Homo sapiens

0 known processes

HELT

HES/HEY-like transcription factor

(Aliases: HCM1228,bHLHb44,HESL,Mgn)

HELT biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.075
Human Mouse
regulation of cellular ketone metabolic process GO:0010565 50 0.060
circulatory system development GO:0072359 262 0.056
Human
post embryonic development GO:0009791 2 0.056
Mouse
organ morphogenesis GO:0009887 147 0.055
regulation of cell differentiation GO:0045595 393 0.053
extraocular skeletal muscle development GO:0002074 1 0.050
cellular amino acid metabolic process GO:0006520 116 0.050
amine metabolic process GO:0009308 44 0.048
regulation of cell cycle GO:0051726 393 0.047
regulation of cellular amino acid metabolic process GO:0006521 6 0.047
organ formation GO:0048645 3 0.046
nervous system development GO:0007399 293 0.045
Mouse
cell fate determination GO:0001709 3 0.044
negative regulation of multicellular organismal process GO:0051241 317 0.044
positive regulation of cellular amine metabolic process GO:0033240 7 0.043
regulation of cellular amine metabolic process GO:0033238 11 0.043
cellular ketone metabolic process GO:0042180 80 0.043
anatomical structure formation involved in morphogenesis GO:0048646 284 0.041
Human
negative regulation of cell differentiation GO:0045596 171 0.040
cellular amine metabolic process GO:0044106 41 0.040
regulation of anatomical structure morphogenesis GO:0022603 286 0.038
regulation of cellular component movement GO:0051270 334 0.038
negative regulation of developmental process GO:0051093 247 0.036
cardiovascular system development GO:0072358 262 0.036
Human
segmentation GO:0035282 4 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.034
regulation of locomotion GO:0040012 329 0.034
multicellular organismal aging GO:0010259 3 0.033
Mouse
central nervous system development GO:0007417 123 0.032
Mouse
cellular component morphogenesis GO:0032989 314 0.031
vasculature development GO:0001944 181 0.031
Human
mitotic cell cycle GO:0000278 326 0.031
positive regulation of cell proliferation GO:0008284 301 0.031
epithelium development GO:0060429 227 0.031
cardiac cell fate determination GO:0060913 3 0.030
skeletal system development GO:0001501 79 0.029
female gamete generation GO:0007292 2 0.029
locomotory behavior GO:0007626 1 0.029
hematopoietic or lymphoid organ development GO:0048534 186 0.028
cellular response to endogenous stimulus GO:0071495 336 0.028
Human
hindbrain development GO:0030902 3 0.028
negative regulation of apoptotic process GO:0043066 316 0.028
positive regulation of developmental process GO:0051094 314 0.028
stem cell differentiation GO:0048863 93 0.028
cell development GO:0048468 328 0.027
Human
negative regulation of protein metabolic process GO:0051248 391 0.027
determination of adult lifespan GO:0008340 2 0.027
positive regulation of cellular component organization GO:0051130 376 0.027
regulation of cell motility GO:2000145 299 0.027
negative regulation of programmed cell death GO:0043069 321 0.026
cellular response to dna damage stimulus GO:0006974 379 0.026
cell projection organization GO:0030030 252 0.026
cranial nerve development GO:0021545 4 0.026
cell morphogenesis GO:0000902 296 0.026
negative regulation of cell death GO:0060548 345 0.026
enzyme linked receptor protein signaling pathway GO:0007167 303 0.024
negative regulation of cellular protein metabolic process GO:0032269 353 0.024
positive regulation of phosphorylation GO:0042327 394 0.024
regulation of mitotic cell cycle GO:0007346 189 0.024
oogenesis GO:0048477 2 0.024
blood vessel morphogenesis GO:0048514 162 0.023
Human
morphogenesis of embryonic epithelium GO:0016331 4 0.023
positive regulation of hydrolase activity GO:0051345 331 0.023
system process GO:0003008 349 0.023
nerve development GO:0021675 4 0.023
specification of organ identity GO:0010092 3 0.023
cellular macromolecule catabolic process GO:0044265 380 0.023
head development GO:0060322 108 0.022
regulation of cell development GO:0060284 161 0.022
positive regulation of apoptotic process GO:0043065 246 0.022
regulation of protein localization GO:0032880 296 0.022
blood vessel development GO:0001568 172 0.022
Human
stem cell development GO:0048864 69 0.022
epithelial cell differentiation GO:0030855 141 0.022
negative regulation of phosphorus metabolic process GO:0010563 267 0.022
