Homo sapiens

33 known processes

MLH1

mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

(Aliases: HNPCC2,COCA2,FCC2,hMLH1,HNPCC,MGC5172)

MLH1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
somatic diversification of immune receptors via somatic mutation GO:0002566 1 1.000
Mouse
mismatch repair GO:0006298 15 0.999
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.985
Mouse
dna repair GO:0006281 198 0.982
nucleotide excision repair GO:0006289 31 0.968
cellular response to dna damage stimulus GO:0006974 379 0.938
gene conversion GO:0035822 1 0.902
meiosis i GO:0007127 4 0.888
Yeast Zebrafish Mouse
dna catabolic process endonucleolytic GO:0000737 37 0.866
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.851
Mouse
anatomical structure homeostasis GO:0060249 100 0.847
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.800
Mouse
maintenance of dna repeat elements GO:0043570 4 0.765
dna double strand break processing GO:0000729 10 0.695
somatic hypermutation of immunoglobulin genes GO:0016446 1 0.688
Mouse
telomere organization GO:0032200 33 0.584
double strand break repair via single strand annealing GO:0045002 4 0.523
interstrand cross link repair GO:0036297 3 0.479
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.340
somatic diversification of immunoglobulins GO:0016445 6 0.309
Mouse
positive regulation of helicase activity GO:0051096 6 0.303
production of molecular mediator of immune response GO:0002440 37 0.300
Mouse
isotype switching GO:0045190 3 0.269
Mouse
immunoglobulin production GO:0002377 12 0.258
Mouse
ribonucleoside catabolic process GO:0042454 406 0.249
Yeast
somatic diversification of immune receptors GO:0002200 8 0.245
Mouse
dna catabolic process GO:0006308 49 0.242
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.240
Mouse
chromosome segregation GO:0007059 114 0.223
Zebrafish Mouse
dna damage checkpoint GO:0000077 68 0.216
ribonucleoside triphosphate catabolic process GO:0009203 391 0.211
Yeast
intrinsic apoptotic signaling pathway GO:0097193 127 0.203
Mouse
immune response GO:0006955 307 0.174
Mouse
purine nucleoside monophosphate catabolic process GO:0009128 158 0.166
Yeast
purine nucleoside catabolic process GO:0006152 398 0.159
Yeast
double strand break repair via homologous recombination GO:0000724 50 0.151
protein modification by small protein conjugation GO:0032446 342 0.147
immune effector process GO:0002252 159 0.139
Mouse
immune system development GO:0002520 195 0.138
Mouse
dna recombination GO:0006310 77 0.136
Yeast Zebrafish Mouse
sex determination GO:0007530 3 0.132
regulation of dna metabolic process GO:0051052 153 0.132
Mouse
nucleoside triphosphate catabolic process GO:0009143 394 0.129
Yeast
ribonucleotide catabolic process GO:0009261 405 0.124
Yeast
leukocyte activation GO:0045321 164 0.123
Mouse
meiotic nuclear division GO:0007126 10 0.123
Yeast Zebrafish Mouse
ribonucleoside monophosphate metabolic process GO:0009161 187 0.120
Yeast
purine ribonucleoside catabolic process GO:0046130 398 0.116
Yeast
purine nucleoside triphosphate metabolic process GO:0009144 412 0.110
Yeast
nuclear division GO:0000280 128 0.110
Yeast Zebrafish Mouse
cell activation GO:0001775 213 0.108
Mouse
dna replication GO:0006260 116 0.107
glycosyl compound catabolic process GO:1901658 413 0.101
Yeast
ribonucleoside monophosphate catabolic process GO:0009158 158 0.100
Yeast
purine nucleoside monophosphate metabolic process GO:0009126 186 0.099
Yeast
multicellular organismal aging GO:0010259 3 0.097
response to organic cyclic compound GO:0014070 204 0.097
hemopoiesis GO:0030097 180 0.094
dna dependent dna replication GO:0006261 44 0.093
cell fate commitment GO:0045165 27 0.092
post embryonic development GO:0009791 2 0.091
organelle fission GO:0048285 149 0.085
Yeast Zebrafish Mouse
purine containing compound catabolic process GO:0072523 411 0.085
Yeast
leukocyte activation involved in immune response GO:0002366 30 0.084
Mouse
chromatin modification GO:0016568 298 0.083
nucleoside monophosphate catabolic process GO:0009125 159 0.080
Yeast
g2 dna damage checkpoint GO:0031572 26 0.078
carbohydrate derivative biosynthetic process GO:1901137 207 0.077
mitotic recombination GO:0006312 8 0.076
Mouse
neural nucleus development GO:0048857 47 0.075
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 5 0.074
Mouse
peptidyl lysine modification GO:0018205 144 0.071
recombinational repair GO:0000725 50 0.068
lymphocyte activation GO:0046649 133 0.067
Mouse
telomere maintenance GO:0000723 32 0.067
meiotic cell cycle process GO:1903046 8 0.065
