|
|
response to nitrosative stress
|
GO:0051409 |
4 |
1.000
|
|
|
|
jun phosphorylation
|
GO:0007258 |
28 |
1.000
|
Fly |
|
|
transposition rna mediated
|
GO:0032197 |
0 |
1.000
|
Yeast |
|
|
inactivation of mapk activity
|
GO:0000188 |
5 |
1.000
|
|
|
|
negative regulation of erk1 and erk2 cascade
|
GO:0070373 |
14 |
1.000
|
|
|
|
peptidyl tyrosine dephosphorylation
|
GO:0035335 |
36 |
1.000
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
1.000
|
Human Fly |
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
1.000
|
Worm Fly |
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
1.000
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
1.000
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
1.000
|
|
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
1.000
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
1.000
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
1.000
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
1.000
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
1.000
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.999
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.999
|
Yeast |
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.999
|
Fly |
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.999
|
Worm Fly |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.999
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.999
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.999
|
Yeast |
|
|
mapk import into nucleus
|
GO:0000189 |
1 |
0.998
|
Rat |
|
|
arachidonic acid metabolic process
|
GO:0019369 |
14 |
0.998
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.998
|
Yeast |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.997
|
Human Yeast Fly |
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.997
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.996
|
Fly |
|
|
negative regulation of small gtpase mediated signal transduction
|
GO:0051058 |
12 |
0.995
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.995
|
Worm |
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.994
|
Mouse |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.994
|
|
|
|
negative regulation of transposition
|
GO:0010529 |
7 |
0.994
|
Yeast |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.993
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.992
|
Yeast |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.992
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.991
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.991
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.990
|
Rat |
|
|
chordate embryonic development
|
GO:0043009 |
34 |
0.989
|
Mouse |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.989
|
Worm Fly |
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.988
|
|
|
|
hyperosmotic response
|
GO:0006972 |
4 |
0.987
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.986
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.986
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.984
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.983
|
Yeast Rat |
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.979
|
Fly |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.979
|
Yeast |
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.978
|
Yeast |
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.976
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.974
|
Human |
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.971
|
|
|
|
tor signaling
|
GO:0031929 |
39 |
0.970
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.970
|
Rat |
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.969
|
Fly |
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.969
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
2 |
0.967
|
Fly |
|
|
negative regulation of ras protein signal transduction
|
GO:0046580 |
11 |
0.961
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.961
|
Rat |
|
|
cartilage condensation
|
GO:0001502 |
1 |
0.961
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.952
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.951
|
Mouse |
|
|
behavioral response to ethanol
|
GO:0048149 |
2 |
0.951
|
Fly |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.950
|
|
|
|
histone phosphorylation
|
GO:0016572 |
16 |
0.949
|
Human |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.949
|
|
|
|
macroautophagy
|
GO:0016236 |
39 |
0.947
|
Fly |
|
|
long chain fatty acid metabolic process
|
GO:0001676 |
30 |
0.946
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.944
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.942
|
|
|
|
cell junction maintenance
|
GO:0034331 |
4 |
0.941
|
Fly |
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.938
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.938
|
Yeast |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.936
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.934
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.933
|
Yeast Worm |
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.928
|
Yeast Worm |
|
|
p38mapk cascade
|
GO:0038066 |
9 |
0.924
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.924
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.924
