Homo sapiens

481 known processes

IL1B

interleukin 1, beta

(Aliases: IL1F2,IL1-BETA,IL-1)

IL1B biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cytokine production GO:0001816 247 0.999
response to nitric oxide GO:0071731 4 0.999
cytokine mediated signaling pathway GO:0019221 109 0.997
negative regulation of interferon gamma secretion GO:1902714 1 0.997
mature natural killer cell chemotaxis GO:0035782 1 0.997
cellular response to molecule of bacterial origin GO:0071219 62 0.996
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.995
response to cytokine GO:0034097 232 0.992
positive regulation of acute inflammatory response GO:0002675 2 0.991
Mouse
eosinophil activation involved in immune response GO:0002278 2 0.990
cellular response to interleukin 1 GO:0071347 35 0.990
Human
positive regulation of cd8 positive alpha beta t cell proliferation GO:2000566 1 0.989
negative regulation of cd4 positive alpha beta t cell proliferation GO:2000562 1 0.989
positive regulation of macrophage chemotaxis GO:0010759 3 0.987
interleukin 2 production GO:0032623 20 0.984
myeloid dendritic cell chemotaxis GO:0002408 3 0.984
cellular response to biotic stimulus GO:0071216 71 0.983
negative regulation of lymphocyte chemotaxis GO:1901624 2 0.983
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.980
negative regulation of chemokine mediated signaling pathway GO:0070100 5 0.972
positive regulation of locomotion GO:0040017 186 0.971
Rat
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.966
regulation of response to external stimulus GO:0032101 222 0.964
Mouse Rat
cd8 positive alpha beta t cell proliferation GO:0035740 1 0.963
positive regulation of leukocyte proliferation GO:0070665 48 0.963
positive regulation of cytokine production GO:0001819 167 0.962
negative regulation of lymphocyte migration GO:2000402 4 0.961
positive regulation of intracellular protein transport GO:0090316 76 0.960
positive regulation of t cell proliferation GO:0042102 33 0.956
response to molecule of bacterial origin GO:0002237 82 0.955
cyclic nucleotide metabolic process GO:0009187 82 0.954
chemokine mediated signaling pathway GO:0070098 16 0.953
regulation of camp metabolic process GO:0030814 52 0.952
cellular response to cytokine stimulus GO:0071345 181 0.952
positive regulation of cell motility GO:2000147 177 0.951
Rat
cellular response to endogenous stimulus GO:0071495 336 0.949
Mouse Rat
defense response GO:0006952 315 0.949
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.945
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.944
negative regulation of g protein coupled receptor protein signaling pathway GO:0045744 18 0.944
regulation of cell migration GO:0030334 289 0.943
Rat
positive regulation of immune system process GO:0002684 283 0.942
response to interleukin 1 GO:0070555 47 0.938
Human
g protein coupled receptor signaling pathway GO:0007186 207 0.937
regulation of defense response GO:0031347 154 0.937
Mouse
regulation of cd8 positive alpha beta t cell proliferation GO:2000564 1 0.934
i kappab kinase nf kappab signaling GO:0007249 166 0.933
regulation of macrophage chemotaxis GO:0010758 4 0.928
regulation of granzyme b production GO:0071661 1 0.928
negative regulation of natural killer cell chemotaxis GO:2000502 1 0.928
regulation of cytokine production GO:0001817 232 0.919
positive regulation of neutrophil chemotaxis GO:0090023 7 0.918
Rat
regulation of protein targeting GO:1903533 91 0.917
regulation of locomotion GO:0040012 329 0.916
Rat
positive regulation of homotypic cell cell adhesion GO:0034112 4 0.913
eosinophil chemotaxis GO:0048245 8 0.911
inflammatory response GO:0006954 79 0.911
negative regulation of cell death GO:0060548 345 0.908
