Homo sapiens

26 known processes

PMS2

PMS2 postmeiotic segregation increased 2 (S. cerevisiae)

(Aliases: PMS2CL,HNPCC4,PMSL2)

PMS2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mismatch repair GO:0006298 15 0.856
somatic diversification of immune receptors via somatic mutation GO:0002566 1 0.770
Mouse
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.705
negative regulation of dna recombination GO:0045910 6 0.665
somatic hypermutation of immunoglobulin genes GO:0016446 1 0.651
Mouse
dna catabolic process GO:0006308 49 0.637
dna repair GO:0006281 198 0.622
meiotic chromosome separation GO:0051307 3 0.535
nucleotide excision repair GO:0006289 31 0.455
immune system development GO:0002520 195 0.408
Mouse
female gamete generation GO:0007292 2 0.377
cellular response to dna damage stimulus GO:0006974 379 0.354
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.341
lymphocyte mediated immunity GO:0002449 48 0.280
anatomical structure homeostasis GO:0060249 100 0.252
meiotic chromosome segregation GO:0045132 4 0.245
meiosis i GO:0007127 4 0.236
Yeast
leukocyte mediated immunity GO:0002443 59 0.227
regulation of dna metabolic process GO:0051052 153 0.210
determination of adult lifespan GO:0008340 2 0.203
leukocyte activation GO:0045321 164 0.186
lymphocyte activation GO:0046649 133 0.167
organelle assembly GO:0070925 176 0.162
nuclear division GO:0000280 128 0.159
Yeast
immune effector process GO:0002252 159 0.151
immune response GO:0006955 307 0.145
multicellular organismal aging GO:0010259 3 0.144
isotype switching GO:0045190 3 0.141
sex determination GO:0007530 3 0.139
adaptive immune response GO:0002250 49 0.129
cellular protein complex assembly GO:0043623 188 0.112
chromosome segregation GO:0007059 114 0.111
rna processing GO:0006396 255 0.106
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.105
dna dependent dna replication GO:0006261 44 0.099
male meiosis GO:0007140 1 0.097
apoptotic signaling pathway GO:0097190 268 0.088
organelle fission GO:0048285 149 0.088
Yeast
double strand break repair GO:0006302 101 0.087
dna recombination GO:0006310 77 0.086
Mouse
atp metabolic process GO:0046034 176 0.086
Yeast
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.086
purine nucleotide catabolic process GO:0006195 405 0.084
Yeast
cellular macromolecular complex assembly GO:0034622 324 0.083
nucleoside triphosphate catabolic process GO:0009143 394 0.080
Yeast
nuclear transcribed mrna catabolic process GO:0000956 48 0.078
post embryonic development GO:0009791 2 0.077
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.076
microtubule based process GO:0007017 210 0.076
negative regulation of dna metabolic process GO:0051053 57 0.075
dna replication GO:0006260 116 0.074
cell activation GO:0001775 213 0.073
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.069
Mouse
purine containing compound catabolic process GO:0072523 411 0.068
Yeast
production of molecular mediator of immune response GO:0002440 37 0.068
Mouse
negative regulation of apoptotic process GO:0043066 316 0.065
resolution of meiotic recombination intermediates GO:0000712 3 0.064
positive regulation of hydrolase activity GO:0051345 331 0.064
mitochondrion organization GO:0007005 156 0.063
response to abiotic stimulus GO:0009628 336 0.062
positive regulation of helicase activity GO:0051096 6 0.058
chromosome separation GO:0051304 23 0.058
ribonucleoside triphosphate catabolic process GO:0009203 391 0.058
Yeast
cellular macromolecule catabolic process GO:0044265 380 0.057
glycosyl compound catabolic process GO:1901658 413 0.056
Yeast
response to uv GO:0009411 73 0.055
intrinsic apoptotic signaling pathway GO:0097193 127 0.053
rna catabolic process GO:0006401 71 0.051