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.921
|
Fly |
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.921
|
|
|
|
negative regulation of macroautophagy
|
GO:0016242 |
4 |
0.911
|
Fly |
|
|
peptidyl lysine acetylation
|
GO:0018394 |
101 |
0.910
|
Human |
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.903
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.901
|
Worm |
|
|
oocyte development
|
GO:0048599 |
1 |
0.900
|
Worm |
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.898
|
Worm |
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.895
|
|
|
|
positive regulation of histone phosphorylation
|
GO:0033129 |
3 |
0.891
|
Human |
|
|
female gamete generation
|
GO:0007292 |
2 |
0.889
|
Worm |
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.886
|
Fly |
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.886
|
Human Fly |
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.884
|
Rat |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.880
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.880
|
Human Mouse |
|
|
interleukin 1 mediated signaling pathway
|
GO:0070498 |
12 |
0.874
|
Human |
|
|
histone h2a s1 phosphorylation
|
GO:0043990 |
1 |
0.869
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.867
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.864
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.863
|
Yeast Rat |
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.857
|
Human |
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.855
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.851
|
Fly |
|
|
organelle inheritance
|
GO:0048308 |
2 |
0.851
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.838
|
Worm Fly |
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.837
|
Yeast |
|
|
regulation of histone phosphorylation
|
GO:0033127 |
5 |
0.827
|
Human |
|
|
regulation of transposition
|
GO:0010528 |
7 |
0.827
|
Yeast |
|
|
immune response
|
GO:0006955 |
307 |
0.818
|
Mouse |
|
|
response to lipid
|
GO:0033993 |
206 |
0.816
|
Mouse Rat |
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.808
|
Yeast |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.805
|
Human Mouse |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.804
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.798
|
|
|
|
system process
|
GO:0003008 |
349 |
0.793
|
Rat |
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.789
|
Human |
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.786
|
Fly |
|
|
muscle system process
|
GO:0003012 |
81 |
0.780
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.775
|
Mouse |
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
44 |
0.774
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.772
|
|
|
|
response to salt stress
|
GO:0009651 |
3 |
0.772
|
|
|
|
negative regulation of cell migration
|
GO:0030336 |
102 |
0.771
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.770
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.770
|
Yeast Rat |
|
|
cellular response to metal ion
|
GO:0071248 |
43 |
0.762
|
Fly |
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.756
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.749
|
Fly |
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.747
|
Worm |
|
|
cell activation
|
GO:0001775 |
213 |
0.740
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.735
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.734
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.725
|
|
|
|
histone serine phosphorylation
|
GO:0035404 |
4 |
0.719
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.719
|
Human Fly |
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.717
|
Fly |
|
|
activation of immune response
|
GO:0002253 |
114 |
0.714
|
Mouse |
|
|
protein import
|
GO:0017038 |
130 |
0.709
|
Rat |
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.706
|
Worm |
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.706
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.702
|
Fly |
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.702
|
Human |
|
|
mucosal immune response
|
GO:0002385 |
21 |
0.701
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.700
|
Fly |
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.692
|
Mouse |
|
|
protein targeting
|
GO:0006605 |
187 |
0.687
|
Rat |
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.687
|
Mouse |
|
|
defense response
|
GO:0006952 |
315 |
0.685
|
|
|
|
cell aggregation
|
GO:0098743 |
1 |
0.679
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
115 |
0.674
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.668
|
Human |
|
|
jnk cascade
|
GO:0007254 |
80 |
0.660
|
Fly |
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.660
|
Human |
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.659
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.655
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.654
|
Yeast Rat |
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.649
|
|
|
|
paracrine signaling
|
GO:0038001 |
1 |
0.645
|
|
|
|
growth
|
GO:0040007 |
202 |
0.642
|
Yeast |
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.638
|
Worm |
|
|
innate immune response
|
GO:0045087 |
178 |
0.638
|
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.637