positive regulation of natural killer cell chemotaxis GO:2000503 5 0.906
negative regulation of multicellular organismal process GO:0051241 317 0.906
Mouse Rat
cellular response to lipid GO:0071396 127 0.902
positive regulation of t cell migration GO:2000406 13 0.900
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.896
erk1 and erk2 cascade GO:0070371 104 0.894
Rat
granulocyte migration GO:0097530 40 0.890
Mouse Rat
cellular response to oxygen containing compound GO:1901701 276 0.888
negative regulation of alpha beta t cell proliferation GO:0046642 1 0.887
cell activation GO:0001775 213 0.885
monocyte aggregation GO:0070487 4 0.883
reactive oxygen species biosynthetic process GO:1903409 4 0.881
regulation of calcium ion transport GO:0051924 79 0.879
establishment of t cell polarity GO:0001768 2 0.879
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.879
positive regulation of release of sequestered calcium ion into cytosol GO:0051281 16 0.878
regulation of inflammatory response GO:0050727 46 0.876
Mouse
positive regulation of transport GO:0051050 336 0.876
response to oxygen containing compound GO:1901700 369 0.875
positive regulation of intracellular transport GO:0032388 104 0.874
regulation of transcription factor import into nucleus GO:0042990 39 0.874
camp mediated signaling GO:0019933 23 0.866
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.863
regulation of reactive oxygen species metabolic process GO:2000377 41 0.863
response to external biotic stimulus GO:0043207 261 0.862
eosinophil degranulation GO:0043308 2 0.859
response to other organism GO:0051707 261 0.857
response to biotic stimulus GO:0009607 276 0.851
myeloid leukocyte migration GO:0097529 62 0.850
Mouse Rat
regulation of lymphocyte proliferation GO:0050670 64 0.848
negative regulation of apoptotic process GO:0043066 316 0.848
acute inflammatory response GO:0002526 21 0.844
Human Mouse Rat
regulation of response to wounding GO:1903034 101 0.843
Mouse
response to wounding GO:0009611 168 0.838
Mouse Rat
positive regulation of calcidiol 1 monooxygenase activity GO:0060559 3 0.838
positive regulation of phosphorylation GO:0042327 394 0.837
lymphocyte migration GO:0072676 28 0.836
regulation of chemokine mediated signaling pathway GO:0070099 6 0.835
positive regulation of response to external stimulus GO:0032103 88 0.833
Mouse Rat
granulocyte chemotaxis GO:0071621 37 0.833
Mouse Rat
chemical homeostasis GO:0048878 306 0.832
Rat
regulation of leukocyte migration GO:0002685 63 0.831
Rat
positive regulation of t cell apoptotic process GO:0070234 4 0.831
cd8 positive alpha beta t cell activation GO:0036037 3 0.829
negative regulation of t cell cytokine production GO:0002725 4 0.828
cellular divalent inorganic cation homeostasis GO:0072503 128 0.824
Rat
regulation of t cell chemotaxis GO:0010819 7 0.819
response to organonitrogen compound GO:0010243 156 0.817
Mouse Rat
viral life cycle GO:0019058 132 0.816
positive regulation of jnk cascade GO:0046330 52 0.816
Mouse Rat
regulation of cell cell adhesion GO:0022407 57 0.813
regulation of camp mediated signaling GO:0043949 13 0.809
regulation of granzyme a production GO:2000511 1 0.806
regulation of cell adhesion GO:0030155 166 0.806
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.801
positive regulation of protein phosphorylation GO:0001934 313 0.798
positive regulation of cd8 positive alpha beta t cell activation GO:2001187 1 0.794
regulation of viral process GO:0050792 103 0.790
regulation of g protein coupled receptor protein signaling pathway GO:0008277 35 0.779
response to bacterium GO:0009617 144 0.773
regulation of cellular amino acid metabolic process GO:0006521 6 0.772
