Homo sapiens

51 known processes

PDE4A

phosphodiesterase 4A, cAMP-specific

(Aliases: DPDE2,PDE4,PDE46)

PDE4A biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
purine ribonucleotide catabolic process GO:0009154 404 0.186
small gtpase mediated signal transduction GO:0007264 78 0.174
purine nucleoside catabolic process GO:0006152 398 0.157
cellular amino acid metabolic process GO:0006520 116 0.143
system process GO:0003008 349 0.142
Mouse Fly
purine nucleotide catabolic process GO:0006195 405 0.141
organophosphate catabolic process GO:0046434 430 0.135
cellular ketone metabolic process GO:0042180 80 0.134
regulation of purine nucleotide metabolic process GO:1900542 264 0.130
regulation of cellular ketone metabolic process GO:0010565 50 0.129
metal ion transport GO:0030001 272 0.129
nucleotide catabolic process GO:0009166 408 0.128
glycosyl compound catabolic process GO:1901658 413 0.125
ribonucleoside triphosphate metabolic process GO:0009199 412 0.123
ras protein signal transduction GO:0007265 73 0.120
cellular response to endogenous stimulus GO:0071495 336 0.117
Human
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.116
regulation of nucleotide metabolic process GO:0006140 269 0.115
locomotory behavior GO:0007626 1 0.115
nucleoside catabolic process GO:0009164 408 0.113
ribonucleotide catabolic process GO:0009261 405 0.111
nucleoside triphosphate metabolic process GO:0009141 422 0.111
post embryonic development GO:0009791 2 0.110
purine ribonucleoside metabolic process GO:0046128 437 0.109
purine ribonucleoside catabolic process GO:0046130 398 0.108
cation transport GO:0006812 331 0.107
ion transmembrane transport GO:0034220 338 0.103
nucleoside triphosphate catabolic process GO:0009143 394 0.101
inorganic ion transmembrane transport GO:0098660 231 0.099
regulation of cellular amino acid metabolic process GO:0006521 6 0.098
g protein coupled receptor signaling pathway GO:0007186 207 0.096
nucleoside phosphate catabolic process GO:1901292 412 0.095
purine nucleoside triphosphate metabolic process GO:0009144 412 0.094
positive regulation of hydrolase activity GO:0051345 331 0.093
regulation of cellular amine metabolic process GO:0033238 11 0.092
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.090
amine metabolic process GO:0009308 44 0.089
ribonucleoside catabolic process GO:0042454 406 0.088
positive regulation of cell proliferation GO:0008284 301 0.086
positive regulation of catabolic process GO:0009896 310 0.085
positive regulation of phosphorylation GO:0042327 394 0.085
signal transduction by phosphorylation GO:0023014 297 0.085
nervous system development GO:0007399 293 0.084
Fly
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.083
vesicle mediated transport GO:0016192 371 0.083
purine containing compound catabolic process GO:0072523 411 0.082
ribonucleoside triphosphate catabolic process GO:0009203 391 0.081
positive regulation of mapk cascade GO:0043410 190 0.081
cell development GO:0048468 328 0.080
Fly
regulation of cell cycle GO:0051726 393 0.080
positive regulation of cellular catabolic process GO:0031331 284 0.079
cation transmembrane transport GO:0098655 238 0.078
cellular amine metabolic process GO:0044106 41 0.077
positive regulation of cellular component organization GO:0051130 376 0.077
regulation of cellular component movement GO:0051270 334 0.076
mapk cascade GO:0000165 288 0.076
guanosine containing compound catabolic process GO:1901069 239 0.075
regulation of nucleoside metabolic process GO:0009118 209 0.075
regulation of locomotion GO:0040012 329 0.075
response to oxygen containing compound GO:1901700 369 0.075
Human
positive regulation of nucleotide metabolic process GO:0045981 230 0.073
gtp catabolic process GO:0006184 237 0.072
gtp metabolic process GO:0046039 239 0.071
regulation of nucleotide catabolic process GO:0030811 205 0.071
