|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.993
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.989
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.988
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
23 |
0.978
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.975
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
18 |
0.968
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.961
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.959
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.959
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.956
|
|
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.954
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.948
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.945
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.936
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001240 |
16 |
0.934
|
|
|
|
positive regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903557 |
22 |
0.932
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.926
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
0.921
|
|
|
|
trail activated apoptotic signaling pathway
|
GO:0036462 |
4 |
0.919
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.916
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.909
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.906
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.894
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.889
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.870
|
|
|
|
negative regulation of neurological system process
|
GO:0031645 |
2 |
0.864
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.864
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.857
|
|
|
|
osteoclast differentiation
|
GO:0030316 |
21 |
0.856
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.854
|
|
|
|
regulation of tyrosine phosphorylation of stat protein
|
GO:0042509 |
30 |
0.846
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.845
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.843
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.831
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.831
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
22 |
0.810
|
|
|
|
positive regulation of membrane protein ectodomain proteolysis
|
GO:0051044 |
13 |
0.806
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.778
|
|
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.760
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.751
|
|
|
|
positive regulation of tyrosine phosphorylation of stat protein
|
GO:0042531 |
28 |
0.747
|
|
|
|
positive regulation of erk1 and erk2 cascade via tnfsf11 mediated signaling
|
GO:0071848 |
2 |
0.746
|
|
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
27 |
0.744
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.743
|
|
|
|
regulation of cdc42 protein signal transduction
|
GO:0032489 |
14 |
0.725
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.723
|
|
|
|
cellular response to hyperoxia
|
GO:0071455 |
4 |
0.719
|
|
|
|
positive regulation of cdc42 gtpase activity
|
GO:0043089 |
6 |
0.713
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.697
|
|
|
|
cellular response to increased oxygen levels
|
GO:0036295 |
4 |
0.682
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.670
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.670
|
|
|
|
response to nitric oxide
|
GO:0071731 |
4 |
0.667
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.660
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.652
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.651
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.649
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
20 |
0.632
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.630
|
|
|
|
positive regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042511 |
8 |
0.621
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.596
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.589
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.579
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.576
|
|
|
|
neuronal action potential
|
GO:0019228 |
9 |
0.568
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.568
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.556
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.556
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.549
|
|
|
|
necroptotic signaling pathway
|
GO:0097527 |
6 |
0.548
|
|
|
|
positive regulation of endothelial cell apoptotic process
|
GO:2000353 |
8 |
0.540
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.538
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.534
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.523
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.517
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.513
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.508
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.508
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.504
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.499
|
|
|
|
action potential
|
GO:0001508 |
34 |
0.486
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.484
|
|
|
|
endothelial cell apoptotic process
|
GO:0072577 |
26 |
0.479
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.469
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.463
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.461
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.455
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.442
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.441
|
|
|
|
membrane protein proteolysis
|
GO:0033619 |
38 |
0.435
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.434
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.432
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.429
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.426
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.422
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.415
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.414
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.412
|
|
|
|
peptidyl serine autophosphorylation
|
GO:0036289 |
2 |
0.410
|
|
|
|
regulation of osteoclast differentiation
|
GO:0045670 |
18 |
0.393
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.393
|
|
|
|
positive regulation of necroptotic process
|
GO:0060545 |
2 |
0.393
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.392
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.392
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.392
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.390
|
|
|
|
positive regulation of osteoclast differentiation
|
GO:0045672 |
9 |
0.386
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.385
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.383
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.377
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.373
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.370
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.369
|
|
|
|
membrane protein ectodomain proteolysis
|
GO:0006509 |
33 |
0.366
|
|
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.365
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.361
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.360
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.359
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.356
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.354
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.351
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.351
|
|
|
|
response to hyperoxia
|
GO:0055093 |
4 |
0.345
|
|
|
