Homo sapiens

130 known processes

SFPQ

splicing factor proline/glutamine-rich

(Aliases: PSF,POMP100)

SFPQ biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.978
rna splicing GO:0008380 131 0.957
mrna metabolic process GO:0016071 175 0.925
positive regulation of response to oxidative stress GO:1902884 7 0.921
positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902177 4 0.896
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.878
neuron intrinsic apoptotic signaling pathway in response to oxidative stress GO:0036480 7 0.871
Human
intrinsic apoptotic signaling pathway GO:0097193 127 0.828
regulation of cellular response to stress GO:0080135 244 0.813
negative regulation of response to oxidative stress GO:1902883 18 0.767
Human
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.750
positive regulation of oxidative stress induced cell death GO:1903209 5 0.736
regulation of meiotic cell cycle GO:0051445 4 0.716
negative regulation of oxidative stress induced cell death GO:1903202 17 0.705
Human
negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903377 5 0.693
Human
regulation of oxidative stress induced cell death GO:1903201 24 0.664
rna processing GO:0006396 255 0.653
positive regulation of programmed cell death GO:0043068 249 0.614
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.590
positive regulation of apoptotic process GO:0043065 246 0.552
alternative mrna splicing via spliceosome GO:0000380 27 0.539
regulation of mrna splicing via spliceosome GO:0048024 32 0.538
regulation of meiosis GO:0040020 3 0.531
positive regulation of apoptotic signaling pathway GO:2001235 70 0.501
regulation of mrna processing GO:0050684 48 0.489
regulation of cellular response to oxidative stress GO:1900407 26 0.485
multicellular organismal aging GO:0010259 3 0.456
regulation of circadian rhythm GO:0042752 11 0.455
Mouse
mrna processing GO:0006397 133 0.455
mitotic cell cycle GO:0000278 326 0.444
regulation of alternative mrna splicing via spliceosome GO:0000381 22 0.411
organelle fission GO:0048285 149 0.408
mrna splicing via spliceosome GO:0000398 89 0.407
cell development GO:0048468 328 0.397
Zebrafish
locomotory behavior GO:0007626 1 0.386
rna interference GO:0016246 4 0.361
regulation of cellular component biogenesis GO:0044087 281 0.348
blastoderm segmentation GO:0007350 2 0.346
regulation of apoptotic signaling pathway GO:2001233 175 0.337
visual perception GO:0007601 27 0.328
Fly
negative regulation of oxidative stress induced neuron death GO:1903204 7 0.318
Human
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.310
Human
neuron death in response to oxidative stress GO:0036475 9 0.292
Human
positive regulation of cellular component organization GO:0051130 376 0.272
cell division GO:0051301 168 0.267
chromatin assembly or disassembly GO:0006333 78 0.261
post embryonic development GO:0009791 2 0.258
Worm
intracellular receptor signaling pathway GO:0030522 104 0.257
dna packaging GO:0006323 77 0.252
epithelium development GO:0060429 227 0.237
posttranscriptional gene silencing by rna GO:0035194 25 0.229
negative regulation of cell death GO:0060548 345 0.212
Human
regulation of mrna stability GO:0043488 23 0.203
sensory perception of light stimulus GO:0050953 35 0.202
Fly
negative regulation of intracellular signal transduction GO:1902532 183 0.181
Human
meiotic nuclear division GO:0007126 10 0.179
nuclear division GO:0000280 128 0.164
nuclear export GO:0051168 69 0.162
regulation of cell cycle GO:0051726 393 0.157
cellular response to dna damage stimulus GO:0006974 379 0.157
negative regulation of cellular protein metabolic process GO:0032269 353 0.152
rna splicing via transesterification reactions GO:0000375 90 0.152
mitotic cell cycle process GO:1903047 286 0.148
heart development GO:0007507 95 0.147
viral process GO:0016032 146 0.143
defense response GO:0006952 315 0.140
reproduction GO:0000003 63 0.139
Worm Fly
sensory organ development GO:0007423 52 0.137
secretion GO:0046903 254 0.129
actin cytoskeleton organization GO:0030036 207 0.129
covalent chromatin modification GO:0016569 254 0.127
Mouse
oogenesis GO:0048477 2 0.125
chromatin silencing at rdna GO:0000183 5 0.123
vesicle mediated transport GO:0016192 371 0.123