regulation of ras protein signal transduction GO:0046578 155 0.070
regulation of cell differentiation GO:0045595 393 0.070
guanosine containing compound metabolic process GO:1901068 244 0.068
purine nucleoside triphosphate catabolic process GO:0009146 392 0.068
regulation of mapk cascade GO:0043408 262 0.066
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.065
multicellular organismal aging GO:0010259 3 0.064
positive regulation of transport GO:0051050 336 0.064
regulation of ion transport GO:0043269 189 0.064
cellular component morphogenesis GO:0032989 314 0.064
Fly
positive regulation of cellular amine metabolic process GO:0033240 7 0.063
inorganic cation transmembrane transport GO:0098662 194 0.061
regulation of purine nucleotide catabolic process GO:0033121 205 0.060
regulation of gtp catabolic process GO:0033124 180 0.060
enzyme linked receptor protein signaling pathway GO:0007167 303 0.060
regulation of kinase activity GO:0043549 314 0.059
regulation of gtpase activity GO:0043087 180 0.059
negative regulation of phosphate metabolic process GO:0045936 267 0.058
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.058
regulation of protein kinase activity GO:0045859 289 0.058
cellular response to oxygen containing compound GO:1901701 276 0.058
Human
regulation of transferase activity GO:0051338 355 0.057
cell morphogenesis GO:0000902 296 0.057
Fly
positive regulation of protein phosphorylation GO:0001934 313 0.057
positive regulation of developmental process GO:0051094 314 0.056
single organism membrane organization GO:0044802 268 0.055
regulation of ion transmembrane transport GO:0034765 132 0.055
response to abiotic stimulus GO:0009628 336 0.053
Fly
regulation of protein localization GO:0032880 296 0.053
negative regulation of cell proliferation GO:0008285 228 0.053
divalent metal ion transport GO:0070838 152 0.051
determination of adult lifespan GO:0008340 2 0.051
neurological system process GO:0050877 163 0.051
Mouse Fly
positive regulation of nucleotide catabolic process GO:0030813 185 0.050
positive regulation of transferase activity GO:0051347 227 0.050
chemical homeostasis GO:0048878 306 0.050
regulation of cellular component biogenesis GO:0044087 281 0.050
membrane organization GO:0061024 292 0.050
positive regulation of programmed cell death GO:0043068 249 0.050
negative regulation of multicellular organismal process GO:0051241 317 0.049
calcium ion transport GO:0006816 147 0.048
regulation of cell motility GO:2000145 299 0.048
regulation of cell migration GO:0030334 289 0.048
transmembrane transport GO:0055085 399 0.048
regulation of small gtpase mediated signal transduction GO:0051056 156 0.048
regulation of cellular response to stress GO:0080135 244 0.048
female gamete generation GO:0007292 2 0.047
positive regulation of gtp catabolic process GO:0033126 166 0.047
organonitrogen compound biosynthetic process GO:1901566 200 0.046
neuron differentiation GO:0030182 138 0.046
Fly
negative regulation of catalytic activity GO:0043086 335 0.046
immune response GO:0006955 307 0.046
Human
divalent inorganic cation transport GO:0072511 158 0.046
secretion GO:0046903 254 0.046
neuromuscular junction development GO:0007528 3 0.045
negative regulation of apoptotic process GO:0043066 316 0.045
regulation of transmembrane transport GO:0034762 139 0.045
cell cell signaling GO:0007267 155 0.044
Fly
single organism cellular localization GO:1902580 332 0.044
cellular homeostasis GO:0019725 196 0.044
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.044
negative regulation of phosphorus metabolic process GO:0010563 267 0.044
cardiovascular system development GO:0072358 262 0.044
secretion by cell GO:0032940 226 0.043
cation homeostasis GO:0055080 189 0.043
positive regulation of apoptotic process GO:0043065 246 0.043
negative regulation of cellular protein metabolic process GO:0032269 353 0.043
