Homo sapiens

6 known processes

PNPLA6

patatin-like phospholipase domain containing 6

(Aliases: NTEMND,SPG39,sws,NTE)

PNPLA6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ras protein signal transduction GO:0007265 73 0.807
ribonucleotide catabolic process GO:0009261 405 0.622
regulation of nucleotide metabolic process GO:0006140 269 0.558
rab protein signal transduction GO:0032482 4 0.510
purine ribonucleotide catabolic process GO:0009154 404 0.506
lipid metabolic process GO:0006629 381 0.444
Fly
gtp metabolic process GO:0046039 239 0.439
gtp catabolic process GO:0006184 237 0.426
nucleoside triphosphate catabolic process GO:0009143 394 0.420
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.416
regulation of gtp catabolic process GO:0033124 180 0.394
guanosine containing compound metabolic process GO:1901068 244 0.376
regulation of ras protein signal transduction GO:0046578 155 0.364
response to hormone GO:0009725 175 0.354
purine ribonucleoside metabolic process GO:0046128 437 0.352
purine nucleoside triphosphate catabolic process GO:0009146 392 0.351
actin cytoskeleton organization GO:0030036 207 0.346
glycosyl compound catabolic process GO:1901658 413 0.345
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.338
purine nucleoside triphosphate metabolic process GO:0009144 412 0.321
regulation of small gtpase mediated signal transduction GO:0051056 156 0.320
purine nucleotide catabolic process GO:0006195 405 0.320
positive regulation of rab gtpase activity GO:0032851 39 0.316
positive regulation of gtp catabolic process GO:0033126 166 0.312
actin filament based process GO:0030029 224 0.306
ribonucleoside triphosphate metabolic process GO:0009199 412 0.297
regulation of nucleotide catabolic process GO:0030811 205 0.291
regulation of nucleoside metabolic process GO:0009118 209 0.286
regulation of purine nucleotide catabolic process GO:0033121 205 0.286
purine nucleoside catabolic process GO:0006152 398 0.285
positive regulation of gtpase activity GO:0043547 166 0.283
ribonucleoside catabolic process GO:0042454 406 0.282
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.277
nucleotide catabolic process GO:0009166 408 0.269
positive regulation of ras gtpase activity GO:0032320 117 0.267
guanosine containing compound catabolic process GO:1901069 239 0.257
nucleoside catabolic process GO:0009164 408 0.246
organophosphate catabolic process GO:0046434 430 0.239
enzyme linked receptor protein signaling pathway GO:0007167 303 0.228
positive regulation of nucleotide catabolic process GO:0030813 185 0.226
cellular ketone metabolic process GO:0042180 80 0.221
positive regulation of nucleotide metabolic process GO:0045981 230 0.215
vesicle mediated transport GO:0016192 371 0.202
positive regulation of cellular catabolic process GO:0031331 284 0.200
ribonucleoside triphosphate catabolic process GO:0009203 391 0.197
nucleoside triphosphate metabolic process GO:0009141 422 0.196
purine containing compound catabolic process GO:0072523 411 0.195
regulation of rab gtpase activity GO:0032313 39 0.194
small gtpase mediated signal transduction GO:0007264 78 0.193
rho protein signal transduction GO:0007266 26 0.191
regulation of gtpase activity GO:0043087 180 0.168
positive regulation of nucleoside metabolic process GO:0045979 186 0.154
positive regulation of hydrolase activity GO:0051345 331 0.152
regulation of cellular ketone metabolic process GO:0010565 50 0.137
cellular amine metabolic process GO:0044106 41 0.136
Fly
membrane organization GO:0061024 292 0.135
Fly
regulation of ras gtpase activity GO:0032318 128 0.131
amine metabolic process GO:0009308 44 0.128
Fly
regulation of rho protein signal transduction GO:0035023 79 0.118
purine ribonucleoside catabolic process GO:0046130 398 0.104
positive regulation of catabolic process GO:0009896 310 0.094
response to abiotic stimulus GO:0009628 336 0.090
regulation of cellular component biogenesis GO:0044087 281 0.088
cellular lipid metabolic process GO:0044255 303 0.088
Fly
chemical homeostasis GO:0048878 306 0.086
histone modification GO:0016570 251 0.082
regulation of purine nucleotide metabolic process GO:1900542 264 0.081
locomotory behavior GO:0007626 1 0.077
hemostasis GO:0007599 76 0.073
lipid biosynthetic process GO:0008610 177 0.071
endomembrane system organization GO:0010256 196 0.070
regulation of body fluid levels GO:0050878 99 0.067
cell development GO:0048468 328 0.067
cell adhesion GO:0007155 325 0.065
