Homo sapiens

0 known processes

KIDINS220

kinase D-interacting substrate, 220kDa

(Aliases: MGC163482,ARMS)

KIDINS220 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.303
nervous system development GO:0007399 293 0.114
Mouse Rat
cellular component morphogenesis GO:0032989 314 0.097
Mouse
actin cytoskeleton organization GO:0030036 207 0.093
ras protein signal transduction GO:0007265 73 0.089
female gamete generation GO:0007292 2 0.089
cell projection organization GO:0030030 252 0.080
Mouse Rat
determination of adult lifespan GO:0008340 2 0.077
system process GO:0003008 349 0.076
response to oxygen containing compound GO:1901700 369 0.076
actin filament based process GO:0030029 224 0.076
cell morphogenesis GO:0000902 296 0.074
Mouse
multicellular organismal aging GO:0010259 3 0.073
nucleoside catabolic process GO:0009164 408 0.071
small gtpase mediated signal transduction GO:0007264 78 0.068
ribonucleoside triphosphate metabolic process GO:0009199 412 0.066
purine ribonucleoside catabolic process GO:0046130 398 0.066
growth GO:0040007 202 0.065
positive regulation of developmental process GO:0051094 314 0.065
Rat
ribonucleotide catabolic process GO:0009261 405 0.063
nucleotide catabolic process GO:0009166 408 0.063
positive regulation of phosphorylation GO:0042327 394 0.061
vesicle mediated transport GO:0016192 371 0.061
nucleoside triphosphate catabolic process GO:0009143 394 0.060
cell adhesion GO:0007155 325 0.056
oogenesis GO:0048477 2 0.056
purine nucleotide catabolic process GO:0006195 405 0.056
cell projection morphogenesis GO:0048858 129 0.056
Mouse
mitotic cell cycle GO:0000278 326 0.055
cell development GO:0048468 328 0.055
Mouse Rat
nucleoside triphosphate metabolic process GO:0009141 422 0.054
organophosphate catabolic process GO:0046434 430 0.054
biological adhesion GO:0022610 331 0.054
regulation of cellular component biogenesis GO:0044087 281 0.053
glycosyl compound catabolic process GO:1901658 413 0.052
positive regulation of cellular component organization GO:0051130 376 0.051
Rat
negative regulation of multicellular organismal process GO:0051241 317 0.051
regulation of cellular amino acid metabolic process GO:0006521 6 0.049
cell morphogenesis involved in differentiation GO:0000904 144 0.049
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.048
purine containing compound catabolic process GO:0072523 411 0.048
locomotory behavior GO:0007626 1 0.048
neuron differentiation GO:0030182 138 0.047
Mouse Rat
anatomical structure formation involved in morphogenesis GO:0048646 284 0.046
membrane organization GO:0061024 292 0.046
dephosphorylation GO:0016311 209 0.046
enzyme linked receptor protein signaling pathway GO:0007167 303 0.044
cellular macromolecular complex assembly GO:0034622 324 0.044
purine ribonucleoside metabolic process GO:0046128 437 0.043
nucleoside phosphate catabolic process GO:1901292 412 0.042
regulation of mapk cascade GO:0043408 262 0.042
regulation of anatomical structure morphogenesis GO:0022603 286 0.041
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.041
neuron projection development GO:0031175 106 0.041
Mouse Rat
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.040
immune response GO:0006955 307 0.040
single organism cellular localization GO:1902580 332 0.040
cellular response to endogenous stimulus GO:0071495 336 0.038
Rat
regulation of purine nucleotide metabolic process GO:1900542 264 0.038
rho protein signal transduction GO:0007266 26 0.038
wnt signaling pathway GO:0016055 156 0.037
generation of neurons GO:0048699 152 0.037
Mouse Rat
mapk cascade GO:0000165 288 0.037
cellular amine metabolic process GO:0044106 41 0.036
cell part morphogenesis GO:0032990 137 0.036
Mouse
ribonucleoside triphosphate catabolic process GO:0009203 391 0.036
ribonucleoside catabolic process GO:0042454 406 0.035