ion homeostasis GO:0050801 230 0.042
anatomical structure formation involved in morphogenesis GO:0048646 284 0.042
regulation of protein serine threonine kinase activity GO:0071900 179 0.042
oogenesis GO:0048477 2 0.041
regulation of synaptic plasticity GO:0048167 3 0.041
mitotic cell cycle GO:0000278 326 0.041
actin filament based process GO:0030029 224 0.041
cellular metal ion homeostasis GO:0006875 146 0.041
positive regulation of nucleoside metabolic process GO:0045979 186 0.040
positive regulation of protein kinase activity GO:0045860 190 0.040
regulation of cell cycle process GO:0010564 266 0.039
positive regulation of kinase activity GO:0033674 204 0.039
cellular chemical homeostasis GO:0055082 180 0.039
response to cytokine GO:0034097 232 0.039
Human
mitotic cell cycle process GO:1903047 286 0.039
organophosphate biosynthetic process GO:0090407 163 0.039
positive regulation of gtpase activity GO:0043547 166 0.038
cellular response to growth factor stimulus GO:0071363 197 0.038
hematopoietic or lymphoid organ development GO:0048534 186 0.038
Human
actin cytoskeleton organization GO:0030036 207 0.038
cellular cation homeostasis GO:0030003 163 0.037
negative regulation of developmental process GO:0051093 247 0.037
regulation of secretion GO:0051046 194 0.037
cellular ion homeostasis GO:0006873 168 0.036
growth GO:0040007 202 0.036
Fly
cell adhesion GO:0007155 325 0.036
circadian behavior GO:0048512 2 0.036
memory GO:0007613 3 0.036
Fly
positive regulation of organelle organization GO:0010638 195 0.036
dephosphorylation GO:0016311 209 0.036
cell projection organization GO:0030030 252 0.035
Fly
positive regulation of synaptic transmission GO:0050806 4 0.035
hindbrain development GO:0030902 3 0.035
response to organic cyclic compound GO:0014070 204 0.035
Human
circulatory system development GO:0072359 262 0.035
negative regulation of cell cycle GO:0045786 193 0.035
regulation of proteolysis GO:0030162 293 0.035
response to nitrogen compound GO:1901698 184 0.034
Human
adult locomotory behavior GO:0008344 1 0.034
response to growth factor GO:0070848 205 0.034
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.034
circulatory system process GO:0003013 113 0.034
cellular divalent inorganic cation homeostasis GO:0072503 128 0.033
response to external biotic stimulus GO:0043207 261 0.033
cell morphogenesis involved in differentiation GO:0000904 144 0.033
Fly
metal ion homeostasis GO:0055065 169 0.033
negative regulation of programmed cell death GO:0043069 321 0.033
negative regulation of protein metabolic process GO:0051248 391 0.033
epithelium development GO:0060429 227 0.033
carbohydrate metabolic process GO:0005975 207 0.033
generation of neurons GO:0048699 152 0.032
Fly
neuron projection development GO:0031175 106 0.032
Fly
regulation of neurotransmitter secretion GO:0046928 3 0.032
segmentation GO:0035282 4 0.032
divalent inorganic cation homeostasis GO:0072507 136 0.032
cell cycle phase transition GO:0044770 173 0.032
rho protein signal transduction GO:0007266 26 0.031
nucleoside phosphate biosynthetic process GO:1901293 109 0.031
response to biotic stimulus GO:0009607 276 0.031
protein localization to membrane GO:0072657 160 0.031
cell growth GO:0016049 160 0.031
Fly
biological adhesion GO:0022610 331 0.031
ameboidal type cell migration GO:0001667 135 0.031
anterior posterior axis specification GO:0009948 2 0.031
rhythmic behavior GO:0007622 2 0.030
apoptotic signaling pathway GO:0097190 268 0.030
positive regulation of ras gtpase activity GO:0032320 117 0.030
positive regulation of cell death GO:0010942 263 0.030
cellular calcium ion homeostasis GO:0006874 117 0.030
cell activation GO:0001775 213 0.030
endomembrane system organization GO:0010256 196 0.030
blood circulation GO:0008015 113 0.030
carbohydrate derivative biosynthetic process GO:1901137 207 0.029
