Homo sapiens

42 known processes

EIF2D

eukaryotic translation initiation factor 2D

(Aliases: HCA56,LGTN)

EIF2D biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.232
oxidation reduction process GO:0055114 396 0.113
negative regulation of cyclin catabolic process GO:2000599 3 0.108
cellular amino acid metabolic process GO:0006520 116 0.070
negative regulation of protein metabolic process GO:0051248 391 0.052
protein processing GO:0016485 226 0.044
cellular lipid metabolic process GO:0044255 303 0.044
female gamete generation GO:0007292 2 0.042
glycerolipid metabolic process GO:0046486 107 0.040
endocytosis GO:0006897 159 0.038
negative regulation of cellular protein metabolic process GO:0032269 353 0.036
positive regulation of developmental process GO:0051094 314 0.036
negative regulation of phosphate metabolic process GO:0045936 267 0.035
regulation of proteolysis GO:0030162 293 0.035
protein maturation GO:0051604 233 0.035
cellular macromolecule catabolic process GO:0044265 380 0.034
regulation of cellular amino acid metabolic process GO:0006521 6 0.033
purine ribonucleoside metabolic process GO:0046128 437 0.032
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.032
purine containing compound catabolic process GO:0072523 411 0.032
proteasomal protein catabolic process GO:0010498 176 0.031
multicellular organismal aging GO:0010259 3 0.030
negative regulation of protein processing GO:0010955 142 0.029
nucleoside monophosphate metabolic process GO:0009123 191 0.028
transmembrane transport GO:0055085 399 0.028
cellular ketone metabolic process GO:0042180 80 0.028
ribonucleotide catabolic process GO:0009261 405 0.028
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.028
negative regulation of protein maturation GO:1903318 142 0.026
regulation of protein catabolic process GO:0042176 155 0.026
regulation of proteasomal protein catabolic process GO:0061136 87 0.025
protein localization to organelle GO:0033365 280 0.024
protein catabolic process GO:0030163 325 0.024
lipid metabolic process GO:0006629 381 0.024
amine metabolic process GO:0009308 44 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.023
ribonucleoside monophosphate metabolic process GO:0009161 187 0.023
mitochondrion organization GO:0007005 156 0.023
nucleotide catabolic process GO:0009166 408 0.023
negative regulation of catalytic activity GO:0043086 335 0.022
negative regulation of proteolysis GO:0045861 132 0.022
purine nucleoside monophosphate metabolic process GO:0009126 186 0.022
response to oxygen containing compound GO:1901700 369 0.022
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.022
regulation of generation of precursor metabolites and energy GO:0043467 27 0.022
modification dependent macromolecule catabolic process GO:0043632 212 0.022
negative regulation of phosphorylation GO:0042326 174 0.022
organonitrogen compound biosynthetic process GO:1901566 200 0.021
regulation of protein processing GO:0070613 150 0.021
negative regulation of cell proliferation GO:0008285 228 0.021
positive regulation of cellular amine metabolic process GO:0033240 7 0.021
negative regulation of protein catabolic process GO:0042177 59 0.021
regulation of cellular amine metabolic process GO:0033238 11 0.021
vesicle mediated transport GO:0016192 371 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.021
oogenesis GO:0048477 2 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.021
regulation of cellular ketone metabolic process GO:0010565 50 0.020
nucleotide biosynthetic process GO:0009165 109 0.020
lipid biosynthetic process GO:0008610 177 0.020
modification dependent protein catabolic process GO:0019941 209 0.020
organophosphate catabolic process GO:0046434 430 0.020
protein modification by small protein conjugation GO:0032446 342 0.020
negative regulation of cellular catabolic process GO:0031330 83 0.020
cellular amine metabolic process GO:0044106 41 0.020
secretion GO:0046903 254 0.020
single organism membrane organization GO:0044802 268 0.019
locomotory behavior GO:0007626 1 0.019
cellular macromolecular complex assembly GO:0034622 324 0.019
nucleoside phosphate catabolic process GO:1901292 412 0.019
regulation of mitotic cell cycle GO:0007346 189 0.019
