Homo sapiens

84 known processes

GDF9

growth differentiation factor 9

GDF9 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular amine metabolic process GO:0033238 11 0.813
regulation of cellular amino acid metabolic process GO:0006521 6 0.661
cellular response to cytokine stimulus GO:0071345 181 0.545
positive regulation of cellular amine metabolic process GO:0033240 7 0.484
cellular amino acid metabolic process GO:0006520 116 0.473
cellular response to endogenous stimulus GO:0071495 336 0.472
regulation of protein kinase activity GO:0045859 289 0.468
cellular ketone metabolic process GO:0042180 80 0.466
sprouting angiogenesis GO:0002040 29 0.456
regulation of endothelial cell migration GO:0010594 67 0.453
amine metabolic process GO:0009308 44 0.427
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.420
positive regulation of protein kinase activity GO:0045860 190 0.339
peptidyl tyrosine modification GO:0018212 170 0.269
cellular response to growth factor stimulus GO:0071363 197 0.268
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.242
post embryonic development GO:0009791 2 0.236
regulation of transferase activity GO:0051338 355 0.217
regulation of protein serine threonine kinase activity GO:0071900 179 0.211
positive regulation of kinase activity GO:0033674 204 0.203
cellular response to hepatocyte growth factor stimulus GO:0035729 6 0.202
response to epidermal growth factor GO:0070849 14 0.191
response to cytokine GO:0034097 232 0.175
response to growth factor GO:0070848 205 0.161
cellular response to tumor necrosis factor GO:0071356 63 0.158
peptidyl tyrosine phosphorylation GO:0018108 170 0.149
regulation of kinase activity GO:0043549 314 0.146
negative regulation of apoptotic process GO:0043066 316 0.141
forelimb morphogenesis GO:0035136 4 0.124
negative regulation of hepatocyte growth factor receptor signaling pathway GO:1902203 1 0.122
positive regulation of phosphorylation GO:0042327 394 0.117
positive regulation of transferase activity GO:0051347 227 0.111
negative regulation of programmed cell death GO:0043069 321 0.109
regulation of map kinase activity GO:0043405 108 0.102
mapk cascade GO:0000165 288 0.097
positive regulation of protein phosphorylation GO:0001934 313 0.093
vasculature development GO:0001944 181 0.092
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.091
positive regulation of endothelial cell migration GO:0010595 39 0.091
response to tumor necrosis factor GO:0034612 76 0.090
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.090
activation of mapk activity GO:0000187 45 0.087
immune response GO:0006955 307 0.086
circulatory system development GO:0072359 262 0.085
epithelial cell migration GO:0010631 119 0.081
positive regulation of mapk cascade GO:0043410 190 0.077
heart development GO:0007507 95 0.077
activation of protein kinase activity GO:0032147 90 0.076
female gamete generation GO:0007292 2 0.076
Mouse
negative regulation of smoothened signaling pathway GO:0045879 3 0.075
defense response GO:0006952 315 0.074
positive regulation of cell death GO:0010942 263 0.073
regulation of cellular component movement GO:0051270 334 0.072
negative regulation of cellular protein metabolic process GO:0032269 353 0.070
cardiovascular system development GO:0072358 262 0.069
regulation of mapk cascade GO:0043408 262 0.065
establishment of nucleus localization GO:0040023 1 0.065
negative regulation of phosphate metabolic process GO:0045936 267 0.064
innate immune response GO:0045087 178 0.064
regulation of epithelial cell migration GO:0010632 93 0.064
positive regulation of programmed cell death GO:0043068 249 0.062
connective tissue development GO:0061448 39 0.062
tissue migration GO:0090130 119 0.060
cellular response to interferon gamma GO:0071346 24 0.060
negative regulation of cell death GO:0060548 345 0.059
anatomical structure formation involved in morphogenesis GO:0048646 284 0.058
angiogenesis GO:0001525 147 0.057
epithelium migration GO:0090132 119 0.055
response to fibroblast growth factor GO:0071774 39 0.051
positive regulation of cell proliferation GO:0008284 301 0.050
peptidyl serine modification GO:0018209 106 0.049
regulation of mitotic cell cycle GO:0007346 189 0.048
cell migration involved in sprouting angiogenesis GO:0002042 19 0.048
apoptotic signaling pathway GO:0097190 268 0.048
