Homo sapiens

65 known processes

TAP1

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

(Aliases: ABC17,TAP1*0102N,TAP1N,RING4,APT1,ABCB2,FLJ26666,D6S114E,PSF1,FLJ41500)

TAP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
antigen processing and presentation via mhc class ib GO:0002475 3 1.000
Human
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 1.000
Rat
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 6 0.999
antigen processing and presentation of endogenous peptide antigen via mhc class ib GO:0002476 2 0.999
Human
negative regulation of leukocyte mediated immunity GO:0002704 14 0.997
Rat
immune response inhibiting cell surface receptor signaling pathway GO:0002767 4 0.993
natural killer cell mediated cytotoxicity GO:0042267 23 0.991
Rat
transport of virus GO:0046794 14 0.991
detection of chemical stimulus GO:0009593 55 0.987
lymphocyte mediated immunity GO:0002449 48 0.986
Rat
negative regulation of leukocyte mediated cytotoxicity GO:0001911 5 0.984
Rat
viral life cycle GO:0019058 132 0.982
regulation by virus of viral protein levels in host cell GO:0046719 4 0.981
viral process GO:0016032 146 0.979
negative regulation of lymphocyte mediated immunity GO:0002707 12 0.970
Rat
multi organism cellular process GO:0044764 156 0.967
immune effector process GO:0002252 159 0.966
Rat
regulation of regulatory t cell differentiation GO:0045589 4 0.965
leukocyte mediated cytotoxicity GO:0001909 27 0.962
Rat
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.962
t cell mediated immunity GO:0002456 25 0.959
antigen processing and presentation of endogenous peptide antigen via mhc class i GO:0019885 5 0.959
intracellular transport of virus GO:0075733 14 0.947
adaptive immune response GO:0002250 49 0.943
positive regulation of leukocyte mediated immunity GO:0002705 24 0.942
defense response GO:0006952 315 0.940
Mouse Rat
positive regulation of leukocyte mediated cytotoxicity GO:0001912 16 0.939
leukocyte mediated immunity GO:0002443 59 0.936
Rat
regulation of adaptive immune response GO:0002819 33 0.936
antigen processing and presentation of peptide antigen via mhc class ib GO:0002428 2 0.932
Human
regulation of immune response GO:0050776 201 0.931
Rat
multi organism transport GO:0044766 14 0.925
positive regulation of cell killing GO:0031343 19 0.906
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.893
positive regulation of t cell mediated immunity GO:0002711 12 0.892
regulation of leukocyte mediated immunity GO:0002703 38 0.892
Rat
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway GO:0002484 3 0.887
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.877
response to other organism GO:0051707 261 0.870
negative regulation of defense response GO:0031348 47 0.856
Rat
interaction with host GO:0051701 42 0.850
multi organism localization GO:1902579 14 0.846
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.846
cytoplasmic transport GO:0016482 379 0.839
response to external biotic stimulus GO:0043207 261 0.829
regulation of t cell mediated immunity GO:0002709 18 0.827
sensory perception of taste GO:0050909 36 0.817
response to bacterium GO:0009617 144 0.815
positive regulation of regulatory t cell differentiation GO:0045591 3 0.808
positive regulation of immune effector process GO:0002699 40 0.804
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.800
immune response GO:0006955 307 0.795
Rat
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.788
regulation of defense response GO:0031347 154 0.773
Rat
antigen processing and presentation GO:0019882 33 0.749
positive regulation of immune system process GO:0002684 283 0.745
response to biotic stimulus GO:0009607 276 0.706
regulation of viral process GO:0050792 103 0.688
regulation of immune effector process GO:0002697 91 0.682
Rat
regulation of innate immune response GO:0045088 97 0.679
Rat
immune response inhibiting signal transduction GO:0002765 4 0.668
regulation of cell killing GO:0031341 22 0.649
Rat
regulation of t cell mediated cytotoxicity GO:0001914 8 0.632
antigen processing and presentation of endogenous antigen GO:0019883 7 0.629
sensory perception of chemical stimulus GO:0007606 38 0.626
regulation of lymphocyte mediated immunity GO:0002706 33 0.608
Rat
antigen processing and presentation of endogenous peptide antigen GO:0002483 6 0.608
detection of external biotic stimulus GO:0098581 19 0.605