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.029
cellular response to dna damage stimulus GO:0006974 379 0.029
regulation of cytoskeleton organization GO:0051493 177 0.029
blastoderm segmentation GO:0007350 2 0.029
regulation of ras gtpase activity GO:0032318 128 0.029
regulation of immune response GO:0050776 201 0.029
Human
regulation of metal ion transport GO:0010959 120 0.028
negative regulation of cell death GO:0060548 345 0.028
sensory perception GO:0007600 103 0.028
Mouse
positive regulation of cell differentiation GO:0045597 211 0.028
cytoplasmic transport GO:0016482 379 0.027
single organism carbohydrate metabolic process GO:0044723 193 0.027
immune system development GO:0002520 195 0.027
Human
calcium ion homeostasis GO:0055074 122 0.027
protein catabolic process GO:0030163 325 0.027
regulation of establishment of protein localization GO:0070201 242 0.027
neurogenesis GO:0022008 169 0.027
Fly
cellular macromolecule catabolic process GO:0044265 380 0.027
negative regulation of protein modification process GO:0031400 200 0.027
mitotic cell cycle phase transition GO:0044772 162 0.026
i kappab kinase nf kappab signaling GO:0007249 166 0.026
intracellular protein transport GO:0006886 270 0.026
stress activated protein kinase signaling cascade GO:0031098 94 0.026
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.026
histone modification GO:0016570 251 0.026
nucleotide biosynthetic process GO:0009165 109 0.026
cell projection morphogenesis GO:0048858 129 0.026
Fly
regulation of system process GO:0044057 101 0.026
camp metabolic process GO:0046058 61 0.025
negative regulation of intracellular signal transduction GO:1902532 183 0.025
myeloid cell differentiation GO:0030099 117 0.025
Human
hemopoiesis GO:0030097 180 0.025
Human
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.025
regulation of intracellular transport GO:0032386 195 0.025
regulation of anatomical structure morphogenesis GO:0022603 286 0.025
negative regulation of synaptic transmission GO:0050805 2 0.025
protein localization to organelle GO:0033365 280 0.025
regulation of neuron differentiation GO:0045664 70 0.025
negative regulation of cellular component organization GO:0051129 235 0.025
associative learning GO:0008306 1 0.025
Fly
sensory perception of pain GO:0019233 4 0.024
cytokine production GO:0001816 247 0.024
Human
regulation of nervous system development GO:0051960 88 0.024
oocyte differentiation GO:0009994 2 0.024
regulation of protein transport GO:0051223 213 0.024
metencephalon development GO:0022037 2 0.024
negative regulation of cell differentiation GO:0045596 171 0.024
behavior GO:0007610 112 0.024
Fly
regulation of mitotic cell cycle GO:0007346 189 0.024
regulation of cell development GO:0060284 161 0.024
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.024
regulation of growth GO:0040008 165 0.023
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.023
positive regulation of ion transport GO:0043270 87 0.023
cellular protein catabolic process GO:0044257 261 0.023
purine containing compound biosynthetic process GO:0072522 88 0.023
cytosolic calcium ion homeostasis GO:0051480 89 0.023
regulation of secretion by cell GO:1903530 177 0.023
ribose phosphate biosynthetic process GO:0046390 82 0.023
protein maturation GO:0051604 233 0.023
positive regulation of intracellular transport GO:0032388 104 0.023
cellular macromolecular complex assembly GO:0034622 324 0.023
purine ribonucleotide biosynthetic process GO:0009152 79 0.022
negative regulation of phosphorylation GO:0042326 174 0.022
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.022
compound eye development GO:0048749 1 0.022
endocytosis GO:0006897 159 0.022
negative regulation of transport GO:0051051 176 0.022
cyclic nucleotide metabolic process GO:0009187 82 0.022
protein ubiquitination GO:0016567 314 0.022
protein targeting GO:0006605 187 0.022