negative regulation of cell proliferation GO:0008285 228 0.772
positive regulation of behavior GO:0048520 60 0.772
Rat
regulation of natural killer cell chemotaxis GO:2000501 6 0.771
sensory perception of pain GO:0019233 4 0.766
response to growth factor GO:0070848 205 0.766
negative regulation of alpha beta t cell activation GO:0046636 3 0.765
positive regulation of leukocyte migration GO:0002687 46 0.763
Rat
sequestering of calcium ion GO:0051208 17 0.760
positive regulation of camp metabolic process GO:0030816 41 0.757
interleukin 1 mediated signaling pathway GO:0070498 12 0.757
Human
negative regulation of myeloid cell differentiation GO:0045638 42 0.750
positive regulation of nf kappab import into nucleus GO:0042346 13 0.750
regulation of establishment of protein localization GO:0070201 242 0.749
response to lipid GO:0033993 206 0.746
regulation of cell activation GO:0050865 125 0.744
lymphocyte chemotaxis GO:0048247 17 0.737
chemotaxis GO:0006935 157 0.736
Mouse Rat
regulation of cd8 positive alpha beta t cell activation GO:2001185 2 0.731
t cell chemotaxis GO:0010818 10 0.724
acute phase response GO:0006953 5 0.724
Human Mouse Rat
cytokine biosynthetic process GO:0042089 37 0.721
female gamete generation GO:0007292 2 0.718
Rat
nitrogen compound transport GO:0071705 191 0.713
regulation of cytoplasmic transport GO:1903649 149 0.712
leukocyte migration GO:0050900 107 0.709
Mouse Rat
peptide hormone secretion GO:0030072 50 0.708
positive regulation of mapk cascade GO:0043410 190 0.708
organonitrogen compound biosynthetic process GO:1901566 200 0.705
cellular amino acid metabolic process GO:0006520 116 0.702
regulation of leukocyte proliferation GO:0070663 67 0.695
regulation of lymphocyte migration GO:2000401 22 0.694
regulation of t helper 1 cell activation GO:2000517 1 0.690
regulation of chemotaxis GO:0050920 74 0.686
Rat
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.683
Rat
positive regulation of vitamin d biosynthetic process GO:0060557 3 0.680
hormone transport GO:0009914 68 0.675
positive regulation of calcium ion transport into cytosol GO:0010524 20 0.673
regulation of calcium ion transport into cytosol GO:0010522 33 0.666
regulation of hormone levels GO:0010817 125 0.665
t helper 1 cell activation GO:0035711 1 0.662
positive regulation of cell differentiation GO:0045597 211 0.658
Rat
granzyme b production GO:0071613 1 0.649
cytoplasmic transport GO:0016482 379 0.648
positive regulation of cell migration GO:0030335 172 0.645
Rat
negative regulation of c c chemokine binding GO:2001264 1 0.640
cyclic nucleotide mediated signaling GO:0019935 26 0.635
natural killer cell chemotaxis GO:0035747 6 0.634
positive regulation of cellular component movement GO:0051272 181 0.633
Rat
neutrophil chemotaxis GO:0030593 24 0.631
Mouse Rat
response to nitrogen compound GO:1901698 184 0.631
Zebrafish Mouse Rat
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.631
secretion by cell GO:0032940 226 0.628
immune response GO:0006955 307 0.627
Zebrafish Rat
tube development GO:0035295 125 0.618
Human
digestive tract development GO:0048565 75 0.617
Human
metal ion homeostasis GO:0055065 169 0.616
Rat
positive regulation of myosin light chain kinase activity GO:0035505 1 0.615
regulation of mapk cascade GO:0043408 262 0.610
response to reactive oxygen species GO:0000302 61 0.607
Rat
eosinophil activation GO:0043307 3 0.607
regulation of myeloid cell differentiation GO:0045637 81 0.607
single organismal cell cell adhesion GO:0016337 148 0.602
regulation of secretion GO:0051046 194 0.600
positive regulation of lymphocyte activation GO:0051251 73 0.592
mapk cascade GO:0000165 288 0.588
