Homo sapiens

308 known processes

TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

(Aliases: TCF4,TCF-4)

TCF7L2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
canonical wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition GO:0044334 2 0.977
cardiac muscle cell cardiac muscle cell adhesion GO:0086042 1 0.962
cerebral cortex cell migration GO:0021795 3 0.926
heart formation GO:0060914 2 0.888
wnt signaling pathway GO:0016055 156 0.859
negative regulation of catagen GO:0051796 1 0.851
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.831
cardiac cell fate specification GO:0060912 1 0.830
negative regulation of wnt signaling pathway GO:0030178 69 0.825
positive regulation of keratinocyte proliferation GO:0010838 4 0.802
canonical wnt signaling pathway GO:0060070 116 0.785
regulation of locomotion GO:0040012 329 0.782
Human
organ formation GO:0048645 3 0.780
regulation of cell differentiation GO:0045595 393 0.758
positive regulation of sulfur metabolic process GO:0051176 3 0.749
regulation of heart induction GO:0090381 2 0.740
negative regulation of cell fate specification GO:0009996 3 0.735
cardiac muscle cell contraction GO:0086003 4 0.735
mesenchymal cell development GO:0014031 50 0.647
Human
ras protein signal transduction GO:0007265 73 0.645
endodermal cell fate commitment GO:0001711 4 0.645
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.598
specification of organ identity GO:0010092 3 0.596
pharynx development GO:0060465 1 0.594
Worm
regulation of cell cell adhesion GO:0022407 57 0.587
Human
sulfur compound biosynthetic process GO:0044272 38 0.586
regulation of organ formation GO:0003156 4 0.584
regulation of mapk cascade GO:0043408 262 0.580
nephron tubule formation GO:0072079 1 0.575
heart field specification GO:0003128 2 0.548
regulation of wnt signaling pathway GO:0030111 123 0.546
regulation of cardioblast differentiation GO:0051890 4 0.544
negative regulation of cell fate commitment GO:0010454 3 0.540
tissue morphogenesis GO:0048729 96 0.539
Worm
positive regulation of intracellular protein transport GO:0090316 76 0.533
epithelium development GO:0060429 227 0.520
Mouse
endodermal cell fate specification GO:0001714 4 0.502
heart induction GO:0003129 4 0.501
regulation of cell migration GO:0030334 289 0.490
Human
positive regulation of proteoglycan biosynthetic process GO:1902730 3 0.489
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 2 0.481
proteoglycan metabolic process GO:0006029 29 0.481
positive regulation of heparan sulfate proteoglycan biosynthetic process GO:0010909 3 0.465
cardiac muscle cell action potential involved in contraction GO:0086002 21 0.451
regulation of striated muscle contraction GO:0006942 37 0.449
negative regulation of gliogenesis GO:0014014 3 0.445
cardiac muscle cell action potential GO:0086001 23 0.443
regulation of stem cell differentiation GO:2000736 56 0.441
positive regulation of programmed cell death GO:0043068 249 0.440
Mouse
melanin biosynthetic process GO:0042438 1 0.431
regulation of canonical wnt signaling pathway GO:0060828 88 0.430
glycoprotein biosynthetic process GO:0009101 91 0.429
photoreceptor cell differentiation GO:0046530 2 0.420
regulation of cellular component movement GO:0051270 334 0.404
Human
tongue development GO:0043586 1 0.403
ectoderm development GO:0007398 3 0.397
cytokine production GO:0001816 247 0.387
Human
heparan sulfate proteoglycan biosynthetic process GO:0015012 8 0.382
negative regulation of heart induction by canonical wnt signaling pathway GO:0003136 1 0.378
lung associated mesenchyme development GO:0060484 1 0.377
desmosome assembly GO:0002159 4 0.373
somatic stem cell maintenance GO:0035019 4 0.371
Mouse
positive regulation of stem cell differentiation GO:2000738 29 0.364
positive regulation of protein phosphorylation GO:0001934 313 0.360
directional locomotion GO:0033058 1 0.357
regulation of smooth muscle cell proliferation GO:0048660 28 0.356
regulation of epithelial to mesenchymal transition GO:0010717 37 0.351
