Homo sapiens

33 known processes

RBX1

ring-box 1, E3 ubiquitin protein ligase

(Aliases: FLJ60363,MGC13357,RNF75,ROC1,MGC1481,BA554C12.1)

RBX1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation GO:0032446 342 0.999
protein neddylation GO:0045116 7 0.998
modification dependent protein catabolic process GO:0019941 209 0.998
cellular macromolecule catabolic process GO:0044265 380 0.997
ubiquitin dependent protein catabolic process GO:0006511 206 0.996
protein ubiquitination GO:0016567 314 0.992
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.988
proteasomal protein catabolic process GO:0010498 176 0.980
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.977
cellular protein catabolic process GO:0044257 261 0.976
scf dependent proteasomal ubiquitin dependent protein catabolic process GO:0031146 15 0.971
cyclin catabolic process GO:0008054 6 0.968
protein catabolic process GO:0030163 325 0.928
regulation of ubiquitin protein transferase activity GO:0051438 28 0.923
post embryonic development GO:0009791 2 0.876
Worm
mitotic cell cycle process GO:1903047 286 0.854
mitotic cell cycle GO:0000278 326 0.828
female gamete generation GO:0007292 2 0.796
modification dependent macromolecule catabolic process GO:0043632 212 0.783
regulation of cell cycle GO:0051726 393 0.747
Worm
regulation of cell cycle process GO:0010564 266 0.707
Worm
regulation of meiotic cell cycle GO:0051445 4 0.617
Worm
microtubule based process GO:0007017 210 0.605
Worm
determination of adult lifespan GO:0008340 2 0.601
Worm
regulation of mitotic cell cycle GO:0007346 189 0.597
Worm
positive regulation of catabolic process GO:0009896 310 0.593
regulation of protein catabolic process GO:0042176 155 0.590
blastoderm segmentation GO:0007350 2 0.569
Worm
regulation of protein ubiquitination GO:0031396 95 0.568
microtubule cytoskeleton organization GO:0000226 176 0.473
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.472
positive regulation of protein catabolic process GO:0045732 75 0.459
embryo development ending in birth or egg hatching GO:0009792 34 0.455
Worm
positive regulation of protein ubiquitination GO:0031398 53 0.454
regulation of ligase activity GO:0051340 29 0.423
embryo development GO:0009790 123 0.416
Worm
multicellular organismal aging GO:0010259 3 0.371
Worm
regulation of mitosis GO:0007088 63 0.370
Worm
regulation of cell cycle phase transition GO:1901987 126 0.340
Worm
single organism reproductive process GO:0044702 98 0.340
Worm
meiotic chromosome segregation GO:0045132 4 0.337
Worm
regulation of mitotic cell cycle phase transition GO:1901990 118 0.332
cell development GO:0048468 328 0.331
Fly
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.302
meiotic cell cycle GO:0051321 13 0.287
Worm
mitotic cell cycle phase transition GO:0044772 162 0.272
dna integrity checkpoint GO:0031570 71 0.255
positive regulation of cell cycle process GO:0090068 106 0.254
Worm
anterior posterior axis specification GO:0009948 2 0.254
Worm
growth GO:0040007 202 0.244
anterior posterior axis specification embryo GO:0008595 2 0.243
Worm
positive regulation of cell cycle GO:0045787 140 0.239
Worm
multicellular organism reproduction GO:0032504 42 0.228
Worm
neurogenesis GO:0022008 169 0.221
Fly
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.210
Worm
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.202
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.195
regulation of proteasomal protein catabolic process GO:0061136 87 0.189
ribonucleoprotein complex biogenesis GO:0022613 116 0.181
positive regulation of transferase activity GO:0051347 227 0.176
oogenesis GO:0048477 2 0.174
segmentation GO:0035282 4 0.173
Worm
reproductive process GO:0022414 106 0.164
Worm
mitotic nuclear division GO:0007067 119 0.163
regulation of kinase activity GO:0043549 314 0.150
nervous system development GO:0007399 293 0.147
Fly
regulation of growth GO:0040008 165 0.146
protein localization to organelle GO:0033365 280 0.144
histone h2a ubiquitination GO:0033522 17 0.137
cell cycle phase transition GO:0044770 173 0.133
Worm
posttranscriptional regulation of gene expression GO:0010608 213 0.125
gonad development GO:0008406 34 0.123
Worm
cell cycle checkpoint GO:0000075 117 0.121
positive regulation of meiotic cell cycle GO:0051446 2 0.119
Worm
positive regulation of cellular amine metabolic process GO:0033240 7 0.112
protein polyubiquitination GO:0000209 110 0.106
