Homo sapiens

34 known processes

TDP1

tyrosyl-DNA phosphodiesterase 1

(Aliases: FLJ11090,MGC104252)

TDP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna repair GO:0006281 198 0.654
cellular response to dna damage stimulus GO:0006974 379 0.550
microtubule based process GO:0007017 210 0.145
regulation of mitotic cell cycle GO:0007346 189 0.116
dna recombination GO:0006310 77 0.114
organophosphate catabolic process GO:0046434 430 0.087
mitotic cell cycle phase transition GO:0044772 162 0.083
base excision repair GO:0006284 21 0.083
mitotic sister chromatid segregation GO:0000070 53 0.081
female gamete generation GO:0007292 2 0.080
regulation of cell cycle GO:0051726 393 0.076
nuclear division GO:0000280 128 0.076
microtubule cytoskeleton organization GO:0000226 176 0.071
cellular response to endogenous stimulus GO:0071495 336 0.068
mitotic cell cycle process GO:1903047 286 0.067
organelle fission GO:0048285 149 0.065
double strand break repair GO:0006302 101 0.064
nucleoside phosphate catabolic process GO:1901292 412 0.062
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.060
mitotic cell cycle GO:0000278 326 0.060
post embryonic development GO:0009791 2 0.060
meiotic chromosome segregation GO:0045132 4 0.056
carbohydrate derivative biosynthetic process GO:1901137 207 0.056
response to abiotic stimulus GO:0009628 336 0.056
cellular protein complex assembly GO:0043623 188 0.054
glycosyl compound catabolic process GO:1901658 413 0.050
regulation of cell cycle process GO:0010564 266 0.049
anatomical structure formation involved in morphogenesis GO:0048646 284 0.048
cellular ketone metabolic process GO:0042180 80 0.047
purine nucleotide catabolic process GO:0006195 405 0.047
histone acetylation GO:0016573 93 0.047
single organism cellular localization GO:1902580 332 0.046
regulation of microtubule based process GO:0032886 74 0.046
nucleotide catabolic process GO:0009166 408 0.044
histone modification GO:0016570 251 0.044
purine containing compound catabolic process GO:0072523 411 0.043
chromosome segregation GO:0007059 114 0.043
organophosphate biosynthetic process GO:0090407 163 0.043
determination of adult lifespan GO:0008340 2 0.043
nervous system development GO:0007399 293 0.042
sister chromatid segregation GO:0000819 54 0.041
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.041
protein catabolic process GO:0030163 325 0.041
cellular amine metabolic process GO:0044106 41 0.040
segmentation GO:0035282 4 0.040
purine nucleoside triphosphate catabolic process GO:0009146 392 0.038
nucleoside triphosphate catabolic process GO:0009143 394 0.038
regulation of protein localization GO:0032880 296 0.038
cell cycle phase transition GO:0044770 173 0.038
negative regulation of cellular component organization GO:0051129 235 0.037
cellular macromolecule catabolic process GO:0044265 380 0.037
nucleoside phosphate biosynthetic process GO:1901293 109 0.036
purine nucleoside catabolic process GO:0006152 398 0.036
nucleoside monophosphate metabolic process GO:0009123 191 0.036
cell activation GO:0001775 213 0.036
meiosis i GO:0007127 4 0.036
regulation of proteolysis GO:0030162 293 0.035
establishment of organelle localization GO:0051656 59 0.034
mitotic nuclear division GO:0007067 119 0.034
dna dependent dna replication GO:0006261 44 0.034
regulation of microtubule cytoskeleton organization GO:0070507 61 0.033
purine nucleoside monophosphate metabolic process GO:0009126 186 0.033
protein processing GO:0016485 226 0.033
double strand break repair via homologous recombination GO:0000724 50 0.032
mitotic cell cycle checkpoint GO:0007093 68 0.032
single organism carbohydrate metabolic process GO:0044723 193 0.032
regulation of cellular amino acid metabolic process GO:0006521 6 0.031
oogenesis GO:0048477 2 0.030
positive regulation of hydrolase activity GO:0051345 331 0.030
negative regulation of cell cycle process GO:0010948 121 0.030
negative regulation of cellular protein metabolic process GO:0032269 353 0.029
negative regulation of protein metabolic process GO:0051248 391 0.029
positive regulation of immune system process GO:0002684 283 0.029
anatomical structure homeostasis GO:0060249 100 0.028
ribonucleoside triphosphate catabolic process GO:0009203 391 0.028
regulation of meiotic cell cycle GO:0051445 4 0.028