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903376 7 0.122
Human
response to oxidative stress GO:0006979 121 0.121
determination of adult lifespan GO:0008340 2 0.116
rna stabilization GO:0043489 18 0.112
negative regulation of cellular response to oxidative stress GO:1900408 18 0.112
Human
lymphocyte mediated immunity GO:0002449 48 0.110
negative regulation of protein metabolic process GO:0051248 391 0.110
oocyte differentiation GO:0009994 2 0.110
cell type specific apoptotic process GO:0097285 125 0.108
Human
cellular response to oxidative stress GO:0034599 85 0.107
neuron apoptotic process GO:0051402 39 0.104
Human
cardiovascular system development GO:0072358 262 0.101
circadian rhythm GO:0007623 21 0.101
Mouse
anterior posterior axis specification GO:0009948 2 0.096
rhythmic process GO:0048511 31 0.096
Mouse
regulation of mitotic cell cycle phase transition GO:1901990 118 0.096
interspecies interaction between organisms GO:0044419 156 0.095
nucleosome assembly GO:0006334 50 0.093
posttranscriptional regulation of gene expression GO:0010608 213 0.092
modification of morphology or physiology of other organism GO:0035821 43 0.091
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.090
adult locomotory behavior GO:0008344 1 0.089
cellular amine metabolic process GO:0044106 41 0.089
actin filament based process GO:0030029 224 0.085
regulation of response to oxidative stress GO:1902882 26 0.084
regulation of cellular amino acid metabolic process GO:0006521 6 0.084
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 10 0.084
Human
positive regulation of developmental process GO:0051094 314 0.084
dna recombination GO:0006310 77 0.081
embryo development GO:0009790 123 0.078
regulation of nervous system development GO:0051960 88 0.077
Zebrafish
positive regulation of cell death GO:0010942 263 0.077
regulation of gene expression epigenetic GO:0040029 73 0.077
negative regulation of apoptotic signaling pathway GO:2001234 97 0.076
Human
regulation of cell cycle phase transition GO:1901987 126 0.072
apoptotic signaling pathway GO:0097190 268 0.071
regulation of cell cycle process GO:0010564 266 0.069
hemopoiesis GO:0030097 180 0.068
neuromuscular junction development GO:0007528 3 0.067
positive regulation of cellular component biogenesis GO:0044089 158 0.067
regulation of neuron apoptotic process GO:0043523 35 0.065
Human
negative regulation of epidermal cell differentiation GO:0045605 4 0.064
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.064
regulation of mrna metabolic process GO:1903311 53 0.062
regulation of leukocyte activation GO:0002694 115 0.061
regulation of epithelial cell proliferation GO:0050678 113 0.061
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.061
reproductive process GO:0022414 106 0.059
Fly
regulation of nuclear division GO:0051783 65 0.059
organ morphogenesis GO:0009887 147 0.058
negative regulation of programmed cell death GO:0043069 321 0.057
Human
mrna stabilization GO:0048255 18 0.056
cell cycle phase transition GO:0044770 173 0.055
negative regulation of apoptotic process GO:0043066 316 0.054
Human
retina development in camera type eye GO:0060041 15 0.053
positive regulation of nervous system development GO:0051962 54 0.052
spermatid development GO:0007286 4 0.052
cellular component morphogenesis GO:0032989 314 0.051
dna conformation change GO:0071103 113 0.051
sensory perception GO:0007600 103 0.050
Fly
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.050
cellular amino acid metabolic process GO:0006520 116 0.050
regulation of cellular amine metabolic process GO:0033238 11 0.050
histone modification GO:0016570 251 0.049
Mouse
cell activation GO:0001775 213 0.049
proteasomal protein catabolic process GO:0010498 176 0.048
negative regulation of multi organism process GO:0043901 92 0.048
microtubule based process GO:0007017 210 0.046
negative regulation of rna splicing GO:0033119 15 0.044
positive regulation of mitotic cell cycle GO:0045931 60 0.043
cell death in response to oxidative stress GO:0036473 29 0.043
cytoplasmic transport GO:0016482 379 0.043
regulation of neuron death GO:1901214 56 0.042
Human
chromosome condensation GO:0030261 15 0.042
regulation of protein stability GO:0031647 87 0.041
tripartite regional subdivision GO:0007351 2 0.041