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.587
Mouse Rat
regulation of neutrophil chemotaxis GO:0090022 10 0.585
Rat
reactive oxygen species metabolic process GO:0072593 75 0.584
positive regulation of apoptotic process GO:0043065 246 0.583
Rat
regulation of interleukin 1 mediated signaling pathway GO:2000659 3 0.583
Human
regulation of neutrophil mediated killing of symbiont cell GO:0070949 1 0.583
positive regulation of alcohol biosynthetic process GO:1902932 9 0.583
cellular response to lipopolysaccharide GO:0071222 57 0.581
granzyme a production GO:0035746 1 0.578
maintenance of location GO:0051235 112 0.574
biological adhesion GO:0022610 331 0.573
calcium ion transport GO:0006816 147 0.572
leukocyte proliferation GO:0070661 74 0.570
negative regulation of cytokine mediated signaling pathway GO:0001960 22 0.567
Human
regulation of neutrophil migration GO:1902622 10 0.566
Rat
regulation of smooth muscle cell proliferation GO:0048660 28 0.561
cellular ketone metabolic process GO:0042180 80 0.557
response to fibroblast growth factor GO:0071774 39 0.556
viral process GO:0016032 146 0.554
regulation of protein localization to nucleus GO:1900180 85 0.554
t cell migration GO:0072678 16 0.552
regulation of lymphocyte chemotaxis GO:1901623 12 0.552
small molecule biosynthetic process GO:0044283 157 0.548
memory GO:0007613 3 0.539
Rat
response to fatty acid GO:0070542 13 0.539
Rat
divalent metal ion transport GO:0070838 152 0.533
divalent inorganic cation transport GO:0072511 158 0.533
positive regulation of granzyme b production GO:0071663 1 0.532
negative regulation of immune system process GO:0002683 136 0.531
regulation of protein transport GO:0051223 213 0.527
negative regulation of programmed cell death GO:0043069 321 0.526
regulation of cytokine mediated signaling pathway GO:0001959 41 0.525
Human
response to oxidative stress GO:0006979 121 0.524
Rat
positive regulation of protein import into nucleus GO:0042307 46 0.523
regulation of c c chemokine binding GO:2001263 1 0.522
regulation of protein localization GO:0032880 296 0.516
positive regulation of cytoplasmic transport GO:1903651 82 0.512
positive regulation of chemotaxis GO:0050921 57 0.508
Rat
camp metabolic process GO:0046058 61 0.508
macrophage chemotaxis GO:0048246 10 0.507
regulation of t cell migration GO:2000404 14 0.505
positive regulation of cell adhesion GO:0045785 84 0.505
regulation of metal ion transport GO:0010959 120 0.505
regulation of mononuclear cell proliferation GO:0032944 65 0.501
neutrophil migration GO:1990266 25 0.498
Mouse Rat
positive regulation of lymphocyte migration GO:2000403 16 0.498
negative regulation of apoptotic signaling pathway GO:2001234 97 0.496
positive regulation of t cell activation GO:0050870 54 0.496
modification by host of symbiont morphology or physiology GO:0051851 26 0.496
cellular response to organonitrogen compound GO:0071417 124 0.493
Mouse Rat
regulation of leukocyte differentiation GO:1902105 61 0.491
Rat
cellular response to organic cyclic compound GO:0071407 127 0.487
sequestering of metal ion GO:0051238 24 0.484
divalent inorganic cation homeostasis GO:0072507 136 0.480
Rat
activation of mapk activity GO:0000187 45 0.479
response to activity GO:0014823 0 0.479
leukocyte activation GO:0045321 164 0.479
regulation of cell motility GO:2000145 299 0.475
Rat
positive regulation of camp mediated signaling GO:0043950 10 0.470
positive regulation of kinase activity GO:0033674 204 0.469
regulation of leukocyte mediated immunity GO:0002703 38 0.466
cell chemotaxis GO:0060326 112 0.461
Mouse Rat
eosinophil mediated immunity GO:0002447 2 0.458
positive regulation of epithelial cell proliferation GO:0050679 65 0.457