heart contraction GO:0060047 62 0.022
ossification GO:0001503 121 0.022
protein oligomerization GO:0051259 173 0.022
positive regulation of immune response GO:0050778 159 0.022
Human
calcium ion transmembrane transport GO:0070588 76 0.021
lipid metabolic process GO:0006629 381 0.021
positive regulation of proteolysis GO:0045862 142 0.021
response to transforming growth factor beta GO:0071559 94 0.021
mitochondrion organization GO:0007005 156 0.021
spermatid differentiation GO:0048515 4 0.021
cellular response to cytokine stimulus GO:0071345 181 0.021
Human
regulation of cytokine production GO:0001817 232 0.021
Human
monovalent inorganic cation transport GO:0015672 128 0.021
regulation of protein catabolic process GO:0042176 155 0.021
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.021
regulation of calcium ion transport GO:0051924 79 0.021
stress activated mapk cascade GO:0051403 93 0.021
muscle system process GO:0003012 81 0.021
positive regulation of immune system process GO:0002684 283 0.021
Human
positive regulation of locomotion GO:0040017 186 0.021
cell part morphogenesis GO:0032990 137 0.021
Fly
synaptic transmission GO:0007268 61 0.021
Fly
interspecies interaction between organisms GO:0044419 156 0.021
oocyte development GO:0048599 1 0.021
innate immune response GO:0045087 178 0.020
microtubule based process GO:0007017 210 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.020
protein autophosphorylation GO:0046777 123 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.020
negative regulation of hydrolase activity GO:0051346 182 0.020
regulation of peptidase activity GO:0052547 180 0.020
response to organonitrogen compound GO:0010243 156 0.020
Human
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.020
negative regulation of immune system process GO:0002683 136 0.020
epithelial cell proliferation GO:0050673 128 0.020
purine nucleotide biosynthetic process GO:0006164 84 0.020
regulation of cell growth GO:0001558 135 0.020
nucleoside monophosphate metabolic process GO:0009123 191 0.020
response to other organism GO:0051707 261 0.020
regulation of actin filament based process GO:0032970 141 0.020
heart development GO:0007507 95 0.020
purine nucleoside monophosphate metabolic process GO:0009126 186 0.019
cellular response to organic cyclic compound GO:0071407 127 0.019
Human
positive regulation of cell cycle GO:0045787 140 0.019
cyclic nucleotide biosynthetic process GO:0009190 61 0.019
erk1 and erk2 cascade GO:0070371 104 0.019
regulation of map kinase activity GO:0043405 108 0.019
protein modification by small protein conjugation GO:0032446 342 0.019
cellular response to nitrogen compound GO:1901699 144 0.019
Human
positive regulation of cell motility GO:2000147 177 0.019
negative regulation of cell migration GO:0030336 102 0.019
neurotransmitter secretion GO:0007269 4 0.019
multi organism cellular process GO:0044764 156 0.019
head development GO:0060322 108 0.019
anterior posterior axis specification embryo GO:0008595 2 0.019
regulation of neurogenesis GO:0050767 82 0.019
regulation of epithelial cell proliferation GO:0050678 113 0.019
positive regulation of cell migration GO:0030335 172 0.019
chromatin organization GO:0006325 351 0.019
epithelium migration GO:0090132 119 0.019
intrinsic apoptotic signaling pathway GO:0097193 127 0.019
defense response GO:0006952 315 0.018
protein acylation GO:0043543 138 0.018
cellular lipid metabolic process GO:0044255 303 0.018
protein processing GO:0016485 226 0.018
regulation of camp biosynthetic process GO:0030817 45 0.018
activation of immune response GO:0002253 114 0.018
Human
tripartite regional subdivision GO:0007351 2 0.018
regulation of heart contraction GO:0008016 50 0.018
atp metabolic process GO:0046034 176 0.018
peptidyl serine modification GO:0018209 106 0.018
protein localization to plasma membrane GO:0072659 93 0.018
