Homo sapiens

49 known processes

PXN

paxillin

(Aliases: FLJ16691)

PXN biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell matrix adhesion involved in ameboidal cell migration GO:0003366 2 0.996
cell adhesion GO:0007155 325 0.977
Human Mouse
regulation of lipoprotein metabolic process GO:0050746 7 0.971
regulation of wnt signaling pathway GO:0030111 123 0.965
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.954
cellular response to growth factor stimulus GO:0071363 197 0.954
ameboidal type cell migration GO:0001667 135 0.953
biological adhesion GO:0022610 331 0.945
Human Mouse
cell matrix adhesion GO:0007160 85 0.943
Human Mouse
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.939
Human
cellular response to endogenous stimulus GO:0071495 336 0.927
digestive tract development GO:0048565 75 0.927
cell projection organization GO:0030030 252 0.927
Mouse
regulation of protein localization to plasma membrane GO:1903076 40 0.926
formation of primary germ layer GO:0001704 42 0.924
regulation of cellular ketone metabolic process GO:0010565 50 0.916
heterotypic cell cell adhesion GO:0034113 28 0.916
cell junction organization GO:0034330 79 0.900
Human Mouse
digestive tract morphogenesis GO:0048546 56 0.896
negative regulation of low density lipoprotein particle receptor biosynthetic process GO:0045715 3 0.894
ectoderm development GO:0007398 3 0.892
positive regulation of cell adhesion GO:0045785 84 0.892
Human
rho protein signal transduction GO:0007266 26 0.885
muscle structure development GO:0061061 98 0.877
Worm Fly
muscle contraction GO:0006936 73 0.876
single organismal cell cell adhesion GO:0016337 148 0.864
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.862
wnt signaling pathway GO:0016055 156 0.855
protein catabolic process GO:0030163 325 0.843
Human
embryonic viscerocranium morphogenesis GO:0048703 1 0.840
positive regulation of axon extension GO:0045773 4 0.837
substrate adhesion dependent cell spreading GO:0034446 41 0.828
Human Mouse
morphogenesis of an epithelium GO:0002009 60 0.827
Mouse
female gamete generation GO:0007292 2 0.825
Fly
post embryonic development GO:0009791 2 0.822
Worm
response to transforming growth factor beta GO:0071559 94 0.819
positive regulation of cell substrate adhesion GO:0010811 37 0.817
Human
single organism cell adhesion GO:0098602 179 0.815
Human Mouse
gastrulation GO:0007369 51 0.810
cell activation GO:0001775 213 0.802
integrin mediated signaling pathway GO:0007229 32 0.801
Mouse
digestive system development GO:0055123 75 0.788
cell migration involved in gastrulation GO:0042074 1 0.784
calcium ion transmembrane transport GO:0070588 76 0.783
urogenital system development GO:0001655 65 0.779
circulatory system development GO:0072359 262 0.762
tube development GO:0035295 125 0.743
Mouse
somatic muscle development GO:0007525 1 0.735
regulation of phagocytosis engulfment GO:0060099 2 0.733
skin development GO:0043588 76 0.728
cell substrate adhesion GO:0031589 132 0.726
Human Mouse
cellular amine metabolic process GO:0044106 41 0.716
protein localization to membrane GO:0072657 160 0.708
leukocyte cell cell adhesion GO:0007159 37 0.705
odontogenesis GO:0042476 25 0.700
regulation of cell adhesion GO:0030155 166 0.689
Human
sensory perception of chemical stimulus GO:0007606 38 0.685
mesodermal cell differentiation GO:0048333 10 0.678
negative regulation of transport GO:0051051 176 0.673
negative regulation of locomotion GO:0040013 118 0.652
enzyme linked receptor protein signaling pathway GO:0007167 303 0.647
regulation of smooth muscle cell migration GO:0014910 15 0.642
cellular ketone metabolic process GO:0042180 80 0.639
integrin activation GO:0033622 8 0.623
cellular extravasation GO:0045123 21 0.621
cilium morphogenesis GO:0060271 75 0.620
cell cell junction organization GO:0045216 69 0.619
Human Mouse
response to growth factor GO:0070848 205 0.609
metal ion transport GO:0030001 272 0.608
plasma membrane organization GO:0007009 115 0.603
