|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.286
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.229
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.207
|
Human |
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.199
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.184
|
Human |
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.178
|
Human Zebrafish |
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.170
|
Zebrafish |
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.170
|
Human |
|
|
circulatory system development
|
GO:0072359 |
262 |
0.162
|
Human Zebrafish |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.161
|
Human |
|
|
cell development
|
GO:0048468 |
328 |
0.160
|
Human Zebrafish Mouse |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.157
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.157
|
Human |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.155
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.152
|
Human Zebrafish Mouse |
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.151
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.150
|
Human |
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.150
|
Human Zebrafish Worm |
|
|
mesenchyme development
|
GO:0060485 |
59 |
0.148
|
Human |
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.146
|
Human Mouse Worm |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.141
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.139
|
Human Zebrafish |
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.138
|
Human |
|
|
skeletal system development
|
GO:0001501 |
79 |
0.135
|
Zebrafish |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.128
|
Human Mouse |
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.127
|
Human |
|
|
segmentation
|
GO:0035282 |
4 |
0.126
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.126
|
Human Zebrafish |
|
|
extraocular skeletal muscle development
|
GO:0002074 |
1 |
0.124
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.122
|
|
|
|
mesenchymal cell differentiation
|
GO:0048762 |
52 |
0.121
|
Human |
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.118
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.115
|
Human |
|
|
stem cell development
|
GO:0048864 |
69 |
0.115
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.114
|
Human |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.113
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.113
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.112
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.109
|
Human Zebrafish |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.109
|
|
|
|
mesenchymal cell development
|
GO:0014031 |
50 |
0.108
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.107
|
Human |
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.104
|
Human |
|
|
neural crest cell development
|
GO:0014032 |
3 |
0.104
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.102
|
Human Mouse |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.101
|
Worm |
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.100
|
Human |
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.097
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.095
|
Human |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.093
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.092
|
Human |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.090
|
Human Mouse |
|
|
regulation of stem cell differentiation
|
GO:2000736 |
56 |
0.089
|
|
|
|
neuron fate commitment
|
GO:0048663 |
2 |
0.087
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.086
|
Human Zebrafish |
|
|
generation of neurons
|
GO:0048699 |
152 |
0.083
|
Human Zebrafish Mouse |
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.081
|
Human Zebrafish Worm |
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.080
|
Human |
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.078
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.077
|
Human Zebrafish Mouse |
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.076
|
Human Worm |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.075
|
Human |
|
|
inner ear morphogenesis
|
GO:0042472 |
4 |
0.074
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.073
|
Zebrafish |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.071
|
Human |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.071
|
Human |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.069
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.067
|
|
|
|
organ formation
|
GO:0048645 |
3 |
0.067
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.067
|
Human Zebrafish Mouse |
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.066
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.065
|
Human |
|
|
oogenesis
|
GO:0048477 |
2 |
0.064
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.063
|
|
|
|
system process
|
GO:0003008 |
349 |
0.063
|
Human |
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.062
|
Human |
|
|
hindbrain development
|
GO:0030902 |
3 |
0.062
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.061
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.061
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.061
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.061
|
Human |
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.061
|
Human |
|
|
connective tissue development
|
GO:0061448 |
39 |
0.060
|
Human |
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.060
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.060
|
Human |
|
|
response to growth factor
|
GO:0070848 |
205 |
0.059
|
|
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.059
|
Human |
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.059
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.059
|
Human Zebrafish |
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.056
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.056
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.056
|
Human |
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.055
|
Human |
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.054
|
Human |