embryonic epithelial tube formation GO:0001838 4 0.022
immune system development GO:0002520 195 0.022
inner ear morphogenesis GO:0042472 4 0.022
regulation of cell migration GO:0030334 289 0.022
positive regulation of cell death GO:0010942 263 0.021
regulation of nucleotide metabolic process GO:0006140 269 0.021
lipid metabolic process GO:0006629 381 0.021
negative regulation of catalytic activity GO:0043086 335 0.021
regulation of cell cycle process GO:0010564 266 0.021
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.021
Human
regulation of establishment of protein localization GO:0070201 242 0.021
regulation of neural precursor cell proliferation GO:2000177 4 0.021
negative regulation of cell cycle GO:0045786 193 0.021
membrane organization GO:0061024 292 0.021
immune response GO:0006955 307 0.021
negative regulation of cell proliferation GO:0008285 228 0.020
single organism membrane organization GO:0044802 268 0.020
single organism cellular localization GO:1902580 332 0.020
cell activation GO:0001775 213 0.020
response to abiotic stimulus GO:0009628 336 0.020
neuron fate commitment GO:0048663 2 0.020
embryo development GO:0009790 123 0.020
regulation of protein kinase activity GO:0045859 289 0.020
cytoplasmic transport GO:0016482 379 0.020
tissue morphogenesis GO:0048729 96 0.020
regulation of proteolysis GO:0030162 293 0.020
negative regulation of cellular component organization GO:0051129 235 0.020
Human
regulation of protein transport GO:0051223 213 0.020
tube development GO:0035295 125 0.019
posttranscriptional regulation of gene expression GO:0010608 213 0.019
regulation of response to external stimulus GO:0032101 222 0.019
tube morphogenesis GO:0035239 95 0.019
regulation of kinase activity GO:0043549 314 0.019
positive regulation of cell differentiation GO:0045597 211 0.019
peripheral nervous system development GO:0007422 2 0.019
positive regulation of programmed cell death GO:0043068 249 0.019
brain development GO:0007420 97 0.019
mitotic cell cycle process GO:1903047 286 0.019
negative regulation of phosphate metabolic process GO:0045936 267 0.019
neurogenesis GO:0022008 169 0.019
Mouse
generation of neurons GO:0048699 152 0.019
Mouse
carbohydrate metabolic process GO:0005975 207 0.019
positive regulation of immune system process GO:0002684 283 0.019
chromatin organization GO:0006325 351 0.019
regulation of cell growth GO:0001558 135 0.018
regulation of stem cell differentiation GO:2000736 56 0.018
growth GO:0040007 202 0.018
Mouse
secretion by cell GO:0032940 226 0.018
neuron differentiation GO:0030182 138 0.018
Mouse
regulation of transferase activity GO:0051338 355 0.018
negative regulation of protein modification process GO:0031400 200 0.018
organonitrogen compound biosynthetic process GO:1901566 200 0.018
cellular macromolecular complex assembly GO:0034622 324 0.018
regulation of cellular response to stress GO:0080135 244 0.018
secretion GO:0046903 254 0.018
cell morphogenesis involved in differentiation GO:0000904 144 0.018
apoptotic signaling pathway GO:0097190 268 0.018
canonical wnt signaling pathway GO:0060070 116 0.018
cellular response to oxygen containing compound GO:1901701 276 0.018
positive regulation of catabolic process GO:0009896 310 0.018
oxidation reduction process GO:0055114 396 0.018
cytokine production GO:0001816 247 0.017
spinal cord development GO:0021510 4 0.017
regeneration GO:0031099 4 0.017
positive regulation of nucleotide metabolic process GO:0045981 230 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.017
biological adhesion GO:0022610 331 0.017
carbohydrate derivative biosynthetic process GO:1901137 207 0.017
response to other organism GO:0051707 261 0.017
mesenchymal cell development GO:0014031 50 0.017
embryonic morphogenesis GO:0048598 85 0.017
cell cell signaling GO:0007267 155 0.017
protein catabolic process GO:0030163 325 0.017
response to growth factor GO:0070848 205 0.017
response to oxygen containing compound GO:1901700 369 0.017
cellular response to cytokine stimulus GO:0071345 181 0.017
positive regulation of cell cycle GO:0045787 140 0.017
wnt signaling pathway GO:0016055 156 0.017
response to lipid GO:0033993 206 0.017
Human
mesenchymal cell differentiation GO:0048762 52 0.017
defense response GO:0006952 315 0.017
forebrain generation of neurons GO:0021872 3 0.017
protein ubiquitination GO:0016567 314 0.017