regulation of heparan sulfate proteoglycan biosynthetic process GO:0010908 3 0.341
cell migration involved in gastrulation GO:0042074 1 0.335
low density lipoprotein particle mediated signaling GO:0055096 1 0.334
nephron tubule epithelial cell differentiation GO:0072160 3 0.332
signal transduction by phosphorylation GO:0023014 297 0.328
positive regulation of mapk cascade GO:0043410 190 0.327
cerebral cortex radially oriented cell migration GO:0021799 1 0.326
cardioblast cell fate commitment GO:0042684 1 0.321
organ induction GO:0001759 4 0.320
cellular response to growth factor stimulus GO:0071363 197 0.319
Mouse
protein modification by small protein conjugation GO:0032446 342 0.317
keratinization GO:0031424 2 0.313
cerebral cortex radial glia guided migration GO:0021801 1 0.306
stem cell differentiation GO:0048863 93 0.301
Human Mouse
positive regulation of phosphorylation GO:0042327 394 0.300
negative regulation of cell differentiation GO:0045596 171 0.299
Mouse
skin development GO:0043588 76 0.297
Mouse
proteoglycan biosynthetic process GO:0030166 20 0.297
embryonic forelimb morphogenesis GO:0035115 4 0.293
cellular response to organic cyclic compound GO:0071407 127 0.291
Human
regulation of kinase activity GO:0043549 314 0.290
somitogenesis GO:0001756 2 0.288
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.284
gastrulation GO:0007369 51 0.284
Worm
negative regulation of developmental process GO:0051093 247 0.282
Mouse Worm
mesendoderm development GO:0048382 1 0.281
regulation of transferase activity GO:0051338 355 0.280
positive regulation of cytoplasmic transport GO:1903651 82 0.279
morphogenesis of embryonic epithelium GO:0016331 4 0.279
positive regulation of cell motility GO:2000147 177 0.279
Human
mesenchymal cell differentiation GO:0048762 52 0.278
Human
positive regulation of transferase activity GO:0051347 227 0.274
enzyme linked receptor protein signaling pathway GO:0007167 303 0.273
Mouse
positive regulation of cell proliferation GO:0008284 301 0.269
Human Mouse
cellular response to oxygen containing compound GO:1901701 276 0.265
Mouse
post embryonic development GO:0009791 2 0.264
Mouse Worm Fly
regulation of protein kinase activity GO:0045859 289 0.263
response to oxygen containing compound GO:1901700 369 0.261
Mouse
regulation of melanosome transport GO:1902908 1 0.261
stem cell development GO:0048864 69 0.258
Human Mouse
cardioblast cell fate specification GO:0042685 1 0.256
blood circulation GO:0008015 113 0.254
cell substrate adhesion GO:0031589 132 0.253
catagen GO:0042637 3 0.251
embryonic epithelial tube formation GO:0001838 4 0.250
mating GO:0007618 1 0.250
regulation of cell development GO:0060284 161 0.242
epithelial cell proliferation GO:0050673 128 0.242
Mouse
positive regulation of protein kinase activity GO:0045860 190 0.241
blood vessel development GO:0001568 172 0.239
hair follicle morphogenesis GO:0031069 2 0.235
regulation of glycoprotein metabolic process GO:1903018 19 0.232
nuclear transport GO:0051169 179 0.228
intracellular protein transport GO:0006886 270 0.227
cellular amino acid metabolic process GO:0006520 116 0.224
system process GO:0003008 349 0.224
Zebrafish Worm
regulation of organ morphogenesis GO:2000027 24 0.223
regulation of protein transport GO:0051223 213 0.222
negative regulation of apoptotic process GO:0043066 316 0.221
cellular response to endogenous stimulus GO:0071495 336 0.218
Human Mouse
positive regulation of locomotion GO:0040017 186 0.215
Human
embryonic morphogenesis GO:0048598 85 0.215
Mouse Worm
vasculature development GO:0001944 181 0.213
positive regulation of apoptotic process GO:0043065 246 0.213
Mouse
negative regulation of multicellular organismal process GO:0051241 317 0.213
Human Mouse Worm
positive regulation of kinase activity GO:0033674 204 0.212
regulation of anatomical structure morphogenesis GO:0022603 286 0.212
regulation of cardiac cell fate specification GO:2000043 1 0.208