maintenance of location GO:0051235 112 0.018
cell fate determination GO:0001709 3 0.018
positive regulation of cellular component movement GO:0051272 181 0.018
leukocyte activation GO:0045321 164 0.018
reactive oxygen species biosynthetic process GO:1903409 4 0.018
plasma membrane organization GO:0007009 115 0.018
small molecule biosynthetic process GO:0044283 157 0.018
regulation of stress activated mapk cascade GO:0032872 84 0.018
muscle contraction GO:0006936 73 0.018
central nervous system development GO:0007417 123 0.018
regeneration GO:0031099 4 0.018
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.018
actin filament organization GO:0007015 128 0.018
multicellular organismal response to stress GO:0033555 1 0.018
establishment of protein localization to organelle GO:0072594 172 0.018
regulation of erk1 and erk2 cascade GO:0070372 99 0.017
establishment of protein localization to membrane GO:0090150 121 0.017
jnk cascade GO:0007254 80 0.017
negative regulation of protein phosphorylation GO:0001933 140 0.017
activation of protein kinase activity GO:0032147 90 0.017
regulation of actin cytoskeleton organization GO:0032956 116 0.017
peptidyl serine phosphorylation GO:0018105 101 0.017
negative regulation of cellular amine metabolic process GO:0033239 3 0.017
nucleocytoplasmic transport GO:0006913 176 0.017
ribonucleotide biosynthetic process GO:0009260 81 0.017
neuron development GO:0048666 113 0.017
Fly
positive regulation of cellular component biogenesis GO:0044089 158 0.017
reactive nitrogen species metabolic process GO:2001057 3 0.017
peptidyl tyrosine phosphorylation GO:0018108 170 0.017
regulation of leukocyte activation GO:0002694 115 0.017
regulation of epithelial cell migration GO:0010632 93 0.017
spermatid development GO:0007286 4 0.017
negative regulation of catabolic process GO:0009895 104 0.017
response to wounding GO:0009611 168 0.017
anion transport GO:0006820 161 0.017
regulation of cell projection organization GO:0031344 107 0.017
lipid biosynthetic process GO:0008610 177 0.017
peptidyl lysine modification GO:0018205 144 0.017
sleep GO:0030431 2 0.017
viral process GO:0016032 146 0.017
atp catabolic process GO:0006200 157 0.017
regulation of male gonad development GO:2000018 4 0.017
negative regulation of cell motility GO:2000146 104 0.017
startle response GO:0001964 3 0.017
cyclic purine nucleotide metabolic process GO:0052652 60 0.017
purine nucleoside monophosphate catabolic process GO:0009128 158 0.017
proteasomal protein catabolic process GO:0010498 176 0.017
regulation of cyclic nucleotide biosynthetic process GO:0030802 49 0.017
negative regulation of growth GO:0045926 97 0.017
posttranscriptional regulation of gene expression GO:0010608 213 0.016
regulation of purine nucleotide biosynthetic process GO:1900371 50 0.016
chromatin modification GO:0016568 298 0.016
response to lipid GO:0033993 206 0.016
negative regulation of locomotion GO:0040013 118 0.016
endosomal transport GO:0016197 129 0.016
regulation of membrane potential GO:0042391 95 0.016
regulation of dephosphorylation GO:0035303 96 0.016
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.016
organic acid biosynthetic process GO:0016053 97 0.016
positive regulation of cell projection organization GO:0031346 64 0.016
myeloid leukocyte differentiation GO:0002573 60 0.016
Human
endothelial cell migration GO:0043542 86 0.016
striated muscle contraction GO:0006941 52 0.016
cerebellum development GO:0021549 2 0.016
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.016
organ formation GO:0048645 3 0.016
cellular response to abiotic stimulus GO:0071214 117 0.016
covalent chromatin modification GO:0016569 254 0.016
regulation of meiotic cell cycle GO:0051445 4 0.016
modification dependent protein catabolic process GO:0019941 209 0.016
action potential GO:0001508 34 0.016
forelimb morphogenesis GO:0035136 4 0.016