ribonucleoside triphosphate catabolic process GO:0009203 391 0.019
cellular protein complex assembly GO:0043623 188 0.019
nervous system development GO:0007399 293 0.019
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.019
ncrna metabolic process GO:0034660 108 0.019
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.019
ribonucleoside triphosphate metabolic process GO:0009199 412 0.018
cellular protein catabolic process GO:0044257 261 0.018
response to endoplasmic reticulum stress GO:0034976 49 0.018
intracellular protein transport GO:0006886 270 0.018
purine nucleoside triphosphate metabolic process GO:0009144 412 0.017
system process GO:0003008 349 0.017
epithelium development GO:0060429 227 0.017
regulation of cellular protein catabolic process GO:1903362 96 0.017
golgi vesicle transport GO:0048193 80 0.017
cytoplasmic transport GO:0016482 379 0.017
single organism cellular localization GO:1902580 332 0.017
plasma membrane organization GO:0007009 115 0.017
ras protein signal transduction GO:0007265 73 0.017
divalent metal ion transport GO:0070838 152 0.017
response to cytokine GO:0034097 232 0.017
regulation of cell differentiation GO:0045595 393 0.016
determination of adult lifespan GO:0008340 2 0.016
regulation of protein maturation GO:1903317 150 0.016
bone mineralization GO:0030282 34 0.016
microtubule cytoskeleton organization GO:0000226 176 0.016
guanosine containing compound metabolic process GO:1901068 244 0.016
regulation of nucleotide metabolic process GO:0006140 269 0.016
negative regulation of apoptotic process GO:0043066 316 0.016
small gtpase mediated signal transduction GO:0007264 78 0.016
regulation of cellular response to stress GO:0080135 244 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.016
purine nucleotide catabolic process GO:0006195 405 0.016
nucleoside triphosphate metabolic process GO:0009141 422 0.015
glycosyl compound catabolic process GO:1901658 413 0.015
ubiquitin dependent protein catabolic process GO:0006511 206 0.015
organophosphate biosynthetic process GO:0090407 163 0.015
cation transmembrane transport GO:0098655 238 0.015
nucleoside phosphate biosynthetic process GO:1901293 109 0.015
regulation of purine nucleotide metabolic process GO:1900542 264 0.015
energy derivation by oxidation of organic compounds GO:0015980 43 0.015
purine ribonucleotide catabolic process GO:0009154 404 0.015
secretion by cell GO:0032940 226 0.015
regulation of cell cycle GO:0051726 393 0.015
positive regulation of biomineral tissue development GO:0070169 20 0.014
segmentation GO:0035282 4 0.014
positive regulation of cellular component organization GO:0051130 376 0.014
regulation of cellular component movement GO:0051270 334 0.014
organic acid biosynthetic process GO:0016053 97 0.014
cellular response to dna damage stimulus GO:0006974 379 0.014
endomembrane system organization GO:0010256 196 0.014
regulation of nucleoside metabolic process GO:0009118 209 0.014
microtubule based process GO:0007017 210 0.014
nucleoside monophosphate catabolic process GO:0009125 159 0.014
positive regulation of cell proliferation GO:0008284 301 0.014
negative regulation of cell death GO:0060548 345 0.014
regulation of nucleotide catabolic process GO:0030811 205 0.014
gmp metabolic process GO:0046037 4 0.014
regulation of cell cycle phase transition GO:1901987 126 0.014
ribose phosphate biosynthetic process GO:0046390 82 0.013
regulation of purine nucleotide catabolic process GO:0033121 205 0.013
regulation of anatomical structure morphogenesis GO:0022603 286 0.013
regulation of cell cycle process GO:0010564 266 0.013
positive regulation of ossification GO:0045778 32 0.013
ion transmembrane transport GO:0034220 338 0.013
cellular chemical homeostasis GO:0055082 180 0.013
cofactor metabolic process GO:0051186 87 0.013
receptor mediated endocytosis GO:0006898 84 0.013
organelle fission GO:0048285 149 0.013
regulation of establishment of protein localization GO:0070201 242 0.013
nucleoside triphosphate catabolic process GO:0009143 394 0.013
oocyte differentiation GO:0009994 2 0.013
regulation of bone mineralization GO:0030500 29 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
mitotic cell cycle GO:0000278 326 0.013
negative regulation of cellular component organization GO:0051129 235 0.013