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.053
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.053
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.053
|
Human Worm |
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.052
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.052
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.052
|
|
|
|
growth
|
GO:0040007 |
202 |
0.051
|
Human Worm |
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.051
|
|
|
|
negative regulation of cell migration
|
GO:0030336 |
102 |
0.051
|
Human |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.051
|
Human |
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.050
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.050
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.049
|
Human |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.049
|
Human |
|
|
head development
|
GO:0060322 |
108 |
0.049
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.049
|
Human |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.049
|
Human |
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.048
|
Human |
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.048
|
Human |
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.048
|
|
|
|
ossification
|
GO:0001503 |
121 |
0.048
|
Human |
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.046
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.046
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.046
|
Human |
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.046
|
Human Mouse |
|
|
neuron projection development
|
GO:0031175 |
106 |
0.046
|
Human Zebrafish |
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.045
|
Human |
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.045
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.045
|
Human |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.045
|
Human |
|
|
chromatin organization
|
GO:0006325 |
351 |
0.045
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.044
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.044
|
Human |
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.044
|
Human |
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.044
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.044
|
|
|
|
nerve development
|
GO:0021675 |
4 |
0.044
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.044
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.044
|
Human |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.044
|
Human |
|
|
pattern specification process
|
GO:0007389 |
43 |
0.044
|
Zebrafish |
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.044
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.043
|
Human |
|
|
epithelial to mesenchymal transition
|
GO:0001837 |
48 |
0.043
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.043
|
Human Zebrafish |
|
|
epithelial tube morphogenesis
|
GO:0060562 |
38 |
0.043
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.042
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.042
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.042
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.042
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.042
|
|
|
|
endoderm development
|
GO:0007492 |
33 |
0.042
|
Human |
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.041
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.041
|
Human |
|
|
chromatin modification
|
GO:0016568 |
298 |
0.041
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.041
|
Human |
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.040
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.040
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.040
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.040
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.039
|
Human |
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.039
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.039
|
Human |
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.039
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.039
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.039
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.039
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.039
|
Human |
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.039
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.038
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.038
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.038
|
Human |
|
|
cell adhesion
|
GO:0007155 |
325 |
0.038
|
Human |
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.038
|
Human |
|
|
regulation of ossification
|
GO:0030278 |
58 |
0.038
|
Human |
|
|
epithelium migration
|
GO:0090132 |
119 |
0.038
|
Human |
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.037
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.037
|
|
|
|
cranial nerve development
|
GO:0021545 |
4 |
0.037
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.037
|
Human |
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.037
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.037
|
Human |
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.037
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.036
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.036
|
Human |
|
|
blood circulation
|
GO:0008015 |
113 |
0.036
|
Human |
|
|
gland development
|
GO:0048732 |
48 |
0.036
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
114 |
0.036
|
Human |
|
|
biological adhesion
|
GO:0022610 |
331 |
0.036
|
Human |
|
|
tissue migration
|
GO:0090130 |
119 |
0.036
|
Human |
|
|
brain development
|
GO:0007420 |
97 |
0.036
|
|
|
|
embryonic camera type eye development
|
GO:0031076 |
2 |
0.036
|
Zebrafish |
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.036
|
Human |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.035
|
Human |
|
|
reproductive process
|
GO:0022414 |
106 |
0.035
|
Human Worm |
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.035
|
Zebrafish |
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.035
|
Human Zebrafish |
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.034
|
|
|
|
negative regulation of cell motility
|
GO:2000146 |
104 |
0.034
