Homo sapiens

16 known processes

NEDD8

neural precursor cell expressed, developmentally down-regulated 8

(Aliases: MGC125897,FLJ43224,NEDD-8,MGC104393,MGC125896)

NEDD8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein ubiquitination GO:0016567 314 0.998
Fly
protein modification by small protein conjugation GO:0032446 342 0.997
protein modification by small protein removal GO:0070646 92 0.995
protein neddylation GO:0045116 7 0.979
cellular macromolecule catabolic process GO:0044265 380 0.939
post embryonic development GO:0009791 2 0.933
Worm
ubiquitin dependent protein catabolic process GO:0006511 206 0.895
modification dependent protein catabolic process GO:0019941 209 0.845
cellular protein catabolic process GO:0044257 261 0.731
cytoplasmic transport GO:0016482 379 0.547
mitotic cell cycle GO:0000278 326 0.488
mitotic cell cycle process GO:1903047 286 0.476
positive regulation of cell death GO:0010942 263 0.471
Worm
determination of adult lifespan GO:0008340 2 0.459
regulation of proteolysis GO:0030162 293 0.454
Fly
cellular response to dna damage stimulus GO:0006974 379 0.424
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.422
proteasomal protein catabolic process GO:0010498 176 0.422
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.420
multicellular organismal aging GO:0010259 3 0.413
intracellular protein transport GO:0006886 270 0.413
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.396
neurogenesis GO:0022008 169 0.369
Fly
positive regulation of catabolic process GO:0009896 310 0.329
ncrna metabolic process GO:0034660 108 0.326
immune system development GO:0002520 195 0.316
regulation of mitotic cell cycle GO:0007346 189 0.302
positive regulation of protein catabolic process GO:0045732 75 0.293
myeloid cell differentiation GO:0030099 117 0.290
dna integrity checkpoint GO:0031570 71 0.275
positive regulation of proteolysis GO:0045862 142 0.239
regulation of proteasomal protein catabolic process GO:0061136 87 0.236
modification dependent macromolecule catabolic process GO:0043632 212 0.220
establishment of protein localization to organelle GO:0072594 172 0.215
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.206
vesicle mediated transport GO:0016192 371 0.199
negative regulation of programmed cell death GO:0043069 321 0.186
cell cycle phase transition GO:0044770 173 0.184
hematopoietic or lymphoid organ development GO:0048534 186 0.181
cell cycle checkpoint GO:0000075 117 0.175
embryo development GO:0009790 123 0.165
Worm
hemopoiesis GO:0030097 180 0.154
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.153
regulation of cell cycle process GO:0010564 266 0.150
regulation of protein catabolic process GO:0042176 155 0.147
regulation of cellular response to stress GO:0080135 244 0.147
regulation of cell cycle GO:0051726 393 0.144
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.144
dna repair GO:0006281 198 0.141
positive regulation of apoptotic process GO:0043065 246 0.135
Worm
positive regulation of protein ubiquitination GO:0031398 53 0.132
regulation of cell cycle phase transition GO:1901987 126 0.130
regulation of mitotic cell cycle phase transition GO:1901990 118 0.122
embryo development ending in birth or egg hatching GO:0009792 34 0.120
Worm
endocytosis GO:0006897 159 0.118
positive regulation of hydrolase activity GO:0051345 331 0.107
sex differentiation GO:0007548 45 0.105
Worm
protein targeting GO:0006605 187 0.104
apoptotic signaling pathway GO:0097190 268 0.104
regulation of protein ubiquitination GO:0031396 95 0.099
Fly
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.099
Fly
positive regulation of programmed cell death GO:0043068 249 0.093
Worm
negative regulation of cell cycle phase transition GO:1901988 89 0.093
negative regulation of cell death GO:0060548 345 0.092
positive regulation of nucleotide metabolic process GO:0045981 230 0.092
female gamete generation GO:0007292 2 0.092