regulation of nucleoside metabolic process GO:0009118 209 0.035
ribonucleoside monophosphate catabolic process GO:0009158 158 0.035
neuromuscular junction development GO:0007528 3 0.034
regulation of cellular response to stress GO:0080135 244 0.034
cellular response to growth factor stimulus GO:0071363 197 0.034
Rat
regulation of cellular amine metabolic process GO:0033238 11 0.034
nucleoside monophosphate catabolic process GO:0009125 159 0.034
purine ribonucleotide catabolic process GO:0009154 404 0.034
endomembrane system organization GO:0010256 196 0.033
taxis GO:0042330 157 0.033
purine nucleoside triphosphate metabolic process GO:0009144 412 0.033
regulation of growth GO:0040008 165 0.033
positive regulation of catabolic process GO:0009896 310 0.033
positive regulation of cell differentiation GO:0045597 211 0.033
Rat
chemotaxis GO:0006935 157 0.033
positive regulation of kinase activity GO:0033674 204 0.032
protein ubiquitination GO:0016567 314 0.032
cellular response to oxygen containing compound GO:1901701 276 0.032
positive regulation of cellular catabolic process GO:0031331 284 0.032
canonical wnt signaling pathway GO:0060070 116 0.032
cytoplasmic transport GO:0016482 379 0.032
Rat
positive regulation of gtpase activity GO:0043547 166 0.032
compound eye development GO:0048749 1 0.031
hindbrain development GO:0030902 3 0.031
secretion GO:0046903 254 0.031
cell growth GO:0016049 160 0.031
regulation of gtpase activity GO:0043087 180 0.030
neurogenesis GO:0022008 169 0.030
Mouse Rat
positive regulation of protein phosphorylation GO:0001934 313 0.030
purine nucleoside catabolic process GO:0006152 398 0.030
negative regulation of phosphorus metabolic process GO:0010563 267 0.030
memory GO:0007613 3 0.030
cardiovascular system development GO:0072358 262 0.030
amine metabolic process GO:0009308 44 0.030
microtubule based process GO:0007017 210 0.029
mitotic cell cycle process GO:1903047 286 0.028
positive regulation of transferase activity GO:0051347 227 0.028
purine nucleoside triphosphate catabolic process GO:0009146 392 0.027
regulation of cytoskeleton organization GO:0051493 177 0.027
regulation of protein kinase activity GO:0045859 289 0.027
Rat
chromatin organization GO:0006325 351 0.027
regulation of wnt signaling pathway GO:0030111 123 0.027
negative regulation of intracellular signal transduction GO:1902532 183 0.027
immune effector process GO:0002252 159 0.027
Human
positive regulation of nucleotide metabolic process GO:0045981 230 0.027
regulation of kinase activity GO:0043549 314 0.026
Rat
negative regulation of catalytic activity GO:0043086 335 0.026
maintenance of location GO:0051235 112 0.026
chromatin modification GO:0016568 298 0.026
negative regulation of developmental process GO:0051093 247 0.026
secretion by cell GO:0032940 226 0.026
cellular homeostasis GO:0019725 196 0.026
cellular macromolecule catabolic process GO:0044265 380 0.026
negative regulation of cellular protein metabolic process GO:0032269 353 0.025
purine nucleoside monophosphate catabolic process GO:0009128 158 0.025
organelle assembly GO:0070925 176 0.025
metencephalon development GO:0022037 2 0.025
cellular component assembly involved in morphogenesis GO:0010927 73 0.025
positive regulation of gtp catabolic process GO:0033126 166 0.025
signal transduction by phosphorylation GO:0023014 297 0.025
response to nitrogen compound GO:1901698 184 0.025
single organism membrane organization GO:0044802 268 0.025
central nervous system development GO:0007417 123 0.025
brain development GO:0007420 97 0.025
regulation of immune response GO:0050776 201 0.025
hemopoiesis GO:0030097 180 0.025
regulation of nucleotide catabolic process GO:0030811 205 0.025
cellular amino acid metabolic process GO:0006520 116 0.025
regulation of locomotion GO:0040012 329 0.025
cellular protein complex assembly GO:0043623 188 0.024