Yeast Zebrafish Mouse
response to uv GO:0009411 73 0.063
covalent chromatin modification GO:0016569 254 0.060
nucleoside monophosphate metabolic process GO:0009123 191 0.058
Yeast
regulation of helicase activity GO:0051095 8 0.056
nucleoside phosphate catabolic process GO:1901292 412 0.056
Yeast
response to inorganic substance GO:0010035 127 0.055
nuclear transport GO:0051169 179 0.052
female gamete generation GO:0007292 2 0.051
Mouse
nucleoside catabolic process GO:0009164 408 0.049
Yeast
regulation of cytokine production GO:0001817 232 0.048
cellular macromolecule catabolic process GO:0044265 380 0.048
Mouse
nucleocytoplasmic transport GO:0006913 176 0.048
small molecule biosynthetic process GO:0044283 157 0.045
regulation of body fluid levels GO:0050878 99 0.043
intra s dna damage checkpoint GO:0031573 4 0.043
purine nucleoside triphosphate catabolic process GO:0009146 392 0.042
Yeast
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.041
Yeast
meiotic gene conversion GO:0006311 1 0.040
cytoplasmic transport GO:0016482 379 0.039
purine ribonucleotide catabolic process GO:0009154 404 0.039
Yeast
reproduction GO:0000003 63 0.039
Yeast Zebrafish Mouse Worm
histone h3 k4 methylation GO:0051568 27 0.036
protein acylation GO:0043543 138 0.035
endocytosis GO:0006897 159 0.035
development of primary male sexual characteristics GO:0046546 23 0.034
g2 m transition of mitotic cell cycle GO:0000086 41 0.034
adaptive immune response GO:0002250 49 0.033
Mouse
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.033
Yeast
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.032
Yeast
cell cycle checkpoint GO:0000075 117 0.031
determination of adult lifespan GO:0008340 2 0.029
double strand break repair GO:0006302 101 0.029
Mouse
tissue homeostasis GO:0001894 63 0.028
secretion by cell GO:0032940 226 0.028
dna replication independent nucleosome assembly GO:0006336 27 0.028
embryo development ending in birth or egg hatching GO:0009792 34 0.028
Worm
protein localization to organelle GO:0033365 280 0.027
translesion synthesis GO:0019985 8 0.027
postreplication repair GO:0006301 12 0.026
response to abiotic stimulus GO:0009628 336 0.026
histone modification GO:0016570 251 0.025
single organism carbohydrate metabolic process GO:0044723 193 0.025
single organism cellular localization GO:1902580 332 0.025
behavioral defense response GO:0002209 0 0.025
blood coagulation GO:0007596 76 0.025
intracellular mrna localization GO:0008298 1 0.025
nucleoside triphosphate metabolic process GO:0009141 422 0.025
Yeast
response to calcium ion GO:0051592 46 0.024
regulation of dna replication GO:0006275 68 0.024
protein acetylation GO:0006473 116 0.024
regulation of cell cycle phase transition GO:1901987 126 0.023
regulation of protein transport GO:0051223 213 0.023
response to steroid hormone GO:0048545 80 0.023
response to radiation GO:0009314 151 0.022
dna integrity checkpoint GO:0031570 71 0.022
carbohydrate metabolic process GO:0005975 207 0.021
regulation of protein secretion GO:0050708 86 0.021
response to light stimulus GO:0009416 87 0.020
leukocyte differentiation GO:0002521 98 0.020
negative regulation of cell cycle GO:0045786 193 0.020
regulation of protein catabolic process GO:0042176 155 0.019
double strand break repair via nonhomologous end joining GO:0006303 10 0.019
Mouse
protein polyubiquitination GO:0000209 110 0.019
protein processing GO:0016485 226 0.019
cellular response to glucocorticoid stimulus GO:0071385 4 0.019
protein maturation GO:0051604 233 0.019
protein ubiquitination GO:0016567 314 0.019
microtubule based process GO:0007017 210 0.019
Mouse
internal protein amino acid acetylation GO:0006475 101 0.018
protein oligomerization GO:0051259 173 0.018
regeneration GO:0031099 4 0.018
ribonucleoside triphosphate metabolic process GO:0009199 412 0.018
Yeast
response to caffeine GO:0031000 3 0.018
telomere maintenance via recombination GO:0000722 4 0.018
organonitrogen compound biosynthetic process GO:1901566 200 0.018
cell projection organization GO:0030030 252 0.018
regulation of peptidase activity GO:0052547 180 0.017
blastocyst development GO:0001824 3 0.017
blastoderm segmentation GO:0007350 2 0.017
microtubule cytoskeleton organization GO:0000226 176 0.017
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.017
meiotic chromosome segregation GO:0045132 4 0.017
Zebrafish Mouse
epithelial cell differentiation GO:0030855 141 0.017
regulation of dna recombination GO:0000018 23 0.016
Mouse
single organism reproductive process GO:0044702 98 0.016