detection of stimulus GO:0051606 85 0.047
oogenesis GO:0048477 2 0.047
Mouse
carbohydrate derivative biosynthetic process GO:1901137 207 0.047
positive regulation of map kinase activity GO:0043406 80 0.046
positive regulation of cellular component movement GO:0051272 181 0.045
forebrain neuron differentiation GO:0021879 3 0.045
positive regulation of apoptotic process GO:0043065 246 0.045
regulation of response to external stimulus GO:0032101 222 0.044
mitotic cell cycle GO:0000278 326 0.044
response to interferon gamma GO:0034341 39 0.043
positive regulation of epithelial cell migration GO:0010634 55 0.042
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.042
regulation of cell migration GO:0030334 289 0.042
blood vessel development GO:0001568 172 0.040
ameboidal type cell migration GO:0001667 135 0.039
regulation of anatomical structure morphogenesis GO:0022603 286 0.038
internal peptidyl lysine acetylation GO:0018393 97 0.037
protein processing GO:0016485 226 0.035
rna processing GO:0006396 255 0.034
positive regulation of hormone biosynthetic process GO:0046886 4 0.034
regulation of endopeptidase activity GO:0052548 170 0.034
positive regulation of proteolysis GO:0045862 142 0.034
positive regulation of cell migration GO:0030335 172 0.033
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.033
organelle fission GO:0048285 149 0.033
regulation of cell cycle process GO:0010564 266 0.033
negative regulation of protein metabolic process GO:0051248 391 0.033
signal transduction by phosphorylation GO:0023014 297 0.032
protein catabolic process GO:0030163 325 0.032
mitotic cell cycle process GO:1903047 286 0.032
oocyte differentiation GO:0009994 2 0.032
Mouse
regulation of cellular ketone metabolic process GO:0010565 50 0.032
cellular amine metabolic process GO:0044106 41 0.032
wnt signaling pathway GO:0016055 156 0.031
regulation of proteolysis GO:0030162 293 0.030
negative regulation of cellular response to hepatocyte growth factor stimulus GO:2001113 1 0.030
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.030
cellular response to organic cyclic compound GO:0071407 127 0.029
negative regulation of cellular component organization GO:0051129 235 0.028
cell development GO:0048468 328 0.028
Mouse
nucleotide catabolic process GO:0009166 408 0.028
negative regulation of developmental process GO:0051093 247 0.027
forebrain generation of neurons GO:0021872 3 0.026
regulation of cellular response to hepatocyte growth factor stimulus GO:2001112 1 0.026
regulation of cell differentiation GO:0045595 393 0.026
regulation of protein localization GO:0032880 296 0.026
reproductive process GO:0022414 106 0.026
response to organic cyclic compound GO:0014070 204 0.026
central nervous system development GO:0007417 123 0.026
cell division GO:0051301 168 0.025
positive regulation of secretion GO:0051047 116 0.025
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.025
stem cell division GO:0017145 2 0.025
response to oxygen containing compound GO:1901700 369 0.024
embryo development GO:0009790 123 0.024
ossification GO:0001503 121 0.024
ubiquitin dependent protein catabolic process GO:0006511 206 0.024
histone modification GO:0016570 251 0.024
camp metabolic process GO:0046058 61 0.024
detection of mechanical stimulus GO:0050982 4 0.023
modification dependent protein catabolic process GO:0019941 209 0.023
spermatid differentiation GO:0048515 4 0.022
response to interleukin 6 GO:0070741 15 0.022
hindlimb morphogenesis GO:0035137 2 0.022
nitrogen compound transport GO:0071705 191 0.021
positive regulation of cell cycle GO:0045787 140 0.021
positive regulation of peptidase activity GO:0010952 88 0.021
peptidyl lysine acetylation GO:0018394 101 0.020
positive regulation of steroid hormone biosynthetic process GO:0090031 2 0.020
protein localization to organelle GO:0033365 280 0.020
glycoprotein metabolic process GO:0009100 110 0.020
cell adhesion GO:0007155 325 0.020
mitotic nuclear division GO:0007067 119 0.019
muscle structure development GO:0061061 98 0.019
prostate gland stromal morphogenesis GO:0060741 1 0.019
neuromuscular junction development GO:0007528 3 0.019
secretion GO:0046903 254 0.019
enzyme linked receptor protein signaling pathway GO:0007167 303 0.019
rna splicing GO:0008380 131 0.019
vesicle mediated transport GO:0016192 371 0.018
spermatid development GO:0007286 4 0.018