regulation of response to dna damage stimulus GO:2001020 94 0.028
enzyme linked receptor protein signaling pathway GO:0007167 303 0.027
dna damage checkpoint GO:0000077 68 0.027
nucleoside catabolic process GO:0009164 408 0.027
immune system development GO:0002520 195 0.027
recombinational repair GO:0000725 50 0.027
purine ribonucleoside metabolic process GO:0046128 437 0.026
sex determination GO:0007530 3 0.026
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.026
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.025
regulation of mitotic cell cycle phase transition GO:1901990 118 0.025
chromatin organization GO:0006325 351 0.025
nucleoside triphosphate metabolic process GO:0009141 422 0.025
negative regulation of cell cycle GO:0045786 193 0.025
positive regulation of apoptotic process GO:0043065 246 0.024
oocyte development GO:0048599 1 0.023
protein autophosphorylation GO:0046777 123 0.023
negative regulation of dna metabolic process GO:0051053 57 0.023
maintenance of location in cell GO:0051651 62 0.023
regulation of dna metabolic process GO:0051052 153 0.023
positive regulation of cell death GO:0010942 263 0.023
response to oxygen containing compound GO:1901700 369 0.023
attachment of spindle microtubules to kinetochore GO:0008608 17 0.023
regulation of cellular response to stress GO:0080135 244 0.023
embryo development GO:0009790 123 0.023
ribonucleotide catabolic process GO:0009261 405 0.022
ribonucleoside monophosphate metabolic process GO:0009161 187 0.022
single organism membrane organization GO:0044802 268 0.022
nucleus organization GO:0006997 28 0.022
regulation of proteasomal protein catabolic process GO:0061136 87 0.022
negative regulation of cellular catabolic process GO:0031330 83 0.022
spindle organization GO:0007051 53 0.022
negative regulation of protein maturation GO:1903318 142 0.022
immune response GO:0006955 307 0.022
leukocyte activation GO:0045321 164 0.022
regulation of protein processing GO:0070613 150 0.022
proteasomal protein catabolic process GO:0010498 176 0.021
mrna metabolic process GO:0016071 175 0.021
regulation of cell division GO:0051302 116 0.021
regulation of cellular amine metabolic process GO:0033238 11 0.021
blastocyst development GO:0001824 3 0.021
purine nucleoside triphosphate metabolic process GO:0009144 412 0.021
ribonucleoside catabolic process GO:0042454 406 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.020
nucleotide excision repair GO:0006289 31 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.020
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.020
nucleoside monophosphate catabolic process GO:0009125 159 0.020
regulation of cellular component movement GO:0051270 334 0.020
regulation of immune response GO:0050776 201 0.020
negative regulation of programmed cell death GO:0043069 321 0.020
regulation of chromosome segregation GO:0051983 44 0.020
positive regulation of developmental process GO:0051094 314 0.020
protein maturation GO:0051604 233 0.020
cell morphogenesis GO:0000902 296 0.020
negative regulation of cell cycle phase transition GO:1901988 89 0.020
cell projection organization GO:0030030 252 0.020
cellular protein catabolic process GO:0044257 261 0.019
nucleotide biosynthetic process GO:0009165 109 0.019
response to growth factor GO:0070848 205 0.019
response to radiation GO:0009314 151 0.019
purine ribonucleotide catabolic process GO:0009154 404 0.019
locomotory behavior GO:0007626 1 0.019
organelle assembly GO:0070925 176 0.019
regulation of cellular ketone metabolic process GO:0010565 50 0.019
mitochondrion organization GO:0007005 156 0.019
negative regulation of proteolysis GO:0045861 132 0.019
cellular response to growth factor stimulus GO:0071363 197 0.018
intracellular mrna localization GO:0008298 1 0.018
multicellular organismal aging GO:0010259 3 0.018
protein localization to organelle GO:0033365 280 0.018
positive regulation of response to dna damage stimulus GO:2001022 43 0.018
response to biotic stimulus GO:0009607 276 0.018
endocytosis GO:0006897 159 0.018
cellular amino acid metabolic process GO:0006520 116 0.018
purine ribonucleoside catabolic process GO:0046130 398 0.018
cellular response to oxygen containing compound GO:1901701 276 0.018
anterior posterior axis specification GO:0009948 2 0.018