jak stat cascade GO:0007259 46 0.457
response to hormone GO:0009725 175 0.453
Human Mouse Rat
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.450
positive regulation of superoxide anion generation GO:0032930 4 0.446
establishment of protein localization to organelle GO:0072594 172 0.446
metal ion transport GO:0030001 272 0.445
cytosolic calcium ion homeostasis GO:0051480 89 0.443
Rat
negative regulation of t helper 1 cell activation GO:2000518 1 0.439
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.438
second messenger mediated signaling GO:0019932 78 0.437
hematopoietic or lymphoid organ development GO:0048534 186 0.437
Rat
positive regulation of jak stat cascade GO:0046427 35 0.433
regulation of sensory perception of pain GO:0051930 3 0.431
positive regulation of cell proliferation GO:0008284 301 0.428
positive regulation of granulocyte macrophage colony stimulating factor production GO:0032725 4 0.423
mhc class ii biosynthetic process GO:0045342 4 0.420
secretion GO:0046903 254 0.419
negative regulation of bone mineralization GO:0030502 7 0.417
regulation of ion transport GO:0043269 189 0.416
Mouse Rat
regulation of hormone secretion GO:0046883 57 0.414
regulation of myosin light chain kinase activity GO:0035504 1 0.414
protein localization to nucleus GO:0034504 136 0.412
cell adhesion GO:0007155 325 0.412
leukocyte differentiation GO:0002521 98 0.411
Rat
regulation of cellular ketone metabolic process GO:0010565 50 0.411
vascular endothelial growth factor production GO:0010573 15 0.410
glial cell migration GO:0008347 4 0.408
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.407
positive regulation of cyclic nucleotide metabolic process GO:0030801 49 0.399
behavior GO:0007610 112 0.394
Rat
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.394
positive regulation of heterotypic cell cell adhesion GO:0034116 8 0.394
leukocyte cell cell adhesion GO:0007159 37 0.391
negative regulation of cytokine production involved in immune response GO:0002719 13 0.390
negative regulation of cd4 positive alpha beta t cell activation GO:2000515 1 0.388
regulation of acute inflammatory response GO:0002673 13 0.380
Mouse
regulation of peptide hormone secretion GO:0090276 41 0.380
disruption by host of symbiont cells GO:0051852 2 0.379
leukocyte aggregation GO:0070486 8 0.379
negative regulation of amine transport GO:0051953 1 0.372
Rat
negative regulation of cellular component movement GO:0051271 106 0.372
regulation of lipid metabolic process GO:0019216 96 0.370
positive regulation of neutrophil mediated cytotoxicity GO:0070960 1 0.365
hormone secretion GO:0046879 65 0.365
muscle cell migration GO:0014812 19 0.365
taxis GO:0042330 157 0.363
Mouse Rat
positive regulation of homeostatic process GO:0032846 47 0.362
Mouse
regulation of protein import into nucleus GO:0042306 78 0.359
positive regulation of granzyme a production GO:2000513 1 0.359
positive regulation of mononuclear cell proliferation GO:0032946 47 0.359
regulation of map kinase activity GO:0043405 108 0.356
regulation of intracellular protein transport GO:0033157 123 0.355
positive regulation of catabolic process GO:0009896 310 0.355
positive regulation of myeloid cell differentiation GO:0045639 39 0.352
positive regulation of leukocyte activation GO:0002696 80 0.351
regulation of monocyte chemotaxis GO:0090025 11 0.351
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.349
Mouse Rat
cell cell signaling GO:0007267 155 0.348
lipid biosynthetic process GO:0008610 177 0.347
apoptotic signaling pathway GO:0097190 268 0.347
myeloid cell differentiation GO:0030099 117 0.342
regulation of single stranded viral rna replication via double stranded dna intermediate GO:0045091 8 0.340