cell morphogenesis involved in differentiation GO:0000904 144 0.018
basement membrane organization GO:0071711 3 0.018
internal protein amino acid acetylation GO:0006475 101 0.018
nucleoside triphosphate catabolic process GO:0009143 394 0.018
chemotaxis GO:0006935 157 0.018
cellular protein catabolic process GO:0044257 261 0.017
developmental process involved in reproduction GO:0003006 66 0.017
positive regulation of aldosterone metabolic process GO:0032346 2 0.017
protein maturation GO:0051604 233 0.017
meiosis i GO:0007127 4 0.017
brain development GO:0007420 97 0.017
regulation of cell cycle GO:0051726 393 0.017
sulfur compound metabolic process GO:0006790 101 0.017
negative regulation of transferase activity GO:0051348 124 0.017
blood coagulation GO:0007596 76 0.016
mrna metabolic process GO:0016071 175 0.016
protein acylation GO:0043543 138 0.016
actin filament organization GO:0007015 128 0.016
cell part morphogenesis GO:0032990 137 0.016
glycosyl compound catabolic process GO:1901658 413 0.016
cerebellum development GO:0021549 2 0.016
cyclic nucleotide biosynthetic process GO:0009190 61 0.016
growth GO:0040007 202 0.016
Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.016
regulation of endocytosis GO:0030100 72 0.016
positive regulation of chondrocyte differentiation GO:0032332 4 0.016
regulation of ossification GO:0030278 58 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.016
determination of adult lifespan GO:0008340 2 0.015
cellular response to dna damage stimulus GO:0006974 379 0.015
cell substrate adhesion GO:0031589 132 0.015
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.015
neuroblast proliferation GO:0007405 4 0.015
protein acetylation GO:0006473 116 0.015
biological adhesion GO:0022610 331 0.015
regulation of dna metabolic process GO:0051052 153 0.015
intrinsic apoptotic signaling pathway GO:0097193 127 0.015
cellular response to epidermal growth factor stimulus GO:0071364 11 0.015
asymmetric stem cell division GO:0098722 1 0.015
regulation of cell motility GO:2000145 299 0.015
regulation of secretion GO:0051046 194 0.015
sensory perception GO:0007600 103 0.015
regulation of exocytosis GO:0017157 46 0.014
protein localization to membrane GO:0072657 160 0.014
positive regulation of cell motility GO:2000147 177 0.014
osteoblast differentiation GO:0001649 92 0.014
cell projection assembly GO:0030031 126 0.014
regulation of cell development GO:0060284 161 0.014
chromatin organization GO:0006325 351 0.014
cellular macromolecule catabolic process GO:0044265 380 0.014
epidermis morphogenesis GO:0048730 3 0.014
monovalent inorganic cation transport GO:0015672 128 0.014
blastocyst development GO:0001824 3 0.014
system process GO:0003008 349 0.014
lipid biosynthetic process GO:0008610 177 0.014
mrna splicing via spliceosome GO:0000398 89 0.014
response to radiation GO:0009314 151 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
cellular response to organonitrogen compound GO:0071417 124 0.014
negative regulation of growth GO:0045926 97 0.014
Mouse
renal water homeostasis GO:0003091 4 0.014
urogenital system development GO:0001655 65 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.014
cyclic nucleotide metabolic process GO:0009187 82 0.014
regulation of cell morphogenesis GO:0022604 153 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.013
negative regulation of platelet aggregation GO:0090331 3 0.013
cellular response to interleukin 6 GO:0071354 14 0.013
oocyte development GO:0048599 1 0.013
Mouse
signal transduction by p53 class mediator GO:0072331 72 0.013
intracellular protein transport GO:0006886 270 0.013
regulation of protein catabolic process GO:0042176 155 0.013
response to light stimulus GO:0009416 87 0.013
response to hepatocyte growth factor GO:0035728 6 0.013
covalent chromatin modification GO:0016569 254 0.013
negative regulation of protein modification process GO:0031400 200 0.013
single organism reproductive process GO:0044702 98 0.013
single organism membrane organization GO:0044802 268 0.013
gtp metabolic process GO:0046039 239 0.013
multicellular organismal aging GO:0010259 3 0.013
patterning of blood vessels GO:0001569 2 0.013
embryonic hindlimb morphogenesis GO:0035116 2 0.013
establishment of protein localization to membrane GO:0090150 121 0.013
prostate gland development GO:0030850 3 0.013