regulation of cell motility GO:2000145 299 0.206
Human
regulation of cardiac muscle cell contraction GO:0086004 23 0.206
negative regulation of cell proliferation GO:0008285 228 0.203
regulation of cytokine production GO:0001817 232 0.202
Human
forelimb morphogenesis GO:0035136 4 0.201
negative regulation of cardioblast cell fate specification GO:0009997 1 0.201
regulation of cell adhesion GO:0030155 166 0.201
Human
regulation of cell morphogenesis GO:0022604 153 0.199
apoptotic signaling pathway GO:0097190 268 0.197
regulation of sulfur metabolic process GO:0042762 5 0.197
glycoprotein metabolic process GO:0009100 110 0.194
vesicle mediated transport GO:0016192 371 0.194
specification of axis polarity GO:0065001 1 0.193
Worm
gastrulation with mouth forming second GO:0001702 1 0.193
response to hormone GO:0009725 175 0.192
Human
tube development GO:0035295 125 0.191
Zebrafish Mouse Worm
response to lipid GO:0033993 206 0.191
Human
morphogenesis of a branching structure GO:0001763 21 0.188
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.184
taxis GO:0042330 157 0.183
Human
regulation of cell cycle GO:0051726 393 0.183
regulation of cardiac muscle contraction GO:0055117 33 0.181
long term memory GO:0007616 2 0.181
regulation of epithelial cell differentiation involved in kidney development GO:2000696 4 0.179
rho protein signal transduction GO:0007266 26 0.179
negative regulation of glial cell differentiation GO:0045686 1 0.176
regulation of embryonic development GO:0045995 20 0.175
amine metabolic process GO:0009308 44 0.173
epithelial to mesenchymal transition GO:0001837 48 0.171
Human
regulation of melanin biosynthetic process GO:0048021 1 0.169
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.166
appendage morphogenesis GO:0035107 16 0.165
Fly
positive regulation of osteoblast differentiation GO:0045669 23 0.162
heart development GO:0007507 95 0.159
Fly
protein targeting GO:0006605 187 0.159
Mouse
circulatory system development GO:0072359 262 0.158
single organismal cell cell adhesion GO:0016337 148 0.157
Human
regulation of heart rate GO:0002027 38 0.156
cellular component morphogenesis GO:0032989 314 0.154
Human
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.153
nucleocytoplasmic transport GO:0006913 176 0.151
mitotic cell cycle process GO:1903047 286 0.151
Worm
regulation of heart morphogenesis GO:2000826 4 0.146
organ morphogenesis GO:0009887 147 0.146
Mouse Fly
response to nitrogen compound GO:1901698 184 0.143
carbohydrate derivative biosynthetic process GO:1901137 207 0.143
tube morphogenesis GO:0035239 95 0.143
Zebrafish Mouse Worm
regulation of muscle contraction GO:0006937 45 0.142
patterning of blood vessels GO:0001569 2 0.142
mitotic cell cycle GO:0000278 326 0.142
Worm
positive regulation of neuroblast proliferation GO:0002052 2 0.141
cellular response to nitrogen compound GO:1901699 144 0.140
neuroblast proliferation GO:0007405 4 0.139
positive regulation of cell differentiation GO:0045597 211 0.139
actin filament based movement GO:0030048 17 0.139
sulfur compound metabolic process GO:0006790 101 0.138
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.138
osteoblast differentiation GO:0001649 92 0.138
Human
morphogenesis of an epithelium GO:0002009 60 0.137
negative regulation of protein metabolic process GO:0051248 391 0.137
Human
cardiac conduction GO:0061337 23 0.137
cardiovascular system development GO:0072358 262 0.136
epithelial cell differentiation GO:0030855 141 0.135
thymus development GO:0048538 3 0.135
regulation of cell fate specification GO:0042659 5 0.134
Worm
cell development GO:0048468 328 0.131
Human Mouse Worm
neural tube formation GO:0001841 3 0.131
atrioventricular valve development GO:0003171 3 0.130
glycosyl compound catabolic process GO:1901658 413 0.129
transmembrane transport GO:0055085 399 0.129
memory GO:0007613 3 0.127
chemotaxis GO:0006935 157 0.127
Human
ion transmembrane transport GO:0034220 338 0.125
