0044764 156 0.011
regulation of tube size GO:0035150 18 0.011
negative regulation of transport GO:0051051 176 0.011
methylation GO:0032259 106 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.011
actin cytoskeleton organization GO:0030036 207 0.011
hemopoiesis GO:0030097 180 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
regulation of mitotic cell cycle phase transition GO:1901990 118 0.011
regulation of cell adhesion GO:0030155 166 0.010
multicellular organism reproduction GO:0032504 42 0.010
nitrogen compound transport GO:0071705 191 0.010
positive regulation of cellular component biogenesis GO:0044089 158 0.010
protein localization to organelle GO:0033365 280 0.010
small molecule biosynthetic process GO:0044283 157 0.010
defense response to bacterium GO:0042742 63 0.010
calcium ion transport into cytosol GO:0060402 48 0.010
regulation of protein localization GO:0032880 296 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.010
cellular senescence GO:0090398 34 0.010
biological adhesion GO:0022610 331 0.010
positive regulation of wnt signaling pathway GO:0030177 54 0.010
regulation of ion transmembrane transport GO:0034765 132 0.010
adult locomotory behavior GO:0008344 1 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.010
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.010
endocytosis GO:0006897 159 0.010
regulation of chromosome organization GO:0033044 103 0.010
negative regulation of protein processing GO:0010955 142 0.010
muscle contraction GO:0006936 73 0.010
macromolecule methylation GO:0043414 97 0.010
signal transduction by p53 class mediator GO:0072331 72 0.010
response to axon injury GO:0048678 1 0.010

MSH4 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.025
disease of cellular proliferation DOID:14566 174 0.025
organ system cancer DOID:0050686 164 0.025
sensory system disease DOID:0050155 203 0.025
nervous system disease DOID:863 431 0.025
central nervous system disease DOID:331 186 0.019
disease of metabolism DOID:0014667 295 0.019
eye and adnexa disease DOID:1492 150 0.016
eye disease DOID:5614 149 0.015
inherited metabolic disorder DOID:655 242 0.014
retinal disease DOID:5679 118 0.014
immune system disease DOID:2914 155 0.013
neurodegenerative disease DOID:1289 102 0.013
musculoskeletal system disease DOID:17 223 0.012
disease of mental health DOID:150 70 0.010