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.636
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.636
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.627
|
Fly |
|
|
regulation of chromatin organization
|
GO:1902275 |
56 |
0.624
|
Human |
|
|
regulation of peptidyl lysine acetylation
|
GO:2000756 |
22 |
0.617
|
Human |
|
|
chromatin modification
|
GO:0016568 |
298 |
0.611
|
Human |
|
|
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902042 |
15 |
0.609
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.608
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.606
|
|
|
|
skeletal system development
|
GO:0001501 |
79 |
0.599
|
|
|
|
cellular response to interleukin 1
|
GO:0071347 |
35 |
0.598
|
Human |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.597
|
|
|
|
negative regulation of stress activated protein kinase signaling cascade
|
GO:0070303 |
19 |
0.597
|
|
|
|
regulation of protein export from nucleus
|
GO:0046825 |
15 |
0.594
|
Yeast |
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.593
|
Yeast |
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.592
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.584
|
Yeast |
|
|
regulation of protein acetylation
|
GO:1901983 |
25 |
0.583
|
Human |
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.582
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.578
|
Zebrafish |
|
|
response to toxic substance
|
GO:0009636 |
37 |
0.576
|
Rat |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.575
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.574
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.573
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.572
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.572
|
|
|
|
dna damage induced protein phosphorylation
|
GO:0006975 |
5 |
0.571
|
Human |
|
|
positive regulation of wound healing
|
GO:0090303 |
20 |
0.568
|
Fly |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.568
|
Human Mouse Fly |
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.568
|
Fly |
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
26 |
0.564
|
Mouse |
|
|
mitotic nuclear division
|
GO:0007067 |
119 |
0.562
|
Fly |
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.561
|
Rat |
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.561
|
Worm |
|
|
negative regulation of jnk cascade
|
GO:0046329 |
16 |
0.559
|
|
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.558
|
Human |
|
|
cellular senescence
|
GO:0090398 |
34 |
0.554
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
48 |
0.549
|
|
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.546
|
Fly |
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.546
|
Yeast |
|
|
histone modification
|
GO:0016570 |
251 |
0.536
|
Human |
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.533
|
Fly |
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.516
|
Mouse |
|
|
blood vessel development
|
GO:0001568 |
172 |
0.513
|
Mouse |
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.512
|
Fly |
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.511
|
Yeast |
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
0.511
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.506
|
Fly |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.503
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.501
|
Human |
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.498
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.496
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.496
|
|
|
|
embryo development ending in birth or egg hatching
|
GO:0009792 |
34 |
0.494
|
Mouse Worm |
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.492
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.492
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.487
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.487
|
|
|
|
tripartite regional subdivision
|
GO:0007351 |
2 |
0.486
|
|
|
|
regulation of muscle system process
|
GO:0090257 |
53 |
0.480
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.471
|
Rat |
|
|
icosanoid metabolic process
|
GO:0006690 |
35 |
0.468
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.462
|
Mouse |
|
|
peroxisome degradation
|
GO:0030242 |
1 |
0.462
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.456
|
Yeast |
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.455
|
|
|
|
response to osmotic stress
|
GO:0006970 |
17 |
0.454
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.451
|
Rat |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.448
|
|
|
|
mrna stabilization
|
GO:0048255 |
18 |
0.444
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.443
|
Yeast |
|
|
regeneration
|
GO:0031099 |
4 |
0.443
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.442
|
|
|
|
fatty acid derivative metabolic process
|
GO:1901568 |
35 |
0.439
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.437
|
Yeast |
|
|
regulation of response to osmotic stress
|
GO:0047484 |
3 |
0.436
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.435
|
Human |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.434
|
|
|
|
mapk export from nucleus
|
GO:0045204 |
1 |
0.426
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.414
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.413