hemopoiesis GO:0030097 180 0.017
mesenchyme development GO:0060485 59 0.016
blastoderm segmentation GO:0007350 2 0.016
regulation of cytokine production GO:0001817 232 0.016
cellular protein catabolic process GO:0044257 261 0.016
thymus development GO:0048538 3 0.016
ribonucleoside triphosphate catabolic process GO:0009203 391 0.016
positive regulation of cytokine production GO:0001819 167 0.016
regulation of cell morphogenesis GO:0022604 153 0.016
regulation of growth GO:0040008 165 0.016
angiogenesis GO:0001525 147 0.016
Human
cellular lipid metabolic process GO:0044255 303 0.016
protein modification by small protein conjugation GO:0032446 342 0.016
response to cytokine GO:0034097 232 0.016
chromatin modification GO:0016568 298 0.016
neuromuscular junction development GO:0007528 3 0.015
regulation of endopeptidase activity GO:0052548 170 0.015
cell growth GO:0016049 160 0.015
nucleoside triphosphate metabolic process GO:0009141 422 0.015
intracellular protein transport GO:0006886 270 0.015
nucleoside phosphate catabolic process GO:1901292 412 0.015
organophosphate catabolic process GO:0046434 430 0.015
positive regulation of transport GO:0051050 336 0.015
protein localization to organelle GO:0033365 280 0.015
cellular response to growth factor stimulus GO:0071363 197 0.015
positive regulation of cellular catabolic process GO:0031331 284 0.015
cardiac right ventricle morphogenesis GO:0003215 3 0.015
vesicle mediated transport GO:0016192 371 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.015
purine nucleoside triphosphate metabolic process GO:0009144 412 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.015
digestive system development GO:0055123 75 0.015
regulation of intracellular transport GO:0032386 195 0.015
chemical homeostasis GO:0048878 306 0.015
ras protein signal transduction GO:0007265 73 0.015
heart development GO:0007507 95 0.014
signal transduction by phosphorylation GO:0023014 297 0.014
modification dependent macromolecule catabolic process GO:0043632 212 0.014
nucleotide catabolic process GO:0009166 408 0.014
memory GO:0007613 3 0.014
positive regulation of transferase activity GO:0051347 227 0.014
spermatid differentiation GO:0048515 4 0.014
purine ribonucleoside metabolic process GO:0046128 437 0.014
positive regulation of cell motility GO:2000147 177 0.014
negative regulation of cellular component movement GO:0051271 106 0.014
metal ion transport GO:0030001 272 0.014
cation transport GO:0006812 331 0.014
single organism carbohydrate metabolic process GO:0044723 193 0.014
regulation of purine nucleotide metabolic process GO:1900542 264 0.014
endocrine system development GO:0035270 26 0.014
pattern specification process GO:0007389 43 0.014
small molecule biosynthetic process GO:0044283 157 0.014
actin filament based process GO:0030029 224 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.014
embryonic camera type eye development GO:0031076 2 0.014
protein maturation GO:0051604 233 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
endomembrane system organization GO:0010256 196 0.014
regulation of peptidase activity GO:0052547 180 0.014
ribonucleoside triphosphate metabolic process GO:0009199 412 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
modification dependent protein catabolic process GO:0019941 209 0.014
ribonucleotide catabolic process GO:0009261 405 0.014
positive regulation of cellular component movement GO:0051272 181 0.014
cell part morphogenesis GO:0032990 137 0.014
response to external biotic stimulus GO:0043207 261 0.014
positive regulation of locomotion GO:0040017 186 0.014
epithelial cell proliferation GO:0050673 128 0.014
neuroblast proliferation GO:0007405 4 0.014
negative regulation of locomotion GO:0040013 118 0.014
nucleoside triphosphate catabolic process GO:0009143 394 0.014
single organism reproductive process GO:0044702 98 0.014
response to biotic stimulus GO:0009607 276 0.013
glycosyl compound catabolic process GO:1901658 413 0.013
positive regulation of mapk cascade GO:0043410 190 0.013
negative regulation of immune system process GO:0002683 136 0.013
protein localization to membrane GO:0072657 160 0.013
regulation of secretion GO:0051046 194 0.013
cell adhesion GO:0007155 325 0.013
cellular homeostasis GO:0019725 196 0.013
ribonucleoside catabolic process GO:0042454 406 0.013