mitotic recombination GO:0006312 8 0.051
ribonucleoside catabolic process GO:0042454 406 0.049
Yeast
negative regulation of programmed cell death GO:0043069 321 0.048
purine nucleoside catabolic process GO:0006152 398 0.047
Yeast
reciprocal meiotic recombination GO:0007131 4 0.047
dna damage checkpoint GO:0000077 68 0.047
negative regulation of cell death GO:0060548 345 0.047
ribonucleotide catabolic process GO:0009261 405 0.043
Yeast
rna 3 end processing GO:0031123 35 0.042
purine nucleoside triphosphate catabolic process GO:0009146 392 0.042
Yeast
mrna catabolic process GO:0006402 56 0.042
b cell mediated immunity GO:0019724 10 0.042
somatic diversification of immunoglobulins GO:0016445 6 0.041
Mouse
actin filament based process GO:0030029 224 0.039
protein maturation GO:0051604 233 0.039
regulation of dna recombination GO:0000018 23 0.039
cell cycle phase transition GO:0044770 173 0.038
dephosphorylation GO:0016311 209 0.037
organelle localization GO:0051640 84 0.037
mrna 3 end processing GO:0031124 24 0.037
oogenesis GO:0048477 2 0.036
meiotic cell cycle process GO:1903046 8 0.036
Yeast
ribonucleoside monophosphate catabolic process GO:0009158 158 0.035
Yeast
maintenance of dna repeat elements GO:0043570 4 0.035
cell development GO:0048468 328 0.034
somatic diversification of immune receptors GO:0002200 8 0.034
Mouse
mrna metabolic process GO:0016071 175 0.034
telomere organization GO:0032200 33 0.034
nucleoside monophosphate metabolic process GO:0009123 191 0.034
Yeast
establishment of organelle localization GO:0051656 59 0.033
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.032
Yeast
nucleoside phosphate catabolic process GO:1901292 412 0.031
Yeast
reciprocal dna recombination GO:0035825 4 0.031
spindle midzone assembly GO:0051255 4 0.031
microtubule cytoskeleton organization GO:0000226 176 0.031
secretion by cell GO:0032940 226 0.031
nuclear transport GO:0051169 179 0.031
response to radiation GO:0009314 151 0.030
mrna processing GO:0006397 133 0.030
protein catabolic process GO:0030163 325 0.030
carbohydrate derivative biosynthetic process GO:1901137 207 0.030
purine ribonucleoside catabolic process GO:0046130 398 0.029
Yeast
developmental process involved in reproduction GO:0003006 66 0.028
meiotic nuclear division GO:0007126 10 0.028
Yeast
cell fate commitment GO:0045165 27 0.028
leukocyte activation involved in immune response GO:0002366 30 0.028
cellular lipid metabolic process GO:0044255 303 0.027
spermatid differentiation GO:0048515 4 0.027
negative regulation of transport GO:0051051 176 0.027
cytoplasmic transport GO:0016482 379 0.027
intracellular protein transport GO:0006886 270 0.027
nucleoside catabolic process GO:0009164 408 0.026
Yeast
nucleoside monophosphate catabolic process GO:0009125 159 0.026
Yeast
gene conversion GO:0035822 1 0.026
peptidyl lysine modification GO:0018205 144 0.026
cell division GO:0051301 168 0.025
cell cycle arrest GO:0007050 71 0.025
lipid metabolic process GO:0006629 381 0.025
cell activation involved in immune response GO:0002263 30 0.025
regulation of dna replication GO:0006275 68 0.025
response to organic cyclic compound GO:0014070 204 0.025
purine nucleoside monophosphate metabolic process GO:0009126 186 0.025
Yeast
dna double strand break processing GO:0000729 10 0.025
secretion GO:0046903 254 0.024
spermatid development GO:0007286 4 0.024
spindle assembly GO:0051225 29 0.024
regulation of protein localization GO:0032880 296 0.024
regulation of proteolysis GO:0030162 293 0.024
nitrogen compound transport GO:0071705 191 0.024
hematopoietic or lymphoid organ development GO:0048534 186 0.024
single organism reproductive process GO:0044702 98 0.024
