Homo sapiens

47 known processes

SGMS1

sphingomyelin synthase 1

(Aliases: MGC17342,TMEM23,SMS1,MOB,hmob33,MOB1)

SGMS1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
vesicle mediated transport GO:0016192 371 0.296
membrane organization GO:0061024 292 0.206
enzyme linked receptor protein signaling pathway GO:0007167 303 0.166
cell morphogenesis GO:0000902 296 0.155
cell projection organization GO:0030030 252 0.119
positive regulation of developmental process GO:0051094 314 0.117
neuromuscular junction development GO:0007528 3 0.114
secretion GO:0046903 254 0.107
nervous system development GO:0007399 293 0.104
chemical homeostasis GO:0048878 306 0.102
positive regulation of cellular component organization GO:0051130 376 0.102
positive regulation of catabolic process GO:0009896 310 0.100
inorganic cation transmembrane transport GO:0098662 194 0.098
regulation of cell differentiation GO:0045595 393 0.094
endosomal transport GO:0016197 129 0.089
cation homeostasis GO:0055080 189 0.089
transmembrane transport GO:0055085 399 0.089
cation transmembrane transport GO:0098655 238 0.088
purine nucleotide catabolic process GO:0006195 405 0.086
actin filament based process GO:0030029 224 0.086
ribonucleoside triphosphate catabolic process GO:0009203 391 0.085
regulation of cell development GO:0060284 161 0.079
cation transport GO:0006812 331 0.079
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.078
small molecule biosynthetic process GO:0044283 157 0.077
nucleoside triphosphate catabolic process GO:0009143 394 0.076
circulatory system development GO:0072359 262 0.076
behavior GO:0007610 112 0.075
single organism membrane organization GO:0044802 268 0.074
regulation of purine nucleotide metabolic process GO:1900542 264 0.074
positive regulation of cellular catabolic process GO:0031331 284 0.072
oogenesis GO:0048477 2 0.070
post embryonic development GO:0009791 2 0.070
epithelium development GO:0060429 227 0.069
response to growth factor GO:0070848 205 0.069
generation of neurons GO:0048699 152 0.068
cellular homeostasis GO:0019725 196 0.067
positive regulation of transport GO:0051050 336 0.065
protein localization to membrane GO:0072657 160 0.065
biological adhesion GO:0022610 331 0.065
ribonucleoside triphosphate metabolic process GO:0009199 412 0.064
cytoplasmic transport GO:0016482 379 0.064
nucleoside catabolic process GO:0009164 408 0.060
cell development GO:0048468 328 0.059
ion homeostasis GO:0050801 230 0.058
ion transmembrane transport GO:0034220 338 0.058
signal transduction by phosphorylation GO:0023014 297 0.057
ribonucleoside catabolic process GO:0042454 406 0.056
neuron projection development GO:0031175 106 0.055
kidney development GO:0001822 53 0.055
purine ribonucleotide catabolic process GO:0009154 404 0.054
neural crest cell migration GO:0001755 2 0.054
sodium ion transport GO:0006814 61 0.053
guanosine containing compound metabolic process GO:1901068 244 0.053
regulation of protein localization GO:0032880 296 0.052
nucleoside triphosphate metabolic process GO:0009141 422 0.052
glycosyl compound catabolic process GO:1901658 413 0.051
maintenance of location GO:0051235 112 0.051
cellular component morphogenesis GO:0032989 314 0.051
positive regulation of gtpase activity GO:0043547 166 0.051
amine metabolic process GO:0009308 44 0.050
protein localization to plasma membrane GO:0072659 93 0.049
organophosphate catabolic process GO:0046434 430 0.048
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.047
regulation of establishment of protein localization GO:0070201 242 0.047
actin cytoskeleton organization GO:0030036 207 0.047
inorganic ion transmembrane transport GO:0098660 231 0.047
cellular macromolecule catabolic process GO:0044265 380 0.046
purine nucleoside triphosphate metabolic process GO:0009144 412 0.045
regulation of cell cycle GO:0051726 393 0.045
interspecies interaction between organisms GO:0044419 156 0.045
proteasomal protein catabolic process GO:0010498 176 0.045
cellular response to oxygen containing compound GO:1901701 276 0.043
secretion by cell GO:0032940 226 0.043
nucleotide catabolic process GO:0009166 408 0.043
protein catabolic process GO:0030163 325 0.042
regulation of locomotion GO:0040012 329 0.042
divalent inorganic cation homeostasis GO:0072507 136 0.041
system process GO:0003008 349 0.041
mapk cascade GO:0000165 288 0.041
digestive system development GO:0055123 75 0.041
metal ion transport GO:0030001 272 0.040
neurogenesis GO:0022008 169 0.040