Zebrafish Mouse
lipid localization GO:0010876 106 0.016
internal peptidyl lysine acetylation GO:0018393 97 0.016
response to metal ion GO:0010038 84 0.016
compound eye development GO:0048749 1 0.016
atp metabolic process GO:0046034 176 0.016
Yeast
hematopoietic or lymphoid organ development GO:0048534 186 0.016
response to biotic stimulus GO:0009607 276 0.015
regulation of secretion GO:0051046 194 0.015
amine metabolic process GO:0009308 44 0.015
positive regulation of cellular component movement GO:0051272 181 0.015
response to nutrient levels GO:0031667 81 0.015
wound healing GO:0042060 115 0.015
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.015
establishment of protein localization to organelle GO:0072594 172 0.015
response to wounding GO:0009611 168 0.015
blood circulation GO:0008015 113 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.014
Yeast
somatic cell dna recombination GO:0016444 6 0.014
Mouse
positive regulation of vesicle fusion GO:0031340 4 0.014
modification dependent protein catabolic process GO:0019941 209 0.014
b cell mediated immunity GO:0019724 10 0.014
Mouse
atp catabolic process GO:0006200 157 0.014
Yeast
secretion GO:0046903 254 0.014
metal ion homeostasis GO:0055065 169 0.014
humoral immune response GO:0006959 49 0.014
mitotic cell cycle phase transition GO:0044772 162 0.014
regulation of protein localization GO:0032880 296 0.014
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.013
multicellular organismal response to stress GO:0033555 1 0.013
purine ribonucleoside metabolic process GO:0046128 437 0.013
Yeast
glycoprotein biosynthetic process GO:0009101 91 0.013
purine nucleotide catabolic process GO:0006195 405 0.013
Yeast
cellular response to external stimulus GO:0071496 111 0.013
developmental process involved in reproduction GO:0003006 66 0.013
Mouse
reciprocal meiotic recombination GO:0007131 4 0.013
Yeast Zebrafish Mouse
meiotic cell cycle GO:0051321 13 0.012
Yeast Zebrafish Mouse
defense response GO:0006952 315 0.012
negative regulation of cell cycle phase transition GO:1901988 89 0.012
activation of cysteine type endopeptidase activity GO:0097202 57 0.012
non recombinational repair GO:0000726 14 0.012
Mouse
substantia nigra development GO:0021762 45 0.012
cytokine production GO:0001816 247 0.012
midbrain development GO:0030901 45 0.012
single organism nuclear import GO:1902593 104 0.012
anterior posterior axis specification GO:0009948 2 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
response to extracellular stimulus GO:0009991 85 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
negative regulation of protein maturation GO:1903318 142 0.012
circulatory system process GO:0003013 113 0.012
regulation of proteolysis GO:0030162 293 0.011
chemical homeostasis GO:0048878 306 0.011
regulation of viral process GO:0050792 103 0.011
negative regulation of dna recombination GO:0045910 6 0.011
Mouse
cell development GO:0048468 328 0.011
Mouse
response to hormone GO:0009725 175 0.011
macromolecule glycosylation GO:0043413 63 0.011
organophosphate biosynthetic process GO:0090407 163 0.010
head development GO:0060322 108 0.010
embryo development GO:0009790 123 0.010
Worm
generation of precursor metabolites and energy GO:0006091 68 0.010
actin mediated cell contraction GO:0070252 12 0.010
lymphocyte mediated immunity GO:0002449 48 0.010
Mouse
response to lipid GO:0033993 206 0.010
cellular protein catabolic process GO:0044257 261 0.010
cellular response to lipid GO:0071396 127 0.010
regulation of intracellular transport GO:0032386 195 0.010
peptidyl lysine acetylation GO:0018394 101 0.010
response to cytokine GO:0034097 232 0.010

MLH1 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.859
aplastic anemia DOID:12449 30 0.859
bone marrow disease DOID:4961 31 0.859
anemia DOID:2355 55 0.859
hematopoietic system disease DOID:74 100 0.859
disease of cellular proliferation DOID:14566 174 0.392
cancer DOID:162 167 0.378
organ system cancer DOID:0050686 164 0.378
congenital hypoplastic anemia DOID:1342 26 0.209
breast cancer DOID:1612 21 0.132
thoracic cancer DOID:5093 21 0.132
auditory system disease DOID:2742 53 0.049
nonsyndromic deafness DOID:0050563 50 0.049
sensory system disease DOID:0050155 203 0.049
nervous system disease DOID:863 431 0.049
disease of metabolism DOID:0014667 295 0.034
reproductive organ cancer DOID:193 23 0.029
neuropathy DOID:870 52 0.023
female reproductive organ cancer DOID:120 10 0.018
fanconi s anemia DOID:13636 16 0.014
neuromuscular disease DOID:440 38 0.013
lynch syndrome DOID:3883 3 0.000