regulation of dna recombination GO:0000018 23 0.041
striated muscle cell differentiation GO:0051146 43 0.040
positive regulation of organelle organization GO:0010638 195 0.039
negative regulation of neuron death GO:1901215 32 0.039
Human
adult behavior GO:0030534 18 0.039
protein stabilization GO:0050821 64 0.039
maintenance of location GO:0051235 112 0.038
segmentation GO:0035282 4 0.037
positive regulation of chromatin assembly or disassembly GO:0045799 2 0.036
protein methylation GO:0006479 74 0.036
chordate embryonic development GO:0043009 34 0.036
spermatid differentiation GO:0048515 4 0.035
regulation of protein complex assembly GO:0043254 147 0.035
growth GO:0040007 202 0.035
Worm
negative regulation of chromatin silencing GO:0031936 4 0.035
determination of bilateral symmetry GO:0009855 15 0.035
amine metabolic process GO:0009308 44 0.034
nucleoside triphosphate catabolic process GO:0009143 394 0.034
negative regulation of organelle organization GO:0010639 126 0.034
ribonucleoprotein complex export from nucleus GO:0071426 4 0.034
multi organism cellular process GO:0044764 156 0.034
response to organic cyclic compound GO:0014070 204 0.034
eye development GO:0001654 42 0.034
posttranscriptional gene silencing GO:0016441 25 0.033
circulatory system development GO:0072359 262 0.032
muscle system process GO:0003012 81 0.032
negative regulation of cellular amine metabolic process GO:0033239 3 0.032
cytokinesis GO:0000910 96 0.032
macromolecule methylation GO:0043414 97 0.031
regulation of cellular component movement GO:0051270 334 0.031
response to transforming growth factor beta GO:0071559 94 0.031
small molecule biosynthetic process GO:0044283 157 0.030
leukocyte activation GO:0045321 164 0.030
ossification GO:0001503 121 0.030
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.030
atrial septum primum morphogenesis GO:0003289 1 0.030
cellular chemical homeostasis GO:0055082 180 0.030
circadian regulation of translation GO:0097167 1 0.030
regulation of cell differentiation GO:0045595 393 0.029
Zebrafish
immune system development GO:0002520 195 0.029
negative regulation of neuron apoptotic process GO:0043524 23 0.029
Human
stem cell maintenance GO:0019827 19 0.029
regulation of growth GO:0040008 165 0.028
photoreceptor cell differentiation GO:0046530 2 0.028
single organism membrane organization GO:0044802 268 0.028
regulation of cell cycle g1 s phase transition GO:1902806 42 0.028
viral transcription GO:0019083 35 0.028
negative regulation of dna metabolic process GO:0051053 57 0.027
purine ribonucleotide catabolic process GO:0009154 404 0.027
immune effector process GO:0002252 159 0.027
nucleoside catabolic process GO:0009164 408 0.027
positive regulation of translation GO:0045727 35 0.027
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.027
negative regulation of cellular component organization GO:0051129 235 0.027
Zebrafish
leukocyte differentiation GO:0002521 98 0.027
hair cycle GO:0042633 28 0.027
positive regulation of cell activation GO:0050867 81 0.027
regulation of cell activation GO:0050865 125 0.027
regulation of mitotic cell cycle GO:0007346 189 0.026
cellular response to organic cyclic compound GO:0071407 127 0.026
regulation of canonical wnt signaling pathway GO:0060828 88 0.026
muscle structure development GO:0061061 98 0.025
hematopoietic progenitor cell differentiation GO:0002244 38 0.025
central nervous system development GO:0007417 123 0.025
Zebrafish
generation of neurons GO:0048699 152 0.024
Zebrafish
dna templated transcription initiation GO:0006352 35 0.024
nucleosome positioning GO:0016584 3 0.024
negative regulation of cell cycle process GO:0010948 121 0.024
chromatin remodeling GO:0006338 55 0.024
chromatin modification GO:0016568 298 0.023
Mouse
alcohol metabolic process GO:0006066 114 0.023
androgen receptor signaling pathway GO:0030521 34 0.023
lymphocyte differentiation GO:0030098 35 0.023
digestive tract morphogenesis GO:0048546 56 0.023
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 16 0.023
regulation of rna stability GO:0043487 23 0.023
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.023
anterior posterior axis specification embryo GO:0008595 2 0.023
nucleotide catabolic process GO:0009166 408 0.022