double strand break repair via homologous recombination GO:0000724 50 0.023
regulation of protein transport GO:0051223 213 0.023
amine metabolic process GO:0009308 44 0.023
cellular component morphogenesis GO:0032989 314 0.023
spindle organization GO:0007051 53 0.023
histone modification GO:0016570 251 0.023
small molecule biosynthetic process GO:0044283 157 0.023
regulation of transferase activity GO:0051338 355 0.023
negative regulation of cellular protein metabolic process GO:0032269 353 0.023
positive regulation of cell death GO:0010942 263 0.022
regulation of protein catabolic process GO:0042176 155 0.022
ribonucleoside triphosphate metabolic process GO:0009199 412 0.022
Yeast
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.022
regulation of cell cycle process GO:0010564 266 0.022
engulfment of apoptotic cell GO:0043652 2 0.022
purine ribonucleotide catabolic process GO:0009154 404 0.021
Yeast
monocarboxylic acid metabolic process GO:0032787 185 0.021
thymocyte apoptotic process GO:0070242 2 0.021
regulation of secretion GO:0051046 194 0.021
ion transmembrane transport GO:0034220 338 0.021
cellular protein catabolic process GO:0044257 261 0.021
cellular amino acid metabolic process GO:0006520 116 0.021
positive regulation of cell proliferation GO:0008284 301 0.020
response to inorganic substance GO:0010035 127 0.020
reproductive process GO:0022414 106 0.020
protein dephosphorylation GO:0006470 81 0.020
nucleoside triphosphate metabolic process GO:0009141 422 0.020
Yeast
leukocyte differentiation GO:0002521 98 0.019
system process GO:0003008 349 0.019
regulation of intracellular transport GO:0032386 195 0.019
purine nucleoside triphosphate metabolic process GO:0009144 412 0.019
Yeast
positive regulation of transport GO:0051050 336 0.018
purine ribonucleoside metabolic process GO:0046128 437 0.018
Yeast
response to hormone GO:0009725 175 0.018
neurotransmitter secretion GO:0007269 4 0.018
regulation of cell cycle phase transition GO:1901987 126 0.018
regulation of peptidase activity GO:0052547 180 0.018
organophosphate biosynthetic process GO:0090407 163 0.018
recombinational repair GO:0000725 50 0.018
non recombinational repair GO:0000726 14 0.018
interstrand cross link repair GO:0036297 3 0.017
regulation of cytokine production GO:0001817 232 0.017
regulation of endopeptidase activity GO:0052548 170 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.017
Yeast
carbohydrate metabolic process GO:0005975 207 0.017
cellular ketone metabolic process GO:0042180 80 0.017
regulation of protein maturation GO:1903317 150 0.017
ubiquitin dependent protein catabolic process GO:0006511 206 0.017
ribonucleoside monophosphate metabolic process GO:0009161 187 0.017
Yeast
regulation of protein kinase activity GO:0045859 289 0.017
generation of precursor metabolites and energy GO:0006091 68 0.017
humoral immune response GO:0006959 49 0.017
hemopoiesis GO:0030097 180 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.016
Yeast
metaphase plate congression GO:0051310 18 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
regulation of kinase activity GO:0043549 314 0.016
actin cytoskeleton organization GO:0030036 207 0.016
extrinsic apoptotic signaling pathway GO:0097191 119 0.016
lipid biosynthetic process GO:0008610 177 0.016
internal peptidyl lysine acetylation GO:0018393 97 0.016
protein localization to nucleus GO:0034504 136 0.016
negative regulation of cell proliferation GO:0008285 228 0.016
positive regulation of endopeptidase activity GO:0010950 84 0.016
negative regulation of catalytic activity GO:0043086 335 0.016
locomotory behavior GO:0007626 1 0.016
lymphocyte activation involved in immune response GO:0002285 20 0.016