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.090
protein catabolic process GO:0030163 325 0.089
reproduction GO:0000003 63 0.088
Worm
microtubule based process GO:0007017 210 0.088
positive regulation of cellular catabolic process GO:0031331 284 0.088
mapk cascade GO:0000165 288 0.086
reactive oxygen species metabolic process GO:0072593 75 0.085
protein maturation GO:0051604 233 0.083
regulation of growth GO:0040008 165 0.082
immune response GO:0006955 307 0.082
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.081
chemical homeostasis GO:0048878 306 0.080
dna damage checkpoint GO:0000077 68 0.080
signal transduction by phosphorylation GO:0023014 297 0.078
mitotic cell cycle checkpoint GO:0007093 68 0.077
cell cell signaling involved in cell fate commitment GO:0045168 5 0.077
negative regulation of mitotic cell cycle GO:0045930 102 0.075
regulation of cellular protein catabolic process GO:1903362 96 0.070
cell development GO:0048468 328 0.067
Fly
protein localization to organelle GO:0033365 280 0.066
negative regulation of apoptotic process GO:0043066 316 0.060
regulation of apoptotic signaling pathway GO:2001233 175 0.058
innate immune response GO:0045087 178 0.057
mitotic cell cycle phase transition GO:0044772 162 0.057
locomotory behavior GO:0007626 1 0.057
purine containing compound catabolic process GO:0072523 411 0.056
purine nucleoside triphosphate catabolic process GO:0009146 392 0.055
cell division GO:0051301 168 0.055
gtp metabolic process GO:0046039 239 0.054
intrinsic apoptotic signaling pathway GO:0097193 127 0.053
nucleoside phosphate catabolic process GO:1901292 412 0.053
reproductive structure development GO:0048608 55 0.052
Worm
nucleoside catabolic process GO:0009164 408 0.051
positive regulation of apoptotic signaling pathway GO:2001235 70 0.049
chromosome segregation GO:0007059 114 0.048
regulation of nucleoside metabolic process GO:0009118 209 0.048
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.048
enzyme linked receptor protein signaling pathway GO:0007167 303 0.046
cellular response to oxygen containing compound GO:1901701 276 0.045
negative regulation of catalytic activity GO:0043086 335 0.044
receptor mediated endocytosis GO:0006898 84 0.042
regulation of gtp catabolic process GO:0033124 180 0.042
mitotic dna integrity checkpoint GO:0044774 30 0.041
cytokinesis GO:0000910 96 0.041
response to cytokine GO:0034097 232 0.040
multicellular organism reproduction GO:0032504 42 0.038
maintenance of location GO:0051235 112 0.038
autophagy GO:0006914 88 0.038
adult locomotory behavior GO:0008344 1 0.037
organophosphate catabolic process GO:0046434 430 0.037
ribonucleoside catabolic process GO:0042454 406 0.036
cullin deneddylation GO:0010388 9 0.035
growth GO:0040007 202 0.035
regulation of reactive oxygen species metabolic process GO:2000377 41 0.034
purine ribonucleoside metabolic process GO:0046128 437 0.034
oogenesis GO:0048477 2 0.034
guanosine containing compound catabolic process GO:1901069 239 0.033
g2 dna damage checkpoint GO:0031572 26 0.033
nucleoside triphosphate metabolic process GO:0009141 422 0.033
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.033
response to light stimulus GO:0009416 87 0.032
aging GO:0007568 66 0.032
regulation of peptidase activity GO:0052547 180 0.032
regulation of mitosis GO:0007088 63 0.032
oocyte development GO:0048599 1 0.031
positive regulation of nucleotide catabolic process GO:0030813 185 0.031
cellular component morphogenesis GO:0032989 314 0.030
Fly
regulation of transferase activity GO:0051338 355 0.029
Fly
nervous system development GO:0007399 293 0.029
Fly
purine nucleoside triphosphate metabolic process GO:0009144 412 0.028
regulation of protein processing GO:0070613 150 0.028
cellular macromolecular complex assembly GO:0034622 324 0.027
regulation of mapk cascade GO:0043408 262 0.027
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.027
lipid localization GO:0010876 106 0.026