endomembrane system organization GO:0010256 196 0.018
oocyte differentiation GO:0009994 2 0.018
ribonucleoside triphosphate metabolic process GO:0009199 412 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.017
atp metabolic process GO:0046034 176 0.017
regulation of viral process GO:0050792 103 0.017
chromatin modification GO:0016568 298 0.017
carbohydrate metabolic process GO:0005975 207 0.017
striated muscle myosin thick filament assembly GO:0071688 2 0.017
negative regulation of organelle organization GO:0010639 126 0.017
reciprocal dna recombination GO:0035825 4 0.017
protein glycosylation GO:0006486 62 0.017
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.017
positive regulation of nucleotide metabolic process GO:0045981 230 0.017
cell division GO:0051301 168 0.017
protein targeting GO:0006605 187 0.017
defense response GO:0006952 315 0.017
internal peptidyl lysine acetylation GO:0018393 97 0.016
intracellular protein transport GO:0006886 270 0.016
cardiovascular system development GO:0072358 262 0.016
negative regulation of immune system process GO:0002683 136 0.016
cellular response to radiation GO:0071478 65 0.016
anterior posterior axis specification embryo GO:0008595 2 0.016
covalent chromatin modification GO:0016569 254 0.016
peptidyl lysine acetylation GO:0018394 101 0.016
regulation of protein maturation GO:1903317 150 0.016
maintenance of protein location GO:0045185 57 0.016
single organism reproductive process GO:0044702 98 0.016
vesicle mediated transport GO:0016192 371 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
cellular macromolecular complex assembly GO:0034622 324 0.016
adult locomotory behavior GO:0008344 1 0.016
mitotic dna integrity checkpoint GO:0044774 30 0.016
positive regulation of cellular amine metabolic process GO:0033240 7 0.016
regulation of cellular component biogenesis GO:0044087 281 0.015
lipid metabolic process GO:0006629 381 0.015
regulation of defense response GO:0031347 154 0.015
regulation of leukocyte activation GO:0002694 115 0.015
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.015
regulation of dna repair GO:0006282 47 0.015
positive regulation of immune response GO:0050778 159 0.015
mitotic sister chromatid separation GO:0051306 18 0.015
cellular response to abiotic stimulus GO:0071214 117 0.015
glycerolipid metabolic process GO:0046486 107 0.015
regulation of nucleotide catabolic process GO:0030811 205 0.015
cytoplasmic transport GO:0016482 379 0.015
protein dephosphorylation GO:0006470 81 0.015
dna geometric change GO:0032392 32 0.015
glycosylation GO:0070085 71 0.015
internal protein amino acid acetylation GO:0006475 101 0.015
cell part morphogenesis GO:0032990 137 0.015
atp catabolic process GO:0006200 157 0.015
regulation of nucleoside metabolic process GO:0009118 209 0.015
protein import into nucleus GO:0006606 104 0.015
secretion GO:0046903 254 0.015
positive regulation of mapk cascade GO:0043410 190 0.014
growth GO:0040007 202 0.014
purine nucleoside monophosphate catabolic process GO:0009128 158 0.014
ras protein signal transduction GO:0007265 73 0.014
negative regulation of phosphorus metabolic process GO:0010563 267 0.014
regulation of lymphocyte activation GO:0051249 103 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
glycoprotein biosynthetic process GO:0009101 91 0.014
protein targeting to nucleus GO:0044744 104 0.014
regulation of protein catabolic process GO:0042176 155 0.014
circulatory system development GO:0072359 262 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
response to oxygen levels GO:0070482 100 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.014
reciprocal meiotic recombination GO:0007131 4 0.014
positive regulation of immunoglobulin production GO:0002639 4 0.013
gtp catabolic process GO:0006184 237 0.013
negative regulation of catalytic activity GO:0043086 335 0.013
ubiquitin dependent protein catabolic process GO:0006511 206 0.013
positive regulation of catabolic process GO:0009896 310 0.013
protein homooligomerization GO:0051260 100 0.013
organonitrogen compound biosynthetic process GO:1901566 200 0.013
glycoprotein metabolic process GO:0009100 110 0.013
cellular lipid metabolic process GO:0044255 303 0.013
central nervous system development GO:0007417 123 0.013