|
|
|
|
regulation of protein localization to plasma membrane
|
GO:1903076 |
40 |
0.413
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.412
|
Mouse |
|
|
cell adhesion
|
GO:0007155 |
325 |
0.410
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.410
|
Mouse Fly |
|
|
placenta development
|
GO:0001890 |
10 |
0.409
|
Mouse |
|
|
sensory perception of pain
|
GO:0019233 |
4 |
0.408
|
Rat |
|
|
associative learning
|
GO:0008306 |
1 |
0.407
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.407
|
Fly |
|
|
translational initiation
|
GO:0006413 |
48 |
0.406
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.406
|
|
|
|
cytoskeleton dependent intracellular transport
|
GO:0030705 |
21 |
0.404
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.389
|
Rat |
|
|
regulation of chromosome organization
|
GO:0033044 |
103 |
0.388
|
Human |
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.385
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.382
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.381
|
|
|
|
positive regulation of chromatin modification
|
GO:1903310 |
30 |
0.380
|
Human |
|
|
unsaturated fatty acid metabolic process
|
GO:0033559 |
37 |
0.380
|
|
|
|
skeletal muscle tissue regeneration
|
GO:0043403 |
2 |
0.379
|
|
|
|
positive regulation of neurogenesis
|
GO:0050769 |
49 |
0.378
|
Fly |
|
|
response to bacterium
|
GO:0009617 |
144 |
0.376
|
Mouse |
|
|
regulation of killing of cells of other organism
|
GO:0051709 |
4 |
0.376
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.375
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.373
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.372
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.370
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
11 |
0.370
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.370
|
|
|
|
positive regulation of meiotic cell cycle
|
GO:0051446 |
2 |
0.365
|
Worm |
|
|
embryo development
|
GO:0009790 |
123 |
0.365
|
Zebrafish Mouse Worm |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.363
|
Fly |
|
|
negative regulation of stress activated mapk cascade
|
GO:0032873 |
19 |
0.361
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.357
|
Mouse |
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.353
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
40 |
0.352
|
Fly |
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.347
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.346
|
Mouse |
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.344
|
Human Fly |
|
|
behavior
|
GO:0007610 |
112 |
0.342
|
Fly |
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.340
|
Fly |
|
|
response to other organism
|
GO:0051707 |
261 |
0.338
|
Mouse |
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.335
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.335
|
Rat |
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.333
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.332
|
|
|
|
internal peptidyl lysine acetylation
|
GO:0018393 |
97 |
0.330
|
Human |
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.330
|
Fly |
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.329
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.326
|
Rat |
|
|
positive regulation of protein export from nucleus
|
GO:0046827 |
6 |
0.324
|
Yeast |
|
|
regulation of translation
|
GO:0006417 |
89 |
0.317
|
Rat |
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.316
|
Human Yeast |
|
|
cell cell junction organization
|
GO:0045216 |
69 |
0.316
|
Fly |
|
|
cellular response to reactive oxygen species
|
GO:0034614 |
50 |
0.311
|
Fly |
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.310
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.308
|
Mouse Worm |
|
|
autophagy
|
GO:0006914 |
88 |
0.308
|
Fly |
|
|
circulatory system development
|
GO:0072359 |
262 |
0.308
|
Mouse |
|
|
negative regulation of t cell receptor signaling pathway
|
GO:0050860 |
4 |
0.307
|
|
|
|
response to axon injury
|
GO:0048678 |
1 |
0.303
|
|
|
|
regulation of hepatic stellate cell activation
|
GO:2000489 |
1 |
0.300
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.297
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.291
|
Mouse |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.291
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
48 |
0.290
|
|
|
|
embryonic placenta development
|
GO:0001892 |
1 |
0.289
|
Mouse |
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.288
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.284
|
Fly |
|
|
wound healing
|
GO:0042060 |
115 |
0.282
|
Fly |
|
|
t cell receptor signaling pathway
|
GO:0050852 |
21 |
0.279
|
Mouse |
|
|
regulation of response to drug
|
GO:2001023 |
3 |
0.279
|
Fly |
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
72 |
0.277
|
|
|
|
central nervous system neuron axonogenesis
|
GO:0021955 |
3 |
0.276
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.271
|
Rat |
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.270
|
|
|
|
regulation of protein polymerization
|
GO:0032271 |
63 |
0.269
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.269
|
Mouse Fly |
|
|
cell aging
|
GO:0007569 |
52 |
0.269
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.267