|
Human |
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.034
|
Human Mouse |
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.034
|
|
|
|
pituitary gland development
|
GO:0021983 |
2 |
0.034
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.034
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.034
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.034
|
Human |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.034
|
Human |
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.034
|
Human |
|
|
cell growth
|
GO:0016049 |
160 |
0.034
|
Human |
|
|
sensory organ development
|
GO:0007423 |
52 |
0.034
|
Zebrafish |
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.033
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.033
|
Human |
|
|
soft palate development
|
GO:0060023 |
3 |
0.033
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.033
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.033
|
Human |
|
|
gastrulation
|
GO:0007369 |
51 |
0.033
|
Human |
|
|
embryonic organ morphogenesis
|
GO:0048562 |
24 |
0.033
|
|
|
|
endothelial cell migration
|
GO:0043542 |
86 |
0.033
|
Human |
|
|
oocyte development
|
GO:0048599 |
1 |
0.033
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.032
|
Human |
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.032
|
Human |
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.032
|
Human |
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.032
|
Worm |
|
|
immune response
|
GO:0006955 |
307 |
0.032
|
Human Worm |
|
|
secretion by cell
|
GO:0032940 |
226 |
0.032
|
Human |
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.032
|
Human |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.031
|
Human |
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.031
|
Human |
|
|
somitogenesis
|
GO:0001756 |
2 |
0.031
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.031
|
Human |
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.031
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.031
|
Human Zebrafish |
|
|
regulation of epithelial to mesenchymal transition
|
GO:0010717 |
37 |
0.031
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.031
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.031
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.031
|
Human |
|
|
heart morphogenesis
|
GO:0003007 |
48 |
0.031
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.030
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.030
|
Human |
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.030
|
Human |
|
|
skeletal system morphogenesis
|
GO:0048705 |
24 |
0.030
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.030
|
Human |
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.030
|
|
|
|
negative regulation of cellular component movement
|
GO:0051271 |
106 |
0.030
|
Human |
|
|
positive regulation of stem cell differentiation
|
GO:2000738 |
29 |
0.030
|
|
|
|
endocrine system development
|
GO:0035270 |
26 |
0.030
|
Human |
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.029
|
|
|
|
endodermal cell fate commitment
|
GO:0001711 |
4 |
0.029
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.029
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.029
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
4 |
0.029
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.029
|
Human |
|
|
response to hormone
|
GO:0009725 |
175 |
0.029
|
Human |
|
|
regulation of growth
|
GO:0040008 |
165 |
0.029
|
Human Worm |
|
|
regulation of osteoblast differentiation
|
GO:0045667 |
38 |
0.029
|
Human |
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.029
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.028
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.028
|
Human |
|
|
formation of primary germ layer
|
GO:0001704 |
42 |
0.028
|
Human |
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.028
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.027
|
Human |
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.027
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.027
|
Human |
|
|
eye development
|
GO:0001654 |
42 |
0.027
|
Zebrafish |
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.027
|
Human |
|
|
nuclear transport
|
GO:0051169 |
179 |
0.027
|
Human |
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.027
|
Human |
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.027
|
Human |
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.027
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.027
|
|
|
|
endochondral bone morphogenesis
|
GO:0060350 |
3 |
0.027
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.027
|
Human |
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.027
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.027
|
Worm |
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.027
|
Human |
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.027
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.027
|
Human |
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.026
|
Human |
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.026
|
Human |
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.026
|
Human |
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.026
|
Human |
|
|
forebrain regionalization
|
GO:0021871 |
3 |
0.026
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.026
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.026
|
|
|
|
negative regulation of wnt signaling pathway
|
GO:0030178 |
69 |
0.026
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.026
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.026
|
Human Mouse |
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.026
|
Human |
|
|
cartilage development involved in endochondral bone morphogenesis
|
GO:0060351 |
2 |
0.026
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.025
|
Human |
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.025
|
Human |
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.025
|
|
|
|
urogenital system development
|
GO:0001655 |
65 |
0.025
|
Human |
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.025
|
|
|
|
regulation of male gonad development
|
GO:2000018 |
4 |
0.025
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.025