positive regulation of cell development GO:0010720 92 0.024
Rat
head development GO:0060322 108 0.024
circulatory system development GO:0072359 262 0.024
protein catabolic process GO:0030163 325 0.024
negative regulation of phosphate metabolic process GO:0045936 267 0.024
gtp catabolic process GO:0006184 237 0.024
positive regulation of protein kinase activity GO:0045860 190 0.024
negative regulation of protein metabolic process GO:0051248 391 0.024
atp catabolic process GO:0006200 157 0.024
actin filament organization GO:0007015 128 0.024
morphogenesis of embryonic epithelium GO:0016331 4 0.024
regulation of microtubule based process GO:0032886 74 0.024
histone modification GO:0016570 251 0.024
regulation of cell morphogenesis GO:0022604 153 0.024
apoptotic signaling pathway GO:0097190 268 0.023
spermatid differentiation GO:0048515 4 0.023
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.023
response to organonitrogen compound GO:0010243 156 0.023
guanosine containing compound catabolic process GO:1901069 239 0.023
regulation of cell development GO:0060284 161 0.023
Rat
positive regulation of cellular amine metabolic process GO:0033240 7 0.023
cell division GO:0051301 168 0.023
positive regulation of hydrolase activity GO:0051345 331 0.023
cerebellum development GO:0021549 2 0.023
cellular response to nitrogen compound GO:1901699 144 0.023
regulation of transferase activity GO:0051338 355 0.023
Rat
atp metabolic process GO:0046034 176 0.023
protein localization to organelle GO:0033365 280 0.023
cellular ketone metabolic process GO:0042180 80 0.023
organelle fission GO:0048285 149 0.023
regulation of actin filament based process GO:0032970 141 0.022
positive regulation of nucleotide catabolic process GO:0030813 185 0.022
negative regulation of cell death GO:0060548 345 0.022
oocyte differentiation GO:0009994 2 0.022
regulation of nucleotide metabolic process GO:0006140 269 0.022
response to abiotic stimulus GO:0009628 336 0.022
endosomal transport GO:0016197 129 0.022
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.022
negative regulation of programmed cell death GO:0043069 321 0.021
regulation of cell differentiation GO:0045595 393 0.021
Rat
regulation of proteolysis GO:0030162 293 0.021
neurological system process GO:0050877 163 0.021
positive regulation of organelle organization GO:0010638 195 0.021
protein localization to membrane GO:0072657 160 0.021
positive regulation of cellular component biogenesis GO:0044089 158 0.021
negative regulation of phosphorylation GO:0042326 174 0.021
ribonucleoside monophosphate metabolic process GO:0009161 187 0.021
reactive oxygen species biosynthetic process GO:1903409 4 0.021
ubiquitin dependent protein catabolic process GO:0006511 206 0.021
nuclear migration GO:0007097 1 0.021
purine nucleoside monophosphate metabolic process GO:0009126 186 0.021
epithelium development GO:0060429 227 0.021
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.020
response to cytokine GO:0034097 232 0.020
leukocyte mediated immunity GO:0002443 59 0.020
regulation of protein localization GO:0032880 296 0.020
guanosine containing compound metabolic process GO:1901068 244 0.020
cytokinesis GO:0000910 96 0.020
rab protein signal transduction GO:0032482 4 0.020
regulation of canonical wnt signaling pathway GO:0060828 88 0.020
covalent chromatin modification GO:0016569 254 0.020
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.020
hematopoietic or lymphoid organ development GO:0048534 186 0.020
negative regulation of cellular component organization GO:0051129 235 0.020
regulation of cell motility GO:2000145 299 0.020
regulation of cell cycle process GO:0010564 266 0.020
metal ion transport GO:0030001 272 0.020
regulation of cellular ketone metabolic process GO:0010565 50 0.020
regulation of cell migration GO:0030334 289 0.020
oocyte development GO:0048599 1 0.019