regulation of myeloid leukocyte differentiation GO:0002761 39 0.339
regulation of vascular endothelial growth factor production GO:0010574 13 0.337
multi organism cellular process GO:0044764 156 0.336
cellular chemical homeostasis GO:0055082 180 0.335
Rat
protein targeting to nucleus GO:0044744 104 0.332
hemopoiesis GO:0030097 180 0.326
Rat
negative regulation of interleukin 1 mediated signaling pathway GO:2000660 2 0.325
Human
immune system development GO:0002520 195 0.324
Rat
interspecies interaction between organisms GO:0044419 156 0.323
signal transduction by phosphorylation GO:0023014 297 0.322
regulation of kinase activity GO:0043549 314 0.322
regulation of ion homeostasis GO:2000021 73 0.317
vesicle mediated transport GO:0016192 371 0.314
regulation of myeloid leukocyte mediated immunity GO:0002886 4 0.310
regulation of insulin secretion GO:0050796 33 0.309
response to radiation GO:0009314 151 0.308
Rat
regulation of cell cell adhesion mediated by integrin GO:0033632 6 0.308
cellular calcium ion homeostasis GO:0006874 117 0.306
Rat
mononuclear cell proliferation GO:0032943 71 0.305
positive regulation of monocyte chemotaxis GO:0090026 10 0.303
stress activated protein kinase signaling cascade GO:0031098 94 0.302
Mouse Rat
positive regulation of nucleotide metabolic process GO:0045981 230 0.301
multi organism metabolic process GO:0044033 41 0.301
regulation of vasculature development GO:1901342 97 0.298
Mouse
positive regulation of oxidoreductase activity GO:0051353 26 0.297
response to lipopolysaccharide GO:0032496 70 0.296
negative regulation of cell differentiation GO:0045596 171 0.295
Rat
negative regulation of mhc class ii biosynthetic process GO:0045347 1 0.289
response to gamma radiation GO:0010332 14 0.289
Rat
cellular lipid metabolic process GO:0044255 303 0.288
Rat
modification of morphology or physiology of other organism GO:0035821 43 0.286
monocyte chemotaxis GO:0002548 20 0.286
negative regulation of secretion by cell GO:1903531 52 0.285
Mouse Rat
regulation of sequestering of calcium ion GO:0051282 41 0.284
response to temperature stimulus GO:0009266 22 0.284
Human Rat
cellular homeostasis GO:0019725 196 0.284
Rat
interleukin 17 production GO:0032620 12 0.283
establishment of lymphocyte polarity GO:0001767 2 0.281
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.280
nuclear transport GO:0051169 179 0.280
chemokine production GO:0032602 32 0.278
cellular metal ion homeostasis GO:0006875 146 0.278
Rat
jnk cascade GO:0007254 80 0.276
Mouse Rat
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.276
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.276
regulation of stress activated mapk cascade GO:0032872 84 0.276
Mouse Rat
organic anion transport GO:0015711 103 0.275
Mouse Rat
activation of phospholipase d activity GO:0031584 3 0.271
peptide secretion GO:0002790 51 0.271
regulation of cytokine secretion GO:0050707 57 0.270
Human
leukocyte chemotaxis GO:0030595 76 0.269
Mouse Rat
negative regulation of immune effector process GO:0002698 38 0.267
regulation of cell killing GO:0031341 22 0.265
cellular response to tumor necrosis factor GO:0071356 63 0.261
cellular amine metabolic process GO:0044106 41 0.260
positive regulation of organelle organization GO:0010638 195 0.258
negative regulation of sequestering of calcium ion GO:0051283 41 0.256
regulation of protein kinase activity GO:0045859 289 0.254
cation transport GO:0006812 331 0.253
response to fungus GO:0009620 4 0.252
regulation of nitric oxide biosynthetic process GO:0045428 17 0.251
positive regulation of alpha beta t cell proliferation GO:0046641 5 0.249
regulation of intracellular transport GO:0032386 195 0.248