|
Human |
|
|
endodermal cell fate specification
|
GO:0001714 |
4 |
0.025
|
|
|
|
cartilage development
|
GO:0051216 |
31 |
0.025
|
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.024
|
Human |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.024
|
Human |
|
|
sensory perception
|
GO:0007600 |
103 |
0.024
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.024
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.024
|
Human Zebrafish |
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.024
|
Worm |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.024
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.024
|
Human Mouse |
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.024
|
Human |
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.024
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.024
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.024
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.024
|
|
|
|
embryonic camera type eye formation
|
GO:0060900 |
2 |
0.024
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.024
|
Human |
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.024
|
Human |
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.024
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.023
|
Human |
|
|
striated muscle tissue development
|
GO:0014706 |
59 |
0.023
|
Zebrafish |
|
|
protein import
|
GO:0017038 |
130 |
0.023
|
Human |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.023
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.023
|
|
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.023
|
Human |
|
|
negative regulation of cell growth
|
GO:0030308 |
83 |
0.023
|
Human |
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.023
|
|
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.023
|
Zebrafish |
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.023
|
Human |
|
|
sex determination
|
GO:0007530 |
3 |
0.023
|
|
|
|
cartilage condensation
|
GO:0001502 |
1 |
0.023
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.023
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
54 |
0.023
|
Human Mouse |
|
|
angiogenesis
|
GO:0001525 |
147 |
0.023
|
Human |
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.023
|
Human |
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.023
|
|
|
|
cardiocyte differentiation
|
GO:0035051 |
23 |
0.022
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.022
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.022
|
Human |
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.022
|
|
|
|
regionalization
|
GO:0003002 |
29 |
0.022
|
Zebrafish |
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.022
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.022
|
Human |
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.022
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.022
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.022
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.022
|
Human |
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.022
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.022
|
|
|
|
renal system development
|
GO:0072001 |
63 |
0.022
|
Human |
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.022
|
Human Worm |
|
|
embryonic organ development
|
GO:0048568 |
36 |
0.022
|
Zebrafish |
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.022
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.021
|
|
|
|
cardiac cell fate determination
|
GO:0060913 |
3 |
0.021
|
|
|
|
muscle cell fate commitment
|
GO:0042693 |
4 |
0.021
|
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
48 |
0.021
|
Human |
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.021
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.021
|
Human Zebrafish |
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.021
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.021
|
|
|
|
neuron projection morphogenesis
|
GO:0048812 |
50 |
0.021
|
Human Zebrafish |
|
|
negative regulation of gliogenesis
|
GO:0014014 |
3 |
0.021
|
|
|
|
biomineral tissue development
|
GO:0031214 |
39 |
0.021
|
Human |
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.021
|
|
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.021
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.021
|
Worm |
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.021
|
Human |
|
|
embryonic eye morphogenesis
|
GO:0048048 |
2 |
0.021
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.021
|
|
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.021
|
|
|
|
limbic system development
|
GO:0021761 |
3 |
0.021
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.021
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.020
|
Human |
|
|
negative regulation of canonical wnt signaling pathway
|
GO:0090090 |
55 |
0.020
|
|
|
|
negative regulation of cell development
|
GO:0010721 |
48 |
0.020
|
Human |
|
|
embryonic camera type eye morphogenesis
|
GO:0048596 |
2 |
0.020
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
92 |
0.020
|
Human |
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.020
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.020
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.020
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.020
|
|
|
|
chordate embryonic development
|
GO:0043009 |
34 |
0.020
|
Zebrafish |
|
|
metencephalon development
|
GO:0022037 |
2 |
0.020
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.020
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.020
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.020
|
Human |
|
|
chemotaxis
|
GO:0006935 |
157 |
0.020
|
Zebrafish |
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.020
|
Human |
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.020
|
|
|
|
sensory organ morphogenesis
|
GO:0090596 |
21 |
0.020
|
Zebrafish |
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.020
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.020
|
Worm |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.020
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.019
|
Human |
|
|
hormone transport
|
GO:0009914 |
68 |
0.019
|
Human |
|
|