nucleocytoplasmic transport GO:0006913 176 0.013
regulation of wnt signaling pathway GO:0030111 123 0.013
purine containing compound catabolic process GO:0072523 411 0.013
cell division GO:0051301 168 0.013
reproductive process GO:0022414 106 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
pharynx development GO:0060465 1 0.013
regulation of mapk cascade GO:0043408 262 0.013
cell cycle phase transition GO:0044770 173 0.013
spermatid development GO:0007286 4 0.013
regulation of response to wounding GO:1903034 101 0.013
positive regulation of organelle organization GO:0010638 195 0.013
morphogenesis of an epithelium GO:0002009 60 0.013
purine ribonucleoside catabolic process GO:0046130 398 0.013
positive regulation of cell migration GO:0030335 172 0.013
response to wounding GO:0009611 168 0.013
neuron development GO:0048666 113 0.013
purine nucleoside triphosphate catabolic process GO:0009146 392 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
histone modification GO:0016570 251 0.013
purine nucleoside catabolic process GO:0006152 398 0.013
protein acylation GO:0043543 138 0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.013
positive regulation of protein phosphorylation GO:0001934 313 0.013
metencephalon development GO:0022037 2 0.013
regulation of cysteine type endopeptidase activity GO:2000116 127 0.013
compound eye development GO:0048749 1 0.013
intracellular receptor signaling pathway GO:0030522 104 0.013
Human
organophosphate biosynthetic process GO:0090407 163 0.013
dephosphorylation GO:0016311 209 0.013
urogenital system development GO:0001655 65 0.013
regulation of secretion by cell GO:1903530 177 0.013
negative regulation of mitotic cell cycle GO:0045930 102 0.013
small gtpase mediated signal transduction GO:0007264 78 0.012
leukocyte activation GO:0045321 164 0.012
regulation of hormone levels GO:0010817 125 0.012
positive regulation of proteolysis GO:0045862 142 0.012
monocarboxylic acid metabolic process GO:0032787 185 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
oocyte development GO:0048599 1 0.012
ubiquitin dependent protein catabolic process GO:0006511 206 0.012
mapk cascade GO:0000165 288 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
purine ribonucleotide catabolic process GO:0009154 404 0.012
innate immune response GO:0045087 178 0.012
chemotaxis GO:0006935 157 0.012
glycoprotein biosynthetic process GO:0009101 91 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.012
rna processing GO:0006396 255 0.012
regulation of epithelial cell proliferation GO:0050678 113 0.012
purine nucleotide catabolic process GO:0006195 405 0.012
cerebellum development GO:0021549 2 0.012
regulation of dna metabolic process GO:0051052 153 0.012
covalent chromatin modification GO:0016569 254 0.012
negative regulation of cell cycle process GO:0010948 121 0.012
proteasomal protein catabolic process GO:0010498 176 0.012
cell projection morphogenesis GO:0048858 129 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
negative regulation of transport GO:0051051 176 0.012
metal ion homeostasis GO:0055065 169 0.012
regulation of multi organism process GO:0043900 157 0.012
positive regulation of endopeptidase activity GO:0010950 84 0.012
mitotic cell cycle phase transition GO:0044772 162 0.012
regulation of cellular component biogenesis GO:0044087 281 0.012
Human
somitogenesis GO:0001756 2 0.012
protein processing GO:0016485 226 0.012
regulation of immune response GO:0050776 201 0.012
endocytosis GO:0006897 159 0.012
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.012
oocyte differentiation GO:0009994 2 0.012
negative regulation of cell development GO:0010721 48 0.012
regulation of protein secretion GO:0050708 86 0.012
microtubule based process GO:0007017 210 0.012
wound healing GO:0042060 115 0.012
epithelial to mesenchymal transition GO:0001837 48 0.012
positive regulation of peptidase activity GO:0010952 88 0.012
neurological system process GO:0050877 163 0.012
positive regulation of kinase activity GO:0033674 204 0.012
taxis GO:0042330 157 0.011
organic hydroxy compound metabolic process GO:1901615 147 0.011
actin cytoskeleton organization GO:0030036 207 0.011
lipid biosynthetic process GO:0008610 177 0.011
cellular response to lipid GO:0071396 127 0.011
Human
nuclear transport GO:0051169 179 0.011