positive regulation of immune system process GO:0002684 283 0.013
purine nucleoside catabolic process GO:0006152 398 0.013
regulation of intracellular transport GO:0032386 195 0.013
purine ribonucleoside catabolic process GO:0046130 398 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
cation homeostasis GO:0055080 189 0.012
maintenance of location GO:0051235 112 0.012
reproduction GO:0000003 63 0.012
cellular response to cytokine stimulus GO:0071345 181 0.012
protein ubiquitination GO:0016567 314 0.012
cellular ion homeostasis GO:0006873 168 0.012
positive regulation of protein phosphorylation GO:0001934 313 0.012
leukocyte activation GO:0045321 164 0.012
oocyte development GO:0048599 1 0.012
immune response GO:0006955 307 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.012
negative regulation of transport GO:0051051 176 0.012
osteoblast differentiation GO:0001649 92 0.012
mitotic cell cycle process GO:1903047 286 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
ion homeostasis GO:0050801 230 0.012
carbohydrate derivative biosynthetic process GO:1901137 207 0.012
positive regulation of cell cycle process GO:0090068 106 0.012
atp metabolic process GO:0046034 176 0.012
regulation of protein transport GO:0051223 213 0.012
cell morphogenesis GO:0000902 296 0.012
apoptotic signaling pathway GO:0097190 268 0.011
regulation of ossification GO:0030278 58 0.011
cellular cation homeostasis GO:0030003 163 0.011
regulation of feeding behavior GO:0060259 3 0.011
cellular modified amino acid metabolic process GO:0006575 64 0.011
protein localization to membrane GO:0072657 160 0.011
neuromuscular junction development GO:0007528 3 0.011
cellular component morphogenesis GO:0032989 314 0.011
negative regulation of peptidase activity GO:0010466 91 0.011
regulation of kinase activity GO:0043549 314 0.011
negative regulation of catabolic process GO:0009895 104 0.011
regulation of atp metabolic process GO:1903578 29 0.011
chemical homeostasis GO:0048878 306 0.011
cell cycle phase transition GO:0044770 173 0.011
negative regulation of programmed cell death GO:0043069 321 0.011
cellular homeostasis GO:0019725 196 0.011
regulation of transferase activity GO:0051338 355 0.011
mapk cascade GO:0000165 288 0.011
phospholipid metabolic process GO:0006644 99 0.011
glycerophospholipid metabolic process GO:0006650 84 0.011
divalent inorganic cation transport GO:0072511 158 0.011
defense response GO:0006952 315 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
lens development in camera type eye GO:0002088 2 0.011
negative regulation of cellular protein catabolic process GO:1903363 38 0.011
positive regulation of phosphorylation GO:0042327 394 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.010
regulation of response to dna damage stimulus GO:2001020 94 0.010
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.010
regulation of osteoblast differentiation GO:0045667 38 0.010
negative regulation of intracellular signal transduction GO:1902532 183 0.010
response to axon injury GO:0048678 1 0.010
positive regulation of nucleotide catabolic process GO:0030813 185 0.010
glycerolipid biosynthetic process GO:0045017 51 0.010
amino acid activation GO:0043038 12 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.010
purine nucleotide biosynthetic process GO:0006164 84 0.010
cilium morphogenesis GO:0060271 75 0.010
regulation of biomineral tissue development GO:0070167 31 0.010
gtp metabolic process GO:0046039 239 0.010
protein oligomerization GO:0051259 173 0.010
rna processing GO:0006396 255 0.010
response to external biotic stimulus GO:0043207 261 0.010
regulation of locomotion GO:0040012 329 0.010
organelle assembly GO:0070925 176 0.010

EIF2D disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.056
inherited metabolic disorder DOID:655 242 0.055
carbohydrate metabolic disorder DOID:2978 55 0.022
urinary system disease DOID:18 40 0.015
central nervous system disease DOID:331 186 0.014
nervous system disease DOID:863 431 0.014
kidney disease DOID:557 36 0.013
musculoskeletal system disease DOID:17 223 0.012
neurodegenerative disease DOID:1289 102 0.012
bone disease DOID:0080001 88 0.011
connective tissue disease DOID:65 109 0.011