amide transport GO:0042886 76 0.248
response to transition metal nanoparticle GO:1990267 29 0.247
Human
positive regulation of lymphocyte proliferation GO:0050671 46 0.246
positive regulation of leukocyte differentiation GO:1902107 37 0.243
Rat
positive regulation of defense response GO:0031349 87 0.243
Mouse
peptidyl tyrosine phosphorylation GO:0018108 170 0.241
regulation of protein secretion GO:0050708 86 0.240
Human
positive regulation of cellular amine metabolic process GO:0033240 7 0.240
negative regulation of secretion GO:0051048 58 0.239
Mouse Rat
ion homeostasis GO:0050801 230 0.238
Rat
cytokine secretion GO:0050663 64 0.237
Human
positive regulation of programmed cell death GO:0043068 249 0.234
Rat
muscle cell proliferation GO:0033002 35 0.229
nf kappab import into nucleus GO:0042348 22 0.227
negative regulation of signal transduction in absence of ligand GO:1901099 16 0.227
cytosolic calcium ion transport GO:0060401 48 0.227
cytokine metabolic process GO:0042107 38 0.226
t cell activation GO:0042110 99 0.225
positive regulation of leukocyte chemotaxis GO:0002690 38 0.224
Rat
negative regulation of biomineral tissue development GO:0070168 8 0.224
calcium ion homeostasis GO:0055074 122 0.224
Rat
negative regulation of lymphocyte apoptotic process GO:0070229 8 0.221
rho protein signal transduction GO:0007266 26 0.219
hematopoietic progenitor cell differentiation GO:0002244 38 0.219
negative regulation of interleukin 17 production GO:0032700 5 0.219
negative regulation of response to cytokine stimulus GO:0060761 25 0.218
Human
negative regulation of homeostatic process GO:0032845 59 0.218
positive regulation of smooth muscle cell proliferation GO:0048661 14 0.218
glucose homeostasis GO:0042593 31 0.218
Rat
response to tumor necrosis factor GO:0034612 76 0.216
cellular response to abiotic stimulus GO:0071214 117 0.216
regulation of endothelial cell proliferation GO:0001936 56 0.212
regulation of alpha beta t cell activation GO:0046634 13 0.212
organic hydroxy compound metabolic process GO:1901615 147 0.212
regulation of granulocyte chemotaxis GO:0071622 16 0.210
Rat
nervous system development GO:0007399 293 0.209
Rat
response to hexose GO:0009746 20 0.209
Rat
response to abiotic stimulus GO:0009628 336 0.208
production of molecular mediator of immune response GO:0002440 37 0.208
regulation of secretion by cell GO:1903530 177 0.203
protein oligomerization GO:0051259 173 0.203
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.201
positive regulation of protein kinase activity GO:0045860 190 0.200
cell type specific apoptotic process GO:0097285 125 0.199
system process GO:0003008 349 0.199
Mouse Rat
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.198
regulation of heterotypic cell cell adhesion GO:0034114 14 0.197
activation of protein kinase activity GO:0032147 90 0.197
regulation of cellular response to stress GO:0080135 244 0.197
Mouse Rat
regulation of release of sequestered calcium ion into cytosol GO:0051279 27 0.196
regulation of killing of cells of other organism GO:0051709 4 0.194
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.190
receptor internalization GO:0031623 43 0.189
regulation of epithelial cell proliferation GO:0050678 113 0.189
protein import GO:0017038 130 0.187
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.186
regulation of cellular component movement GO:0051270 334 0.184
Rat
positive regulation of lipid metabolic process GO:0045834 50 0.183
regulation of purine nucleotide metabolic process GO:1900542 264 0.182
regulation of cellular amine metabolic process GO:0033238 11 0.182
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.182
amine metabolic process GO:0009308 44 0.182