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.593
regulation of arf protein signal transduction GO:0032012 1 0.584
cell junction assembly GO:0034329 67 0.582
Human Mouse
endoderm formation GO:0001706 33 0.575
organelle assembly GO:0070925 176 0.565
entry into cell of other organism involved in symbiotic interaction GO:0051806 25 0.563
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.563
ras protein signal transduction GO:0007265 73 0.559
cellular component assembly involved in morphogenesis GO:0010927 73 0.553
Fly
salivary gland morphogenesis GO:0007435 4 0.541
cell chemotaxis GO:0060326 112 0.539
regulation of cellular component biogenesis GO:0044087 281 0.528
Human
vasodilation GO:0042311 4 0.525
regulation of protein catabolic process GO:0042176 155 0.520
muscle cell migration GO:0014812 19 0.516
lens morphogenesis in camera type eye GO:0002089 2 0.514
positive regulation of cellular component organization GO:0051130 376 0.511
Human
negative regulation of apoptotic process GO:0043066 316 0.506
endodermal cell differentiation GO:0035987 31 0.504
leukocyte migration GO:0050900 107 0.501
blood vessel development GO:0001568 172 0.498
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.497
actin filament based process GO:0030029 224 0.496
endomembrane system organization GO:0010256 196 0.493
negative regulation of cell migration GO:0030336 102 0.487
anatomical structure formation involved in morphogenesis GO:0048646 284 0.486
Fly
inorganic ion transmembrane transport GO:0098660 231 0.471
establishment of protein localization to plasma membrane GO:0090002 68 0.460
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.456
tube morphogenesis GO:0035239 95 0.454
Mouse
entry into host GO:0044409 25 0.448
regulation of neuron differentiation GO:0045664 70 0.448
single organism cellular localization GO:1902580 332 0.446
embryonic morphogenesis GO:0048598 85 0.444
glycosyl compound catabolic process GO:1901658 413 0.438
Human Fly
dephosphorylation GO:0016311 209 0.437
negative regulation of cell death GO:0060548 345 0.433
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.433
striated muscle cell differentiation GO:0051146 43 0.427
Fly
response to wounding GO:0009611 168 0.422
movement in environment of other organism involved in symbiotic interaction GO:0052192 25 0.421
negative regulation of anoikis GO:2000811 15 0.419
actin filament organization GO:0007015 128 0.419
post embryonic organ development GO:0048569 1 0.419
endoderm development GO:0007492 33 0.417
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.416
behavior GO:0007610 112 0.416
Worm
regulation of apoptotic signaling pathway GO:2001233 175 0.412
organ morphogenesis GO:0009887 147 0.404
maintenance of location GO:0051235 112 0.403
adherens junction organization GO:0034332 36 0.400
Human Mouse
elastic fiber assembly GO:0048251 3 0.393
adherens junction assembly GO:0034333 34 0.392
Human Mouse
negative regulation of cellular component movement GO:0051271 106 0.390
entry into other organism involved in symbiotic interaction GO:0051828 25 0.386
regulation of cell migration GO:0030334 289 0.379
ephrin receptor signaling pathway GO:0048013 15 0.375
kidney development GO:0001822 53 0.372
generation of neurons GO:0048699 152 0.369
immune response GO:0006955 307 0.368
cellular component morphogenesis GO:0032989 314 0.366
Human Mouse Fly
regulation of protein homodimerization activity GO:0043496 9 0.358
oogenesis GO:0048477 2 0.356
Fly
immune response activating signal transduction GO:0002757 90 0.355
Human
viral life cycle GO:0019058 132 0.347
membrane organization GO:0061024 292 0.342
muscle cell development GO:0055001 29 0.338
negative regulation of cell differentiation GO:0045596 171 0.337
renal system development GO:0072001 63 0.335
regulation of phagocytosis GO:0050764 21 0.329
striated muscle contraction GO:0006941 52 0.328
morphogenesis of an epithelial sheet GO:0002011 12 0.327