nervous system development GO:0007399 293 0.063
cell projection organization GO:0030030 252 0.061
regulation of anatomical structure morphogenesis GO:0022603 286 0.059
determination of adult lifespan GO:0008340 2 0.059
negative regulation of phosphate metabolic process GO:0045936 267 0.058
cellular amino acid metabolic process GO:0006520 116 0.058
protein localization to organelle GO:0033365 280 0.057
single organism cellular localization GO:1902580 332 0.057
response to other organism GO:0051707 261 0.054
nucleoside phosphate catabolic process GO:1901292 412 0.054
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.054
positive regulation of protein phosphorylation GO:0001934 313 0.053
negative regulation of cellular protein metabolic process GO:0032269 353 0.052
regulation of protein kinase activity GO:0045859 289 0.051
positive regulation of cellular amine metabolic process GO:0033240 7 0.050
protein localization to membrane GO:0072657 160 0.049
cellular response to endogenous stimulus GO:0071495 336 0.048
regulation of kinase activity GO:0043549 314 0.047
multicellular organismal aging GO:0010259 3 0.047
glycerolipid metabolic process GO:0046486 107 0.047
Fly
system process GO:0003008 349 0.046
Fly
negative regulation of transport GO:0051051 176 0.046
regulation of cell differentiation GO:0045595 393 0.045
protein targeting GO:0006605 187 0.045
actin filament organization GO:0007015 128 0.045
segmentation GO:0035282 4 0.045
defense response GO:0006952 315 0.044
maintenance of location GO:0051235 112 0.044
regulation of cellular component movement GO:0051270 334 0.043
cytoplasmic transport GO:0016482 379 0.043
cell substrate adhesion GO:0031589 132 0.043
chromatin organization GO:0006325 351 0.042
transmembrane transport GO:0055085 399 0.041
cellular homeostasis GO:0019725 196 0.040
organophosphate biosynthetic process GO:0090407 163 0.040
regulation of locomotion GO:0040012 329 0.040
positive regulation of cellular component organization GO:0051130 376 0.039
regulation of neuron differentiation GO:0045664 70 0.039
cellular component morphogenesis GO:0032989 314 0.039
regulation of rab protein signal transduction GO:0032483 39 0.039
cellular macromolecule catabolic process GO:0044265 380 0.039
covalent chromatin modification GO:0016569 254 0.039
neuromuscular junction development GO:0007528 3 0.038
inorganic ion transmembrane transport GO:0098660 231 0.038
regulation of transferase activity GO:0051338 355 0.038
organelle assembly GO:0070925 176 0.038
response to biotic stimulus GO:0009607 276 0.037
negative regulation of phosphorus metabolic process GO:0010563 267 0.037
cellular response to external stimulus GO:0071496 111 0.037
lipid modification GO:0030258 84 0.037
cell morphogenesis GO:0000902 296 0.037
glycerophospholipid metabolic process GO:0006650 84 0.037
Fly
regulation of response to external stimulus GO:0032101 222 0.036
positive regulation of transport GO:0051050 336 0.036
secretion by cell GO:0032940 226 0.036
response to oxygen containing compound GO:1901700 369 0.036
mapk cascade GO:0000165 288 0.036
response to extracellular stimulus GO:0009991 85 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.035
signal transduction by phosphorylation GO:0023014 297 0.035
regulation of cellular amine metabolic process GO:0033238 11 0.035
inorganic cation transmembrane transport GO:0098662 194 0.033
biological adhesion GO:0022610 331 0.033
nitrogen compound transport GO:0071705 191 0.033
alcohol metabolic process GO:0006066 114 0.032
Fly
negative regulation of catalytic activity GO:0043086 335 0.032
negative regulation of cellular component organization GO:0051129 235 0.032
monocarboxylic acid biosynthetic process GO:0072330 67 0.031
endosomal transport GO:0016197 129 0.031
cell matrix adhesion GO:0007160 85 0.031
positive regulation of rho gtpase activity GO:0032321 56 0.031
ion homeostasis GO:0050801 230 0.030
ameboidal type cell migration GO:0001667 135 0.030
proteasomal protein catabolic process GO:0010498 176 0.030
cell junction assembly GO:0034329 67 0.030
regulation of proteolysis GO:0030162 293 0.029
single organism membrane organization GO:0044802 268 0.029
ruffle organization GO:0031529 18 0.029
cellular cation homeostasis GO:0030003 163 0.029
peptidyl tyrosine phosphorylation GO:0018108 170 0.029
regulation of mapk cascade GO:0043408 262 0.028
regulation of cellular response to stress GO:0080135 244 0.028
nucleoside phosphate biosynthetic process GO:1901293 109 0.028