regulation of multi organism process GO:0043900 157 0.601
positive regulation of cytokine production GO:0001819 167 0.580
positive regulation of developmental process GO:0051094 314 0.573
intracellular protein transport GO:0006886 270 0.555
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.547
positive regulation of adaptive immune response GO:0002821 21 0.534
immune response regulating signaling pathway GO:0002764 97 0.525
t cell proliferation GO:0042098 45 0.479
regulation of interferon gamma production GO:0032649 36 0.472
multi organism intracellular transport GO:1902583 14 0.448
natural killer cell mediated immunity GO:0002228 23 0.446
Rat
innate immune response GO:0045087 178 0.414
Rat
interspecies interaction between organisms GO:0044419 156 0.395
sensory perception of bitter taste GO:0050913 28 0.390
mononuclear cell proliferation GO:0032943 71 0.385
chemical homeostasis GO:0048878 306 0.370
regulation of interleukin 12 production GO:0032655 15 0.341
positive regulation of natural killer cell mediated immunity GO:0002717 12 0.335
positive regulation of leukocyte activation GO:0002696 80 0.327
lymphocyte proliferation GO:0046651 70 0.308
antigen processing and presentation of peptide antigen GO:0048002 18 0.307
positive regulation of antigen processing and presentation GO:0002579 1 0.302
t cell mediated cytotoxicity GO:0001913 9 0.302
detection of biotic stimulus GO:0009595 21 0.298
regulation of leukocyte mediated cytotoxicity GO:0001910 19 0.293
Rat
regulation of leukocyte activation GO:0002694 115 0.291
amide transport GO:0042886 76 0.289
positive regulation of t cell mediated cytotoxicity GO:0001916 7 0.287
import into cell GO:0098657 2 0.273
cytokine production GO:0001816 247 0.272
negative regulation of immune effector process GO:0002698 38 0.270
Rat
positive regulation of innate immune response GO:0045089 79 0.259
interferon gamma production GO:0032609 39 0.251
positive regulation of defense response GO:0031349 87 0.251
positive regulation of immune response GO:0050778 159 0.251
negative regulation of t cell proliferation GO:0042130 8 0.243
regulation of lymphocyte proliferation GO:0050670 64 0.241
multicellular organismal homeostasis GO:0048871 67 0.240
regulation of t cell differentiation GO:0045580 19 0.231
peptide transport GO:0015833 74 0.230
lymphocyte activation GO:0046649 133 0.221
t cell tolerance induction GO:0002517 4 0.221
response to molecule of bacterial origin GO:0002237 82 0.214
positive regulation of interferon gamma production GO:0032729 26 0.204
regulation of lymphocyte activation GO:0051249 103 0.203
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.200
t cell activation GO:0042110 99 0.197
cell activation GO:0001775 213 0.191
regulation of t cell tolerance induction GO:0002664 4 0.191
regulation of cytokine production GO:0001817 232 0.188
negative regulation of immune system process GO:0002683 136 0.181
Rat
positive regulation of cell differentiation GO:0045597 211 0.171
detection of stimulus involved in sensory perception GO:0050906 43 0.163
negative regulation of developmental process GO:0051093 247 0.162
antigen processing and presentation of exogenous antigen GO:0019884 4 0.160
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.159
detection of stimulus GO:0051606 85 0.159
iron ion import into cell GO:0097459 2 0.158
hematopoietic or lymphoid organ development GO:0048534 186 0.156
regulation of leukocyte proliferation GO:0070663 67 0.152
regulation of cell differentiation GO:0045595 393 0.151
cell adhesion GO:0007155 325 0.148
intracellular transport of viral protein in host cell GO:0019060 4 0.143
regulation of t cell activation GO:0050863 77 0.143
regulation of mononuclear cell proliferation GO:0032944 65 0.142
regulation of leukocyte differentiation GO:1902105 61 0.129
negative regulation of leukocyte activation GO:0002695 26 0.123
regulation of t cell proliferation GO:0042129 42 0.118
type i interferon signaling pathway GO:0060337 11 0.117
negative regulation of multicellular organismal process GO:0051241 317 0.116
positive regulation of lymphocyte differentiation GO:0045621 13 0.114
immune response activating signal transduction GO:0002757 90 0.113
post embryonic development GO:0009791 2 0.113
cell killing GO:0001906 34 0.110
Rat
negative regulation of viral process GO:0048525 66 0.108
regulation of viral entry into host cell GO:0046596 17 0.102