regulation of organelle assembly GO:1902115 40 0.013
photoreceptor cell differentiation GO:0046530 2 0.013
nucleocytoplasmic transport GO:0006913 176 0.013
positive regulation of exocytosis GO:0045921 35 0.013
nucleus localization GO:0051647 1 0.013
negative regulation of cellular component movement GO:0051271 106 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.013
cellular response to hormone stimulus GO:0032870 125 0.012
retina vasculature morphogenesis in camera type eye GO:0061299 3 0.012
chromatin modification GO:0016568 298 0.012
response to abiotic stimulus GO:0009628 336 0.012
cyclic purine nucleotide metabolic process GO:0052652 60 0.012
regulation of wnt signaling pathway GO:0030111 123 0.012
regulation of intracellular protein transport GO:0033157 123 0.012
positive regulation of organelle assembly GO:1902117 17 0.012
negative regulation of cell differentiation GO:0045596 171 0.012
cell cycle phase transition GO:0044770 173 0.012
regulation of platelet aggregation GO:0090330 4 0.012
organelle assembly GO:0070925 176 0.012
protein localization to plasma membrane GO:0072659 93 0.012
plasma membrane organization GO:0007009 115 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
vesicle organization GO:0016050 62 0.012
negative regulation of cell proliferation GO:0008285 228 0.012
negative regulation of catalytic activity GO:0043086 335 0.012
regulation of dephosphorylation GO:0035303 96 0.012
nerve development GO:0021675 4 0.012
positive regulation of catabolic process GO:0009896 310 0.012
positive regulation of mitotic cell cycle GO:0045931 60 0.012
tube morphogenesis GO:0035239 95 0.012
regulation of receptor mediated endocytosis GO:0048259 32 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
regulation of gtpase activity GO:0043087 180 0.012
intracellular receptor signaling pathway GO:0030522 104 0.012
locomotory behavior GO:0007626 1 0.011
negative regulation of camp biosynthetic process GO:0030818 9 0.011
peptidyl lysine modification GO:0018205 144 0.011
camp biosynthetic process GO:0006171 47 0.011
regulation of cell division GO:0051302 116 0.011
regulation of vesicle mediated transport GO:0060627 130 0.011
negative regulation of glomerulus development GO:0090194 2 0.011
negative regulation of wnt signaling pathway GO:0030178 69 0.011
response to oxygen levels GO:0070482 100 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.011
nucleobase containing compound transport GO:0015931 51 0.011
forebrain neuron development GO:0021884 2 0.011
hyaluranon cable assembly GO:0036118 3 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
mesendoderm development GO:0048382 1 0.011
detection of abiotic stimulus GO:0009582 15 0.011
interspecies interaction between organisms GO:0044419 156 0.011
negative regulation of locomotion GO:0040013 118 0.011
negative regulation of multi organism process GO:0043901 92 0.011
regulation of reactive oxygen species metabolic process GO:2000377 41 0.011
regulation of caveolin mediated endocytosis GO:2001286 2 0.011
negative regulation of steroid hormone biosynthetic process GO:0090032 4 0.011
membrane organization GO:0061024 292 0.010
cell projection organization GO:0030030 252 0.010
single organism cell adhesion GO:0098602 179 0.010
organophosphate catabolic process GO:0046434 430 0.010
cellular response to abiotic stimulus GO:0071214 117 0.010
cellular component morphogenesis GO:0032989 314 0.010
negative regulation of cell adhesion GO:0007162 64 0.010
cell projection morphogenesis GO:0048858 129 0.010
receptor mediated endocytosis GO:0006898 84 0.010
nuclear division GO:0000280 128 0.010
regulation of odontogenesis GO:0042481 4 0.010
negative regulation of wound healing GO:0061045 25 0.010
positive regulation of ossification GO:0045778 32 0.010
kidney development GO:0001822 53 0.010
hematopoietic or lymphoid organ development GO:0048534 186 0.010
proteasomal protein catabolic process GO:0010498 176 0.010
endosomal transport GO:0016197 129 0.010
negative regulation of hydrolase activity GO:0051346 182 0.010
regulation of camp biosynthetic process GO:0030817 45 0.010

GDF9 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of mental health DOID:150 70 0.018
sensory system disease DOID:0050155 203 0.015
nervous system disease DOID:863 431 0.015
musculoskeletal system disease DOID:17 223 0.012