immunoglobulin mediated immune response GO:0016064 10 0.016
modification dependent macromolecule catabolic process GO:0043632 212 0.015
memory GO:0007613 3 0.015
negative regulation of cell cycle GO:0045786 193 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.015
Yeast
positive regulation of catabolic process GO:0009896 310 0.015
cell projection assembly GO:0030031 126 0.015
cellular amine metabolic process GO:0044106 41 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.015
b cell activation GO:0042113 33 0.015
dna catabolic process endonucleolytic GO:0000737 37 0.015
reproduction GO:0000003 63 0.015
Yeast
response to cytokine GO:0034097 232 0.015
proteasomal protein catabolic process GO:0010498 176 0.015
negative regulation of protein modification process GO:0031400 200 0.015
covalent chromatin modification GO:0016569 254 0.015
protein acetylation GO:0006473 116 0.015
oocyte differentiation GO:0009994 2 0.015
protein processing GO:0016485 226 0.015
embryo development GO:0009790 123 0.014
Worm
fatty acid metabolic process GO:0006631 115 0.014
regulation of cellular amino acid metabolic process GO:0006521 6 0.014
nucleotide catabolic process GO:0009166 408 0.014
Yeast
neuromuscular junction development GO:0007528 3 0.014
membrane organization GO:0061024 292 0.014
regulation of gene expression epigenetic GO:0040029 73 0.014
multicellular organism reproduction GO:0032504 42 0.014
cell cell signaling GO:0007267 155 0.014
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 14 0.014
regulation of secretion by cell GO:1903530 177 0.014
central nervous system development GO:0007417 123 0.014
mitotic cell cycle phase transition GO:0044772 162 0.014
dna integrity checkpoint GO:0031570 71 0.013
nucleocytoplasmic transport GO:0006913 176 0.013
mitochondrial respiratory chain complex assembly GO:0033108 23 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
regulation of cellular component movement GO:0051270 334 0.013
protein localization to organelle GO:0033365 280 0.013
telomere maintenance GO:0000723 32 0.013
protein ubiquitination GO:0016567 314 0.013
modification dependent protein catabolic process GO:0019941 209 0.013
mitotic cell cycle GO:0000278 326 0.013
g2 dna damage checkpoint GO:0031572 26 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
positive regulation of kinase activity GO:0033674 204 0.013
muscle system process GO:0003012 81 0.013
internal protein amino acid acetylation GO:0006475 101 0.013
negative regulation of mitotic cell cycle GO:0045930 102 0.013
protein acylation GO:0043543 138 0.013
double strand break repair via nonhomologous end joining GO:0006303 10 0.013
double strand break repair via single strand annealing GO:0045002 4 0.012
cellular component disassembly involved in execution phase of apoptosis GO:0006921 13 0.012
response to bacterium GO:0009617 144 0.012
somatic cell dna recombination GO:0016444 6 0.012
Mouse
nervous system development GO:0007399 293 0.012
rho protein signal transduction GO:0007266 26 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
positive regulation of cellular amine metabolic process GO:0033240 7 0.012
oocyte development GO:0048599 1 0.012
cell morphogenesis GO:0000902 296 0.012
sexual reproduction GO:0019953 37 0.012
negative regulation of protein processing GO:0010955 142 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.012
regulation of establishment of protein localization GO:0070201 242 0.012
adult locomotory behavior GO:0008344 1 0.012
regulation of cellular ketone metabolic process GO:0010565 50 0.012
activation of cysteine type endopeptidase activity GO:0097202 57 0.012
regulation of cellular amine metabolic process GO:0033238 11 0.012
stem cell division GO:0017145 2 0.012