secondary metabolite biosynthetic process GO:0044550 2 0.124
regulation of wnt signaling pathway involved in heart development GO:0003307 3 0.121
cellular amine metabolic process GO:0044106 41 0.121
divalent inorganic cation transport GO:0072511 158 0.121
small gtpase mediated signal transduction GO:0007264 78 0.120
histone modification GO:0016570 251 0.120
Human
regulation of neurogenesis GO:0050767 82 0.119
Mouse
response to lithium ion GO:0010226 2 0.118
negative regulation of cell adhesion GO:0007162 64 0.118
Human
response to wounding GO:0009611 168 0.116
locomotory behavior GO:0007626 1 0.116
pituitary gland development GO:0021983 2 0.115
Mouse
regulation of ras protein signal transduction GO:0046578 155 0.113
embryo development GO:0009790 123 0.112
Mouse Worm Fly
cell fate determination GO:0001709 3 0.112
Worm
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 2 0.111
actin mediated cell contraction GO:0070252 12 0.109
cell adhesion GO:0007155 325 0.108
Human
mesenchyme development GO:0060485 59 0.107
Human
neural crest cell development GO:0014032 3 0.107
regulation of intracellular protein transport GO:0033157 123 0.107
single organism cellular localization GO:1902580 332 0.107
Mouse
actin filament based process GO:0030029 224 0.106
negative regulation of cardiac cell fate specification GO:2000044 1 0.104
angiogenesis GO:0001525 147 0.104
cellular ketone metabolic process GO:0042180 80 0.103
Mouse
cell fate commitment involved in formation of primary germ layer GO:0060795 6 0.103
Worm
regulation of system process GO:0044057 101 0.101
Worm
regulation of intracellular transport GO:0032386 195 0.100
negative regulation of cell death GO:0060548 345 0.099
positive regulation of developmental process GO:0051094 314 0.099
cell morphogenesis involved in differentiation GO:0000904 144 0.099
Human
hindbrain development GO:0030902 3 0.098
cell chemotaxis GO:0060326 112 0.098
Human
positive regulation of intracellular transport GO:0032388 104 0.097
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000059 3 0.097
midgut development GO:0007494 1 0.096
single organism cell adhesion GO:0098602 179 0.095
Human
smoothened signaling pathway GO:0007224 14 0.095
morphogenesis of a polarized epithelium GO:0001738 3 0.094
generation of neurons GO:0048699 152 0.094
Mouse Worm
negative regulation of epithelial cell proliferation GO:0050680 48 0.094
protein localization to membrane GO:0072657 160 0.093
mapk cascade GO:0000165 288 0.093
axis elongation GO:0003401 4 0.092
protein oligomerization GO:0051259 173 0.092
metal ion transport GO:0030001 272 0.091
inner ear morphogenesis GO:0042472 4 0.091
neuron fate commitment GO:0048663 2 0.091
actin cytoskeleton organization GO:0030036 207 0.091
cell morphogenesis GO:0000902 296 0.090
Human
regulation of nervous system development GO:0051960 88 0.090
Mouse
cardiac muscle contraction GO:0060048 34 0.089
ventricular cardiac muscle cell action potential GO:0086005 15 0.089
digestive tract morphogenesis GO:0048546 56 0.088
Zebrafish Mouse Worm
positive regulation of glycoprotein biosynthetic process GO:0010560 6 0.088
oogenesis GO:0048477 2 0.088
ossification GO:0001503 121 0.087
Human Mouse
ameboidal type cell migration GO:0001667 135 0.087
positive regulation of transport GO:0051050 336 0.086
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.085
regulation of establishment of protein localization GO:0070201 242 0.085
regulation of nephron tubule epithelial cell differentiation GO:0072182 3 0.085
positive regulation of cellular component organization GO:0051130 376 0.085
protein localization to organelle GO:0033365 280 0.084
Mouse
motor neuron axon guidance GO:0008045 2 0.084
response to growth factor GO:0070848 205 0.084
Mouse
response to low density lipoprotein particle GO:0055098 4 0.083
cell matrix adhesion GO:0007160 85 0.083
regulation of cell matrix adhesion GO:0001952 42 0.082
nervous system development GO:0007399 293 0.082
Mouse Worm
calcium ion transport GO:0006816 147 0.082