extracellular transport GO:0006858 4 0.102
leukocyte differentiation GO:0002521 98 0.101
positive regulation of cell activation GO:0050867 81 0.095
positive regulation of lymphocyte activation GO:0051251 73 0.094
regulation of lymphocyte differentiation GO:0045619 22 0.092
protection from natural killer cell mediated cytotoxicity GO:0042270 3 0.092
Rat
regulation of cell activation GO:0050865 125 0.092
positive regulation of interleukin 12 production GO:0032735 8 0.089
leukocyte activation GO:0045321 164 0.080
activation of immune response GO:0002253 114 0.079
dendritic cell differentiation GO:0097028 13 0.079
negative regulation of cell proliferation GO:0008285 228 0.079
regulation of apoptotic signaling pathway GO:2001233 175 0.078
positive regulation of interleukin 13 production GO:0032736 4 0.077
defense response to other organism GO:0098542 129 0.075
lymphocyte differentiation GO:0030098 35 0.075
cd8 positive alpha beta t cell activation GO:0036037 3 0.071
apoptotic signaling pathway GO:0097190 268 0.071
cation transport GO:0006812 331 0.071
system process GO:0003008 349 0.071
antigen processing and presentation of exogenous peptide antigen GO:0002478 4 0.068
negative regulation of cell activation GO:0050866 33 0.067
nuclear export GO:0051168 69 0.065
regulation of natural killer cell mediated immunity GO:0002715 16 0.064
Rat
response to abiotic stimulus GO:0009628 336 0.063
immune system development GO:0002520 195 0.063
t cell differentiation GO:0030217 29 0.062
cellular protein complex assembly GO:0043623 188 0.062
positive regulation of programmed cell death GO:0043068 249 0.062
regulation of cell cycle GO:0051726 393 0.061
response to peptidoglycan GO:0032494 3 0.060
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.059
regulation of transferase activity GO:0051338 355 0.059
purine containing compound catabolic process GO:0072523 411 0.058
Human Rat
cellular response to cytokine stimulus GO:0071345 181 0.057
positive regulation of apoptotic process GO:0043065 246 0.056
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway tap independent GO:0002486 3 0.056
mitotic cell cycle process GO:1903047 286 0.054
positive regulation of leukocyte differentiation GO:1902107 37 0.053
positive regulation of interleukin 4 biosynthetic process GO:0045404 1 0.053
nucleoside phosphate biosynthetic process GO:1901293 109 0.052
negative regulation of cell cycle GO:0045786 193 0.048
cellular response to dna damage stimulus GO:0006974 379 0.047
negative regulation of viral genome replication GO:0045071 35 0.046
regulation of proteolysis GO:0030162 293 0.046
tissue homeostasis GO:0001894 63 0.046
negative regulation of phosphate metabolic process GO:0045936 267 0.046
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.046
positive regulation of memory t cell activation GO:2000568 1 0.044
extrinsic apoptotic signaling pathway GO:0097191 119 0.043
activation of innate immune response GO:0002218 55 0.042
negative regulation of multi organism process GO:0043901 92 0.042
positive regulation of mhc class i biosynthetic process GO:0045345 4 0.041
natural killer cell differentiation GO:0001779 2 0.041
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.040
anatomical structure homeostasis GO:0060249 100 0.040
cellular response to external stimulus GO:0071496 111 0.040
positive regulation of t cell activation GO:0050870 54 0.039
negative regulation of dendritic cell differentiation GO:2001199 2 0.038
biological adhesion GO:0022610 331 0.038
cellular response to interferon gamma GO:0071346 24 0.038
detection of other organism GO:0098543 13 0.038
cellular response to lipid GO:0071396 127 0.034
positive regulation of cell death GO:0010942 263 0.034
cellular macromolecule catabolic process GO:0044265 380 0.034
cell cycle arrest GO:0007050 71 0.034
regulation of transmembrane transport GO:0034762 139 0.034
inorganic ion import into cell GO:0099587 2 0.033
pattern recognition receptor signaling pathway GO:0002221 48 0.032
regulation of dendritic cell differentiation GO:2001198 3 0.032
regulation of antigen processing and presentation of peptide antigen GO:0002583 4 0.031
leukocyte proliferation GO:0070661 74 0.030
response to virus GO:0009615 126 0.030
mitotic spindle elongation GO:0000022 4 0.029
negative regulation of phosphorus metabolic process GO:0010563 267 0.029