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097192 |
22 |
0.342
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.340
|
|
|
|
tyrosine phosphorylation of stat1 protein
|
GO:0042508 |
11 |
0.339
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
0.335
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.335
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.331
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.328
|
|
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
44 |
0.326
|
|
|
|
cdc42 protein signal transduction
|
GO:0032488 |
4 |
0.322
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.320
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.318
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.313
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.311
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.307
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.307
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.306
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.299
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.299
|
|
|
|
positive regulation of protein homodimerization activity
|
GO:0090073 |
5 |
0.298
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.297
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.296
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.293
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.288
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.286
|
|
|
|
positive regulation of nik nf kappab signaling
|
GO:1901224 |
10 |
0.284
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.280
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.280
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.278
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.278
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.275
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.271
|
|
|
|
interleukin 6 production
|
GO:0032635 |
37 |
0.271
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.270
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.256
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.255
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
20 |
0.251
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.246
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.244
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.243
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.241
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.235
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.234
|
|
|
|
necrotic cell death
|
GO:0070265 |
21 |
0.234
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.232
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.228
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.227
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.225
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.224
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.224
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.224
|
|
|
|
regulation of oxidoreductase activity
|
GO:0051341 |
43 |
0.223
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.221
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.220
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.219
|
|
|
|
regulation of immunoglobulin secretion
|
GO:0051023 |
1 |
0.218
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.217
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.214
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.210
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.208
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
42 |
0.208
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.207
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.207
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.203
|
|
|
|
response to increased oxygen levels
|
GO:0036296 |
4 |
0.203
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.202
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.202
|
|
|
|
positive regulation of protein kinase c signaling
|
GO:0090037 |
5 |
0.201
|
|
|
|
response to estrogen
|
GO:0043627 |
47 |
0.198
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.196
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.194
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.193
|
|
|
|
positive regulation of tumor necrosis factor production
|
GO:0032760 |
21 |
0.192
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.192
|
|
|
|
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
|
GO:0070059 |
12 |
0.190
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.189
|
|
|
|
necroptotic process
|
GO:0070266 |
16 |
0.187
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.187
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.184
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.184
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.183
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.183
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.183
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.181
|
|
|
|
regulation of protein kinase c signaling
|
GO:0090036 |
8 |
0.180
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.180
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.178
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.176
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.176
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.174
|
|
|
|
multicellular organismal signaling
|
GO:0035637 |
34 |
0.174
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.172
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.172
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.171
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.169
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.169
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.166
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.163
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.161
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.160
|
|
|
|
regulation of lipid catabolic process
|
GO:0050994 |
23 |
0.159
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.159
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.158
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.157
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.157
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.156
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.156
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.153
|
|
|
|
signal transduction in absence of ligand
|
GO:0038034 |
22 |
0.153
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.152
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.152
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.152
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.151
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.151
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.151
|
|
|
|
toll like receptor 2 signaling pathway
|
GO:0034134 |
4 |
0.147
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.144
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.144
|
Mouse |
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.144
|
|
|
|
ribonucleoside monophosphate catabolic process
|
GO:0009158 |
158 |
0.143
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
49 |
0.142
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.141
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.140
|
|
|
|
negative regulation of myelination
|
GO:0031642 |
1 |
0.140
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.139
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.139
|
|
|
|
regulation of immunoglobulin production
|
GO:0002637 |
4 |
0.136
|
|
|
|