regulation of vesicle mediated transport GO:0060627 130 0.040
memory GO:0007613 3 0.040
cell adhesion GO:0007155 325 0.040
negative regulation of cell proliferation GO:0008285 228 0.039
positive regulation of nucleoside metabolic process GO:0045979 186 0.039
regulation of response to external stimulus GO:0032101 222 0.039
nucleoside phosphate catabolic process GO:1901292 412 0.038
immune response GO:0006955 307 0.038
positive regulation of programmed cell death GO:0043068 249 0.038
neuron differentiation GO:0030182 138 0.038
response to cytokine GO:0034097 232 0.038
regulation of secretion GO:0051046 194 0.037
monovalent inorganic cation transport GO:0015672 128 0.037
female gamete generation GO:0007292 2 0.037
lipid metabolic process GO:0006629 381 0.037
segmentation GO:0035282 4 0.037
regulation of growth GO:0040008 165 0.037
ras protein signal transduction GO:0007265 73 0.037
calcium ion transmembrane transport GO:0070588 76 0.037
tissue morphogenesis GO:0048729 96 0.037
microtubule based process GO:0007017 210 0.037
growth GO:0040007 202 0.036
epithelial tube morphogenesis GO:0060562 38 0.036
positive regulation of cell proliferation GO:0008284 301 0.036
maintenance of protein location GO:0045185 57 0.036
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.036
response to oxygen containing compound GO:1901700 369 0.035
embryonic epithelial tube formation GO:0001838 4 0.035
protein ubiquitination GO:0016567 314 0.035
cellular ion homeostasis GO:0006873 168 0.034
endocytosis GO:0006897 159 0.034
regulation of nucleotide metabolic process GO:0006140 269 0.034
regulation of cell migration GO:0030334 289 0.034
cellular response to starvation GO:0009267 58 0.034
regulation of mapk cascade GO:0043408 262 0.033
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.033
gtp metabolic process GO:0046039 239 0.033
determination of adult lifespan GO:0008340 2 0.033
positive regulation of immune system process GO:0002684 283 0.033
blastoderm segmentation GO:0007350 2 0.032
morphogenesis of an epithelium GO:0002009 60 0.032
negative regulation of protein metabolic process GO:0051248 391 0.032
ubiquitin dependent protein catabolic process GO:0006511 206 0.031
regulation of cellular ketone metabolic process GO:0010565 50 0.031
negative regulation of transport GO:0051051 176 0.031
purine nucleoside triphosphate catabolic process GO:0009146 392 0.031
glycoprotein metabolic process GO:0009100 110 0.030
positive regulation of hydrolase activity GO:0051345 331 0.030
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.030
tube morphogenesis GO:0035239 95 0.030
regulation of transferase activity GO:0051338 355 0.030
long term memory GO:0007616 2 0.030
positive regulation of phosphorylation GO:0042327 394 0.030
heart development GO:0007507 95 0.030
modification dependent macromolecule catabolic process GO:0043632 212 0.030
small gtpase mediated signal transduction GO:0007264 78 0.029
somitogenesis GO:0001756 2 0.029
regulation of neuron differentiation GO:0045664 70 0.029
digestive tract development GO:0048565 75 0.029
positive regulation of cellular amine metabolic process GO:0033240 7 0.029
regulation of cellular amino acid metabolic process GO:0006521 6 0.028
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.028
purine ribonucleoside catabolic process GO:0046130 398 0.028
cellular divalent inorganic cation homeostasis GO:0072503 128 0.028
central nervous system development GO:0007417 123 0.028
lipid transport GO:0006869 90 0.028
locomotory behavior GO:0007626 1 0.028
single organism cell adhesion GO:0098602 179 0.028
regulation of cellular amine metabolic process GO:0033238 11 0.028
neural tube formation GO:0001841 3 0.028
neurological system process GO:0050877 163 0.028
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.027
cellular response to external stimulus GO:0071496 111 0.027
cellular macromolecular complex assembly GO:0034622 324 0.027
ribonucleoside monophosphate metabolic process GO:0009161 187 0.027
cellular protein catabolic process GO:0044257 261 0.027
protein localization to organelle GO:0033365 280 0.027
regulation of cell morphogenesis GO:0022604 153 0.027
ribonucleotide catabolic process GO:0009261 405 0.026
positive regulation of protein phosphorylation GO:0001934 313 0.026
cellular chemical homeostasis GO:0055082 180 0.026
viral process GO:0016032 146 0.026
regulation of multi organism process GO:0043900 157 0.026
calcium ion homeostasis GO:0055074 122 0.025