|
Fly |
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.264
|
Human |
|
|
translation
|
GO:0006412 |
132 |
0.264
|
Rat |
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.262
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.259
|
Fly |
|
|
regulation of antigen receptor mediated signaling pathway
|
GO:0050854 |
10 |
0.258
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.257
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.257
|
|
|
|
cellular response to inorganic substance
|
GO:0071241 |
45 |
0.253
|
Fly |
|
|
regulation of wound healing
|
GO:0061041 |
56 |
0.246
|
Fly |
|
|
microtubule based process
|
GO:0007017 |
210 |
0.244
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.243
|
Fly |
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.241
|
|
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.237
|
Fly |
|
|
carbohydrate transport
|
GO:0008643 |
37 |
0.236
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.235
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.235
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.234
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.228
|
|
|
|
positive regulation of nucleocytoplasmic transport
|
GO:0046824 |
54 |
0.227
|
Yeast |
|
|
tissue regeneration
|
GO:0042246 |
3 |
0.227
|
|
|
|
regulation of histone acetylation
|
GO:0035065 |
19 |
0.224
|
Human |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.224
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.218
|
Rat |
|
|
negative regulation of cellular component movement
|
GO:0051271 |
106 |
0.216
|
|
|
|
cartilage development
|
GO:0051216 |
31 |
0.216
|
|
|
|
regulation of syncytium formation by plasma membrane fusion
|
GO:0060142 |
2 |
0.214
|
|
|
|
regulation of meiotic cell cycle
|
GO:0051445 |
4 |
0.210
|
Worm |
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.209
|
|
|
|
pattern specification process
|
GO:0007389 |
43 |
0.208
|
Fly |
|
|
response to temperature stimulus
|
GO:0009266 |
22 |
0.203
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.202
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
35 |
0.200
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.199
|
|
|
|
negative regulation of response to extracellular stimulus
|
GO:0032105 |
5 |
0.199
|
Fly |
|
|
response to insulin
|
GO:0032868 |
45 |
0.198
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.198
|
|
|
|
foam cell differentiation
|
GO:0090077 |
15 |
0.197
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.196
|
|
|
|
microtubule based movement
|
GO:0007018 |
32 |
0.196
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.195
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.193
|
|
|
|
sensory perception
|
GO:0007600 |
103 |
0.192
|
Rat |
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.191
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.187
|
Worm |
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.185
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.181
|
|
|
|
pigmentation
|
GO:0043473 |
22 |
0.180
|
|
|
|
cellular response to starvation
|
GO:0009267 |
58 |
0.178
|
Fly |
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.178
|
|
|
|
positive regulation of small gtpase mediated signal transduction
|
GO:0051057 |
12 |
0.177
|
Fly |
|
|
circadian behavior
|
GO:0048512 |
2 |
0.176
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.175
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.172
|
|
|
|
positive regulation of growth
|
GO:0045927 |
58 |
0.170
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.169
|
Mouse Worm |
|
|
centrosome separation
|
GO:0051299 |
3 |
0.169
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.169
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.169
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.168
|
Fly |
|
|
positive regulation of organic acid transport
|
GO:0032892 |
3 |
0.168
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.168
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.167
|
Mouse |
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.165
|
Yeast |
|
|
negative regulation of binding
|
GO:0051100 |
57 |
0.160
|
|
|
|
cellular hyperosmotic response
|
GO:0071474 |
4 |
0.159
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.157
|
|
|
|
response to cadmium ion
|
GO:0046686 |
10 |
0.157
|
Fly |
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.156
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.154
|
Fly |
|
|
negative regulation of cell adhesion
|
GO:0007162 |
64 |
0.154
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.152
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.152
|
|
|
|
actin filament capping
|
GO:0051693 |
4 |
0.150
|
|
|
|
positive regulation of histone acetylation
|
GO:0035066 |
11 |
0.150
|
Human |
|
|
peptidyl serine autophosphorylation
|
GO:0036289 |
2 |
0.148
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.148
|
|
|
|
defense response to fungus
|
GO:0050832 |
4 |
0.148
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.147
|
Human |
|
|
circulatory system process
|
GO:0003013 |
113 |
0.147
|
|
|
|
aging
|
GO:0007568 |
66 |
0.146
|
Worm |
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.146
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
42 |
0.146
|
|
|