cation transport GO:0006812 331 0.019
regulation of protein stability GO:0031647 87 0.019
regulation of microtubule cytoskeleton organization GO:0070507 61 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
positive regulation of nucleoside metabolic process GO:0045979 186 0.019
limbic system development GO:0021761 3 0.019
cell substrate adhesion GO:0031589 132 0.019
tissue morphogenesis GO:0048729 96 0.019
segmentation GO:0035282 4 0.019
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.019
regulation of ras protein signal transduction GO:0046578 155 0.018
endocytosis GO:0006897 159 0.018
regulation of reactive oxygen species metabolic process GO:2000377 41 0.018
carbohydrate metabolic process GO:0005975 207 0.018
intracellular protein transport GO:0006886 270 0.018
ameboidal type cell migration GO:0001667 135 0.018
nucleus localization GO:0051647 1 0.018
regulation of purine nucleotide catabolic process GO:0033121 205 0.018
reproductive process GO:0022414 106 0.018
cell junction organization GO:0034330 79 0.017
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.017
protein polyubiquitination GO:0000209 110 0.017
adult locomotory behavior GO:0008344 1 0.017
reactive oxygen species metabolic process GO:0072593 75 0.017
positive regulation of locomotion GO:0040017 186 0.017
cytokine production GO:0001816 247 0.017
neuroblast proliferation GO:0007405 4 0.017
positive regulation of cell death GO:0010942 263 0.017
microtubule cytoskeleton organization GO:0000226 176 0.017
cellular response to organonitrogen compound GO:0071417 124 0.017
protein modification by small protein conjugation GO:0032446 342 0.017
regulation of protein transport GO:0051223 213 0.017
positive regulation of mapk cascade GO:0043410 190 0.017
mating GO:0007618 1 0.016
regulation of gtp catabolic process GO:0033124 180 0.016
cell projection assembly GO:0030031 126 0.016
negative regulation of transport GO:0051051 176 0.016
innate immune response GO:0045087 178 0.016
morphogenesis of a polarized epithelium GO:0001738 3 0.016
negative regulation of apoptotic process GO:0043066 316 0.016
positive regulation of immune system process GO:0002684 283 0.016
forebrain generation of neurons GO:0021872 3 0.016
regulation of apoptotic signaling pathway GO:2001233 175 0.016
axonogenesis GO:0007409 31 0.016
establishment of nucleus localization GO:0040023 1 0.016
positive regulation of apoptotic process GO:0043065 246 0.016
organ morphogenesis GO:0009887 147 0.016
positive regulation of programmed cell death GO:0043068 249 0.016
single organism reproductive process GO:0044702 98 0.016
regulation of establishment of protein localization GO:0070201 242 0.016
nuclear division GO:0000280 128 0.016
chemical homeostasis GO:0048878 306 0.016
spermatid development GO:0007286 4 0.016
protein targeting GO:0006605 187 0.015
cellular component disassembly GO:0022411 92 0.015
positive regulation of axon extension GO:0045773 4 0.015
transmembrane transport GO:0055085 399 0.015
regulation of neuron differentiation GO:0045664 70 0.015
Rat
establishment of protein localization to organelle GO:0072594 172 0.015
cellular protein catabolic process GO:0044257 261 0.015
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.015
regulation of cell growth GO:0001558 135 0.015
immune system development GO:0002520 195 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.015
regulation of actin cytoskeleton organization GO:0032956 116 0.015
positive regulation of ras gtpase activity GO:0032320 117 0.015
cell activation GO:0001775 213 0.015
positive regulation of wnt signaling pathway GO:0030177 54 0.015
striated muscle contraction GO:0006941 52 0.015
divalent inorganic cation transport GO:0072511 158 0.015
single organism carbohydrate metabolic process GO:0044723 193 0.015
actin filament bundle assembly GO:0051017 54 0.015