cellular calcium ion homeostasis GO:0006874 117 0.025
posttranscriptional regulation of gene expression GO:0010608 213 0.025
actin filament organization GO:0007015 128 0.025
cell part morphogenesis GO:0032990 137 0.025
cellular protein complex assembly GO:0043623 188 0.025
renal system development GO:0072001 63 0.025
plasma membrane organization GO:0007009 115 0.025
regulation of purine nucleotide catabolic process GO:0033121 205 0.025
innate immune response GO:0045087 178 0.025
receptor metabolic process GO:0043112 81 0.025
positive regulation of cell migration GO:0030335 172 0.025
regulation of protein catabolic process GO:0042176 155 0.025
organic anion transport GO:0015711 103 0.024
muscle cell fate commitment GO:0042693 4 0.024
cell morphogenesis involved in differentiation GO:0000904 144 0.024
phospholipid translocation GO:0045332 2 0.024
regulation of secretion by cell GO:1903530 177 0.024
cellular response to glucocorticoid stimulus GO:0071385 4 0.024
regulation of cell projection organization GO:0031344 107 0.024
regulation of cell cycle process GO:0010564 266 0.023
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.023
multicellular organismal aging GO:0010259 3 0.023
positive regulation of cell development GO:0010720 92 0.023
regulation of nucleotide catabolic process GO:0030811 205 0.023
single organism cellular localization GO:1902580 332 0.023
head development GO:0060322 108 0.023
regulation of growth rate GO:0040009 1 0.023
cholesterol transport GO:0030301 39 0.023
regulation of cellular component biogenesis GO:0044087 281 0.023
Human
purine nucleoside catabolic process GO:0006152 398 0.023
cellular metal ion homeostasis GO:0006875 146 0.023
negative regulation of phosphorylation GO:0042326 174 0.023
positive regulation of cell motility GO:2000147 177 0.023
chemotaxis GO:0006935 157 0.023
organelle assembly GO:0070925 176 0.022
negative regulation of phosphate metabolic process GO:0045936 267 0.022
regulation of cell motility GO:2000145 299 0.022
cardiovascular system development GO:0072358 262 0.022
divalent inorganic cation transport GO:0072511 158 0.022
epithelial cell differentiation GO:0030855 141 0.022
peptidyl serine phosphorylation GO:0018105 101 0.022
protein modification by small protein conjugation GO:0032446 342 0.022
regulation of cellular component movement GO:0051270 334 0.022
negative regulation of catalytic activity GO:0043086 335 0.022
cellular response to endogenous stimulus GO:0071495 336 0.022
cellular response to nutrient levels GO:0031669 69 0.022
positive regulation of ras gtpase activity GO:0032320 117 0.021
ossification GO:0001503 121 0.021
regulation of cellular response to growth factor stimulus GO:0090287 76 0.021
neural crest cell development GO:0014032 3 0.021
response to wounding GO:0009611 168 0.021
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.021
cellular amino acid metabolic process GO:0006520 116 0.021
organic acid biosynthetic process GO:0016053 97 0.021
neuron development GO:0048666 113 0.021
multi organism cellular process GO:0044764 156 0.021
positive regulation of locomotion GO:0040017 186 0.021
cellular response to organonitrogen compound GO:0071417 124 0.021
nitrogen compound transport GO:0071705 191 0.020
anatomical structure formation involved in morphogenesis GO:0048646 284 0.020
regulation of ras gtpase activity GO:0032318 128 0.020
modification dependent protein catabolic process GO:0019941 209 0.020
cellular ketone metabolic process GO:0042180 80 0.020
positive regulation of cell differentiation GO:0045597 211 0.020
negative regulation of intracellular signal transduction GO:1902532 183 0.020
positive regulation of growth GO:0045927 58 0.020
regulation of nervous system development GO:0051960 88 0.020
lysosomal transport GO:0007041 33 0.019
maintenance of location in cell GO:0051651 62 0.019
oocyte development GO:0048599 1 0.019
embryonic morphogenesis GO:0048598 85 0.019
response to tumor necrosis factor GO:0034612 76 0.019
viral life cycle GO:0019058 132 0.019
response to metal ion GO:0010038 84 0.019
associative learning GO:0008306 1 0.018
tube development GO:0035295 125 0.018
metal ion homeostasis GO:0055065 169 0.018
regulation of anatomical structure morphogenesis GO:0022603 286 0.018
response to lipid GO:0033993 206 0.018
neuron projection morphogenesis GO:0048812 50 0.018
embryo development GO:0009790 123 0.018
negative regulation of cellular component organization GO:0051129 235 0.018