neural tube formation GO:0001841 3 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.011
neuron projection development GO:0031175 106 0.011
glycoprotein metabolic process GO:0009100 110 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
positive regulation of cell development GO:0010720 92 0.011
primary neural tube formation GO:0014020 3 0.011
immune effector process GO:0002252 159 0.011
regulation of neurogenesis GO:0050767 82 0.011
positive regulation of protein transport GO:0051222 135 0.011
hemostasis GO:0007599 76 0.011
positive regulation of protein kinase activity GO:0045860 190 0.011
receptor metabolic process GO:0043112 81 0.011
muscle tissue development GO:0060537 62 0.011
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
anterior posterior axis specification GO:0009948 2 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.011
cellular protein complex assembly GO:0043623 188 0.011
photoreceptor cell differentiation GO:0046530 2 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.011
negative regulation of organelle organization GO:0010639 126 0.011
negative regulation of cell growth GO:0030308 83 0.011
regulation of vasculature development GO:1901342 97 0.011
ion homeostasis GO:0050801 230 0.011
maintenance of location GO:0051235 112 0.011
forebrain neuron differentiation GO:0021879 3 0.011
regulation of protein complex assembly GO:0043254 147 0.011
Human
neural crest cell development GO:0014032 3 0.011
dna repair GO:0006281 198 0.011
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.011
digestive tract development GO:0048565 75 0.011
rho protein signal transduction GO:0007266 26 0.011
embryonic eye morphogenesis GO:0048048 2 0.011
negative regulation of cell motility GO:2000146 104 0.011
nitrogen compound transport GO:0071705 191 0.011
positive regulation of secretion GO:0051047 116 0.011
muscle structure development GO:0061061 98 0.011
Human
positive regulation of neural precursor cell proliferation GO:2000179 2 0.011
regulation of defense response GO:0031347 154 0.011
protein oligomerization GO:0051259 173 0.011
regulation of mitotic cell cycle phase transition GO:1901990 118 0.011
sensory organ development GO:0007423 52 0.010
regulation of cytoskeleton organization GO:0051493 177 0.010
response to hypoxia GO:0001666 96 0.010
epidermis development GO:0008544 59 0.010
negative regulation of transferase activity GO:0051348 124 0.010
adult locomotory behavior GO:0008344 1 0.010
regulation of purine nucleotide catabolic process GO:0033121 205 0.010
positive regulation of cell cycle process GO:0090068 106 0.010
soft palate development GO:0060023 3 0.010
protein secretion GO:0009306 98 0.010
limbic system development GO:0021761 3 0.010
positive regulation of secretion by cell GO:1903532 108 0.010
regulation of protein serine threonine kinase activity GO:0071900 179 0.010
sex determination GO:0007530 3 0.010
protein targeting GO:0006605 187 0.010
regulation of body fluid levels GO:0050878 99 0.010
response to oxygen levels GO:0070482 100 0.010
epithelial tube morphogenesis GO:0060562 38 0.010
positive regulation of cellular component biogenesis GO:0044089 158 0.010
transmembrane transport GO:0055085 399 0.010
response to decreased oxygen levels GO:0036293 96 0.010
embryonic forelimb morphogenesis GO:0035115 4 0.010
regulation of cell cycle phase transition GO:1901987 126 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.010
somatic stem cell maintenance GO:0035019 4 0.010
plasma membrane organization GO:0007009 115 0.010
response to fungus GO:0009620 4 0.010
multi organism cellular process GO:0044764 156 0.010
tripartite regional subdivision GO:0007351 2 0.010
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.010
regulation of homeostatic process GO:0032844 121 0.010
single organismal cell cell adhesion GO:0016337 148 0.010
tube closure GO:0060606 3 0.010

HELT disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.020
nervous system disease DOID:863 431 0.020
eye and adnexa disease DOID:1492 150 0.018
disease of metabolism DOID:0014667 295 0.017
eye disease DOID:5614 149 0.015
musculoskeletal system disease DOID:17 223 0.015
central nervous system disease DOID:331 186 0.014
disease of cellular proliferation DOID:14566 174 0.011
cancer DOID:162 167 0.011
organ system cancer DOID:0050686 164 0.011
inherited metabolic disorder DOID:655 242 0.011