Homo sapiens

98 known processes

PNPLA8

patatin-like phospholipase domain containing 8

(Aliases: IPLA2G,IPLA2-2,IPLA2(GAMMA))

PNPLA8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
modification dependent protein catabolic process GO:0019941 209 0.171
cellular protein catabolic process GO:0044257 261 0.121
protein ubiquitination GO:0016567 314 0.109
post embryonic development GO:0009791 2 0.101
modification dependent macromolecule catabolic process GO:0043632 212 0.082
nucleoside phosphate catabolic process GO:1901292 412 0.081
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.079
cellular macromolecule catabolic process GO:0044265 380 0.077
oogenesis GO:0048477 2 0.076
gtp metabolic process GO:0046039 239 0.074
organophosphate catabolic process GO:0046434 430 0.071
proteasomal protein catabolic process GO:0010498 176 0.069
posttranscriptional regulation of gene expression GO:0010608 213 0.068
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.065
ubiquitin dependent protein catabolic process GO:0006511 206 0.064
protein catabolic process GO:0030163 325 0.064
purine containing compound catabolic process GO:0072523 411 0.063
lipid metabolic process GO:0006629 381 0.061
amine metabolic process GO:0009308 44 0.058
cytoplasmic transport GO:0016482 379 0.057
intracellular protein transport GO:0006886 270 0.052
positive regulation of nucleoside metabolic process GO:0045979 186 0.051
response to wounding GO:0009611 168 0.051
ribonucleoside triphosphate metabolic process GO:0009199 412 0.051
protein localization to organelle GO:0033365 280 0.049
female gamete generation GO:0007292 2 0.047
purine ribonucleoside metabolic process GO:0046128 437 0.047
regulation of cellular response to stress GO:0080135 244 0.046
purine ribonucleoside catabolic process GO:0046130 398 0.046
positive regulation of cellular catabolic process GO:0031331 284 0.045
nucleoside triphosphate metabolic process GO:0009141 422 0.042
cellular lipid metabolic process GO:0044255 303 0.042
cellular amine metabolic process GO:0044106 41 0.039
ras protein signal transduction GO:0007265 73 0.038
positive regulation of catabolic process GO:0009896 310 0.038
positive regulation of gtp catabolic process GO:0033126 166 0.038
positive regulation of gtpase activity GO:0043547 166 0.038
regulation of gtpase activity GO:0043087 180 0.037
chondroitin sulfate proteoglycan biosynthetic process GO:0050650 10 0.037
single organism cellular localization GO:1902580 332 0.037
ribonucleoside catabolic process GO:0042454 406 0.037
purine nucleoside catabolic process GO:0006152 398 0.036
regulation of cellular amino acid metabolic process GO:0006521 6 0.036
positive regulation of transport GO:0051050 336 0.035
purine ribonucleotide catabolic process GO:0009154 404 0.035
negative regulation of protein metabolic process GO:0051248 391 0.033
glycoprotein metabolic process GO:0009100 110 0.033
ribonucleoside triphosphate catabolic process GO:0009203 391 0.033
regulation of cytoplasmic transport GO:1903649 149 0.032
positive regulation of cellular amine metabolic process GO:0033240 7 0.032
unidimensional cell growth GO:0009826 1 0.031
cellular component morphogenesis GO:0032989 314 0.031
cell morphogenesis GO:0000902 296 0.030
purine nucleoside triphosphate metabolic process GO:0009144 412 0.030
regulation of nucleoside metabolic process GO:0009118 209 0.030
negative regulation of phosphate metabolic process GO:0045936 267 0.029
purine nucleotide catabolic process GO:0006195 405 0.029
regulation of nucleotide metabolic process GO:0006140 269 0.029
response to abiotic stimulus GO:0009628 336 0.029
wnt signaling pathway GO:0016055 156 0.028
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.028
regulation of intracellular transport GO:0032386 195 0.028
regulation of nucleotide catabolic process GO:0030811 205 0.028
carbohydrate derivative biosynthetic process GO:1901137 207 0.028
negative regulation of cellular protein metabolic process GO:0032269 353 0.028
guanosine containing compound catabolic process GO:1901069 239 0.027
purine nucleoside triphosphate catabolic process GO:0009146 392 0.027
cellular ketone metabolic process GO:0042180 80 0.027
mechanosensory behavior GO:0007638 4 0.026