negative regulation of lipid metabolic process
|
GO:0045833 |
38 |
0.135
|
|
|
|
cellular response to muramyl dipeptide
|
GO:0071225 |
3 |
0.135
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.131
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
11 |
0.131
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.130
|
|
|
|
regulation of interleukin 6 production
|
GO:0032675 |
37 |
0.128
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.126
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.126
|
|
|
|
protein import into nucleus translocation
|
GO:0000060 |
22 |
0.124
|
|
|
|
positive regulation of interleukin 8 biosynthetic process
|
GO:0045416 |
8 |
0.124
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.124
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.122
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
25 |
0.122
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.121
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
37 |
0.121
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.121
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.119
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.118
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.115
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.115
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.112
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.112
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.111
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.110
|
|
|
|
positive regulation of reactive oxygen species biosynthetic process
|
GO:1903428 |
2 |
0.110
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.109
|
|
|
|
regulation of protein homodimerization activity
|
GO:0043496 |
9 |
0.109
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
37 |
0.106
|
|
|
|
circulatory system process
|
GO:0003013 |
113 |
0.106
|
|
|
|
t cell proliferation
|
GO:0042098 |
45 |
0.104
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.103
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.103
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.102
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.102
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.102
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.102
|
|
|
|
peptidyl threonine modification
|
GO:0018210 |
45 |
0.101
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.101
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.101
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.097
|
|
|
|
negative regulation of signal transduction in absence of ligand
|
GO:1901099 |
16 |
0.096
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.096
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.095
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.095
|
|
|
|
tnfsf11 mediated signaling pathway
|
GO:0071847 |
2 |
0.095
|
|
|
|
golgi to plasma membrane cftr protein transport
|
GO:0043000 |
1 |
0.095
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.094
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.094
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.093
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.093
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.093
|
|
|
|
protein heterooligomerization
|
GO:0051291 |
16 |
0.093
|
|
|
|
negative regulation of alpha beta t cell activation
|
GO:0046636 |
3 |
0.092
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.091
|
|
|
|
tetrapyrrole metabolic process
|
GO:0033013 |
11 |
0.091
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.090
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.090
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
114 |
0.090
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.090
|
|
|
|
positive regulation of interleukin 8 production
|
GO:0032757 |
36 |
0.089
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.089
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.088
|
|
|
|
regulation of cellular extravasation
|
GO:0002691 |
8 |
0.088
|
|
|
|
regulation of anion transport
|
GO:0044070 |
25 |
0.087
|
|
|
|
regulation of membrane protein ectodomain proteolysis
|
GO:0051043 |
17 |
0.087
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.087
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.085
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.085
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.085
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.084
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.084
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.083
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.083
|
|
|
|
negative regulation of nervous system development
|
GO:0051961 |
28 |
0.082
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.082
|
|
|
|
positive regulation of calcidiol 1 monooxygenase activity
|
GO:0060559 |
3 |
0.082
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.081
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.080
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.080
|
|
|
|
nucleobase containing compound transport
|
GO:0015931 |
51 |
0.079
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.079
|
|
|
|
regulation of myelination
|
GO:0031641 |
1 |
0.079
|
|
|
|
viral process
|
GO:0016032 |
146 |
0.079
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.079
|
|
|
|
cytokine production involved in immune response
|
GO:0002367 |
27 |
0.079
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
11 |
0.079
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.078
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.077
|
|
|
|
nucleoside monophosphate catabolic process
|
GO:0009125 |
159 |
0.074
|
|
|
|
positive regulation of interferon gamma production
|
GO:0032729 |
26 |
0.074
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.073
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.073
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
25 |
0.072
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.072
|
|
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
4 |
0.072
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.071
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.071
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.070
|
|
|
|
negative regulation of t cell apoptotic process
|
GO:0070233 |
4 |
0.069
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.068
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.068
|
|
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.067
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
24 |
0.067
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.067
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
21 |
0.067
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.067
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.067
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.067
|
|
|
|
chemokine c x c motif ligand 2 production
|
GO:0072567 |
3 |
0.066
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.066
|
|
|
|
organic hydroxy compound biosynthetic process
|
GO:1901617 |
71 |
0.066
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.065
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.065
|
|
|
|
fat soluble vitamin metabolic process
|
GO:0006775 |
19 |
0.064
|
|
|
|
carbohydrate derivative transport
|
GO:1901264 |
20 |
0.064
|
|
|
|
positive regulation of leukocyte migration
|
GO:0002687 |
46 |
0.063
|
|
|
|
regulation of neurological system process
|
GO:0031644 |
6 |
0.063
|
|
|
|
positive regulation of protein import into nucleus
|
GO:0042307 |
46 |
0.063
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.062
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.062
|
|
|
|
negative regulation of secretion by cell