sex determination GO:0007530 3 0.028
protein processing GO:0016485 226 0.028
anion transport GO:0006820 161 0.028
chromatin modification GO:0016568 298 0.028
vacuole organization GO:0007033 44 0.028
regulation of cell projection organization GO:0031344 107 0.027
cellular response to hormone stimulus GO:0032870 125 0.027
epithelium development GO:0060429 227 0.027
microtubule cytoskeleton organization GO:0000226 176 0.027
immune effector process GO:0002252 159 0.027
cellular response to peptide hormone stimulus GO:0071375 56 0.026
amide transport GO:0042886 76 0.026
post embryonic development GO:0009791 2 0.026
cellular protein catabolic process GO:0044257 261 0.026
homotypic cell cell adhesion GO:0034109 47 0.026
protein localization to plasma membrane GO:0072659 93 0.025
cell junction organization GO:0034330 79 0.025
negative regulation of multicellular organismal process GO:0051241 317 0.025
regulation of protein localization GO:0032880 296 0.024
negative regulation of protein kinase activity GO:0006469 98 0.024
establishment of protein localization to membrane GO:0090150 121 0.024
autophagy GO:0006914 88 0.024
vesicle organization GO:0016050 62 0.024
cellular response to extracellular stimulus GO:0031668 72 0.024
cell chemotaxis GO:0060326 112 0.024
cytokine production GO:0001816 247 0.023
cellular chemical homeostasis GO:0055082 180 0.023
regulation of nervous system development GO:0051960 88 0.023
negative regulation of phosphorylation GO:0042326 174 0.023
negative regulation of protein metabolic process GO:0051248 391 0.023
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.023
neurological system process GO:0050877 163 0.022
Fly
regulation of cellular amino acid metabolic process GO:0006521 6 0.022
peptidyl threonine modification GO:0018210 45 0.022
secretion GO:0046903 254 0.022
receptor metabolic process GO:0043112 81 0.022
response to organonitrogen compound GO:0010243 156 0.022
embryo development GO:0009790 123 0.022
response to nitrogen compound GO:1901698 184 0.022
blood coagulation GO:0007596 76 0.022
growth GO:0040007 202 0.022
purine nucleoside monophosphate catabolic process GO:0009128 158 0.022
protein catabolic process GO:0030163 325 0.022
compound eye development GO:0048749 1 0.021
single organism cell adhesion GO:0098602 179 0.021
regulation of secretion by cell GO:1903530 177 0.021
mitotic cell cycle GO:0000278 326 0.021
negative regulation of protein phosphorylation GO:0001933 140 0.021
cellular response to starvation GO:0009267 58 0.021
female gamete generation GO:0007292 2 0.020
positive regulation of kinase activity GO:0033674 204 0.020
ruffle assembly GO:0097178 10 0.020
protein targeting to nucleus GO:0044744 104 0.020
regulation of dephosphorylation GO:0035303 96 0.020
regulation of cell development GO:0060284 161 0.020
cation homeostasis GO:0055080 189 0.020
positive regulation of phosphorylation GO:0042327 394 0.020
modification dependent macromolecule catabolic process GO:0043632 212 0.020
nucleus localization GO:0051647 1 0.020
nucleoside monophosphate metabolic process GO:0009123 191 0.020
plasma membrane organization GO:0007009 115 0.020
cell morphogenesis involved in differentiation GO:0000904 144 0.020
regulation of cell motility GO:2000145 299 0.020
regulation of immune response GO:0050776 201 0.020
protein import into nucleus GO:0006606 104 0.020
cellular ion homeostasis GO:0006873 168 0.020
pattern specification process GO:0007389 43 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.019
protein autophosphorylation GO:0046777 123 0.019
blastoderm segmentation GO:0007350 2 0.019
neuron projection development GO:0031175 106 0.019
cell migration involved in gastrulation GO:0042074 1 0.019
response to peptide GO:1901652 65 0.019
mitotic cell cycle phase transition GO:0044772 162 0.019
epithelial cell migration GO:0010631 119 0.019
endocytosis GO:0006897 159 0.019
cellular response to oxygen containing compound GO:1901701 276 0.018
activation of protein kinase activity GO:0032147 90 0.018
negative regulation of apoptotic process GO:0043066 316 0.018
cell activation GO:0001775 213 0.018
negative regulation of protein modification process GO:0031400 200 0.018
regulation of establishment of protein localization GO:0070201 242 0.018
cation transport GO:0006812 331 0.018
response to external biotic stimulus GO:0043207 261 0.018
ribonucleoside monophosphate metabolic process GO:0009161 187 0.018