epithelial cell migration GO:0010631 119 0.318
muscle system process GO:0003012 81 0.318
regulation of cellular amino acid metabolic process GO:0006521 6 0.309
negative regulation of programmed cell death GO:0043069 321 0.309
vesicle mediated transport GO:0016192 371 0.308
cardiovascular system development GO:0072358 262 0.303
regulation of cell cell adhesion GO:0022407 57 0.300
regulation of cell projection organization GO:0031344 107 0.298
positive regulation of protein phosphorylation GO:0001934 313 0.297
Mouse
cell substrate junction assembly GO:0007044 35 0.295
Human Mouse
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.294
Human
arf protein signal transduction GO:0032011 0 0.293
apoptotic cell clearance GO:0043277 12 0.291
protein localization to plasma membrane GO:0072659 93 0.283
cellular response to nitrogen compound GO:1901699 144 0.282
foam cell differentiation GO:0090077 15 0.281
regulation of smooth muscle cell proliferation GO:0048660 28 0.277
regulation of cell adhesion mediated by integrin GO:0033628 22 0.273
cellular macromolecule catabolic process GO:0044265 380 0.271
Human
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.267
Human
positive regulation of catabolic process GO:0009896 310 0.267
Human
regulation of vesicle mediated transport GO:0060627 130 0.264
regulation of blood circulation GO:1903522 59 0.263
single organism membrane organization GO:0044802 268 0.259
mesoderm development GO:0007498 14 0.256
anterior posterior axis specification GO:0009948 2 0.255
lipoprotein metabolic process GO:0042157 42 0.254
nail development GO:0035878 3 0.251
oocyte development GO:0048599 1 0.251
positive regulation of phosphoprotein phosphatase activity GO:0032516 9 0.249
lipid localization GO:0010876 106 0.248
engulfment of apoptotic cell GO:0043652 2 0.247
osteoblast differentiation GO:0001649 92 0.244
actin cytoskeleton organization GO:0030036 207 0.244
negative regulation of phosphorylation GO:0042326 174 0.241
cation transmembrane transport GO:0098655 238 0.241
regulation of establishment of protein localization to plasma membrane GO:0090003 30 0.240
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.235
negative regulation of protein binding GO:0032091 35 0.228
cell development GO:0048468 328 0.228
Human Mouse Fly
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.227
Human
positive regulation of neurogenesis GO:0050769 49 0.227
regulation of ras protein signal transduction GO:0046578 155 0.226
Fly
negative regulation of mapk cascade GO:0043409 56 0.225
hindbrain development GO:0030902 3 0.225
neuron differentiation GO:0030182 138 0.223
cell morphogenesis GO:0000902 296 0.218
Human Mouse
regulation of stress fiber assembly GO:0051492 32 0.218
regulation of locomotion GO:0040012 329 0.218
positive regulation of cell matrix adhesion GO:0001954 23 0.211
Human
negative regulation of lipid transport GO:0032369 18 0.209
regulation of entry of bacterium into host cell GO:2000535 2 0.209
regulation of cell matrix adhesion GO:0001952 42 0.209
Human
blood vessel endothelial cell migration GO:0043534 42 0.208
regulation of actin cytoskeleton organization GO:0032956 116 0.206
negative regulation of apoptotic signaling pathway GO:2001234 97 0.206
cellular response to organic cyclic compound GO:0071407 127 0.204
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.203
Human
viral entry into host cell GO:0046718 24 0.202
erk1 and erk2 cascade GO:0070371 104 0.202
amine metabolic process GO:0009308 44 0.201
negative regulation of phagocytosis GO:0050765 4 0.200
cellular response to oxygen containing compound GO:1901701 276 0.199
signal transduction by phosphorylation GO:0023014 297 0.197
Mouse
myosin filament assembly GO:0031034 2 0.196
negative regulation of protein metabolic process GO:0051248 391 0.196
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.195
Human
regulation of cell morphogenesis GO:0022604 153 0.194
Human Mouse
negative chemotaxis GO:0050919 11 0.194