centromeric sister chromatid cohesion GO:0070601 3 0.082
regulation of epithelial cell proliferation GO:0050678 113 0.081
Mouse
connective tissue development GO:0061448 39 0.081
detection of mechanical stimulus GO:0050982 4 0.081
regulation of binding GO:0051098 111 0.080
regulation of nucleocytoplasmic transport GO:0046822 98 0.080
positive regulation of endothelial cell differentiation GO:0045603 2 0.080
response to cytokine GO:0034097 232 0.080
Human
mesenchymal to epithelial transition GO:0060231 6 0.080
regulation of blood circulation GO:1903522 59 0.079
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.079
lens morphogenesis in camera type eye GO:0002089 2 0.079
segmentation GO:0035282 4 0.078
negative regulation of locomotion GO:0040013 118 0.078
negative regulation of glial cell proliferation GO:0060253 2 0.077
anatomical structure formation involved in morphogenesis GO:0048646 284 0.077
Worm
positive regulation of map kinase activity GO:0043406 80 0.076
positive regulation of cell cycle GO:0045787 140 0.076
Human
neuroendocrine cell differentiation GO:0061101 2 0.075
regulation of actin filament based movement GO:1903115 24 0.075
regulation of glial cell differentiation GO:0045685 3 0.073
Mouse
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.073
determination of adult lifespan GO:0008340 2 0.072
establishment of organelle localization GO:0051656 59 0.072
negative regulation of heart induction GO:1901320 1 0.072
regulation of protein targeting GO:1903533 91 0.072
negative regulation of interleukin 5 production GO:0032714 3 0.071
Human
detection of stimulus GO:0051606 85 0.071
positive regulation of cellular component movement GO:0051272 181 0.071
Human
protein import GO:0017038 130 0.071
Mouse
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.071
multicellular organismal aging GO:0010259 3 0.071
forebrain generation of neurons GO:0021872 3 0.070
posttranscriptional regulation of gene expression GO:0010608 213 0.070
Worm
positive regulation of cell death GO:0010942 263 0.070
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.070
regulation of cellular ketone metabolic process GO:0010565 50 0.070
Mouse
protein import into nucleus GO:0006606 104 0.070
Mouse
regulation of myeloid leukocyte differentiation GO:0002761 39 0.070
Human
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.069
cell projection organization GO:0030030 252 0.069
regulation of neuroblast proliferation GO:1902692 3 0.069
plasma membrane organization GO:0007009 115 0.068
response to alcohol GO:0097305 64 0.067
lens development in camera type eye GO:0002088 2 0.066
regulation of protein import into nucleus GO:0042306 78 0.066
branching morphogenesis of an epithelial tube GO:0048754 19 0.066
stem cell division GO:0017145 2 0.066
protein localization to nucleus GO:0034504 136 0.065
Mouse
hair cycle phase GO:0044851 3 0.064
hematopoietic or lymphoid organ development GO:0048534 186 0.064
Human
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.064
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.064
regulation of small gtpase mediated signal transduction GO:0051056 156 0.064
neuron differentiation GO:0030182 138 0.063
Worm
smooth muscle cell proliferation GO:0048659 28 0.063
regulation of cell projection organization GO:0031344 107 0.063
positive regulation of mesenchymal cell proliferation GO:0002053 2 0.062
regulation of cellular amino acid metabolic process GO:0006521 6 0.062
digestive system development GO:0055123 75 0.061
Zebrafish Mouse Worm
regulation of determination of dorsal identity GO:2000015 2 0.061
embryonic skeletal joint development GO:0072498 2 0.061
endocytosis GO:0006897 159 0.061
regulation of cellular amine metabolic process GO:0033238 11 0.060
epidermis morphogenesis GO:0048730 3 0.060
trophectodermal cell differentiation GO:0001829 3 0.060
regulation of ion transport GO:0043269 189 0.060
regulation of apoptotic signaling pathway GO:2001233 175 0.060
regulation of protein sumoylation GO:0033233 13 0.060