regulation of protein import into nucleus
|
GO:0042306 |
78 |
0.019
|
Human |
|
|
hormone secretion
|
GO:0046879 |
65 |
0.019
|
Human |
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.019
|
Human |
|
|
signal release
|
GO:0023061 |
70 |
0.019
|
Human |
|
|
protein targeting
|
GO:0006605 |
187 |
0.019
|
Human |
|
|
cardiac muscle tissue development
|
GO:0048738 |
39 |
0.019
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.019
|
|
|
|
forelimb morphogenesis
|
GO:0035136 |
4 |
0.019
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.019
|
|
|
|
response to acid chemical
|
GO:0001101 |
66 |
0.019
|
|
|
|
mesodermal cell fate commitment
|
GO:0001710 |
2 |
0.019
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.019
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.019
|
Human |
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.019
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.019
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.019
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.019
|
|
|
|
atrioventricular valve development
|
GO:0003171 |
3 |
0.019
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.019
|
Human |
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.019
|
Human |
|
|
spinal cord development
|
GO:0021510 |
4 |
0.019
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.018
|
|
|
|
memory
|
GO:0007613 |
3 |
0.018
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.018
|
|
|
|
endoderm formation
|
GO:0001706 |
33 |
0.018
|
Human |
|
|
amide transport
|
GO:0042886 |
76 |
0.018
|
Human |
|
|
photoreceptor cell differentiation
|
GO:0046530 |
2 |
0.018
|
Zebrafish |
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.018
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.018
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.018
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.018
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.018
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.018
|
|
|
|
circulatory system process
|
GO:0003013 |
113 |
0.018
|
Human |
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.018
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.017
|
|
|
|
negative regulation of cell adhesion
|
GO:0007162 |
64 |
0.017
|
|
|
|
neural crest cell migration
|
GO:0001755 |
2 |
0.017
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.017
|
Worm |
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.017
|
Human |
|
|
chondrocyte differentiation
|
GO:0002062 |
17 |
0.017
|
|
|
|
positive regulation of cell morphogenesis involved in differentiation
|
GO:0010770 |
50 |
0.017
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.017
|
|
|
|
positive regulation of ossification
|
GO:0045778 |
32 |
0.017
|
Human |
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.017
|
Human Worm |
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.017
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.017
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.017
|
|
|
|
sex differentiation
|
GO:0007548 |
45 |
0.017
|
Worm |
|
|
cardiac right ventricle morphogenesis
|
GO:0003215 |
3 |
0.017
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.017
|
Human |
|
|
limb bud formation
|
GO:0060174 |
1 |
0.017
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.017
|
Worm |
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.017
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.017
|
|
|
|
muscle system process
|
GO:0003012 |
81 |
0.017
|
Human |
|
|
appendage morphogenesis
|
GO:0035107 |
16 |
0.017
|
|
|
|
translation
|
GO:0006412 |
132 |
0.017
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.017
|
Human |
|
|
forebrain development
|
GO:0030900 |
26 |
0.017
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.017
|
Human |
|
|
mesodermal cell fate specification
|
GO:0007501 |
2 |
0.017
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.016
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
40 |
0.016
|
Human Mouse |
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.016
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.016
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.016
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.016
|
|
|
|
endothelial cell proliferation
|
GO:0001935 |
65 |
0.016
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.016
|
|
|
|
positive regulation of epithelial cell migration
|
GO:0010634 |
55 |
0.016
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.016
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.016
|
|
|
|
primary neural tube formation
|
GO:0014020 |
3 |
0.016
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
110 |
0.016
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.016
|
|
|
|
tripartite regional subdivision
|
GO:0007351 |
2 |
0.016
|
|
|
|
muscle organ development
|
GO:0007517 |
56 |
0.016
|
Zebrafish |
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.016
|
|
|
|
somatic stem cell maintenance
|
GO:0035019 |
4 |
0.016
|
|
|
|
limb development
|
GO:0060173 |
23 |
0.016
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.016
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.016
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.016
|
|
|
|
menstrual cycle phase
|
GO:0022601 |
2 |
0.016
|
|
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.016
|
|
|
|
cell matrix adhesion
|
GO:0007160 |
85 |
0.016
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.016
|
|
|
|
appendage development
|
GO:0048736 |
23 |
0.016
|
|
|
|
embryonic forelimb morphogenesis
|
GO:0035115 |
4 |
0.016
|
|
|
|
detection of stimulus
|
GO:0051606 |
85 |
0.015
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.015
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.015
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.015
|
Human |
|
|
membrane organization
|
GO:0061024 |
292 |
0.015
|
|
|
|
pharynx development
|
GO:0060465 |
1 |
0.015
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.015
|
Zebrafish |
|
|
odontogenesis
|
GO:0042476 |
25 |
0.015
|
|
|
|
prostate gland development
|
GO:0030850 |
3 |
0.015
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.015
|
Human |
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.015
|
|