taxis GO:0042330 157 0.194
cell projection morphogenesis GO:0048858 129 0.192
regulation of bmp signaling pathway GO:0030510 27 0.192
actomyosin structure organization GO:0031032 59 0.192
regulation of cell development GO:0060284 161 0.191
Human
positive regulation of actin filament polymerization GO:0030838 38 0.190
negative regulation of rho protein signal transduction GO:0035024 7 0.187
regulation of leukocyte proliferation GO:0070663 67 0.187
negative regulation of intracellular signal transduction GO:1902532 183 0.186
hormone metabolic process GO:0042445 61 0.184
smooth muscle cell migration GO:0014909 18 0.183
purine nucleotide catabolic process GO:0006195 405 0.183
Human Fly
regulation of neural precursor cell proliferation GO:2000177 4 0.182
cation transport GO:0006812 331 0.181
negative regulation of binding GO:0051100 57 0.176
multicellular organismal response to stress GO:0033555 1 0.176
epithelial cell differentiation GO:0030855 141 0.171
Fly
stress fiber assembly GO:0043149 40 0.171
positive regulation of protein localization to plasma membrane GO:1903078 20 0.169
cell part morphogenesis GO:0032990 137 0.168
establishment of protein localization to membrane GO:0090150 121 0.166
actin filament bundle organization GO:0061572 54 0.166
oocyte differentiation GO:0009994 2 0.166
gland development GO:0048732 48 0.165
cellular response to hepatocyte growth factor stimulus GO:0035729 6 0.165
negative regulation of cell motility GO:2000146 104 0.163
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.162
extrinsic apoptotic signaling pathway GO:0097191 119 0.161
single organism behavior GO:0044708 28 0.161
movement in host environment GO:0052126 25 0.160
syncytium formation by plasma membrane fusion GO:0000768 2 0.159
Fly
neuromuscular junction development GO:0007528 3 0.158
regulation of collagen catabolic process GO:0010710 3 0.157
actin filament bundle assembly GO:0051017 54 0.156
cell cell adhesion mediated by integrin GO:0033631 8 0.156
odontogenesis of dentin containing tooth GO:0042475 10 0.156
negative regulation of multicellular organismal process GO:0051241 317 0.154
guanosine containing compound metabolic process GO:1901068 244 0.154
Human Fly
growth GO:0040007 202 0.154
negative regulation of b cell receptor signaling pathway GO:0050859 2 0.152
Human
regeneration GO:0031099 4 0.151
regulation of canonical wnt signaling pathway GO:0060828 88 0.150
tissue morphogenesis GO:0048729 96 0.150
Mouse
negative regulation of epithelial cell migration GO:0010633 38 0.146
embryo development GO:0009790 123 0.146
Worm
regulation of establishment of protein localization GO:0070201 242 0.144
lens development in camera type eye GO:0002088 2 0.144
mapk cascade GO:0000165 288 0.142
Mouse
neurological system process GO:0050877 163 0.141
somatic stem cell maintenance GO:0035019 4 0.141
cell adhesion mediated by integrin GO:0033627 27 0.141
regulation of jnk cascade GO:0046328 73 0.140
regulation of actin filament based process GO:0032970 141 0.139
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 19 0.139
regulation of endocytosis GO:0030100 72 0.137
posttranscriptional regulation of gene expression GO:0010608 213 0.136
segmentation GO:0035282 4 0.135
lipid transport GO:0006869 90 0.135
phagocytosis engulfment GO:0006911 7 0.132
endocrine system development GO:0035270 26 0.131
vasculature development GO:0001944 181 0.129
divalent inorganic cation transport GO:0072511 158 0.127
glial cell migration GO:0008347 4 0.126
regulation of vasodilation GO:0042312 4 0.126
erbb signaling pathway GO:0038127 44 0.126
positive regulation of cell proliferation GO:0008284 301 0.124
positive regulation of cellular catabolic process GO:0031331 284 0.123
Human
regulation of protein localization GO:0032880 296 0.118
regulation of nucleoside metabolic process GO:0009118 209 0.117
Human Fly
nephron development GO:0072006 30 0.117
actin filament polymerization GO:0030041 45 0.117
regulation of cellular amine metabolic process GO:0033238 11 0.116