negative regulation of protein maturation GO:1903318 142 0.016
reactive oxygen species metabolic process GO:0072593 75 0.016
regulation of excitatory postsynaptic membrane potential GO:0060079 1 0.015
response to axon injury GO:0048678 1 0.015
tube development GO:0035295 125 0.015
negative regulation of cellular component movement GO:0051271 106 0.015
tissue migration GO:0090130 119 0.015
regulation of cell morphogenesis GO:0022604 153 0.015
morphogenesis of embryonic epithelium GO:0016331 4 0.015
nuclear transport GO:0051169 179 0.015
organ morphogenesis GO:0009887 147 0.015
ubiquitin dependent protein catabolic process GO:0006511 206 0.015
exocytosis GO:0006887 71 0.015
vasculature development GO:0001944 181 0.015
response to radiation GO:0009314 151 0.015
lymphocyte activation GO:0046649 133 0.015
positive regulation of cell cycle process GO:0090068 106 0.015
cellular potassium ion transport GO:0071804 60 0.015
regulation of transporter activity GO:0032409 82 0.015
regulation of binding GO:0051098 111 0.015
inner ear morphogenesis GO:0042472 4 0.015
somatic stem cell maintenance GO:0035019 4 0.015
sequestering of metal ion GO:0051238 24 0.015
regulation of ion transmembrane transporter activity GO:0032412 72 0.015
microtubule cytoskeleton organization GO:0000226 176 0.015
protein localization to nucleus GO:0034504 136 0.015
positive regulation of cytokine production GO:0001819 167 0.015
Human
regulation of vesicle mediated transport GO:0060627 130 0.015
regulation of cell cycle phase transition GO:1901987 126 0.015
heart process GO:0003015 62 0.014
regulation of apoptotic signaling pathway GO:2001233 175 0.014
peptidyl tyrosine modification GO:0018212 170 0.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.014
syncytium formation by plasma membrane fusion GO:0000768 2 0.014
regulation of response to external stimulus GO:0032101 222 0.014
regulation of camp metabolic process GO:0030814 52 0.014
motor neuron axon guidance GO:0008045 2 0.014
negative regulation of transferase activity GO:0051348 124 0.014
brain development GO:0007420 97 0.014
limbic system development GO:0021761 3 0.014
long term memory GO:0007616 2 0.014
negative regulation of cellular catabolic process GO:0031330 83 0.014
response to activity GO:0014823 0 0.014
wound healing GO:0042060 115 0.014
negative regulation of organelle organization GO:0010639 126 0.014
morphogenesis of a polarized epithelium GO:0001738 3 0.014
regulation of jnk cascade GO:0046328 73 0.014
potassium ion transport GO:0006813 62 0.014
regulation of canonical wnt signaling pathway GO:0060828 88 0.014
monocarboxylic acid metabolic process GO:0032787 185 0.014
sex determination GO:0007530 3 0.014
regulation of protein maturation GO:1903317 150 0.014
regulation of endopeptidase activity GO:0052548 170 0.014
osteoblast differentiation GO:0001649 92 0.014
epithelial cell migration GO:0010631 119 0.014
regulation of cytoplasmic transport GO:1903649 149 0.014
organelle assembly GO:0070925 176 0.014
visual behavior GO:0007632 2 0.014
positive regulation of stress activated mapk cascade GO:0032874 60 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.014
regulation of wnt signaling pathway GO:0030111 123 0.014

PDE4A disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.046
Human
disease of metabolism DOID:0014667 295 0.025
central nervous system disease DOID:331 186 0.022
nervous system disease DOID:863 431 0.022
cardiovascular system disease DOID:1287 106 0.020
connective tissue disease DOID:65 109 0.019
Human
sensory system disease DOID:0050155 203 0.019
myopathy DOID:423 104 0.015
muscular disease DOID:0080000 114 0.015
muscle tissue disease DOID:66 113 0.015
disease of cellular proliferation DOID:14566 174 0.015
cancer DOID:162 167 0.014
organ system cancer DOID:0050686 164 0.014
inherited metabolic disorder DOID:655 242 0.014