|
regulation of cell killing
|
GO:0031341 |
22 |
0.145
|
|
|
|
positive regulation of multi organism process
|
GO:0043902 |
56 |
0.145
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.145
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.144
|
Rat |
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.141
|
|
|
|
histone acetylation
|
GO:0016573 |
93 |
0.138
|
Human |
|
|
protein acetylation
|
GO:0006473 |
116 |
0.138
|
Human |
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.137
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.135
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.135
|
|
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.134
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.134
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.134
|
|
|
|
positive regulation of chromosome organization
|
GO:2001252 |
41 |
0.132
|
Human |
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.132
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.131
|
Fly |
|
|
negative regulation of protein polymerization
|
GO:0032272 |
16 |
0.130
|
|
|
|
actin polymerization or depolymerization
|
GO:0008154 |
56 |
0.130
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.130
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.129
|
Human |
|
|
nuclear export
|
GO:0051168 |
69 |
0.129
|
Yeast |
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.128
|
|
|
|
reproduction
|
GO:0000003 |
63 |
0.127
|
Yeast Worm |
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.126
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.122
|
Fly |
|
|
protein acylation
|
GO:0043543 |
138 |
0.121
|
Human |
|
|
negative regulation of intracellular transport
|
GO:0032387 |
60 |
0.120
|
|
|
|
striated muscle tissue development
|
GO:0014706 |
59 |
0.119
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.118
|
|
|
|
regulation of developmental pigmentation
|
GO:0048070 |
2 |
0.116
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.115
|
Yeast |
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.115
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.115
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.112
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.111
|
|
|
|
dna damage response signal transduction resulting in transcription
|
GO:0042772 |
12 |
0.111
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.111
|
|
|
|
negative regulation of protein complex assembly
|
GO:0031333 |
43 |
0.109
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.109
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.108
|
Worm |
|
|
nuclear import
|
GO:0051170 |
106 |
0.107
|
Rat |
|
|
positive regulation of mitotic cell cycle
|
GO:0045931 |
60 |
0.107
|
|
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.107
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.106
|
Fly |
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.104
|
Rat |
|
|
neuron development
|
GO:0048666 |
113 |
0.103
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
78 |
0.102
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.101
|
|
|
|
regulation of macroautophagy
|
GO:0016241 |
19 |
0.100
|
Fly |
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.100
|
Mouse Rat |
|
|
negative regulation of autophagy
|
GO:0010507 |
14 |
0.099
|
Fly |
|
|
cell development
|
GO:0048468 |
328 |
0.099
|
Worm Fly |
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.098
|
|
|
|
regulation of glucose import
|
GO:0046324 |
21 |
0.098
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.097
|
|
|
|
negative regulation of homotypic cell cell adhesion
|
GO:0034111 |
3 |
0.096
|
|
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.095
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.094
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.094
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.093
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.093
|
Mouse |
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.093
|
|
|
|
central nervous system neuron development
|
GO:0021954 |
7 |
0.092
|
|
|
|
histone h2a phosphorylation
|
GO:1990164 |
3 |
0.092
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.092
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.091
|
Mouse |
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.091
|
|
|
|
microtubule based transport
|
GO:0010970 |
21 |
0.090
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.090
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.089
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.089
|
|
|
|
cellular response to osmotic stress
|
GO:0071470 |
8 |
0.089
|
|
|
|
regulation of protein dephosphorylation
|
GO:0035304 |
18 |
0.089
|
|
|
|
regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902041 |
24 |
0.088
|
|
|
|
axon development
|
GO:0061564 |
34 |
0.088
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.088
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.087
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.086
|
Fly |
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.086
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.085
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.085
|
|
|
|
protein localization to plasma membrane
|
GO:0072659 |
93 |
0.084
|
|