metal ion transport GO:0030001 272 0.029
regulation of cellular protein catabolic process GO:1903362 96 0.029
negative regulation of apoptotic process GO:0043066 316 0.028
cellular protein catabolic process GO:0044257 261 0.028
negative regulation of protein metabolic process GO:0051248 391 0.028
defense response to virus GO:0051607 71 0.028
negative regulation of lymphocyte activation GO:0051250 24 0.028
response to mechanical stimulus GO:0009612 51 0.027
spindle elongation GO:0051231 4 0.027
negative regulation of mononuclear cell proliferation GO:0032945 15 0.027
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.027
Human Rat
iron ion transport GO:0006826 12 0.027
modification dependent protein catabolic process GO:0019941 209 0.027
nucleotide catabolic process GO:0009166 408 0.027
Human Rat
hemopoiesis GO:0030097 180 0.026
regulation of cell migration GO:0030334 289 0.026
microtubule organizing center organization GO:0031023 62 0.026
interleukin 13 production GO:0032616 7 0.026
negative regulation of apoptotic signaling pathway GO:2001234 97 0.025
sensory perception GO:0007600 103 0.025
centrosome organization GO:0051297 58 0.025
protein export from nucleus GO:0006611 29 0.025
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.025
purine nucleotide catabolic process GO:0006195 405 0.024
Human Rat
entry into host cell GO:0030260 25 0.023
intracellular protein transport in other organism involved in symbiotic interaction GO:0051708 4 0.023
negative regulation of immune response GO:0050777 40 0.023
Rat
regulation of interleukin 4 biosynthetic process GO:0045402 2 0.023
regulation of tolerance induction GO:0002643 4 0.022
regeneration GO:0031099 4 0.022
posttranscriptional regulation of gene expression GO:0010608 213 0.022
positive regulation of cytokine biosynthetic process GO:0042108 25 0.022
regulation of viral transcription GO:0046782 34 0.022
regulation of natural killer cell differentiation GO:0032823 2 0.022
positive regulation of apoptotic signaling pathway GO:2001235 70 0.022
negative regulation of cell motility GO:2000146 104 0.021
protein catabolic process GO:0030163 325 0.021
microtubule cytoskeleton organization GO:0000226 176 0.021
regulation of type i interferon production GO:0032479 26 0.021
negative regulation of natural killer cell mediated immunity GO:0002716 5 0.021
Rat
mitotic cell cycle GO:0000278 326 0.021
t cell differentiation in thymus GO:0033077 4 0.021
positive regulation of cellular component biogenesis GO:0044089 158 0.021
purine nucleoside triphosphate metabolic process GO:0009144 412 0.021
Human Rat
multi organism metabolic process GO:0044033 41 0.021
positive regulation of interferon beta production GO:0032728 17 0.021
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.020
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.020
innate immune response activating signal transduction GO:0002758 48 0.020
protein localization to organelle GO:0033365 280 0.019
regulation of cd8 positive alpha beta t cell proliferation GO:2000564 1 0.019
guanosine containing compound catabolic process GO:1901069 239 0.019
interleukin 4 biosynthetic process GO:0042097 2 0.019
nucleocytoplasmic transport GO:0006913 176 0.019
determination of adult lifespan GO:0008340 2 0.018
negative regulation of interleukin 2 secretion GO:1900041 2 0.018
regulation of protein localization GO:0032880 296 0.018
positive regulation of proteolysis GO:0045862 142 0.018
microtubule based process GO:0007017 210 0.018
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.018
interleukin 2 production GO:0032623 20 0.018
negative regulation of cell differentiation GO:0045596 171 0.017
purine ribonucleotide catabolic process GO:0009154 404 0.017
Human Rat
negative regulation of cell death GO:0060548 345 0.017
regulation of purine nucleotide metabolic process GO:1900542 264 0.017
regulation of cell cycle phase transition GO:1901987 126 0.017
nucleoside phosphate catabolic process GO:1901292 412 0.017
Human Rat
regulation of kinase activity GO:0043549 314 0.017
memory t cell activation GO:0035709 1 0.017
ribonucleoside triphosphate catabolic process GO:0009203 391 0.017
Human Rat
negative regulation of leukocyte differentiation GO:1902106 24 0.016
protein refolding GO:0042026 14 0.016
positive regulation of cellular catabolic process GO:0031331 284 0.016
regulation of cytokine biosynthetic process GO:0042035 35 0.016