|
GO:1903531 |
52 |
0.062
|
|
|
|
interleukin 8 production
|
GO:0032637 |
51 |
0.061
|
|
|
|
protein k63 linked ubiquitination
|
GO:0070534 |
31 |
0.061
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.061
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.061
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.060
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.060
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.060
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.059
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.059
|
|
|
|
protein autoubiquitination
|
GO:0051865 |
37 |
0.059
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.058
|
|
|
|
inflammatory response
|
GO:0006954 |
79 |
0.057
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.057
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.056
|
|
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.056
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.056
|
|
|
|
positive regulation of vitamin metabolic process
|
GO:0046136 |
3 |
0.056
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.056
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.055
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.055
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.055
|
|
|
|
myelination
|
GO:0042552 |
6 |
0.055
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902043 |
3 |
0.055
|
|
|
|
positive regulation of chemokine biosynthetic process
|
GO:0045080 |
3 |
0.054
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.054
|
|
|
|
positive regulation of angiogenesis
|
GO:0045766 |
51 |
0.054
|
|
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
25 |
0.054
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.054
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.053
|
|
|
|
activation of mapkkk activity
|
GO:0000185 |
7 |
0.053
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
23 |
0.053
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.053
|
|
|
|
i kappab phosphorylation
|
GO:0007252 |
7 |
0.053
|
|
|
|
thymus development
|
GO:0048538 |
3 |
0.053
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.052
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.052
|
|
|
|
positive regulation of lymphocyte migration
|
GO:2000403 |
16 |
0.052
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.052
|
|
|
|
rna catabolic process
|
GO:0006401 |
71 |
0.052
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.052
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
0.051
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.051
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.051
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.050
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.050
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.050
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
4 |
0.050
|
|
|
|
cellular response to estrogen stimulus
|
GO:0071391 |
16 |
0.050
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.050
|
|
|
|
response to ethanol
|
GO:0045471 |
11 |
0.049
|
|
|
|
negative regulation of inflammatory response
|
GO:0050728 |
22 |
0.049
|
|
|
|
regulation of dna binding
|
GO:0051101 |
37 |
0.048
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.048
|
|
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
42 |
0.047
|
|
|
|
response to estradiol
|
GO:0032355 |
23 |
0.047
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.047
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.047
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.046
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.045
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
46 |
0.045
|
|
|
|
negative regulation of leukocyte apoptotic process
|
GO:2000107 |
16 |
0.045
|
|
|
|
regulation of lipid biosynthetic process
|
GO:0046890 |
47 |
0.044
|
|
|
|
protein trimerization
|
GO:0070206 |
20 |
0.044
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.043
|
|
|
|
positive regulation of nucleocytoplasmic transport
|
GO:0046824 |
54 |
0.043
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.043
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.043
|
|
|
|
cellular response to reactive nitrogen species
|
GO:1902170 |
2 |
0.043
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.043
|
|
|
|
regulation of vasculature development
|
GO:1901342 |
97 |
0.042
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.042
|
|
|
|
positive regulation of binding
|
GO:0051099 |
45 |
0.042
|
|
|
|
regulation of protein import into nucleus translocation
|
GO:0033158 |
10 |
0.042
|
|
|
|
positive regulation of protein binding
|
GO:0032092 |
24 |
0.042
|
|
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
24 |
0.042
|
|
|
|
aging
|
GO:0007568 |
66 |
0.042
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.041
|
|
|
|
regulation of t cell apoptotic process
|
GO:0070232 |
8 |
0.041
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
47 |
0.041
|
|
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.041
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.041
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.041
|
|
|
|
cellular response to estradiol stimulus
|
GO:0071392 |
9 |
0.040
|
|
|
|
regulation of viral genome replication
|
GO:0045069 |
48 |
0.040
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.040
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.040
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
43 |
0.040
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.040
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.040
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
92 |
0.039
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.039
|
|
|
|
negative regulation of lipid catabolic process
|
GO:0050995 |
9 |
0.039
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.039
|
|
|
|
cellular extravasation
|
GO:0045123 |
21 |
0.039
|
|
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.039
|
|
|
|
negative regulation of interleukin 6 production
|
GO:0032715 |
13 |
0.039
|
|
|
|
regulation of neurotransmitter secretion
|
GO:0046928 |
3 |
0.039
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
4 |
0.038
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.038
|
|
|
|
interleukin 2 production
|
GO:0032623 |
20 |
0.038
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.037
|
|
|
|
interferon gamma production
|
GO:0032609 |
39 |
0.037
|
|
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
84 |
0.037
|
|
|
|
response to acid chemical
|
GO:0001101 |
66 |
0.037
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.037
|
|
|
|
response to oxygen levels
|
GO:0070482 |
100 |
0.037
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.037
|
|
|
|
activation induced cell death of t cells
|
GO:0006924 |
2 |
0.036
|
|
|
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
191 |
0.036
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.036
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.036
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.036
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.036
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.035
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.035
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.035
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.035
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.035
|
|
|
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.035
|
|
|
|
regulation of nik nf kappab signaling
|
GO:1901222 |
11 |
0.035
|
|
|
|
hair cycle
|
GO:0042633 |
28 |
0.035
|
Mouse |
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.034
|
|
|
|
immunoglobulin secretion
|
GO:0048305 |
1 |
0.034
|
|