negative regulation of protein secretion GO:0050709 29 0.181
positive regulation of steroid biosynthetic process GO:0010893 6 0.180
viral genome replication GO:0019079 50 0.179
negative regulation of lipid catabolic process GO:0050995 9 0.178
positive regulation of transcription factor import into nucleus GO:0042993 25 0.177
positive regulation of lipid biosynthetic process GO:0046889 22 0.175
regulation of viral genome replication GO:0045069 48 0.175
positive regulation of vitamin metabolic process GO:0046136 3 0.175
negative regulation of t cell proliferation GO:0042130 8 0.174
induction of positive chemotaxis GO:0050930 8 0.173
positive regulation of calcium ion transport GO:0051928 51 0.173
regulation of angiogenesis GO:0045765 92 0.172
Mouse
cellular cation homeostasis GO:0030003 163 0.171
Rat
response to prostaglandin e GO:0034695 6 0.169
negative regulation of t cell apoptotic process GO:0070233 4 0.169
regulation of nucleoside metabolic process GO:0009118 209 0.168
mucopolysaccharide metabolic process GO:1903510 27 0.167
nitric oxide biosynthetic process GO:0006809 20 0.167
negative regulation of leukocyte chemotaxis GO:0002689 5 0.165
regulation of nf kappab import into nucleus GO:0042345 22 0.164
single organism cell adhesion GO:0098602 179 0.163
protein import into nucleus GO:0006606 104 0.162
heterotypic cell cell adhesion GO:0034113 28 0.161
cellular response to growth factor stimulus GO:0071363 197 0.160
regulation of leukocyte mediated cytotoxicity GO:0001910 19 0.159
positive regulation of immune response GO:0050778 159 0.158
inflammatory response to antigenic stimulus GO:0002437 4 0.158
Rat
negative regulation of locomotion GO:0040013 118 0.158
interferon gamma production GO:0032609 39 0.158
regulation of leukocyte activation GO:0002694 115 0.158
single organism nuclear import GO:1902593 104 0.157
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.157
regulation of t cell proliferation GO:0042129 42 0.156
chemokine c c motif ligand 21 signaling pathway GO:0038116 1 0.155
positive regulation of steroid metabolic process GO:0045940 13 0.155
regulation of multi organism process GO:0043900 157 0.155
regulation of nucleotide metabolic process GO:0006140 269 0.153
calcium ion transport into cytosol GO:0060402 48 0.153
calcium mediated signaling GO:0019722 44 0.152
negative regulation of cytokine production GO:0001818 82 0.152
positive regulation of monocyte chemotactic protein 1 production GO:0071639 3 0.151
regulation of rho gtpase activity GO:0032319 66 0.150
interaction with symbiont GO:0051702 26 0.150
chemokine metabolic process GO:0050755 4 0.150
Mouse
cellular ion homeostasis GO:0006873 168 0.150
Rat
bone mineralization GO:0030282 34 0.150
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.149
regulation of protein complex assembly GO:0043254 147 0.148
cytolysis GO:0019835 8 0.148
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.146
t cell proliferation GO:0042098 45 0.146
positive regulation of ion transport GO:0043270 87 0.144
Mouse
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.143
Rat
oxidation reduction process GO:0055114 396 0.143
positive regulation of cell death GO:0010942 263 0.142
Rat
regulation of cell cycle process GO:0010564 266 0.139
viral rna genome replication GO:0039694 9 0.137
positive regulation of proteolysis GO:0045862 142 0.135
peptidyl tyrosine modification GO:0018212 170 0.134
regulation of biomineral tissue development GO:0070167 31 0.134

IL1B disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.390
disease of cellular proliferation DOID:14566 174 0.390
organ system cancer DOID:0050686 164 0.390
disease by infectious agent DOID:0050117 34 0.151