protein targeting GO:0006605 187 0.012
positive regulation of immune system process GO:0002684 283 0.012
myosin filament assembly GO:0031034 2 0.012
regulation of vesicle mediated transport GO:0060627 130 0.012
glycerophospholipid metabolic process GO:0006650 84 0.011
actin filament organization GO:0007015 128 0.011
endosomal transport GO:0016197 129 0.011
negative regulation of secretion GO:0051048 58 0.011
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 5 0.011
nerve development GO:0021675 4 0.011
cell type specific apoptotic process GO:0097285 125 0.011
cellular response to endogenous stimulus GO:0071495 336 0.011
peripheral nervous system development GO:0007422 2 0.011
organophosphate catabolic process GO:0046434 430 0.011
Yeast
multicellular organismal reproductive process GO:0048609 40 0.011
negative regulation of protein maturation GO:1903318 142 0.011
purine nucleoside monophosphate catabolic process GO:0009128 158 0.011
Yeast
glycerolipid metabolic process GO:0046486 107 0.011
negative regulation of protein metabolic process GO:0051248 391 0.011
immunoglobulin production GO:0002377 12 0.011
Mouse
b cell activation involved in immune response GO:0002312 5 0.011
peptidyl tyrosine dephosphorylation GO:0035335 36 0.011
chemical homeostasis GO:0048878 306 0.011
monocarboxylic acid biosynthetic process GO:0072330 67 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
cell projection organization GO:0030030 252 0.011
regulation of protein secretion GO:0050708 86 0.011
negative regulation of phosphate metabolic process GO:0045936 267 0.011
regeneration GO:0031099 4 0.011
protein modification by small protein conjugation GO:0032446 342 0.010
nuclear export GO:0051168 69 0.010
segmentation GO:0035282 4 0.010
phospholipid metabolic process GO:0006644 99 0.010
regulation of lymphocyte activation GO:0051249 103 0.010
regulation of mitotic cell cycle GO:0007346 189 0.010
negative regulation of hydrolase activity GO:0051346 182 0.010
organonitrogen compound biosynthetic process GO:1901566 200 0.010
regulation of cellular protein catabolic process GO:1903362 96 0.010
neurogenesis GO:0022008 169 0.010
skin development GO:0043588 76 0.010
regulation of nucleotide metabolic process GO:0006140 269 0.010
positive regulation of gtpase activity GO:0043547 166 0.010
response to tumor necrosis factor GO:0034612 76 0.010
protein import into nucleus GO:0006606 104 0.010
response to lipid GO:0033993 206 0.010
neuron death GO:0070997 65 0.010
single organism carbohydrate metabolic process GO:0044723 193 0.010
muscle contraction GO:0006936 73 0.010
gtp metabolic process GO:0046039 239 0.010

PMS2 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.745
anemia DOID:2355 55 0.745
hematopoietic system disease DOID:74 100 0.745
disease of cellular proliferation DOID:14566 174 0.369
cancer DOID:162 167 0.316
organ system cancer DOID:0050686 164 0.212
congenital hypoplastic anemia DOID:1342 26 0.065
aplastic anemia DOID:12449 30 0.065
bone marrow disease DOID:4961 31 0.065
disease of metabolism DOID:0014667 295 0.054
reproductive organ cancer DOID:193 23 0.048
breast cancer DOID:1612 21 0.029
thoracic cancer DOID:5093 21 0.029
nervous system disease DOID:863 431 0.027
neuropathy DOID:870 52 0.027
neuromuscular disease DOID:440 38 0.026
heart disease DOID:114 68 0.019
cardiovascular system disease DOID:1287 106 0.019
sensory system disease DOID:0050155 203 0.018
fanconi s anemia DOID:13636 16 0.015
musculoskeletal system disease DOID:17 223 0.015
central nervous system disease DOID:331 186 0.013
muscular disease DOID:0080000 114 0.013
epilepsy syndrome DOID:1826 41 0.012
brain disease DOID:936 73 0.012
muscle tissue disease DOID:66 113 0.011