mitotic dna integrity checkpoint GO:0044774 30 0.105
dna repair GO:0006281 198 0.105
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.104
histone h2a monoubiquitination GO:0035518 11 0.101
multicellular organismal reproductive process GO:0048609 40 0.100
Worm
neuron projection development GO:0031175 106 0.098
cell fate commitment involved in pattern specification GO:0060581 1 0.096
negative regulation of cell death GO:0060548 345 0.092
developmental process involved in reproduction GO:0003006 66 0.091
Worm
organelle fission GO:0048285 149 0.090
Worm
oocyte differentiation GO:0009994 2 0.090
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.089
cellular amine metabolic process GO:0044106 41 0.088
negative regulation of mitotic cell cycle GO:0045930 102 0.088
cardiovascular system development GO:0072358 262 0.087
cellular response to dna damage stimulus GO:0006974 379 0.086
regulation of cellular protein catabolic process GO:1903362 96 0.085
endocytosis GO:0006897 159 0.085
protein import GO:0017038 130 0.082
tripartite regional subdivision GO:0007351 2 0.080
Worm
reproductive structure development GO:0048608 55 0.078
Worm
histone monoubiquitination GO:0010390 20 0.076
regulation of cell division GO:0051302 116 0.076
Worm
intracellular receptor signaling pathway GO:0030522 104 0.074
oocyte development GO:0048599 1 0.071
cell projection organization GO:0030030 252 0.071
nuclear transcribed mrna catabolic process GO:0000956 48 0.069
multi organism reproductive process GO:0044703 54 0.067
Worm
nuclear division GO:0000280 128 0.066
Worm
covalent chromatin modification GO:0016569 254 0.065
neuron development GO:0048666 113 0.064
Fly
regulation of protein stability GO:0031647 87 0.063
sleep GO:0030431 2 0.063
single organism cellular localization GO:1902580 332 0.062
reproduction GO:0000003 63 0.060
Worm
mitotic cell cycle checkpoint GO:0007093 68 0.059
cell cell signaling involved in cell fate commitment GO:0045168 5 0.059
nuclear import GO:0051170 106 0.057
histone ubiquitination GO:0016574 31 0.056
positive regulation of ubiquitin protein transferase activity GO:0051443 18 0.056
establishment of nucleus localization GO:0040023 1 0.056
Worm
blastocyst development GO:0001824 3 0.054
protein import into nucleus GO:0006606 104 0.053
positive regulation of protein phosphorylation GO:0001934 313 0.051
hematopoietic or lymphoid organ development GO:0048534 186 0.051
behavior GO:0007610 112 0.051
cullin deneddylation GO:0010388 9 0.050
nuclear migration GO:0007097 1 0.049
Worm
development of primary sexual characteristics GO:0045137 35 0.048
Worm
multi organism behavior GO:0051705 14 0.048
response to biotic stimulus GO:0009607 276 0.044
cellular metal ion homeostasis GO:0006875 146 0.043
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.042
signal transduction by phosphorylation GO:0023014 297 0.042
rna interference GO:0016246 4 0.042
positive regulation of transport GO:0051050 336 0.042
cell part morphogenesis GO:0032990 137 0.041
regulation of cellular amino acid metabolic process GO:0006521 6 0.040
establishment of protein localization to organelle GO:0072594 172 0.040
cerebral cortex radially oriented cell migration GO:0021799 1 0.040
g2 m transition of mitotic cell cycle GO:0000086 41 0.039
generation of neurons GO:0048699 152 0.039
Fly
meiosis i GO:0007127 4 0.038
negative regulation of cell cycle phase transition GO:1901988 89 0.038
positive regulation of cellular protein catabolic process GO:1903364 37 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.037
negative regulation of immune system process GO:0002683 136 0.036
circulatory system development GO:0072359 262 0.036
spermatid differentiation GO:0048515 4 0.035
dna replication GO:0006260 116 0.035
cellular ketone metabolic process GO:0042180 80 0.035
negative regulation of cell cycle process GO:0010948 121 0.034
meiotic nuclear division GO:0007126 10 0.034
Worm
protein targeting GO:0006605 187 0.034
sexual reproduction GO:0019953 37 0.034
Worm
receptor mediated endocytosis GO:0006898 84 0.034
regulation of meiosis GO:0040020 3 0.033
defense response GO:0006952 315 0.033
cation homeostasis GO:0055080 189 0.033
spindle organization GO:0007051 53 0.033
cell projection morphogenesis GO:0048858 129 0.033
regulation of cellular response to stress GO:0080135 244 0.032
cellular macromolecular complex assembly GO:0034622 324 0.032