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.026
response to abiotic stimulus GO:0009628 336 0.026
multicellular organismal reproductive process GO:0048609 40 0.026
negative regulation of cell cycle process GO:0010948 121 0.026
regulation of purine nucleotide catabolic process GO:0033121 205 0.025
blastoderm segmentation GO:0007350 2 0.025
meiotic chromosome segregation GO:0045132 4 0.025
oocyte differentiation GO:0009994 2 0.025
positive regulation of protein phosphorylation GO:0001934 313 0.025
regulation of endopeptidase activity GO:0052548 170 0.025
cellular response to endogenous stimulus GO:0071495 336 0.024
ribonucleoside triphosphate catabolic process GO:0009203 391 0.024
response to organonitrogen compound GO:0010243 156 0.023
cell projection morphogenesis GO:0048858 129 0.023
Fly
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.023
regulation of purine nucleotide metabolic process GO:1900542 264 0.023
ribosome biogenesis GO:0042254 48 0.022
regulation of response to dna damage stimulus GO:2001020 94 0.022
negative regulation of proteolysis GO:0045861 132 0.021
positive regulation of nucleoside metabolic process GO:0045979 186 0.021
nucleoside monophosphate metabolic process GO:0009123 191 0.021
tripartite regional subdivision GO:0007351 2 0.020
positive regulation of transport GO:0051050 336 0.020
response to metal ion GO:0010038 84 0.020
glycosyl compound catabolic process GO:1901658 413 0.020
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.020
regulation of immune response GO:0050776 201 0.020
segmentation GO:0035282 4 0.020
protein polyubiquitination GO:0000209 110 0.020
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
organelle fission GO:0048285 149 0.019
guanosine containing compound metabolic process GO:1901068 244 0.019
generation of neurons GO:0048699 152 0.019
Fly
protein localization to nucleus GO:0034504 136 0.018
posttranscriptional regulation of gene expression GO:0010608 213 0.018
Fly
negative regulation of cellular catabolic process GO:0031330 83 0.018
mitotic dna damage checkpoint GO:0044773 28 0.018
regulation of nucleotide metabolic process GO:0006140 269 0.018
reproductive process GO:0022414 106 0.017
Worm
response to other organism GO:0051707 261 0.017
developmental process involved in reproduction GO:0003006 66 0.017
Worm
purine ribonucleoside catabolic process GO:0046130 398 0.017
anterior posterior axis specification GO:0009948 2 0.017
regulation of protein localization GO:0032880 296 0.017
development of primary sexual characteristics GO:0045137 35 0.017
Worm
ncrna processing GO:0034470 83 0.017
microtubule cytoskeleton organization GO:0000226 176 0.016
purine nucleotide catabolic process GO:0006195 405 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.016
cellular amine metabolic process GO:0044106 41 0.016
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.016
negative regulation of protein maturation GO:1903318 142 0.016
methylation GO:0032259 106 0.016
protein deneddylation GO:0000338 10 0.015
response to external biotic stimulus GO:0043207 261 0.015
cell type specific apoptotic process GO:0097285 125 0.015
single organism reproductive process GO:0044702 98 0.015
Worm
cellular response to nitrogen compound GO:1901699 144 0.015
establishment of nucleus localization GO:0040023 1 0.015
regulation of protein maturation GO:1903317 150 0.015
cell aging GO:0007569 52 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.015
mitotic nuclear division GO:0007067 119 0.015
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.015
regulation of response to external stimulus GO:0032101 222 0.015
rrna metabolic process GO:0016072 40 0.015
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.015
protein import GO:0017038 130 0.014
negative regulation of protein processing GO:0010955 142 0.014
mitochondrion organization GO:0007005 156 0.014
purine ribonucleotide catabolic process GO:0009154 404 0.014