regulation of cytoskeleton organization GO:0051493 177 0.016
regulation of antigen processing and presentation GO:0002577 6 0.016
positive regulation of tolerance induction GO:0002645 2 0.015
regulation of protein catabolic process GO:0042176 155 0.015
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 5 0.015
Rat
protein oligomerization GO:0051259 173 0.015
purine nucleoside catabolic process GO:0006152 398 0.015
Human Rat
rna catabolic process GO:0006401 71 0.015
regulation of cellular component movement GO:0051270 334 0.015
mitotic cell cycle phase transition GO:0044772 162 0.015
response to type i interferon GO:0034340 14 0.015
negative regulation of catalytic activity GO:0043086 335 0.014
transition metal ion transport GO:0000041 23 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.014
negative regulation of phosphorylation GO:0042326 174 0.014
mitotic spindle organization GO:0007052 27 0.014
modification dependent macromolecule catabolic process GO:0043632 212 0.014
cellular macromolecular complex assembly GO:0034622 324 0.014
nucleoside triphosphate metabolic process GO:0009141 422 0.013
Human Rat
regulation of response to cytokine stimulus GO:0060759 46 0.013
negative regulation of kinase activity GO:0033673 106 0.013
entry into host GO:0044409 25 0.013
regulation of purine nucleotide catabolic process GO:0033121 205 0.013
regulatory t cell differentiation GO:0045066 5 0.013
response to muramyl dipeptide GO:0032495 4 0.013
response to interferon gamma GO:0034341 39 0.013
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.013
mapk cascade GO:0000165 288 0.013
detection of peptidoglycan GO:0032499 1 0.012
positive regulation of interleukin 2 production GO:0032743 11 0.012
positive regulation of protein complex assembly GO:0031334 86 0.012
osteoblast differentiation GO:0001649 92 0.012
positive regulation of secretion GO:0051047 116 0.012
negative regulation of leukocyte proliferation GO:0070664 16 0.012
regulation of anatomical structure morphogenesis GO:0022603 286 0.012
regulation of cysteine type endopeptidase activity GO:2000116 127 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
regulation of intracellular transport GO:0032386 195 0.012
negative regulation of transferase activity GO:0051348 124 0.012
ubiquitin dependent protein catabolic process GO:0006511 206 0.012
negative regulation of cellular protein metabolic process GO:0032269 353 0.012
alpha beta t cell differentiation GO:0046632 7 0.012
negative regulation of t cell activation GO:0050868 18 0.011
regulation of viral genome replication GO:0045069 48 0.011
negative regulation of viral release from host cell GO:1902187 12 0.011
nucleoside triphosphate catabolic process GO:0009143 394 0.011
Human Rat
negative regulation of protein modification process GO:0031400 200 0.011
cytokine biosynthetic process GO:0042089 37 0.011
glycosyl compound catabolic process GO:1901658 413 0.011
Human Rat
negative regulation of innate immune response GO:0045824 18 0.011
Rat
single organism cellular localization GO:1902580 332 0.011
positive regulation of synaptic transmission GO:0050806 4 0.011
neurogenesis GO:0022008 169 0.011
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 22 0.011
proteasomal ubiquitin independent protein catabolic process GO:0010499 3 0.011
interleukin 12 production GO:0032615 15 0.010
negative regulation of mitotic cell cycle GO:0045930 102 0.010
regulation of nucleoside metabolic process GO:0009118 209 0.010
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.010
gtp catabolic process GO:0006184 237 0.010
positive regulation of interleukin 4 production GO:0032753 3 0.010

TAP1 disease predictions

Disease DO term ID Size Probability Func Analog Org
primary immunodeficiency disease DOID:612 36 0.984
severe combined immunodeficiency DOID:627 10 0.984
combined t cell and b cell immunodeficiency DOID:628 12 0.984
immune system disease DOID:2914 155 0.984
cancer DOID:162 167 0.045
disease of cellular proliferation DOID:14566 174 0.045
organ system cancer DOID:0050686 164 0.045
disease by infectious agent DOID:0050117 34 0.028
viral infectious disease DOID:934 13 0.028
musculoskeletal system disease DOID:17 223 0.022
acquired immunodeficiency syndrome DOID:635 13 0.011
human immunodeficiency virus infectious disease DOID:526 13 0.011
mhc class i deficiency DOID:0060009 3 0.001