peripheral nervous system development GO:0007422 2 0.060
single organism nuclear import GO:1902593 104 0.060
Mouse
cell activation GO:0001775 213 0.059
negative regulation of cellular component movement GO:0051271 106 0.059
hair follicle maturation GO:0048820 3 0.059
negative regulation of cell cell adhesion GO:0022408 27 0.059
Human
embryonic skeletal joint morphogenesis GO:0060272 2 0.058
negative regulation of cell motility GO:2000146 104 0.058
activation of protein kinase activity GO:0032147 90 0.058
cell fate commitment GO:0045165 27 0.058
negative regulation of cardioblast differentiation GO:0051892 2 0.058
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.058
Human
regulation of ion transmembrane transport GO:0034765 132 0.058
guanosine containing compound metabolic process GO:1901068 244 0.058
positive regulation of neural precursor cell proliferation GO:2000179 2 0.057
negative regulation of hair follicle maturation GO:0048817 1 0.056
cellular response to lipid GO:0071396 127 0.056
Human
keratinocyte proliferation GO:0043616 17 0.056
activation of mapkk activity GO:0000186 18 0.055
regulation of glial cell proliferation GO:0060251 4 0.055
cardiac cell fate commitment GO:0060911 7 0.055
embryonic hindlimb morphogenesis GO:0035116 2 0.055
regulation of cytoskeleton organization GO:0051493 177 0.055
semicircular canal morphogenesis GO:0048752 1 0.055
positive regulation of protein import into nucleus GO:0042307 46 0.054
appendage development GO:0048736 23 0.054
Fly
protein ubiquitination GO:0016567 314 0.054
positive regulation of immune system process GO:0002684 283 0.054
Human
lymphocyte activation GO:0046649 133 0.054
circulatory system process GO:0003013 113 0.054
female gamete generation GO:0007292 2 0.054
microtubule cytoskeleton organization GO:0000226 176 0.053
Worm
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.053
i kappab kinase nf kappab signaling GO:0007249 166 0.053
brain morphogenesis GO:0048854 1 0.053
cell type specific apoptotic process GO:0097285 125 0.053
protein targeting to nucleus GO:0044744 104 0.052
Mouse
salivary gland morphogenesis GO:0007435 4 0.052
Fly
regulation of chemotaxis GO:0050920 74 0.052
monocarboxylic acid metabolic process GO:0032787 185 0.052
regulation of neuron migration GO:2001222 3 0.052
lung cell differentiation GO:0060479 1 0.052
positive regulation of epithelial to mesenchymal transition GO:0010718 22 0.052
epithelial cell migration GO:0010631 119 0.052
kidney morphogenesis GO:0060993 19 0.052
regulation of nucleoside metabolic process GO:0009118 209 0.052
establishment of blood brain barrier GO:0060856 1 0.051
endodermal cell differentiation GO:0035987 31 0.051
cellular response to organonitrogen compound GO:0071417 124 0.051
cell communication involved in cardiac conduction GO:0086065 18 0.051
establishment of protein localization to organelle GO:0072594 172 0.050
Mouse
positive regulation of cell migration GO:0030335 172 0.050
Human
organophosphate catabolic process GO:0046434 430 0.050
regulation of stem cell proliferation GO:0072091 15 0.050
Fly
protein localization to adherens junction GO:0071896 2 0.050
nucleoside catabolic process GO:0009164 408 0.049
neural tube patterning GO:0021532 2 0.049
cytoplasmic transport GO:0016482 379 0.049
positive regulation of glycoprotein metabolic process GO:1903020 8 0.049
pattern specification process GO:0007389 43 0.049
Worm Fly
response to organonitrogen compound GO:0010243 156 0.049
neurogenesis GO:0022008 169 0.049
Mouse Worm
chromatin modification GO:0016568 298 0.049
Human
convergent extension involved in gastrulation GO:0060027 1 0.049
cuticle development GO:0042335 1 0.049
central nervous system development GO:0007417 123 0.048
Mouse
sprouting angiogenesis GO:0002040 29 0.048
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.048
secretion by cell GO:0032940 226 0.048
regulation of cell substrate adhesion GO:0010810 68 0.048
intracellular receptor signaling pathway GO:0030522 104 0.048