cellular macromolecular complex assembly GO:0034622 324 0.116
guanosine containing compound catabolic process GO:1901069 239 0.116
Human Fly
cellular amino acid metabolic process GO:0006520 116 0.114
embryonic placenta development GO:0001892 1 0.113
multi organism cellular process GO:0044764 156 0.112
striated muscle myosin thick filament assembly GO:0071688 2 0.112
cell growth GO:0016049 160 0.110
negative regulation of homeostatic process GO:0032845 59 0.109
endocytosis GO:0006897 159 0.108
regulation of cytoplasmic transport GO:1903649 149 0.108
nucleoside triphosphate metabolic process GO:0009141 422 0.106
Human Fly
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.106
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.105
canonical wnt signaling pathway GO:0060070 116 0.103
receptor biosynthetic process GO:0032800 18 0.103
negative regulation of multi organism process GO:0043901 92 0.102
negative regulation of protein catabolic process GO:0042177 59 0.102
mesenchymal cell development GO:0014031 50 0.101
Human
small gtpase mediated signal transduction GO:0007264 78 0.101
cell morphogenesis involved in differentiation GO:0000904 144 0.100
Human Mouse
system process GO:0003008 349 0.099
angiogenesis GO:0001525 147 0.097
response to alcohol GO:0097305 64 0.097
positive regulation of programmed cell death GO:0043068 249 0.095
regulation of protein binding GO:0043393 66 0.095
regulation of phosphatase activity GO:0010921 81 0.094
regulation of protein serine threonine kinase activity GO:0071900 179 0.094
Mouse
negative regulation of macrophage derived foam cell differentiation GO:0010745 7 0.093
modification dependent macromolecule catabolic process GO:0043632 212 0.093
Human
regulation of actin filament bundle assembly GO:0032231 36 0.091
positive regulation of mapk cascade GO:0043410 190 0.091
Mouse
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.089
somitogenesis GO:0001756 2 0.088
regulation of receptor biosynthetic process GO:0010869 15 0.086
regulation of antigen receptor mediated signaling pathway GO:0050854 10 0.085
Human
homotypic cell cell adhesion GO:0034109 47 0.085
negative regulation of developmental process GO:0051093 247 0.085
divalent metal ion transport GO:0070838 152 0.084
mesoderm formation GO:0001707 10 0.084
cell migration involved in sprouting angiogenesis GO:0002042 19 0.084
positive regulation of focal adhesion assembly GO:0051894 11 0.083
Human
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.083
Fly
leukocyte tethering or rolling GO:0050901 15 0.082
negative regulation of smooth muscle cell migration GO:0014912 7 0.082
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.082
positive regulation of leukocyte migration GO:0002687 46 0.081
regulation of metal ion transport GO:0010959 120 0.080
regulation of cell junction assembly GO:1901888 29 0.080
Human
striated muscle cell development GO:0055002 27 0.080
peptidyl tyrosine phosphorylation GO:0018108 170 0.080
Mouse
cellular protein complex assembly GO:0043623 188 0.080
regulation of lamellipodium morphogenesis GO:2000392 4 0.079
negative regulation of wnt signaling pathway GO:0030178 69 0.079
receptor mediated endocytosis GO:0006898 84 0.079
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.078
multicellular organismal signaling GO:0035637 34 0.077
regulation of cellular response to growth factor stimulus GO:0090287 76 0.077
Human
regulation of anatomical structure morphogenesis GO:0022603 286 0.075
Human Mouse Fly
positive regulation of gtp catabolic process GO:0033126 166 0.075
Human
pattern specification process GO:0007389 43 0.075
t cell activation GO:0042110 99 0.075
neurogenesis GO:0022008 169 0.074
response to mercury ion GO:0046689 4 0.073
regulation of cell motility GO:2000145 299 0.073
cell type specific apoptotic process GO:0097285 125 0.072
morphogenesis of embryonic epithelium GO:0016331 4 0.072
positive regulation of cell development GO:0010720 92 0.071