nucleoside monophosphate metabolic process GO:0009123 191 0.015
regulation of cell projection organization GO:0031344 107 0.015
Rat
positive regulation of growth GO:0045927 58 0.015
spindle elongation GO:0051231 4 0.015
regulation of homeostatic process GO:0032844 121 0.015
neural tube formation GO:0001841 3 0.014
actin filament based movement GO:0030048 17 0.014
protein dephosphorylation GO:0006470 81 0.014
stress activated mapk cascade GO:0051403 93 0.014
ion homeostasis GO:0050801 230 0.014
sequestering of calcium ion GO:0051208 17 0.014
regulation of cytokine production GO:0001817 232 0.014
embryonic epithelial tube formation GO:0001838 4 0.014
protein modification by small protein removal GO:0070646 92 0.014
regulation of nervous system development GO:0051960 88 0.014
Rat
leukocyte activation GO:0045321 164 0.014
lymphocyte mediated immunity GO:0002449 48 0.014
regulation of ras gtpase activity GO:0032318 128 0.014
engulfment of apoptotic cell GO:0043652 2 0.014
establishment of protein localization to membrane GO:0090150 121 0.014
actomyosin structure organization GO:0031032 59 0.014
negative regulation of immune system process GO:0002683 136 0.014
negative regulation of organelle organization GO:0010639 126 0.014
regulation of small gtpase mediated signal transduction GO:0051056 156 0.014
primary neural tube formation GO:0014020 3 0.014
organonitrogen compound biosynthetic process GO:1901566 200 0.014
negative regulation of hydrolase activity GO:0051346 182 0.013
embryonic placenta development GO:0001892 1 0.013
regulation of dephosphorylation GO:0035303 96 0.013
autophagy GO:0006914 88 0.013
regulation of dna metabolic process GO:0051052 153 0.013
carbohydrate derivative biosynthetic process GO:1901137 207 0.013
vasculature development GO:0001944 181 0.013
regulation of protein catabolic process GO:0042176 155 0.013
peptidyl lysine modification GO:0018205 144 0.013
regulation of phosphatase activity GO:0010921 81 0.013
protein processing GO:0016485 226 0.013
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.013
protein oligomerization GO:0051259 173 0.013
neuron development GO:0048666 113 0.013
Mouse Rat
response to axon injury GO:0048678 1 0.013
positive regulation of neuron differentiation GO:0045666 40 0.013
Rat
reactive nitrogen species metabolic process GO:2001057 3 0.013
microtubule organizing center organization GO:0031023 62 0.013
modification dependent macromolecule catabolic process GO:0043632 212 0.013
mitochondrion organization GO:0007005 156 0.013
single organism cell adhesion GO:0098602 179 0.013
behavior GO:0007610 112 0.013
cell junction assembly GO:0034329 67 0.013
inorganic cation transmembrane transport GO:0098662 194 0.013
mitotic spindle elongation GO:0000022 4 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
circadian behavior GO:0048512 2 0.013
cell killing GO:0001906 34 0.013
regulation of cellular component movement GO:0051270 334 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.013
regulation of protein serine threonine kinase activity GO:0071900 179 0.012
regulation of neurogenesis GO:0050767 82 0.012
Rat
cell fate determination GO:0001709 3 0.012
regulation of ion transmembrane transport GO:0034765 132 0.012
glycoprotein metabolic process GO:0009100 110 0.012
regulation of autophagy GO:0010506 52 0.012
lysosomal transport GO:0007041 33 0.012
cellular lipid metabolic process GO:0044255 303 0.012
positive regulation of proteolysis GO:0045862 142 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
divalent metal ion transport GO:0070838 152 0.012
motor neuron axon guidance GO:0008045 2 0.012
forebrain neuron differentiation GO:0021879 3 0.012
glycoprotein biosynthetic process GO:0009101 91 0.012
stress activated protein kinase signaling cascade GO:0031098 94 0.012
jnk cascade GO:0007254 80 0.012
g protein coupled receptor signaling pathway GO:0007186 207 0.012