mitotic sister chromatid separation GO:0051306 18 0.032
regulation of transferase activity GO:0051338 355 0.032
cytokine production GO:0001816 247 0.032
chemical homeostasis GO:0048878 306 0.032
immune system development GO:0002520 195 0.031
cellular response to endogenous stimulus GO:0071495 336 0.031
ion homeostasis GO:0050801 230 0.031
posttranscriptional gene silencing by rna GO:0035194 25 0.031
multicellular organismal response to stress GO:0033555 1 0.030
glial cell migration GO:0008347 4 0.030
organelle assembly GO:0070925 176 0.030
cell growth GO:0016049 160 0.030
ncrna processing GO:0034470 83 0.029
negative regulation of apoptotic process GO:0043066 316 0.028
regulation of sister chromatid segregation GO:0033045 27 0.028
Worm
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.027
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.026
cellular response to peptide GO:1901653 59 0.026
i kappab kinase nf kappab signaling GO:0007249 166 0.026
neuron remodeling GO:0016322 2 0.025
Fly
cellular chemical homeostasis GO:0055082 180 0.025
negative regulation of glial cell proliferation GO:0060253 2 0.025
negative regulation of cell cycle GO:0045786 193 0.025
organ formation GO:0048645 3 0.025
intracellular protein transport GO:0006886 270 0.025
cell division GO:0051301 168 0.024
protein localization to nucleus GO:0034504 136 0.024
positive regulation of cytokine production GO:0001819 167 0.024
methylation GO:0032259 106 0.024
reproductive system development GO:0061458 56 0.024
Worm
dna damage checkpoint GO:0000077 68 0.024
cytoplasmic transport GO:0016482 379 0.024
tissue regeneration GO:0042246 3 0.024
double strand break repair via homologous recombination GO:0000724 50 0.024
positive regulation of mitotic cell cycle GO:0045931 60 0.023
protein targeting to nucleus GO:0044744 104 0.023
response to light stimulus GO:0009416 87 0.023
mapk cascade GO:0000165 288 0.023
regulation of mitotic sister chromatid segregation GO:0033047 27 0.023
Worm
regulation of protein import into nucleus GO:0042306 78 0.023
negative regulation of protein metabolic process GO:0051248 391 0.023
response to abiotic stimulus GO:0009628 336 0.023
negative regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061428 4 0.023
negative regulation of catalytic activity GO:0043086 335 0.022
histone modification GO:0016570 251 0.022
cellular response to oxygen containing compound GO:1901701 276 0.022
regulation of myeloid cell differentiation GO:0045637 81 0.022
response to organic cyclic compound GO:0014070 204 0.021
negative regulation of cell growth GO:0030308 83 0.021
regulation of establishment of protein localization GO:0070201 242 0.021
regulation of gene expression epigenetic GO:0040029 73 0.021
positive regulation of phosphorylation GO:0042327 394 0.021
regulation of nucleocytoplasmic transport GO:0046822 98 0.021
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.021
negative regulation of programmed cell death GO:0043069 321 0.021
regulation of cellular amine metabolic process GO:0033238 11 0.020
multi multicellular organism process GO:0044706 18 0.020
cellular component morphogenesis GO:0032989 314 0.020
protein modification by small protein removal GO:0070646 92 0.020
neurological system process GO:0050877 163 0.020
mrna processing GO:0006397 133 0.019
positive regulation of protein polyubiquitination GO:1902916 3 0.019
positive regulation of nucleotide catabolic process GO:0030813 185 0.019
cell morphogenesis GO:0000902 296 0.019
spermatid development GO:0007286 4 0.019
neuron differentiation GO:0030182 138 0.019
Fly
response to metal ion GO:0010038 84 0.019
g1 s transition of mitotic cell cycle GO:0000082 78 0.019
response to inorganic substance GO:0010035 127 0.019
vesicle mediated transport GO:0016192 371 0.019
regulation of cellular component biogenesis GO:0044087 281 0.018
positive regulation of cell proliferation GO:0008284 301 0.018
cell cycle g2 m phase transition GO:0044839 43 0.018
cellular protein complex assembly GO:0043623 188 0.018
stress activated protein kinase signaling cascade GO:0031098 94 0.018
intrinsic apoptotic signaling pathway GO:0097193 127 0.018
negative regulation of intracellular signal transduction GO:1902532 183 0.017
cell fate determination GO:0001709 3 0.017
establishment of organelle localization GO:0051656 59 0.017
Worm
response to radiation GO:0009314 151 0.017
system process GO:0003008 349 0.017