Human
negative regulation of catalytic activity GO:0043086 335 0.071
negative regulation of protein homodimerization activity GO:0090074 1 0.071
cellular protein catabolic process GO:0044257 261 0.070
Human
gland morphogenesis GO:0022612 8 0.069
tissue migration GO:0090130 119 0.069
establishment of epithelial cell polarity GO:0090162 2 0.069
endothelial cell migration GO:0043542 86 0.069
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 11 0.069
regulation of epithelial cell migration GO:0010632 93 0.067
response to biotic stimulus GO:0009607 276 0.067
eye morphogenesis GO:0048592 16 0.066
ossification GO:0001503 121 0.066
pericardium development GO:0060039 2 0.065
metal ion homeostasis GO:0055065 169 0.065
sensory organ morphogenesis GO:0090596 21 0.065
blood vessel morphogenesis GO:0048514 162 0.064
establishment of apical basal cell polarity GO:0035089 1 0.064
cell activation involved in immune response GO:0002263 30 0.064
negative regulation of phosphate metabolic process GO:0045936 267 0.064
regulation of muscle cell differentiation GO:0051147 31 0.063
Fly
myoblast fusion GO:0007520 1 0.063
Fly
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.062
positive regulation of neuron projection development GO:0010976 34 0.062
negative regulation of cellular protein metabolic process GO:0032269 353 0.062
negative regulation of phosphorus metabolic process GO:0010563 267 0.062
organ formation GO:0048645 3 0.061
positive regulation of protein kinase b signaling GO:0051897 42 0.061
regulation of system process GO:0044057 101 0.061
positive regulation of transport GO:0051050 336 0.060
response to organic cyclic compound GO:0014070 204 0.060
regulation of anoikis GO:2000209 19 0.060
photoreceptor cell differentiation GO:0046530 2 0.059
response to oxygen containing compound GO:1901700 369 0.059
axonogenesis GO:0007409 31 0.059
regulation of intracellular transport GO:0032386 195 0.058
determination of adult lifespan GO:0008340 2 0.058
regulation of cytoskeleton organization GO:0051493 177 0.058
negative regulation of erk1 and erk2 cascade GO:0070373 14 0.058
wound healing GO:0042060 115 0.057
astrocyte differentiation GO:0048708 4 0.057
epithelium development GO:0060429 227 0.057
Mouse Fly
positive regulation of nucleotide catabolic process GO:0030813 185 0.057
Human
regulation of t cell activation GO:0050863 77 0.056
negative regulation of protein transport GO:0051224 75 0.056
regulation of neurogenesis GO:0050767 82 0.055
macrophage derived foam cell differentiation GO:0010742 15 0.055
neuron development GO:0048666 113 0.054
establishment of tissue polarity GO:0007164 3 0.054
negative regulation of neural precursor cell proliferation GO:2000178 1 0.053
regulation of growth GO:0040008 165 0.053
positive regulation of cell motility GO:2000147 177 0.053
negative regulation of lipid storage GO:0010888 11 0.053
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.053
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.053
developmental cell growth GO:0048588 18 0.053
epithelium migration GO:0090132 119 0.052
dna integrity checkpoint GO:0031570 71 0.052
i kappab kinase nf kappab signaling GO:0007249 166 0.052
negative regulation of entry of bacterium into host cell GO:2000536 1 0.052
establishment or maintenance of monopolar cell polarity GO:0061339 1 0.052
convergent extension involved in gastrulation GO:0060027 1 0.052
viral process GO:0016032 146 0.051
neuron death GO:0070997 65 0.051
cardiac muscle contraction GO:0060048 34 0.051
regulation of erbb signaling pathway GO:1901184 27 0.050
regulation of phosphoprotein phosphatase activity GO:0043666 23 0.050
blood coagulation GO:0007596 76 0.050
regulation of kinase activity GO:0043549 314 0.050
Mouse
proteasomal protein catabolic process GO:0010498 176 0.050
positive regulation of nucleoside metabolic process GO:0045979 186 0.050
Human
immune response regulating signaling pathway GO:0002764 97 0.050
Human