protein glycosylation GO:0006486 62 0.012
inner ear morphogenesis GO:0042472 4 0.012
positive regulation of transport GO:0051050 336 0.012
regulation of cell adhesion GO:0030155 166 0.012
anion transport GO:0006820 161 0.012
mitotic nuclear division GO:0007067 119 0.012
embryo development GO:0009790 123 0.012
Mouse
neuron projection morphogenesis GO:0048812 50 0.012
Mouse
establishment of planar polarity GO:0001736 3 0.012
regulation of response to external stimulus GO:0032101 222 0.012
negative regulation of cell cycle GO:0045786 193 0.012
axon development GO:0061564 34 0.012
centrosome organization GO:0051297 58 0.012
blood vessel development GO:0001568 172 0.011
regulation of membrane potential GO:0042391 95 0.011
myosin filament organization GO:0031033 2 0.011
nitrogen compound transport GO:0071705 191 0.011
regulation of intracellular transport GO:0032386 195 0.011
negative regulation of protein modification process GO:0031400 200 0.011
response to growth factor GO:0070848 205 0.011
Rat
mitochondrion distribution GO:0048311 3 0.011
methylation GO:0032259 106 0.011
t cell differentiation in thymus GO:0033077 4 0.011
axis elongation GO:0003401 4 0.011
forebrain neuron development GO:0021884 2 0.011
negative regulation of multi organism process GO:0043901 92 0.011
Human
central nervous system neuron axonogenesis GO:0021955 3 0.011
nuclear transport GO:0051169 179 0.011
cellular response to dna damage stimulus GO:0006974 379 0.011
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.011
camp metabolic process GO:0046058 61 0.011
neural tube closure GO:0001843 3 0.011
cerebral cortex radially oriented cell migration GO:0021799 1 0.011
positive regulation of cytoskeleton organization GO:0051495 83 0.011
extrinsic apoptotic signaling pathway GO:0097191 119 0.011
regulation of meiotic cell cycle GO:0051445 4 0.011
protein deubiquitination GO:0016579 79 0.011
regulation of meiosis GO:0040020 3 0.011
lipid transport GO:0006869 90 0.011
hippocampus development GO:0021766 1 0.011
positive regulation of cellular component movement GO:0051272 181 0.011
maintenance of location in cell GO:0051651 62 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
meiotic chromosome segregation GO:0045132 4 0.011
tissue migration GO:0090130 119 0.011
muscle contraction GO:0006936 73 0.011
monovalent inorganic cation transport GO:0015672 128 0.011
dna repair GO:0006281 198 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
mitotic cell cycle phase transition GO:0044772 162 0.011
cell cycle phase transition GO:0044770 173 0.011
muscle system process GO:0003012 81 0.010
sequestering of metal ion GO:0051238 24 0.010
blastoderm segmentation GO:0007350 2 0.010
associative learning GO:0008306 1 0.010
response to biotic stimulus GO:0009607 276 0.010
Human
nerve development GO:0021675 4 0.010
lipid localization GO:0010876 106 0.010
calcium ion homeostasis GO:0055074 122 0.010
response to light stimulus GO:0009416 87 0.010
developmental growth GO:0048589 48 0.010
positive regulation of cell projection organization GO:0031346 64 0.010
Rat
myeloid cell differentiation GO:0030099 117 0.010
bmp signaling pathway GO:0030509 49 0.010
gtp metabolic process GO:0046039 239 0.010
rhythmic behavior GO:0007622 2 0.010
striated muscle myosin thick filament assembly GO:0071688 2 0.010

KIDINS220 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.034
nervous system disease DOID:863 431 0.034
cancer DOID:162 167 0.024
Human
disease of cellular proliferation DOID:14566 174 0.024
Human
organ system cancer DOID:0050686 164 0.024
Human
disease of metabolism DOID:0014667 295 0.023
inherited metabolic disorder DOID:655 242 0.022
neurodegenerative disease DOID:1289 102 0.016
musculoskeletal system disease DOID:17 223 0.014
immune system disease DOID:2914 155 0.012
connective tissue disease DOID:65 109 0.011