mrna splicing via spliceosome GO:0000398 89 0.017
anterior posterior pattern specification GO:0009952 9 0.017
Worm
hindbrain development GO:0030902 3 0.016
regulation of cytoplasmic transport GO:1903649 149 0.016
chordate embryonic development GO:0043009 34 0.016
protein k63 linked ubiquitination GO:0070534 31 0.016
positive regulation of programmed cell death GO:0043068 249 0.016
regulation of chromosome organization GO:0033044 103 0.016
Worm
regulation of anatomical structure size GO:0090066 101 0.016
apoptotic signaling pathway GO:0097190 268 0.015
cell maturation GO:0048469 11 0.015
Fly
organelle localization GO:0051640 84 0.015
Worm
regulation of mitotic sister chromatid separation GO:0010965 27 0.015
Worm
positive regulation of ligase activity GO:0051351 19 0.015
cerebral cortex cell migration GO:0021795 3 0.015
behavioral fear response GO:0001662 0 0.014
engulfment of apoptotic cell GO:0043652 2 0.014
embryonic axis specification GO:0000578 5 0.014
Worm
guanosine containing compound metabolic process GO:1901068 244 0.014
sex differentiation GO:0007548 45 0.014
Worm
neuromuscular junction development GO:0007528 3 0.014
transcription factor import into nucleus GO:0042991 40 0.014
stress activated mapk cascade GO:0051403 93 0.014
neuron projection morphogenesis GO:0048812 50 0.014
negative regulation of growth GO:0045926 97 0.014
vasculature development GO:0001944 181 0.013
regulation of epithelial cell proliferation GO:0050678 113 0.013
epithelial cell proliferation GO:0050673 128 0.013
rna catabolic process GO:0006401 71 0.013
amine metabolic process GO:0009308 44 0.013
gene silencing GO:0016458 49 0.013
embryonic pattern specification GO:0009880 5 0.013
Worm
negative regulation of endopeptidase activity GO:0010951 84 0.012
establishment of cell polarity GO:0030010 22 0.012
positive regulation of kinase activity GO:0033674 204 0.012
negative regulation of multicellular organismal process GO:0051241 317 0.012
positive regulation of proteolysis GO:0045862 142 0.012
aging GO:0007568 66 0.012
Worm
cytosolic calcium ion homeostasis GO:0051480 89 0.012
mitotic g2 m transition checkpoint GO:0044818 9 0.012
maintenance of location GO:0051235 112 0.012
Fly
immune response GO:0006955 307 0.012
regulation of protein localization GO:0032880 296 0.012
response to virus GO:0009615 126 0.012
regulation of cellular component size GO:0032535 82 0.012
regulation of cytoskeleton organization GO:0051493 177 0.012
calcium ion transport GO:0006816 147 0.012
stem cell development GO:0048864 69 0.012
regulation of protein processing GO:0070613 150 0.012
cellular response to nitrogen compound GO:1901699 144 0.011
peptide transport GO:0015833 74 0.011
cellular calcium ion homeostasis GO:0006874 117 0.011
negative regulation of transport GO:0051051 176 0.011
ameboidal type cell migration GO:0001667 135 0.011
chromatin organization GO:0006325 351 0.011
regulation of proteolysis GO:0030162 293 0.011
positive regulation of apoptotic process GO:0043065 246 0.011
regulation of centrosome cycle GO:0046605 15 0.011
cellular cation homeostasis GO:0030003 163 0.011
positive regulation of cell death GO:0010942 263 0.011
cellular process involved in reproduction in multicellular organism GO:0022412 15 0.011
regulation of cellular ketone metabolic process GO:0010565 50 0.011
negative regulation of cellular protein metabolic process GO:0032269 353 0.011
response to oxygen containing compound GO:1901700 369 0.011
ncrna metabolic process GO:0034660 108 0.011
regionalization GO:0003002 29 0.011
Worm
response to external biotic stimulus GO:0043207 261 0.011
regulation of protein localization to nucleus GO:1900180 85 0.010
metal ion homeostasis GO:0055065 169 0.010
tissue morphogenesis GO:0048729 96 0.010
hemopoiesis GO:0030097 180 0.010
defense response to other organism GO:0098542 129 0.010
negative regulation of cellular catabolic process GO:0031330 83 0.010
protein stabilization GO:0050821 64 0.010

RBX1 disease predictions

Disease DO term ID Size Probability Func Analog Org
kidney cancer DOID:263 11 0.023
urinary system cancer DOID:3996 15 0.023
nonpapillary renal cell carcinoma DOID:0050387 6 0.023
hereditary renal cell carcinoma DOID:4455 6 0.023
renal cell carcinoma DOID:4450 8 0.023
renal carcinoma DOID:4451 8 0.023
cancer DOID:162 167 0.023
disease of cellular proliferation DOID:14566 174 0.023
organ system cancer DOID:0050686 164 0.023