regulation of protein localization GO:0032880 296 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.026
protein stabilization GO:0050821 64 0.026
protein modification by small protein conjugation GO:0032446 342 0.026
positive regulation of hydrolase activity GO:0051345 331 0.025
regulation of gtp catabolic process GO:0033124 180 0.025
gtp catabolic process GO:0006184 237 0.025
nucleoside catabolic process GO:0009164 408 0.025
glycosyl compound catabolic process GO:1901658 413 0.025
regulation of response to external stimulus GO:0032101 222 0.024
regulation of intracellular protein transport GO:0033157 123 0.023
regulation of proteolysis GO:0030162 293 0.023
positive regulation of nucleotide catabolic process GO:0030813 185 0.023
regulation of anatomical structure morphogenesis GO:0022603 286 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.023
lipid biosynthetic process GO:0008610 177 0.022
cellular amino acid metabolic process GO:0006520 116 0.022
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.022
negative regulation of cellular component organization GO:0051129 235 0.022
guanosine containing compound metabolic process GO:1901068 244 0.022
chemical homeostasis GO:0048878 306 0.021
actin mediated cell contraction GO:0070252 12 0.021
negative regulation of phosphorus metabolic process GO:0010563 267 0.021
nucleotide catabolic process GO:0009166 408 0.021
regulation of protein kinase activity GO:0045859 289 0.021
regulation of cellular ketone metabolic process GO:0010565 50 0.021
cell growth GO:0016049 160 0.020
regulation of protein stability GO:0031647 87 0.020
multicellular organismal aging GO:0010259 3 0.020
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 43 0.020
regulation of transferase activity GO:0051338 355 0.020
positive regulation of cell death GO:0010942 263 0.019
determination of adult lifespan GO:0008340 2 0.019
positive regulation of exocytosis GO:0045921 35 0.019
small gtpase mediated signal transduction GO:0007264 78 0.019
regulation of cell cycle process GO:0010564 266 0.019
regulation of cell cycle GO:0051726 393 0.019
regulation of cellular amine metabolic process GO:0033238 11 0.019
regulation of apoptotic signaling pathway GO:2001233 175 0.019
organonitrogen compound biosynthetic process GO:1901566 200 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
endomembrane system organization GO:0010256 196 0.018
positive regulation of nucleotide metabolic process GO:0045981 230 0.018
cellular cation homeostasis GO:0030003 163 0.018
dephosphorylation GO:0016311 209 0.018
secretion by cell GO:0032940 226 0.018
protein polyubiquitination GO:0000209 110 0.018
defense response GO:0006952 315 0.018
cilium morphogenesis GO:0060271 75 0.017
glycerolipid metabolic process GO:0046486 107 0.017
chromatin modification GO:0016568 298 0.017
positive regulation of cellular component organization GO:0051130 376 0.017
regulation of kinase activity GO:0043549 314 0.017
regulation of vesicle mediated transport GO:0060627 130 0.017
positive regulation of secretion by cell GO:1903532 108 0.017
vesicle mediated transport GO:0016192 371 0.016
negative regulation of programmed cell death GO:0043069 321 0.016
negative regulation of apoptotic process GO:0043066 316 0.016
negative regulation of phosphorylation GO:0042326 174 0.016
regulation of purine nucleotide catabolic process GO:0033121 205 0.016
regulation of tor signaling GO:0032006 30 0.016
monovalent inorganic cation transport GO:0015672 128 0.015
response to oxidative stress GO:0006979 121 0.015
chromatin organization GO:0006325 351 0.015
cation transport GO:0006812 331 0.015
nitrogen compound transport GO:0071705 191 0.015
mitochondrion organization GO:0007005 156 0.015
protein localization to nucleus GO:0034504 136 0.015
metal ion transport GO:0030001 272 0.015
fatty acid metabolic process GO:0006631 115 0.015
regulation of establishment of protein localization GO:0070201 242 0.015
positive regulation of secretion GO:0051047 116 0.015
regulation of protein transport GO:0051223 213 0.015
ribonucleotide catabolic process GO:0009261 405 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
somatic muscle development GO:0007525 1 0.014
protein import into nucleus GO:0006606 104 0.014
cell projection organization GO:0030030 252 0.014