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.022
regulation of chromatin modification GO:1903308 51 0.022
membrane organization GO:0061024 292 0.022
mesenchymal cell differentiation GO:0048762 52 0.022
negative regulation of locomotion GO:0040013 118 0.022
ras protein signal transduction GO:0007265 73 0.021
cellular ion homeostasis GO:0006873 168 0.021
regulation of proteolysis GO:0030162 293 0.021
regulation of response to dna damage stimulus GO:2001020 94 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.020
modulation by host of viral transcription GO:0043921 20 0.020
regulation of cell division GO:0051302 116 0.020
negative regulation of catalytic activity GO:0043086 335 0.020
regulation of anatomical structure morphogenesis GO:0022603 286 0.020
pattern specification process GO:0007389 43 0.019
muscle tissue development GO:0060537 62 0.019
negative regulation of protein modification process GO:0031400 200 0.019
ventricular septum morphogenesis GO:0060412 3 0.019
sexual reproduction GO:0019953 37 0.019
Fly
positive regulation of immune system process GO:0002684 283 0.019
regulation of chromatin organization GO:1902275 56 0.019
regulation of dna metabolic process GO:0051052 153 0.018
nucleosome organization GO:0034728 66 0.018
positive regulation of lymphocyte activation GO:0051251 73 0.018
positive regulation of multi organism process GO:0043902 56 0.018
protein catabolic process GO:0030163 325 0.018
regulation of cell morphogenesis GO:0022604 153 0.018
regulation of lymphocyte activation GO:0051249 103 0.018
negative regulation of gene expression epigenetic GO:0045814 19 0.018
epithelial cell differentiation GO:0030855 141 0.018
dna templated transcription termination GO:0006353 3 0.018
positive regulation of cell differentiation GO:0045597 211 0.018
rna transport GO:0050658 39 0.017
dephosphorylation GO:0016311 209 0.017
nervous system development GO:0007399 293 0.017
Zebrafish
regulation of establishment of protein localization GO:0070201 242 0.017
negative regulation of growth GO:0045926 97 0.017
response to wounding GO:0009611 168 0.017
Zebrafish
neurological system process GO:0050877 163 0.017
Fly
cell growth GO:0016049 160 0.016
sex determination GO:0007530 3 0.016
molting cycle GO:0042303 28 0.016
erythrocyte development GO:0048821 3 0.016
regulation of viral transcription GO:0046782 34 0.016
muscle cell differentiation GO:0042692 63 0.016
organelle assembly GO:0070925 176 0.016
single organism reproductive process GO:0044702 98 0.016
myeloid cell differentiation GO:0030099 117 0.016
cellular response to endogenous stimulus GO:0071495 336 0.016
actomyosin structure organization GO:0031032 59 0.016
cellular ketone metabolic process GO:0042180 80 0.015
negative regulation of cell motility GO:2000146 104 0.015
regulation of response to external stimulus GO:0032101 222 0.015
Zebrafish
macromolecule deacylation GO:0098732 41 0.015
Mouse
epidermis development GO:0008544 59 0.015
nitrogen compound transport GO:0071705 191 0.015
mitotic chromosome condensation GO:0007076 11 0.015
behavior GO:0007610 112 0.015
Fly
positive regulation of dna metabolic process GO:0051054 73 0.015
chromatin organization GO:0006325 351 0.015
Mouse
lipid localization GO:0010876 106 0.015
wnt signaling pathway GO:0016055 156 0.015
positive regulation of chromosome organization GO:2001252 41 0.015
positive regulation of epithelial cell proliferation GO:0050679 65 0.014
system process GO:0003008 349 0.014
Fly
gene silencing by mirna GO:0035195 23 0.014
snrna metabolic process GO:0016073 15 0.014
regulation of wound healing GO:0061041 56 0.014
dna repair GO:0006281 198 0.014
female gamete generation GO:0007292 2 0.014
gene silencing by rna GO:0031047 26 0.014
stem cell differentiation GO:0048863 93 0.014
response to nutrient levels GO:0031667 81 0.014
regulation of wnt signaling pathway GO:0030111 123 0.014
genitalia development GO:0048806 10 0.014
positive regulation of immunoglobulin production GO:0002639 4 0.014
response to abiotic stimulus GO:0009628 336 0.014
organonitrogen compound biosynthetic process GO:1901566 200 0.014
striated muscle cell development GO:0055002 27 0.013
regulation of mapk cascade GO:0043408 262 0.013
neurogenesis GO:0022008 169 0.013