regulation of membrane potential GO:0042391 95 0.014
negative regulation of cell cycle GO:0045786 193 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
regulation of gtpase activity GO:0043087 180 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
regulation of protein kinase activity GO:0045859 289 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
positive regulation of gtp catabolic process GO:0033126 166 0.014
cellular chemical homeostasis GO:0055082 180 0.014
multi organism reproductive process GO:0044703 54 0.014
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.014
cellular ketone metabolic process GO:0042180 80 0.013
purine nucleoside catabolic process GO:0006152 398 0.013
regulation of kinase activity GO:0043549 314 0.013
ribosomal large subunit biogenesis GO:0042273 10 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
regulation of peptidyl serine phosphorylation GO:0033135 50 0.013
mitotic g2 m transition checkpoint GO:0044818 9 0.013
defense response to other organism GO:0098542 129 0.013
negative regulation of cell proliferation GO:0008285 228 0.013
gtp catabolic process GO:0006184 237 0.013
protein monoubiquitination GO:0006513 39 0.013
regulation of map kinase activity GO:0043405 108 0.012
positive regulation of cellular amine metabolic process GO:0033240 7 0.012
regulation of cellular amine metabolic process GO:0033238 11 0.012
anterior posterior axis specification embryo GO:0008595 2 0.012
cellular response to oxidative stress GO:0034599 85 0.012
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.012
cellular response to hydrogen peroxide GO:0070301 37 0.012
positive regulation of cellular component organization GO:0051130 376 0.012
chromosome separation GO:0051304 23 0.012
regulation of stress activated mapk cascade GO:0032872 84 0.012
response to biotic stimulus GO:0009607 276 0.012
regulation of cellular component movement GO:0051270 334 0.012
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.012
mitotic g2 dna damage checkpoint GO:0007095 7 0.012
mitotic cytokinesis GO:0000281 19 0.012
negative regulation of multicellular organismal process GO:0051241 317 0.012
organelle localization GO:0051640 84 0.012
ribonucleotide catabolic process GO:0009261 405 0.011
regulation of ubiquitin protein transferase activity GO:0051438 28 0.011
Fly
positive regulation of spindle checkpoint GO:0090232 7 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
response to acid chemical GO:0001101 66 0.011
cytokine production GO:0001816 247 0.011
positive regulation of gtpase activity GO:0043547 166 0.011
positive regulation of phosphorylation GO:0042327 394 0.011
behavior GO:0007610 112 0.011
ras protein signal transduction GO:0007265 73 0.011
cytosolic calcium ion homeostasis GO:0051480 89 0.011
amine metabolic process GO:0009308 44 0.011
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.011
regulation of nucleotide catabolic process GO:0030811 205 0.011
negative regulation of transport GO:0051051 176 0.011
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.010
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.010
cell growth GO:0016049 160 0.010
cellular response to acid chemical GO:0071229 44 0.010
ribonucleoside triphosphate metabolic process GO:0009199 412 0.010
response to nitrogen compound GO:1901698 184 0.010
stress activated protein kinase signaling cascade GO:0031098 94 0.010

NEDD8 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.084
bone marrow disease DOID:4961 31 0.084
hematopoietic system disease DOID:74 100 0.084
anemia DOID:2355 55 0.019
sensory system disease DOID:0050155 203 0.017
eye and adnexa disease DOID:1492 150 0.017
nervous system disease DOID:863 431 0.017
congenital hypoplastic anemia DOID:1342 26 0.011
aplastic anemia DOID:12449 30 0.011
endocrine gland cancer DOID:170 26 0.011
cancer DOID:162 167 0.011
disease of cellular proliferation DOID:14566 174 0.011
organ system cancer DOID:0050686 164 0.011