dephosphorylation GO:0016311 209 0.018
peptidyl threonine phosphorylation GO:0018107 41 0.018
positive regulation of cellular component movement GO:0051272 181 0.018
establishment of protein localization to organelle GO:0072594 172 0.018
rhythmic behavior GO:0007622 2 0.017
response to wounding GO:0009611 168 0.017
regulation of lipid metabolic process GO:0019216 96 0.017
neurogenesis GO:0022008 169 0.017
positive regulation of locomotion GO:0040017 186 0.017
regulation of protein complex assembly GO:0043254 147 0.017
positive regulation of mapk cascade GO:0043410 190 0.017
regulation of cell migration GO:0030334 289 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
positive regulation of transferase activity GO:0051347 227 0.017
protein secretion GO:0009306 98 0.016
focal adhesion assembly GO:0048041 30 0.016
interleukin 12 mediated signaling pathway GO:0035722 3 0.016
internal protein amino acid acetylation GO:0006475 101 0.016
regulation of growth GO:0040008 165 0.016
positive regulation of cell division GO:0051781 59 0.016
regulation of secretion GO:0051046 194 0.016
response to peptide hormone GO:0043434 61 0.016
neuron differentiation GO:0030182 138 0.016
peptidyl serine modification GO:0018209 106 0.016
negative regulation of transferase activity GO:0051348 124 0.016
phosphatidic acid biosynthetic process GO:0006654 4 0.016
organonitrogen compound biosynthetic process GO:1901566 200 0.016
cellular response to nutrient levels GO:0031669 69 0.016
memory GO:0007613 3 0.016
protein dephosphorylation GO:0006470 81 0.015
monocarboxylic acid metabolic process GO:0032787 185 0.015
regulation of cell activation GO:0050865 125 0.015
lipid localization GO:0010876 106 0.015
negative regulation of hydrolase activity GO:0051346 182 0.015
intracellular protein transport GO:0006886 270 0.015
positive regulation of developmental process GO:0051094 314 0.015
peptide transport GO:0015833 74 0.015
neuron development GO:0048666 113 0.015
peptidyl serine phosphorylation GO:0018105 101 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.015
protein localization to nucleus GO:0034504 136 0.015
protein maturation GO:0051604 233 0.015
regionalization GO:0003002 29 0.015
negative regulation of developmental process GO:0051093 247 0.015
regulation of ion transport GO:0043269 189 0.015
regulation of cell cycle GO:0051726 393 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
regulation of plasma lipoprotein particle levels GO:0097006 32 0.015
negative regulation of cell death GO:0060548 345 0.015
chemotaxis GO:0006935 157 0.015
negative regulation of protein processing GO:0010955 142 0.015
negative regulation of protein maturation GO:1903318 142 0.014
head development GO:0060322 108 0.014
golgi organization GO:0007030 38 0.014
peptidyl lysine modification GO:0018205 144 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
positive regulation of secretion GO:0051047 116 0.014
spermatid differentiation GO:0048515 4 0.014
circadian behavior GO:0048512 2 0.014
regulation of cell adhesion GO:0030155 166 0.014
brain development GO:0007420 97 0.014
negative regulation of organelle organization GO:0010639 126 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.014
single organismal cell cell adhesion GO:0016337 148 0.014
phospholipid biosynthetic process GO:0008654 44 0.014
adherens junction organization GO:0034332 36 0.014
purine nucleoside monophosphate metabolic process GO:0009126 186 0.014
spermatid development GO:0007286 4 0.014
positive regulation of protein kinase activity GO:0045860 190 0.014
fatty acid biosynthetic process GO:0006633 46 0.013
regulation of cell morphogenesis GO:0022604 153 0.013
regulation of intracellular transport GO:0032386 195 0.013
cell cell junction organization GO:0045216 69 0.013
positive regulation of cell development GO:0010720 92 0.013
cation transmembrane transport GO:0098655 238 0.013
steroid metabolic process GO:0008202 94 0.013
anatomical structure formation involved in morphogenesis GO:0048646 284 0.013
Mouse
taxis GO:0042330 157 0.013
small molecule biosynthetic process GO:0044283 157 0.013
cell substrate adherens junction assembly GO:0007045 30 0.013
cell part morphogenesis GO:0032990 137 0.013
nucleocytoplasmic transport GO:0006913 176 0.013
cytokine mediated signaling pathway GO:0019221 109 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.013
wound healing GO:0042060 115 0.013
macroautophagy GO:0016236 39 0.013
tissue migration GO:0090130 119 0.013