regulation of cell motility GO:2000145 299 0.013
nuclear import GO:0051170 106 0.013
neurogenesis GO:0022008 169 0.013
response to external biotic stimulus GO:0043207 261 0.013
regulation of nuclear division GO:0051783 65 0.013
regulation of nucleotide metabolic process GO:0006140 269 0.013
regulation of multi organism process GO:0043900 157 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.013
dna integrity checkpoint GO:0031570 71 0.013
protein oligomerization GO:0051259 173 0.013
positive regulation of cellular catabolic process GO:0031331 284 0.012
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.012
membrane organization GO:0061024 292 0.012
response to organonitrogen compound GO:0010243 156 0.012
brain development GO:0007420 97 0.012
epithelium development GO:0060429 227 0.012
response to hypoxia GO:0001666 96 0.012
dephosphorylation GO:0016311 209 0.012
regulation of gene expression epigenetic GO:0040029 73 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
neuromuscular junction development GO:0007528 3 0.012
cellular component disassembly GO:0022411 92 0.012
regulation of cell cycle phase transition GO:1901987 126 0.012
apoptotic signaling pathway GO:0097190 268 0.012
cellular response to organonitrogen compound GO:0071417 124 0.012
regulation of kinase activity GO:0043549 314 0.012
establishment of protein localization to organelle GO:0072594 172 0.012
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.012
chemical homeostasis GO:0048878 306 0.012
regeneration GO:0031099 4 0.012
cell development GO:0048468 328 0.012
regulation of meiosis GO:0040020 3 0.012
microtubule anchoring GO:0034453 24 0.012
regulation of purine nucleotide metabolic process GO:1900542 264 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
maintenance of location GO:0051235 112 0.011
protein acylation GO:0043543 138 0.011
protein localization to nucleus GO:0034504 136 0.011
hematopoietic or lymphoid organ development GO:0048534 186 0.011
spindle elongation GO:0051231 4 0.011
reproduction GO:0000003 63 0.011
cell projection morphogenesis GO:0048858 129 0.011
hemopoiesis GO:0030097 180 0.011
cytokine production GO:0001816 247 0.011
regulation of intracellular transport GO:0032386 195 0.011
cell cycle checkpoint GO:0000075 117 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
ribonucleotide biosynthetic process GO:0009260 81 0.011
cellular component morphogenesis GO:0032989 314 0.011
regulation of intracellular protein transport GO:0033157 123 0.011
dna catabolic process GO:0006308 49 0.011
guanosine containing compound metabolic process GO:1901068 244 0.011
actin filament based process GO:0030029 224 0.011
positive regulation of protein transport GO:0051222 135 0.011
amine metabolic process GO:0009308 44 0.011
head development GO:0060322 108 0.011
lipid biosynthetic process GO:0008610 177 0.011
response to other organism GO:0051707 261 0.011
maintenance of protein location in cell GO:0032507 56 0.010
negative regulation of apoptotic process GO:0043066 316 0.010
positive regulation of nucleoside metabolic process GO:0045979 186 0.010
neuron differentiation GO:0030182 138 0.010
negative regulation of mitotic cell cycle GO:0045930 102 0.010
regulation of locomotion GO:0040012 329 0.010
dna strand elongation involved in dna replication GO:0006271 3 0.010
oxidation reduction process GO:0055114 396 0.010
establishment or maintenance of cell polarity GO:0007163 31 0.010
immune effector process GO:0002252 159 0.010
signal transduction in response to dna damage GO:0042770 57 0.010
positive regulation of nucleotide catabolic process GO:0030813 185 0.010
ribose phosphate biosynthetic process GO:0046390 82 0.010

TDP1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.055
inherited metabolic disorder DOID:655 242 0.055
disease of cellular proliferation DOID:14566 174 0.053
cancer DOID:162 167 0.050
breast cancer DOID:1612 21 0.022
thoracic cancer DOID:5093 21 0.022
organ system cancer DOID:0050686 164 0.022
nervous system disease DOID:863 431 0.014
neuropathy DOID:870 52 0.014
central nervous system disease DOID:331 186 0.012
disease of mental health DOID:150 70 0.011
neurodegenerative disease DOID:1289 102 0.004
spinocerebellar degeneration DOID:2478 27 0.001
spinocerebellar ataxia DOID:1441 26 0.001