anterior posterior axis specification embryo GO:0008595 2 0.018
cellular response to growth factor stimulus GO:0071363 197 0.018
leukocyte activation GO:0045321 164 0.018
regulation of protein transport GO:0051223 213 0.018
regulation of cell growth GO:0001558 135 0.018
membrane budding GO:0006900 28 0.018
neurotransmitter secretion GO:0007269 4 0.018
regulation of meiotic cell cycle GO:0051445 4 0.018
negative regulation of apoptotic process GO:0043066 316 0.018
Mouse
cell cell signaling GO:0007267 155 0.018
cell projection morphogenesis GO:0048858 129 0.017
negative regulation of cellular protein metabolic process GO:0032269 353 0.017
purine containing compound catabolic process GO:0072523 411 0.017
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.017
morphogenesis of embryonic epithelium GO:0016331 4 0.017
regulation of proteolysis GO:0030162 293 0.017
cellular response to nitrogen compound GO:1901699 144 0.017
response to nutrient levels GO:0031667 81 0.017
guanosine containing compound catabolic process GO:1901069 239 0.017
tripartite regional subdivision GO:0007351 2 0.017
angiogenesis GO:0001525 147 0.017
compound eye development GO:0048749 1 0.017
synaptic transmission GO:0007268 61 0.016
response to salt stress GO:0009651 3 0.016
negative regulation of multicellular organismal process GO:0051241 317 0.016
sterol transport GO:0015918 39 0.016
leukocyte migration GO:0050900 107 0.016
golgi vesicle transport GO:0048193 80 0.016
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.016
lipid localization GO:0010876 106 0.016
organ morphogenesis GO:0009887 147 0.016
cell division GO:0051301 168 0.016
regulation of kinase activity GO:0043549 314 0.016
response to calcium ion GO:0051592 46 0.016
negative regulation of programmed cell death GO:0043069 321 0.016
Mouse
taxis GO:0042330 157 0.016
protein autophosphorylation GO:0046777 123 0.016
defense response GO:0006952 315 0.016
regulation of cellular response to stress GO:0080135 244 0.016
formation of primary germ layer GO:0001704 42 0.016
cellular component disassembly GO:0022411 92 0.016
muscle structure development GO:0061061 98 0.016
positive regulation of cell death GO:0010942 263 0.015
potassium ion transport GO:0006813 62 0.015
regulation of cell division GO:0051302 116 0.015
adult locomotory behavior GO:0008344 1 0.015
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.015
response to starvation GO:0042594 59 0.015
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.015
peptidyl threonine phosphorylation GO:0018107 41 0.015
peptidyl serine modification GO:0018209 106 0.015
regulation of neuronal synaptic plasticity GO:0048168 1 0.015
regulation of gtp catabolic process GO:0033124 180 0.015
regulation of cytoskeleton organization GO:0051493 177 0.015
atp catabolic process GO:0006200 157 0.015
response to inorganic substance GO:0010035 127 0.014
regulation of reactive oxygen species metabolic process GO:2000377 41 0.014
regulation of protein kinase activity GO:0045859 289 0.014
divalent metal ion transport GO:0070838 152 0.014
negative regulation of developmental process GO:0051093 247 0.014
response to extracellular stimulus GO:0009991 85 0.014
hindbrain development GO:0030902 3 0.014
cellular cation homeostasis GO:0030003 163 0.014
regulation of neuron projection development GO:0010975 57 0.014
purine ribonucleoside metabolic process GO:0046128 437 0.014
peptidyl tyrosine phosphorylation GO:0018108 170 0.014
intracellular protein transport GO:0006886 270 0.014
endomembrane system organization GO:0010256 196 0.014
regulation of defense response GO:0031347 154 0.014
positive regulation of mapk cascade GO:0043410 190 0.014
brain development GO:0007420 97 0.014
gastrulation with mouth forming second GO:0001702 1 0.014
primary neural tube formation GO:0014020 3 0.014
cellular response to extracellular stimulus GO:0031668 72 0.013
cellular lipid metabolic process GO:0044255 303 0.013
calcium ion transport GO:0006816 147 0.013
cellular component assembly involved in morphogenesis GO:0010927 73 0.013
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.013
mitotic cell cycle GO:0000278 326 0.013
response to oxidative stress GO:0006979 121 0.013
renal sodium ion absorption GO:0070294 2 0.013
regulation of nucleoside metabolic process GO:0009118 209 0.013
regulation of gtpase activity GO:0043087 180 0.013
regulation of cell adhesion GO:0030155 166 0.013
regulation of ossification GO:0030278 58 0.013