inorganic cation transmembrane transport GO:0098662 194 0.049
negative regulation of catabolic process GO:0009895 104 0.049
regulation of dephosphorylation GO:0035303 96 0.049
calcium ion transport GO:0006816 147 0.049
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 28 0.049
Human
single organism reproductive process GO:0044702 98 0.049
Fly
cytoplasmic transport GO:0016482 379 0.048
epithelial cell cell adhesion GO:0090136 7 0.048
response to external biotic stimulus GO:0043207 261 0.048
positive regulation of establishment of protein localization to plasma membrane GO:0090004 18 0.048
mitotic cell cycle GO:0000278 326 0.048
calcium independent cell matrix adhesion GO:0007161 1 0.047
regulation of nucleotide catabolic process GO:0030811 205 0.047
Human Fly
response to fatty acid GO:0070542 13 0.047
cerebral cortex radially oriented cell migration GO:0021799 1 0.047
regulation of lipid transport GO:0032368 44 0.047
response to prostaglandin e GO:0034695 6 0.047
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.046
Human
lamellipodium organization GO:0097581 30 0.046
Mouse
wound healing spreading of epidermal cells GO:0035313 6 0.046
regulation of neuron death GO:1901214 56 0.046
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.045
positive regulation of immune system process GO:0002684 283 0.045
Human
platelet derived growth factor receptor signaling pathway GO:0048008 14 0.045
positive regulation of locomotion GO:0040017 186 0.045
cell aggregation GO:0098743 1 0.045
neuron apoptotic process GO:0051402 39 0.045
regulation of rho protein signal transduction GO:0035023 79 0.045
Fly
rap protein signal transduction GO:0032486 7 0.045
cell cell adhesion GO:0098609 19 0.045
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000058 7 0.044
regulation of embryonic development GO:0045995 20 0.044
negative regulation of cell projection organization GO:0031345 22 0.044
response to other organism GO:0051707 261 0.044
negative regulation of protein kinase b signaling GO:0051898 17 0.044
heart development GO:0007507 95 0.043
motor neuron axon guidance GO:0008045 2 0.043
neuron projection development GO:0031175 106 0.043
isg15 protein conjugation GO:0032020 5 0.042
platelet activation GO:0030168 44 0.042
nucleoside phosphate catabolic process GO:1901292 412 0.041
Human Fly
regulation of small gtpase mediated signal transduction GO:0051056 156 0.041
Fly
maintenance of location in cell GO:0051651 62 0.041
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.040
regulation of blood vessel size GO:0050880 18 0.040
positive regulation of developmental process GO:0051094 314 0.040
Human
memory GO:0007613 3 0.039
male genitalia development GO:0030539 1 0.039
regulation of protein complex assembly GO:0043254 147 0.039
hepatocyte growth factor receptor signaling pathway GO:0048012 8 0.039
cellular homeostasis GO:0019725 196 0.039
steroid metabolic process GO:0008202 94 0.039
platelet aggregation GO:0070527 32 0.039
negative regulation of transferase activity GO:0051348 124 0.039
cilium organization GO:0044782 68 0.039
embryonic organ development GO:0048568 36 0.039
epiboly GO:0090504 9 0.038
interspecies interaction between organisms GO:0044419 156 0.038
regulation of cell cycle GO:0051726 393 0.038
anoikis GO:0043276 22 0.038
cellular response to camp GO:0071320 21 0.037
regulation of gtpase activity GO:0043087 180 0.037
Human Fly
sensory perception of smell GO:0007608 2 0.037
leukocyte differentiation GO:0002521 98 0.036
regulation of cellular response to stress GO:0080135 244 0.036
myeloid cell differentiation GO:0030099 117 0.036
cellular response to organonitrogen compound GO:0071417 124 0.036

PXN disease predictions

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 114 0.068
musculoskeletal system disease DOID:17 223 0.068
disease of cellular proliferation DOID:14566 174 0.047
gastrointestinal system cancer DOID:3119 52 0.040
cancer DOID:162 167 0.040
organ system cancer DOID:0050686 164 0.040