autonomic nervous system development GO:0048483 1 0.047
blastocyst development GO:0001824 3 0.047
negative regulation of embryonic development GO:0045992 4 0.047
wnt signaling pathway involved in heart development GO:0003306 5 0.047
keratinocyte differentiation GO:0030216 36 0.047
muscle structure development GO:0061061 98 0.047
regulation of centromeric sister chromatid cohesion GO:0070602 2 0.047
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.046
positive regulation of gtpase activity GO:0043547 166 0.046
positive regulation of jnk cascade GO:0046330 52 0.046
protein processing GO:0016485 226 0.046
Human
kidney development GO:0001822 53 0.046
establishment of protein localization to membrane GO:0090150 121 0.046
neural tube development GO:0021915 9 0.046
Mouse
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.046
cellular response to dna damage stimulus GO:0006974 379 0.046
regulation of odontogenesis GO:0042481 4 0.045
hair cycle GO:0042633 28 0.045
regulation of neuron differentiation GO:0045664 70 0.045
negative regulation of protein modification process GO:0031400 200 0.044
regulation of transmembrane transport GO:0034762 139 0.044
growth GO:0040007 202 0.044
Human Mouse
negative regulation of wnt signaling pathway involved in heart development GO:0003308 2 0.044
regulation of protein localization GO:0032880 296 0.044
associative learning GO:0008306 1 0.044
regulation of cellular response to stress GO:0080135 244 0.044
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.044
negative regulation of cell cycle GO:0045786 193 0.044
regeneration GO:0031099 4 0.044
negative regulation of stem cell proliferation GO:2000647 3 0.043
single organism reproductive process GO:0044702 98 0.043
Mouse Worm
molting cycle process GO:0022404 12 0.043
maintenance of location GO:0051235 112 0.043
neurological system process GO:0050877 163 0.043
cation transport GO:0006812 331 0.043
regulation of rho protein signal transduction GO:0035023 79 0.042
convergent extension GO:0060026 1 0.042
muscle contraction GO:0006936 73 0.042
atrioventricular valve morphogenesis GO:0003181 2 0.042
calcium ion import GO:0070509 23 0.042
embryonic eye morphogenesis GO:0048048 2 0.042
peptidyl tyrosine phosphorylation GO:0018108 170 0.042
negative regulation of stem cell differentiation GO:2000737 22 0.042
formation of primary germ layer GO:0001704 42 0.042
Worm
homotypic cell cell adhesion GO:0034109 47 0.041
cell projection morphogenesis GO:0048858 129 0.041
cell surface receptor signaling pathway involved in heart development GO:0061311 8 0.041
jnk cascade GO:0007254 80 0.041
regulation of epidermis development GO:0045682 19 0.041
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.040
regulation of endopeptidase activity GO:0052548 170 0.040
Human
neuron projection development GO:0031175 106 0.040
nucleoside triphosphate catabolic process GO:0009143 394 0.040
positive regulation of gtp catabolic process GO:0033126 166 0.040
response to biotic stimulus GO:0009607 276 0.040
regionalization GO:0003002 29 0.040
Worm
regulation of leukocyte differentiation GO:1902105 61 0.039
Human
ectodermal placode formation GO:0060788 1 0.039
hemopoiesis GO:0030097 180 0.039
Human
t cell activation GO:0042110 99 0.039

TCF7L2 disease predictions

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 104 0.472
muscular disease DOID:0080000 114 0.472
heart disease DOID:114 68 0.472
cardiomyopathy DOID:0050700 50 0.472
intrinsic cardiomyopathy DOID:0060036 50 0.472
cardiovascular system disease DOID:1287 106 0.472
musculoskeletal system disease DOID:17 223 0.472
muscle tissue disease DOID:66 113 0.472
cancer DOID:162 167 0.098
disease of cellular proliferation DOID:14566 174 0.098
organ system cancer DOID:0050686 164 0.064
reproductive organ cancer DOID:193 23 0.064
female reproductive organ cancer DOID:120 10 0.064
dilated cardiomyopathy DOID:12930 32 0.054
gastrointestinal system cancer DOID:3119 52 0.041