mesenchymal cell development GO:0014031 50 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
response to other organism GO:0051707 261 0.013
response to endoplasmic reticulum stress GO:0034976 49 0.013
retrograde transport endosome to golgi GO:0042147 45 0.013
nucleocytoplasmic transport GO:0006913 176 0.013
cell activation GO:0001775 213 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
response to transforming growth factor beta GO:0071559 94 0.013
mitochondrion organization GO:0007005 156 0.012
nuclear transport GO:0051169 179 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
proteasomal ubiquitin independent protein catabolic process GO:0010499 3 0.012
positive regulation of nervous system development GO:0051962 54 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.012
positive regulation of proteolysis GO:0045862 142 0.012
blood vessel morphogenesis GO:0048514 162 0.012
steroid metabolic process GO:0008202 94 0.012
regulation of endocytosis GO:0030100 72 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.012
regulation of synaptic plasticity GO:0048167 3 0.012
organonitrogen compound biosynthetic process GO:1901566 200 0.012
spermatid differentiation GO:0048515 4 0.012
response to nitrogen compound GO:1901698 184 0.012
organic hydroxy compound transport GO:0015850 63 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
immune system development GO:0002520 195 0.011
regulation of leukocyte migration GO:0002685 63 0.011
anterior posterior axis specification GO:0009948 2 0.011
covalent chromatin modification GO:0016569 254 0.011
negative regulation of transferase activity GO:0051348 124 0.011
stem cell differentiation GO:0048863 93 0.011
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
establishment of protein localization to membrane GO:0090150 121 0.011
cell growth GO:0016049 160 0.011
circadian sleep wake cycle sleep GO:0050802 2 0.011
negative regulation of growth GO:0045926 97 0.011
protein k48 linked ubiquitination GO:0070936 38 0.011
response to abiotic stimulus GO:0009628 336 0.011
post golgi vesicle mediated transport GO:0006892 36 0.011
response to external biotic stimulus GO:0043207 261 0.011
positive regulation of gtp catabolic process GO:0033126 166 0.011
protein oligomerization GO:0051259 173 0.011
ribonucleoside monophosphate catabolic process GO:0009158 158 0.011
rhythmic behavior GO:0007622 2 0.011
regulation of innate immune response GO:0045088 97 0.011
urogenital system development GO:0001655 65 0.011
establishment of protein localization to plasma membrane GO:0090002 68 0.011
nucleoside monophosphate catabolic process GO:0009125 159 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
regulation of phagocytosis engulfment GO:0060099 2 0.011
regulation of wnt signaling pathway GO:0030111 123 0.011
exocytosis GO:0006887 71 0.011
mitotic cell cycle process GO:1903047 286 0.011
cytokinesis GO:0000910 96 0.010
maintenance of protein location in cell GO:0032507 56 0.010
reproductive process GO:0022414 106 0.010
positive regulation of organelle organization GO:0010638 195 0.010
positive regulation of endocytosis GO:0045807 42 0.010
response to transition metal nanoparticle GO:1990267 29 0.010
metencephalon development GO:0022037 2 0.010
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.010
renal sodium ion transport GO:0003096 2 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.010
fibroblast growth factor receptor signaling pathway GO:0008543 26 0.010
cellular amino acid biosynthetic process GO:0008652 30 0.010
cell migration involved in gastrulation GO:0042074 1 0.010
nuclear export GO:0051168 69 0.010
positive regulation of secretion by cell GO:1903532 108 0.010
carbohydrate derivative biosynthetic process GO:1901137 207 0.010
distal tubule development GO:0072017 4 0.010
amide transport GO:0042886 76 0.010
rho protein signal transduction GO:0007266 26 0.010

SGMS1 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.061
sensory system disease DOID:0050155 203 0.046
eye and adnexa disease DOID:1492 150 0.046
nervous system disease DOID:863 431 0.046
eye disease DOID:5614 149 0.046
central nervous system disease DOID:331 186 0.040
neurodegenerative disease DOID:1289 102 0.040
retinal disease DOID:5679 118 0.027
retinal degeneration DOID:8466 89 0.022
muscular disease DOID:0080000 114 0.019
muscle tissue disease DOID:66 113 0.019
cancer DOID:162 167 0.014
disease of cellular proliferation DOID:14566 174 0.014
organ system cancer DOID:0050686 164 0.012