response to growth factor GO:0070848 205 0.013
negative regulation of kinase activity GO:0033673 106 0.013
cyclic nucleotide biosynthetic process GO:0009190 61 0.013
nuclear transport GO:0051169 179 0.013
response to fungus GO:0009620 4 0.013
phospholipid metabolic process GO:0006644 99 0.012
Fly
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.012
innate immune response GO:0045087 178 0.012
stem cell division GO:0017145 2 0.012
atp catabolic process GO:0006200 157 0.012
ribonucleotide biosynthetic process GO:0009260 81 0.012
regulation of response to wounding GO:1903034 101 0.012
hormone secretion GO:0046879 65 0.012
response to bacterium GO:0009617 144 0.012
circulatory system development GO:0072359 262 0.012
Mouse
neuroblast proliferation GO:0007405 4 0.012
positive regulation of neuron differentiation GO:0045666 40 0.012
ribose phosphate biosynthetic process GO:0046390 82 0.012
metal ion transport GO:0030001 272 0.012
positive regulation of cytoskeleton organization GO:0051495 83 0.012
atp metabolic process GO:0046034 176 0.012
regulation of chromatin modification GO:1903308 51 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
protein acylation GO:0043543 138 0.012
regulation of protein processing GO:0070613 150 0.012
regulation of neuron projection development GO:0010975 57 0.012
response to cytokine GO:0034097 232 0.012
regulation of cell cycle process GO:0010564 266 0.012
platelet aggregation GO:0070527 32 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.011
actin cytoskeleton reorganization GO:0031532 37 0.011
positive regulation of cytokinesis GO:0032467 29 0.011
microtubule based process GO:0007017 210 0.011
cellular response to tumor necrosis factor GO:0071356 63 0.011
regulation of dna metabolic process GO:0051052 153 0.011
ectodermal placode development GO:0071696 1 0.011
epithelial cell differentiation GO:0030855 141 0.011
maintenance of location in cell GO:0051651 62 0.011
positive regulation of cell projection organization GO:0031346 64 0.011
cellular response to peptide GO:1901653 59 0.011
regulation of cell division GO:0051302 116 0.011
cell cycle arrest GO:0007050 71 0.011
positive regulation of cellular component biogenesis GO:0044089 158 0.011
regulation of protein maturation GO:1903317 150 0.011
receptor mediated endocytosis GO:0006898 84 0.011
adherens junction assembly GO:0034333 34 0.011
response to hypoxia GO:0001666 96 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.011
positive regulation of response to external stimulus GO:0032103 88 0.011
response to decreased oxygen levels GO:0036293 96 0.011
regulation of neurogenesis GO:0050767 82 0.011
camp biosynthetic process GO:0006171 47 0.011
immune system development GO:0002520 195 0.011
cellular response to organonitrogen compound GO:0071417 124 0.011
regulation of epithelial cell proliferation GO:0050678 113 0.011
positive regulation of cell motility GO:2000147 177 0.011
cell projection morphogenesis GO:0048858 129 0.011
response to inorganic substance GO:0010035 127 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.011
convergent extension GO:0060026 1 0.011
adult locomotory behavior GO:0008344 1 0.011
regulation of phosphatase activity GO:0010921 81 0.010
regulation of map kinase activity GO:0043405 108 0.010
regulation of defense response GO:0031347 154 0.010
monovalent inorganic cation transport GO:0015672 128 0.010
modification dependent protein catabolic process GO:0019941 209 0.010
inorganic anion transport GO:0015698 60 0.010
internal peptidyl lysine acetylation GO:0018393 97 0.010
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.010
epithelium migration GO:0090132 119 0.010
cellular response to nitrogen compound GO:1901699 144 0.010
neural tube formation GO:0001841 3 0.010
cellular response to interleukin 12 GO:0071349 3 0.010
generation of neurons GO:0048699 152 0.010
g protein coupled receptor signaling pathway GO:0007186 207 0.010

PNPLA6 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.025
nervous system disease DOID:863 431 0.025
neurodegenerative disease DOID:1289 102 0.015
bone remodeling disease DOID:0080005 26 0.013
bone disease DOID:0080001 88 0.013
osteopetrosis DOID:13533 9 0.013
musculoskeletal system disease DOID:17 223 0.013
connective tissue disease DOID:65 109 0.013
osteosclerosis DOID:4254 16 0.013
immune system disease DOID:2914 155 0.010
paraplegia DOID:607 19 0.002
hereditary spastic paraplegia DOID:2476 19 0.002