Zebrafish
specification of symmetry GO:0009799 16 0.013
regulation of rna splicing GO:0043484 62 0.013
negative regulation of axonogenesis GO:0050771 4 0.013
cellular cation homeostasis GO:0030003 163 0.013
protein dna complex subunit organization GO:0071824 80 0.013
regulation of innate immune response GO:0045088 97 0.013
ribosomal large subunit export from nucleus GO:0000055 3 0.013
intracellular protein transport GO:0006886 270 0.013
protein ubiquitination GO:0016567 314 0.013
negative regulation of cell growth GO:0030308 83 0.013
embryo development ending in birth or egg hatching GO:0009792 34 0.013
regulation of neuron differentiation GO:0045664 70 0.013
Zebrafish
heart looping GO:0001947 7 0.013
regulation of dna templated transcription initiation GO:2000142 9 0.012
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.012
g1 s transition of mitotic cell cycle GO:0000082 78 0.012
lymphocyte activation involved in immune response GO:0002285 20 0.012
response to nitrogen compound GO:1901698 184 0.012
regulation of ion transport GO:0043269 189 0.012
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.012
positive regulation of response to alcohol GO:1901421 3 0.012
compound eye development GO:0048749 1 0.012
endomembrane system organization GO:0010256 196 0.012
b cell activation GO:0042113 33 0.012
regulation of histone modification GO:0031056 47 0.012
viral life cycle GO:0019058 132 0.012
nucleus organization GO:0006997 28 0.012
cellular macromolecule catabolic process GO:0044265 380 0.012
negative regulation of developmental process GO:0051093 247 0.012
Zebrafish Worm
peripheral nervous system development GO:0007422 2 0.012
tissue regeneration GO:0042246 3 0.012
gene silencing GO:0016458 49 0.012
adaptive immune response GO:0002250 49 0.012
cardiac muscle contraction GO:0060048 34 0.012
nucleobase containing compound transport GO:0015931 51 0.012
organophosphate catabolic process GO:0046434 430 0.012
nucleoside triphosphate metabolic process GO:0009141 422 0.011
detection of stimulus GO:0051606 85 0.011
negative regulation of cell cycle GO:0045786 193 0.011
positive regulation of secretion GO:0051047 116 0.011
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.011
regulation of cellular ketone metabolic process GO:0010565 50 0.011
purine containing compound catabolic process GO:0072523 411 0.011
hard palate development GO:0060022 1 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
myosin filament assembly GO:0031034 2 0.011
secretion by cell GO:0032940 226 0.011
modification dependent macromolecule catabolic process GO:0043632 212 0.011
mitotic nuclear division GO:0007067 119 0.011
dna replication GO:0006260 116 0.011
regulation of multi organism process GO:0043900 157 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
regulation of cardiac muscle cell proliferation GO:0060043 4 0.011
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.011
regulation of viral process GO:0050792 103 0.011
striated muscle myosin thick filament assembly GO:0071688 2 0.011
rna export from nucleus GO:0006405 33 0.010
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.010
lymphocyte activation GO:0046649 133 0.010
glycosyl compound catabolic process GO:1901658 413 0.010
multi organism metabolic process GO:0044033 41 0.010
hematopoietic or lymphoid organ development GO:0048534 186 0.010
heart morphogenesis GO:0003007 48 0.010
positive regulation of mrna processing GO:0050685 17 0.010
cellular metal ion homeostasis GO:0006875 146 0.010
sex differentiation GO:0007548 45 0.010
ribonucleoside triphosphate catabolic process GO:0009203 391 0.010
modification dependent protein catabolic process GO:0019941 209 0.010
oocyte development GO:0048599 1 0.010
carbohydrate derivative biosynthetic process GO:1901137 207 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.010
negative regulation of phosphate metabolic process GO:0045936 267 0.010

SFPQ disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.057
nervous system disease DOID:863 431 0.057
musculoskeletal system disease DOID:17 223 0.038
sensory system disease DOID:0050155 203 0.029
eye and adnexa disease DOID:1492 150 0.029
neurodegenerative disease DOID:1289 102 0.015
muscular disease DOID:0080000 114 0.015