establishment of protein localization to organelle GO:0072594 172 0.014
single organism nuclear import GO:1902593 104 0.014
cellular macromolecular complex assembly GO:0034622 324 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
regulation of secretion GO:0051046 194 0.013
regulation of nucleocytoplasmic transport GO:0046822 98 0.013
positive regulation of cell proliferation GO:0008284 301 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.013
regulation of cellular component biogenesis GO:0044087 281 0.013
immune response GO:0006955 307 0.013
neurotransmitter secretion GO:0007269 4 0.013
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.013
regulation of cell projection organization GO:0031344 107 0.013
cilium organization GO:0044782 68 0.013
post golgi vesicle mediated transport GO:0006892 36 0.013
secretion GO:0046903 254 0.013
regulation of gene expression epigenetic GO:0040029 73 0.013
mitotic cell cycle GO:0000278 326 0.013
rho protein signal transduction GO:0007266 26 0.013
cellular chemical homeostasis GO:0055082 180 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
regulation of dna metabolic process GO:0051052 153 0.013
negative regulation of cell cycle GO:0045786 193 0.013
golgi vesicle transport GO:0048193 80 0.012
regulation of immune response GO:0050776 201 0.012
regulation of neurotransmitter secretion GO:0046928 3 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
apoptotic signaling pathway GO:0097190 268 0.012
vacuolar transport GO:0007034 34 0.012
histone modification GO:0016570 251 0.012
plasma membrane organization GO:0007009 115 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
lipid transport GO:0006869 90 0.012
g protein coupled receptor signaling pathway GO:0007186 207 0.012
nuclear transport GO:0051169 179 0.012
axon cargo transport GO:0008088 2 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.012
negative regulation of axonogenesis GO:0050771 4 0.012
cilium assembly GO:0042384 63 0.012
negative regulation of protein modification process GO:0031400 200 0.011
cellular ion homeostasis GO:0006873 168 0.011
endosomal transport GO:0016197 129 0.011
negative regulation of growth GO:0045926 97 0.011
response to organic cyclic compound GO:0014070 204 0.011
mitotic cell cycle process GO:1903047 286 0.011
response to oxygen containing compound GO:1901700 369 0.011
autophagy GO:0006914 88 0.011
negative regulation of axon extension GO:0030517 2 0.011
regulation of proteasomal protein catabolic process GO:0061136 87 0.011
negative regulation of cell cycle process GO:0010948 121 0.011
i kappab kinase nf kappab signaling GO:0007249 166 0.011
regulation of cell morphogenesis GO:0022604 153 0.011
rna interference GO:0016246 4 0.011
spermatid development GO:0007286 4 0.011
gastrulation with mouth forming second GO:0001702 1 0.011
membrane lipid metabolic process GO:0006643 53 0.011
negative regulation of catalytic activity GO:0043086 335 0.011
cellular response to endogenous stimulus GO:0071495 336 0.011
maintenance of location GO:0051235 112 0.011
covalent chromatin modification GO:0016569 254 0.011
negative regulation of transport GO:0051051 176 0.011
nucleoside triphosphate catabolic process GO:0009143 394 0.011
actin filament based process GO:0030029 224 0.011
positive regulation of immune response GO:0050778 159 0.011
ion homeostasis GO:0050801 230 0.011
protein import GO:0017038 130 0.011
hindbrain development GO:0030902 3 0.010
regulation of protein catabolic process GO:0042176 155 0.010
positive regulation of organelle organization GO:0010638 195 0.010
canonical wnt signaling pathway GO:0060070 116 0.010
cell cycle checkpoint GO:0000075 117 0.010
tissue regeneration GO:0042246 3 0.010
liposaccharide metabolic process GO:1903509 27 0.010

PNPLA8 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.025
cancer DOID:162 167 0.019
organ system cancer DOID:0050686 164 0.019
sensory system disease DOID:0050155 203 0.019
nervous system disease DOID:863 431 0.019
disease of metabolism DOID:0014667 295 0.012
central nervous system disease DOID:331 186 0.010
brain disease DOID:936 73 0.010
retinal disease DOID:5679 118 0.010
eye and adnexa disease DOID:1492 150 0.010
eye disease DOID:5614 149 0.010